Now showing items 1-4 of 4
Estudo da atividade biológica do motivo ECD do domínio tipo-desintegrina da botropasina
(Universidade Federal de São Carlos, 2011-05-10)
Integrins are cell surface receptors that mediate cell adhesion and platelet aggregation, although they do part of important physiological processes in the organism, are also related pathologies such as tumorigenesis, ...
Planejamento de inibidores da cruzaína baseado em fragmentos
(Universidade Federal de São Carlos, 2011-07-27)
The Chagas disease, described in 1909 by the Brazilian sanitary physician, scientist and bacteriologist Dr. Carlos Chagas, is caused by the Trypanosomatid parasite Trypanosoma cruzi. Current treatments involve the use of ...
Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH
(Universidade Federal de São Carlos, 2011-08-11)
Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...
Terpenóides e seu metabolismo em fungos: um estudo de Scleroderma sp. e Xylaria sp.
(Universidade Federal de São Carlos, 2011-08-05)
In the present work, the lanostane triterpenes Lanosta-8,24-diene-3β,23-diol and Lanosta-8,23-diene-3β,25-diol were isolated from the basidiomycete Scleroderma sp., an extremely rich source of triterpenes and not ...