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Planejamento e avaliação de fragmentos moleculares como inibidores da enzima cruzaína
(Universidade Federal de São Carlos, 2015-08-24)
The available drugs for treating Chagas disease are not
effective, therefore the development of new therapies is needed. Cruzain is the major
Trypanosoma cruzi cysteine protease, the causative agent of the disease, and ...
Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH
(Universidade Federal de São Carlos, 2011-08-11)
Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...
Planejamento de inibidores da cruzaína baseado em fragmentos
(Universidade Federal de São Carlos, 2011-07-27)
The Chagas disease, described in 1909 by the Brazilian sanitary physician, scientist and bacteriologist Dr. Carlos Chagas, is caused by the Trypanosomatid parasite Trypanosoma cruzi. Current treatments involve the use of ...