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Clonagem e caracterização das isoformas de luciferases de lanternas e corpo gorduroso do vagalume Aspisoma lineatum (Lampyridae: Cratomorphini): origem estrutural e evolutiva das luciferases pH-sensitivas mais eficientes à partir de ancestrais pH-insensitivas
(Universidade Federal de São Carlos, 2020-10-31)
Firefly luciferases emit yellow-green light with high efficiency at physiological pH. However, under acidic conditions, in the presence of heavy metals or high temperatures, they emit red light. To understand the structural ...
Cistatinas de cana-de-açúcar: produção recombinante em vacúolos de cana-de-açúcar transgênica (e outros sistemas de expressão em plantas) e estudos de interação com uma pseudo protease do coleóptero Sphenophorus levis
(Universidade Federal de São Carlos, 2021-03-29)
Sphenophorus levis (Curculionidae: Coleoptera) is one of the major pests of sugarcane crop in Brazil and presents cysteine proteases as main digestive enzymes. In this project, we report the characterization of Sl-CathL-CS, ...
Estudo dos efeitos antiangiogênicos da desintegrina-símile Alternagina-C (ALT-C) em células endoteliais (HUVEC), tendo como alvo a integrina α2β1
(Universidade Federal de São Carlos, 2020-03-04)
Angiogenesis is a crucial process in tumor progression, and it is mainly regulated by the vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. Studies have shown that VEGF/VEGFR2 axis signaling is directly ...
Imunoterapia com IL-2 e TRAIL expressas por Salmonella recombinante contra o câncer de bexiga
(Universidade Federal de São Carlos, 2022-12-19)
IL-2 and TRAIL are therapeutic agents known for their antitumor role, but they can be rapidly
cleared by the body or be toxic, compromising their function. To reverse this impasse, the synthesis
of these agents by living ...
Papel da proteína Fbxo7 no perfil de citocinas produzidas em linhagem celular monocítica humana (THP-1) estimulada por lipopolissacarídeo
(Universidade Federal de São Carlos, 2021-05-24)
The canonical function of SCF E3 ubiquitin ligase complexes is the ubiquitination of their substrates, directing them to proteasomal degradation or modulation of function. From these complexes, F-box protein class is the ...
Efeito do tratamento com hidroxiureia sobre a expressão gênica de ATF4, MSN, PBXIPI e SNCA em pacientes com anemia falciforme e em células K562
(Universidade Federal de São Carlos, 2020-03-06)
Our study aimed to analyze the expression and protein content of four genes (ATF4, MSN, PBXIP1 and SNCA) by qPCR and Western Blotting in individuals with sickle cell anemia treated and not treated with hydroxyurea (HU) in ...
Análise funcional do gene que codifica xiluloquinase em Xanthomonas citri
(Universidade Federal de São Carlos, 2022-06-23)
Citrus canker causes a decrease in the productivity and quality of citrus fruits due to the lack of efficient control and eradication measures and is caused by the bacterium Xanthomonas citri subsp citri (XAC). In proteomics ...
Nova proposta didática para o ensino de biologia molecular na educação básica
(Universidade Federal de São Carlos, 2022-04-07)
The teaching of science and biology in basic education aims to provide minimum content so that individuals can deal with new information and are able to understand, question and position themselves in the face of ethical ...