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A integrina a2b1 na progressão tumoral mamária: papel no microambiente tumoral e na metástase
(Universidade Federal de São Carlos, 2019-08-23)
The harmonic functioning of cells involves an orchestrated synchronization of signaling that maintains the balance between proliferation and cell death in healthy tissues. Eventually, gene mutations can occur and the ...
Imunoterapia com IL-2 e TRAIL expressas por Salmonella recombinante contra o câncer de bexiga
(Universidade Federal de São Carlos, 2022-12-19)
IL-2 and TRAIL are therapeutic agents known for their antitumor role, but they can be rapidly
cleared by the body or be toxic, compromising their function. To reverse this impasse, the synthesis
of these agents by living ...
Citogenética comparativa em espécies de Hypostomus (Siluriformes, Loricariidae, Hypostominae). Contribuição da fração repetitiva do genoma para a diversidade cromossômica do grupo
(Universidade Federal de São Carlos, 2012-11-14)
Hypostomus is the widest genus of the armored catfishes in South America. This group presents a great diversity in color pattern and morphology, and shows not conservative chromosomal features. Different classes of repetitive ...
Estudos evolutivos em Auchenipteridae (Siluriformes): citogenética, DNA mitocondrial e DNA satélite
(Universidade Federal de São Carlos, 2013-02-04)
The neotropical freshwater fish fauna is the most diverse in the world, with more than 4.000 descrbed spcecies. In Brazil, about 2.500 species of freshwater fishes are considered valid, and the most formallyand a small ...
Papel da proteína Fbxo7 no perfil de citocinas produzidas em linhagem celular monocítica humana (THP-1) estimulada por lipopolissacarídeo
(Universidade Federal de São Carlos, 2021-05-24)
The canonical function of SCF E3 ubiquitin ligase complexes is the ubiquitination of their substrates, directing them to proteasomal degradation or modulation of function. From these complexes, F-box protein class is the ...
Efeito do tratamento com hidroxiureia sobre a expressão gênica de ATF4, MSN, PBXIPI e SNCA em pacientes com anemia falciforme e em células K562
(Universidade Federal de São Carlos, 2020-03-06)
Our study aimed to analyze the expression and protein content of four genes (ATF4, MSN, PBXIP1 and SNCA) by qPCR and Western Blotting in individuals with sickle cell anemia treated and not treated with hydroxyurea (HU) in ...
Genética populacional de felinos e as ameaças para Puma concolor: estruturação populacional recente e atropelamentos
(Universidade Federal de São Carlos, 2018-06-25)
Species around the world are increasingly exposed to new threats due to human activities. The main threat is the landscape modification by human activities, resulting in demographic and genetic pattern changes of species ...
Caracterização funcional parcial de dois genes de Xanthomonas citri potencialmente relacionados com a patogenicidade: XAC1006 (malato desidrogenase) e XAC0223 (proteína hipotética conservada)
(Universidade Federal de São Carlos, 2019-02-12)
The bacterium Xanthomonas citri subsp. citri (XAC) is the cause of citrus canker, a disease that affects many species of citric plants, causing drop in productivity and losses to producers. Many proteins have been detected ...
Análise funcional do gene que codifica xiluloquinase em Xanthomonas citri
(Universidade Federal de São Carlos, 2022-06-23)
Citrus canker causes a decrease in the productivity and quality of citrus fruits due to the lack of efficient control and eradication measures and is caused by the bacterium Xanthomonas citri subsp citri (XAC). In proteomics ...
Nova proposta didática para o ensino de biologia molecular na educação básica
(Universidade Federal de São Carlos, 2022-04-07)
The teaching of science and biology in basic education aims to provide minimum content so that individuals can deal with new information and are able to understand, question and position themselves in the face of ethical ...