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Identificação e clonagem de genes espécie-específicos de Leishmania infantum para expressão piloto de proteínas recombinantes com potencial para o diagnóstico de Leishmaniose Visceral
(Universidade Federal de São Carlos, 2023-02-16)
Leishmaniasis is a public health problem observed in several countries, being considered by the World Health Organization (WHO) one of the 10 neglected tropical diseases. It is caused by Leishmania parasites that affect ...
Ferramentas moleculares aplicadas ao estudo de parasitas emergentes em Leishmaniose visceral
(Universidade Federal de São Carlos, 2023-09-27)
Leishmaniases are neglected tropical diseases considered important to public health. Visceral Leishmaniasis (VL) is the most severe form of the disease, which affects organs such as spleen, bone marrow, liver and lymph ...
Mapeamento proteico da matriz do esmalte de incisivos de camundongos susceptíveis e resistentes à fluorose dentária
(Universidade Federal de São Carlos, 2015-08-12)
Enamel formation is a two-step complex process by which proteins are first secreted to forming an extracellular matrix, followed by massive protein degradation simultaneously with the completion of mineralization. Excessive ...
Caracterização fisiológica e avaliação do transcriptoma de linhagens de Saccharomyces cerevisiae termotolerantes isoladas durante a produção industrial de etanol
(Universidade Federal de São Carlos, 2022-12-02)
The use of thermotolerant yeast strains can improve productivity in the ethanol production process, allowing fermentation to occur at temperatures above 40°C. This characteristic can benefit, for example, the production ...
Expressão recombinante e ensaios de atividade de duas thaumatin-like proteins do Maqui (Aristotelia chilensis)
(Universidade Federal de São Carlos, 2022-10-24)
Thaumatin-like Proteins (TLP) are members of the Pathogenesis-Related Proteins family 5 (PR-5), and are present in fungi, plants and invertebrates. In plants, these proteins are involved both in the host’s defense, often ...
Efeito da microvibração sobre a produção in vitro de embriões bovinos
(Universidade Federal de São Carlos, 2022-11-07)
Much effort has been employed to improve the quality of embryos obtained by in vitro production (IVP) given the relevance of this technology to current livestock systems. In this context, dynamic IVP systems have been shown ...
Avaliação de três nanopartículas funcionais com atividade citotóxica para o tratamento do câncer de Bexiga
(Universidade Federal de São Carlos, 2022-04-20)
Bladder cancer is considered one of the most frequent neoplasms in the world. Although chemotherapy, surgery, immunotherapy and therapy have been accepted and practical methods for decades, they may not respond to due to ...
Identificação de ligantes e substratos do complexo E3 ubiquitina-ligase SCF(FBXL17)
(Universidade Federal de São Carlos, 2022-02-10)
Fbxl17 is one of the 69 F-box (Fbx) proteins in humans capable of interaction with SKP1,
Cullin 1 and Rbx1 to form the E3 ubiquitin ligase complex SCF(Fbxl17). The SCF(Fbxl17)
complex is the major class of human E3 ...
Cistatinas de maqui: produção recombinante e inibição de cisteíno peptidases
(Universidade Federal de São Carlos, 2022-02-15)
Cystatins are tight binding competitive inhibitors of cysteine peptidases. In plants, they act regulating different physiological mechanisms, as well as defending from biotic and abiotic stresses, making them of potential ...
Potencial antitumoral das proteínas TRAIL e IL-2 expressas e veiculadas por Salmonella Typhimurium atenuada em modelo de câncer colorretal
(Universidade Federal de São Carlos, 2019-10-14)
Colorectal cancer is the third most diagnosed malignant disease and the fourth leading cause of cancer-related deaths in the world. Cancer treatments are not fully effective and low selectivity to tumor tissue has marked ...