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Potencial antitumoral das proteínas TRAIL e IL-2 expressas e veiculadas por Salmonella Typhimurium atenuada em modelo de câncer colorretal
(Universidade Federal de São Carlos, 2019-10-14)
Colorectal cancer is the third most diagnosed malignant disease and the fourth leading cause of cancer-related deaths in the world. Cancer treatments are not fully effective and low selectivity to tumor tissue has marked ...
Estudo comparativo do efeito da temperatura na estabilidade e espectros de bioluminescência das luciferases de Phrixotrix hirtus e outros besouros bioluminescentes
(Universidade Federal de São Carlos, 2019-03-22)
Firefly luciferases have been extensively used as bioanalytical reagents and their cDNAs as reporter genes and bioimaging biosensors. Luciferases of fireflies, “rail-road” worm and "tec-tec" beetles, have different ...
Mecanismos de regulação da via de sinalização Wnt pela E3 ubiquitina ligase SCF(Fbxo7)
(Universidade Federal de São Carlos, 2019-02-22)
SCF complexes are composed by Skp1, Cullin1, Rbx1 and an F-box protein (FBP), which are responsible to give specificity to the complexes, as they interact with substrates, allowing ligation of an ubiquitin molecule to the ...
Evolução cromossômica e diversidade genética em espécies de peixes da família Arapaimidae (Teleostei: Osteoglossiformes)
(Universidade Federal de São Carlos, 2019-07-12)
The Neotropical region exhibits the largest diversity of freshwater fishes in the world and the demographic history of several taxa is related to the geomorphological and climatic history of this region. Among the ...
Identificação de redes gênicas de coexpressão e dos mecanismos regulatórios associados à composição mineral e qualidade de carne em bovinos
(Universidade Federal de São Carlos, 2019-10-11)
Meat quality and mineral composition are complex traits genetically regulated. Growing evidence suggests that minerals play a central role in regulatory and physiological functions related to meat tenderness and fat ...
Análises bioinformáticas de proteínas de resistência do tipo nucleotide binding site-leucine rich repeat (NBS-LRR) de café
(Universidade Federal de São Carlos, 2019-02-15)
The molecular factors involved in the coffee’s resistance to rust and other diseases have not been completely known, but related projects have been developed since the last century. One of the main problems that make ...
Validação de kit imunocromatográfico rápido para diagnóstico da Hepatite C
(Universidade Federal de São Carlos, 2019-09-17)
Hepatitis C is an infectious disease caused by the Hepatitis C Virus (HCV) and usually asymptomatic in the acute phase. Globally, an estimated 71 million people are infected with HCV and approximately 400,000 deaths happen ...
Inibidores de poligalacturonase (PGIPs) oriundos do feijão: produção recombinante e estudos funcionais
(Universidade Federal de São Carlos, 2019-03-01)
Pectic substances are components of the middle lamella of the plant cell wall and are composed of partially methyl-esterified galacturonic acid residues linked by α-1,4 glycosidic bonds. These substances are naturally ...
Identificação taxonômica, potencial agrícola e biotecnológico de bactérias endofíticas e rizosféricas associadas a Paspalum atratum e P. notatum
(Universidade Federal de São Carlos, 2019-08-02)
The genus Paspalum belongs to the family Poaceae and has several species native to Brazil. The Germplasm Bank of Paspalum of Embrapa Pecuária Sudeste has about 450 accessions of 50 species. Among the conserved accessions, ...
A integrina a2b1 na progressão tumoral mamária: papel no microambiente tumoral e na metástase
(Universidade Federal de São Carlos, 2019-08-23)
The harmonic functioning of cells involves an orchestrated synchronization of signaling that maintains the balance between proliferation and cell death in healthy tissues. Eventually, gene mutations can occur and the ...