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Efeito do knockout da Mitofusina 1 sobre a fertilidade de oócitos murinos
(Universidade Federal de São Carlos, 2018-08-31)
Fertility is directly related to oocyte developmental competence. In this context, oocyte mitochondria play a crucial role and have become an important target in assisted reproduction therapies. However, the molecular ...
Efeito do nocaute da mitofusina 2 sobre a mitocôndria, o retículo endoplasmático e a mitofagia em oócitos murinos
(Universidade Federal de São Carlos, 2018-08-24)
Mitofusins 1 (MFN1) and 2 (MFN2) are transmembrane GTPases present in the outer mitochondrial membrane and involved in the regulation of mitochondrial fusion. Since MFN2 is also present in the membrane of the endoplasmic ...
Impacto da deleção oócito-específica de Rad51 sobre o DNA mitocondrial e a divisão meiótica em murinos
(Universidade Federal de São Carlos, 2020-02-28)
RAD51 is a protein of eukaryotic organisms, with a central role in the DNA repair pathway by homologous recombination. Its function in the nucleus of somatic cells is well established, being necessary for the maintenance ...