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Imunoterapia com IL-2 e TRAIL expressas por Salmonella recombinante contra o câncer de bexiga
(Universidade Federal de São Carlos, 2022-12-19)
IL-2 and TRAIL are therapeutic agents known for their antitumor role, but they can be rapidly
cleared by the body or be toxic, compromising their function. To reverse this impasse, the synthesis
of these agents by living ...
Nova proposta didática para o ensino de biologia molecular na educação básica
(Universidade Federal de São Carlos, 2022-04-07)
The teaching of science and biology in basic education aims to provide minimum content so that individuals can deal with new information and are able to understand, question and position themselves in the face of ethical ...
Sítios cromossômicos instáveis e diversificação cariotípica em Loricariidae: análise citogenética e molecular
(Universidade Federal de São Carlos, 2022-07-15)
Loricariidae includes species vulgarly known as armored catfishes. Cytogenetic data revealed wide chromosomal diversity in this family, resulted from both diploid number (2n) variation, because of centric fusion events, ...
Caracterização de pontos de quebras de DNA e rearranjos cromossômicos no gênero Harttia (Siluriformes: Loricariidae)
(Universidade Federal de São Carlos, 2022-04-04)
Harttia genus comprises a fish group widely distributed in hydrographic basins of South
America. In the cytogenetic point of view, present large karyotypic variation, including
an extensive variation in position of ...
Papel das integrinas αvβ3 e α5β1 na migração de células de tumor de mama triplo negativo e células endoteliais em hipóxia
(Universidade Federal de São Carlos, 2022-04-14)
Breast tumors show high incidence and mortality for female oncologic cases in 2020. Tumor microenvironment presents several elements, such as extracellular matrix (ECM). ECM proteins bind to cells through receptors such ...
Avaliação de três nanopartículas funcionais com atividade citotóxica para o tratamento do câncer de Bexiga
(Universidade Federal de São Carlos, 2022-04-20)
Bladder cancer is considered one of the most frequent neoplasms in the world. Although chemotherapy, surgery, immunotherapy and therapy have been accepted and practical methods for decades, they may not respond to due to ...
Estratégias para o desenvolvimento de produtos contra o desgaste dentário erosivo por meio da engenharia de película adquirida com CaneCPI-5: translação das ciências básicas para a clínica
(Universidade Federal de São Carlos, 2022-09-30)
Currently, the scientific development of sugarcane-derived cystatin (CaneCPI-5) has gained strength in the control of erosive tooth wear (ETW). However, for this recombinant protein to be commercially used, it is important ...
Isolamento e caracterização de vB_XciM_LucasX, um novo bacteriófago lítico de Xanthomonas citri e Xanthomonas fuscans
(Universidade Federal de São Carlos, 2022-09-16)
Citrus canker, which is caused by the bacteria Xanthomonas citri and Xanthomonas fuscans, is one of the main diseases that affect the citrus industry in Brazil. Disease control methods are available, but new methods are ...
Identificação de ligantes e substratos do complexo E3 ubiquitina-ligase SCF(FBXL17)
(Universidade Federal de São Carlos, 2022-02-10)
Fbxl17 is one of the 69 F-box (Fbx) proteins in humans capable of interaction with SKP1,
Cullin 1 and Rbx1 to form the E3 ubiquitin ligase complex SCF(Fbxl17). The SCF(Fbxl17)
complex is the major class of human E3 ...
Caracterização funcional e bioquímica do fator de transcrição HsfA e estudo da termotolerância, composição lipídica e integridade da parede celular de Aspergillus fumigatus
(Universidade Federal de São Carlos, 2022-02-02)
The filamentous and saprophytic fungus Aspergillus fumigatus is the main causative pathogen of invasive pulmonary aspergillosis (API) in immunocompromised individuals. One of its most important determinants of virulence ...