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Ferramentas moleculares aplicadas ao estudo de parasitas emergentes em Leishmaniose visceral
(Universidade Federal de São Carlos, 2023-09-27)
Leishmaniases are neglected tropical diseases considered important to public health. Visceral Leishmaniasis (VL) is the most severe form of the disease, which affects organs such as spleen, bone marrow, liver and lymph ...
Mapeamento proteico da matriz do esmalte de incisivos de camundongos susceptíveis e resistentes à fluorose dentária
(Universidade Federal de São Carlos, 2015-08-12)
Enamel formation is a two-step complex process by which proteins are first secreted to forming an extracellular matrix, followed by massive protein degradation simultaneously with the completion of mineralization. Excessive ...
Caracterização fisiológica e avaliação do transcriptoma de linhagens de Saccharomyces cerevisiae termotolerantes isoladas durante a produção industrial de etanol
(Universidade Federal de São Carlos, 2022-12-02)
The use of thermotolerant yeast strains can improve productivity in the ethanol production process, allowing fermentation to occur at temperatures above 40°C. This characteristic can benefit, for example, the production ...
Avaliação de três nanopartículas funcionais com atividade citotóxica para o tratamento do câncer de Bexiga
(Universidade Federal de São Carlos, 2022-04-20)
Bladder cancer is considered one of the most frequent neoplasms in the world. Although chemotherapy, surgery, immunotherapy and therapy have been accepted and practical methods for decades, they may not respond to due to ...
Identificação de ligantes e substratos do complexo E3 ubiquitina-ligase SCF(FBXL17)
(Universidade Federal de São Carlos, 2022-02-10)
Fbxl17 is one of the 69 F-box (Fbx) proteins in humans capable of interaction with SKP1,
Cullin 1 and Rbx1 to form the E3 ubiquitin ligase complex SCF(Fbxl17). The SCF(Fbxl17)
complex is the major class of human E3 ...
Potencial antitumoral das proteínas TRAIL e IL-2 expressas e veiculadas por Salmonella Typhimurium atenuada em modelo de câncer colorretal
(Universidade Federal de São Carlos, 2019-10-14)
Colorectal cancer is the third most diagnosed malignant disease and the fourth leading cause of cancer-related deaths in the world. Cancer treatments are not fully effective and low selectivity to tumor tissue has marked ...
Caracterização funcional e bioquímica do fator de transcrição rlmA e da interação de PkcA e Hsp90 no fungo Aspergillus fumigatus
(Universidade Federal de São Carlos, 2017-12-18)
Aspergillus fumigatus is an opportunistic human pathogen that causes systemic infections, including invasive pulmonary aspergillosis in immunocompromised individuals. Survival of this fungus is highly dependent on the cell ...
Efeito modulador do extrato total do Paenibacillus polymyxa RNC-D em macrófagos e Leishmania (Leishmania) amazonensis in vitro
(Universidade Federal de São Carlos, 2018-04-20)
Leishmaniasis is an infection caused by Leishmania gender protozoa. The treatment of the disease is generally problematic, as the drugs used on clinical practice are toxic. One of the paths in the search for new therapeutic ...
Estudo comparativo do efeito da temperatura na estabilidade e espectros de bioluminescência das luciferases de Phrixotrix hirtus e outros besouros bioluminescentes
(Universidade Federal de São Carlos, 2019-03-22)
Firefly luciferases have been extensively used as bioanalytical reagents and their cDNAs as reporter genes and bioimaging biosensors. Luciferases of fireflies, “rail-road” worm and "tec-tec" beetles, have different ...
Cistatinas recombinantes de cana-de-açúcar : especificidade, produção em biorreator e conservação por liofilização
(Universidade Federal de São Carlos, 2018-03-02)
Phytocystatins are inhibitors of cysteine peptidases found naturally in plants.
Sugarcane cystatins are distinguished by their high inhibitory activity and possible
biotechnological applications. In this work, a comparative ...