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Clonagem e caracterização das isoformas de luciferases de lanternas e corpo gorduroso do vagalume Aspisoma lineatum (Lampyridae: Cratomorphini): origem estrutural e evolutiva das luciferases pH-sensitivas mais eficientes à partir de ancestrais pH-insensitivas
(Universidade Federal de São Carlos, 2020-10-31)
Firefly luciferases emit yellow-green light with high efficiency at physiological pH. However, under acidic conditions, in the presence of heavy metals or high temperatures, they emit red light. To understand the structural ...
Análise funcional do gene que codifica xiluloquinase em Xanthomonas citri
(Universidade Federal de São Carlos, 2022-06-23)
Citrus canker causes a decrease in the productivity and quality of citrus fruits due to the lack of efficient control and eradication measures and is caused by the bacterium Xanthomonas citri subsp citri (XAC). In proteomics ...
Estudos evolutivos em Auchenipteridae (Siluriformes): citogenética, DNA mitocondrial e DNA satélite
(Universidade Federal de São Carlos, 2013-02-04)
The neotropical freshwater fish fauna is the most diverse in the world, with more than 4.000 descrbed spcecies. In Brazil, about 2.500 species of freshwater fishes are considered valid, and the most formallyand a small ...
Cistatinas de cana-de-açúcar: produção recombinante em vacúolos de cana-de-açúcar transgênica (e outros sistemas de expressão em plantas) e estudos de interação com uma pseudo protease do coleóptero Sphenophorus levis
(Universidade Federal de São Carlos, 2021-03-29)
Sphenophorus levis (Curculionidae: Coleoptera) is one of the major pests of sugarcane crop in Brazil and presents cysteine proteases as main digestive enzymes. In this project, we report the characterization of Sl-CathL-CS, ...
Estudo dos efeitos antiangiogênicos da desintegrina-símile Alternagina-C (ALT-C) em células endoteliais (HUVEC), tendo como alvo a integrina α2β1
(Universidade Federal de São Carlos, 2020-03-04)
Angiogenesis is a crucial process in tumor progression, and it is mainly regulated by the vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. Studies have shown that VEGF/VEGFR2 axis signaling is directly ...
A integrina a2b1 na progressão tumoral mamária: papel no microambiente tumoral e na metástase
(Universidade Federal de São Carlos, 2019-08-23)
The harmonic functioning of cells involves an orchestrated synchronization of signaling that maintains the balance between proliferation and cell death in healthy tissues. Eventually, gene mutations can occur and the ...
Nova proposta didática para o ensino de biologia molecular na educação básica
(Universidade Federal de São Carlos, 2022-04-07)
The teaching of science and biology in basic education aims to provide minimum content so that individuals can deal with new information and are able to understand, question and position themselves in the face of ethical ...
Citogenética comparativa em espécies de Hypostomus (Siluriformes, Loricariidae, Hypostominae). Contribuição da fração repetitiva do genoma para a diversidade cromossômica do grupo
(Universidade Federal de São Carlos, 2012-11-14)
Hypostomus is the widest genus of the armored catfishes in South America. This group presents a great diversity in color pattern and morphology, and shows not conservative chromosomal features. Different classes of repetitive ...
Imunoterapia com IL-2 e TRAIL expressas por Salmonella recombinante contra o câncer de bexiga
(Universidade Federal de São Carlos, 2022-12-19)
IL-2 and TRAIL are therapeutic agents known for their antitumor role, but they can be rapidly
cleared by the body or be toxic, compromising their function. To reverse this impasse, the synthesis
of these agents by living ...
Identificação e clonagem de genes espécie-específicos de Leishmania infantum para expressão piloto de proteínas recombinantes com potencial para o diagnóstico de Leishmaniose Visceral
(Universidade Federal de São Carlos, 2023-02-16)
Leishmaniasis is a public health problem observed in several countries, being considered by the World Health Organization (WHO) one of the 10 neglected tropical diseases. It is caused by Leishmania parasites that affect ...