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Efeito modulador do extrato total do Paenibacillus polymyxa RNC-D em macrófagos e Leishmania (Leishmania) amazonensis in vitro
(Universidade Federal de São Carlos, 2018-04-20)
Leishmaniasis is an infection caused by Leishmania gender protozoa. The treatment of the disease is generally problematic, as the drugs used on clinical practice are toxic. One of the paths in the search for new therapeutic ...
Isolamento e caracterização de cepas termotolerantes de Saccharomyces cerevisiae e análise da expressão de genes possivelmente envolvidos com a termotolerância
(Universidade Federal de São Carlos, 2018-03-28)
Brazil is the world’s second largest producer of ethanol, which is produced, in our country, from the fermentation of sugarcane sucrose by Saccharomyces cerevisiae yeast. Despite having a high capacity for ethanol production, ...
Produção heteróloga de inibidores de pectina metil esterase (PMEI), para ensaios de inibição com PME e Invertase, enzimas intestinais do Sphenophorus levis
(Universidade Federal de São Carlos, 2018-02-20)
The pectin is a fundamental part of the cell wall from plants and it is composed mainly by 4 polysaccharides. The polysaccharide most abundant is the homogalacturonan (HG) representing up to 65% from pectin, and it is a ...
Comparação da capacidade de formulações medicamentosas de diferentes quimioterápicos em induzir morte celular em células da linhagem MB49 de tumor de bexiga murino
(Universidade Federal de São Carlos, 2018-03-29)
Despite recent advances in cancer prevention and treatment, bladder urothelial carcinoma continues to be one of the most common types of malignant neoplasms in the world, with a 20% mortality rate. The cells and molecules ...
Efeito do knockout da Mitofusina 1 sobre a fertilidade de oócitos murinos
(Universidade Federal de São Carlos, 2018-08-31)
Fertility is directly related to oocyte developmental competence. In this context, oocyte mitochondria play a crucial role and have become an important target in assisted reproduction therapies. However, the molecular ...
Avaliação de potenciais antígenos vacinais e geração de aptâmeros por cell-SELEX em Erysipelothrix rhusiopathiae
(Universidade Federal de São Carlos, 2018-02-28)
Erysipelothrix rhusiopathiae is a Gram-positive bacterium that causes the disease known as swine erysipelas. Available veterinary vaccines against the disease have several limitations and methods for detecting the bacterium ...
Análise e contribuições para o ensino de biologia molecular em um município do interior paulista
(Universidade Federal de São Carlos, 2018-10-01)
Currently the number of works that seek to understand the difficulties involved in the teaching and learning process in Biology field, more specifically in the Molecular Biology subfield, has been grown exponentially. Such ...
Cistatinas recombinantes de cana-de-açúcar : especificidade, produção em biorreator e conservação por liofilização
(Universidade Federal de São Carlos, 2018-03-02)
Phytocystatins are inhibitors of cysteine peptidases found naturally in plants.
Sugarcane cystatins are distinguished by their high inhibitory activity and possible
biotechnological applications. In this work, a comparative ...
Degradação de matéria orgânica terrestre por microrganismos do rio Amazonas – Metagenômica e genômica populacional
(Universidade Federal de São Carlos, 2018-12-14)
Microbes from Amazon river basin represent an unexplored biodiversity, with a huge metabolic potential. This ecosystem receives large amounts of terrestrial organic matter (OM), which promotes heterotrophic microbial growth. ...
Efeito do nocaute da mitofusina 2 sobre a mitocôndria, o retículo endoplasmático e a mitofagia em oócitos murinos
(Universidade Federal de São Carlos, 2018-08-24)
Mitofusins 1 (MFN1) and 2 (MFN2) are transmembrane GTPases present in the outer mitochondrial membrane and involved in the regulation of mitochondrial fusion. Since MFN2 is also present in the membrane of the endoplasmic ...