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Síntese e caracterização de complexos de Prata (I): investigação da citotoxidade e interação com o DNA
(Universidade Federal de São Carlos, 2020-06-23)
The inorganic compound, cisplatin, is used on a large scale to different types of cancer. This complex acts in DNA structure by covalent bonds. However, the chemotherapy agent presents several side effects and some tumors ...
Sensores nanoestruturados compostos por nanofibras de dióxido de titânio modificadas com polímeros condutores visando monitoramento de compostos orgânicos voláteis
(Universidade Federal de São Carlos, 2020-03-18)
The growth of urbanization and anthropogenic activities have been increasing the emission of polluting gases in the atmosphere. Considering the high toxicity of some of these gases, it becomes necessary to develop new ...
Tetra(tien-2-il)porfirina e seus complexos com metais da primeira-série de transição: síntese, caracterização, investigação da citotoxicidade e interação com DNA
(Universidade Federal de São Carlos, 2020-07-21)
Cancer is a generic term for over 100 diseases with uncontrolled cell growth. Each year, all cancer forms are responsible for millions of deaths worldwide and are the leading cause of deaths linked to disease. Therefore, ...
Influência da estrutura de estanhossílicas mesoporosas na isomerização da glicose
(Universidade Federal de São Carlos, 2020-10-30)
The use of biomass in order to obtain chemicals and fuels that can substitute the fossil matrix has been investigated and treated with high interest. This way, the research in catalysis becomes essential to overpass barriers ...
Estudos teóricos e experimentais de complexos de cobre: propriedades espectroscópicas e atividade biológica
(Universidade Federal de São Carlos, 2020-07-28)
Cancer is the second leading cause of death in the world. The scientific community is mobilizing to study new compounds with cytotoxic potential and that can be used as molecular probes. However It is important to highlight ...
Calibração multivias em Laser-Induced Breakdown Spectroscopy (LIBS) para determinação de Ca, K e Mg em amostras de suplemento mineral para humanos
(Universidade Federal de São Carlos, 2021-03-25)
This work intends to present a new approach for modeling LIBS data resolved in time using multiway algorithms, aiming to achieve the advantage of second order. The algorithms evaluated in this study were: Multivariate Curve ...
Planejamento experimental aplicado aos estudos de degradação forçada do fármaco Ticagrelor
(Universidade Federal de São Carlos, 2020-08-31)
Stability indicating tests are an essential part during pharmaceutical drug production, besides being a mandatory step for the regulation and approval from the regulatory agencies. Forced degradation consist of an exposure ...
Estudo espectroscópico por FTIR da conversão de etanol em catalisadores de Au suportados
(Universidade Federal de São Carlos, 2020-07-25)
In this work, an FTIR spectroscopic study of gold catalysts supported on monoclinic zirconia (with Au content of 2,5% w/w), was carried out in order to elucidate the surface nature of this catalyst in the dehydrogenation ...
Avaliação in vitro da ação fotodinâmica antimicrobiana e antitumoral do complexo cis-[Ru(phen)2(pPDIp)]2+
(Universidade Federal de São Carlos, 2021-02-19)
Photodynamic therapy (PDT) activates a photosensitizer by visible or infrared light to generate cytotoxic oxygen species that lead to cell death. PDT is generally used in applications in superficial lesions and can be used ...
Imagens espectrais do processo de agregação da insulina por complexos metálicos luminescentes
(Universidade Federal de São Carlos, 2021-03-01)
Insulin is a protein hormone synthesized by β cells in the pancreas, which regulates the level of glucose in the blood. This protein was the first biopharmaceutical produced on an industrial scale for the treatment of ...