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Avaliação in vitro da ação fotodinâmica antimicrobiana e antitumoral do complexo cis-[Ru(phen)2(pPDIp)]2+
(Universidade Federal de São Carlos, 2021-02-19)
Photodynamic therapy (PDT) activates a photosensitizer by visible or infrared light to generate cytotoxic oxygen species that lead to cell death. PDT is generally used in applications in superficial lesions and can be used ...
Imagens espectrais do processo de agregação da insulina por complexos metálicos luminescentes
(Universidade Federal de São Carlos, 2021-03-01)
Insulin is a protein hormone synthesized by β cells in the pancreas, which regulates the level of glucose in the blood. This protein was the first biopharmaceutical produced on an industrial scale for the treatment of ...
Avaliação da atividade citotóxica de complexos fosfínicos de Ru(II) com ligantes mercaptos e aciltioureias
(Universidade Federal de São Carlos, 2020-12-11)
In this thesis, two series of new Ru-phosphine complexes containing mercapto or acylthiourea ligands were synthesized, characterized and assessed their cytotoxic activities. The first series is composed of five complexes ...
Síntese de complexos de Mg(II), atividade antioxidante e citotóxica
(Universidade Federal de São Carlos, 2021-03-09)
The objective of this work was to develop metal complexes containing natural products that have antioxidant activity to be applied in the cosmetics sector. For that, 3 [Mg(phen)2PN]+ metal complexes were synthesized and ...
Evaluation of the biological activity of the disintegrin-like and cysteine-rich domains of Bothropasin, a metalloproteinase from Bothrops jararaca
(Universidade Federal de São Carlos, 2021-05-17)
Bothropasin is a 48kDa hemorrhagic class III Snake Venom Metalloproteinase (SVMP). As a multi-domain protein, it contains catalytic metalloproteinase (M), disintegrin-like (D), and cysteine rich domains (C). Integrins ...
Estudo fitoquímico biomonitorado de Duguetia lanceolata e Lithraea molleoides no controle de pragas agrícolas e processos de nanoencapsulamento
(Universidade Federal de São Carlos, 2016-04-29)
Leafcutter ants and maize weevil are responsible for great losses in Brazilian agriculture due to the difficult control of these pests. Natural products are becoming increasingly important, mainly in the search for non-toxic ...
Determinação de Si e Y em amostras agronômicas por espectrometria de emissão óptica com plasma induzido por micro-ondas
(Universidade Federal de São Carlos, 2021-05-20)
Different demands for analytical responses are presented in agricultural research. In this approach, this dissertation, divided into two chapters, seeks to offer analytical alternatives for plant breeding and fish nutrition ...
Desenvolvimento de biossensores eletroquímicos baseados em acetilcolinesterase visando identificar extratos e substâncias para o controle de formigas cortadeiras
(Universidade Federal de São Carlos, 2019-10-31)
Brazil, which is a continental country, has an appropriate climate for various agricultural practices. Insects, in general, are considered pests for agricultural areas, among them, an Atta sexdens rubropilosa (leafcutter ...
Eletrodo de pasta de carbono modificado com solvente eutético profundo hidrofóbico e sua aplicação voltamétrica
(Universidade Federal de São Carlos, 2021-03-01)
In this work, the use of hydrophobic deep eutectic solvent was proposed for the modification of carbon paste electrodes. Different HDES were prepared using fatty acids: octanoic, decanoic, and dodecanoic acids, and ...
Desenvolvimento de eletrodo modificado com o solvente eutético profundo cloreto de colina/glicerol para a determinação simultânea de paracetamol e diclofenaco
(Universidade Federal de São Carlos, 2021-04-22)
In this master’s dissertation has investigated the use of deep eutectic solvents (DES) for the development of electrochemical sensors. DES was immobilized on the surface of a glassy carbon electrode (GCE) within carbon ...