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Efeito do fluoreto de sódio sobre a qualidade óssea das vértebras lombares de ratas ovariectomizadas
(Universidade Federal de São Carlos, 2004-06-16) Villar, Lidiângela Dias; Nonaka, Keico Okino; https://lattes.cnpq.br/4551036775738296
Osteoporosis is characterised by a reduced bone mass, followed by microstructural changes in the bone tissue, which increase the susceptibility to bone fractures. This pathology is most commonly found in women after menopause, being responsible for severe social and economic consequences. The use of fluoride has demonstrated the possibility to increase bone mass, especially of the axial skeleton. However, its effects on the bone quality are still controversial. The aim of this work was to investigate the effects of fluoride, as sodium fluoride (NaF), on bone tissue of ovariectomized rats (Ovx), which were used as an experimental model for osteoporosis, through the analysis of biomechanical, physical and biochemical parameters of the lumbar vertebrae. Wistar female rats of four-month age were divided in the following experimental groups: Baseline (sacrificed at the beginning of the experiment); Intact; Ovx; Ovx + 20, 40, 60, 80 and 100 ppm of NaF, delivered in drinking water. These groups were sacrificed after different periods of time (4, 6, and 8 months). Biometrical, biomechanical, physical and biochemical parameters of the vertebral body (L5) of the animals were measured, together with the fluoride content of the right tibia. Fluoride content present in the right tibia showed a good numerical correlation with the administered dosage for the three different periods of treatment. The ovariectomy promoted a higher body weight gain, and also, a decrease in the values of the biomechanical, physical and biochemical parameters of the vertebral body of the animals for all the periods analysed. Treatment using fluoride at high dosage levels (60, 80, and 100 ppm of NaF) resulted in an increase of bone mass, for the periods of 4 and 8 month of treatment. However, this increase did not induce a higher mechanical resistance of the bones, although at low dosages, 20 and 40 ppm, administered during a 6-month period, a protective effect on the bone tissue was observed, thus preventing a decrease in the biomechanical parameters induced by ovariectomy. As a conclusion, this study showed that low dosages of fluoride can act as a promising therapeutic agent for the prevention of human postmenopausal osteoporosis.
Jovens em movimento: o processo de formação da Pastoral da Juventude do Brasil.
(Universidade Federal de São Carlos, 2004-06-16) Sofiati, Flávio Munhoz; Freston, Paul Charles
The object of this research is the formation process of the PJB, be it, its pedagogic method and its political options. The analysis is developed from a historical background in order to identify the changes occurred in the PJB method along the 1980 and 1990 decades. We can conclude that, during the 1980s, the PJB emphasized the political dimension in its formation activities and participated in several social movements, which were being organized around the proposal of Brazilian redemocratization. However, along the 1990s a reformulation of the method occurs and it passes to direct its formation to the personal and theological dimensions, having its practice turned to the inside of the Catholic Church. Internal factors, such as the back of Pentecostal movement to the catholic religious scenery, which has represented some drawbacks to the PJB articulation with the parish youth groups, as well as external factors, such as the arrival of the postmodern culture to the Brazilian society, which has brought the predominance for individualist practices, be it, without collective/communitarian basis, both contributed to these changes.