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A Faculdade de Medicina de Ribeirão Preto - USP (1948 - 1975)
(Universidade Federal de São Carlos, 2007-03-12) Araújo, Marcelo José; Nosella, Paolo; https://lattes.cnpq.br/7159165045266256; https://lattes.cnpq.br/2567470400482142
This work carries through a historical survey of the creation process, installation and development of the Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP) in the period from 1948 the 1975. Part of its ampler historical context until the its more specific approach, that is, to its constituent characteristics, elements and, over all, to its social meaning. The text initiates approaching the historical antecedents of the medicine in Brazil in the end of century XIX and the beginning of the XX, giving has detached to the controls of the endemic diseases and its protagonists, the creation of the Faculdade de Medicina de São Paulo and the necessity of installation of a College of Medicine in the interior of the state of São Paulo. After that, it approaches the circumstances of the creation, installation and of the developing of the FMRP, detaching the didactic structure of the course, the faculty, the student body, the employees, the first university entrance examination, your discipline them and the departments, the developed research, the Hospital of the Clinics etc. These circumstances meet inserted in the First Part of the work. In the Second Part, in turn, are characterized and analyzed some considered problems important to help to better understand the relation between the FMRP and the society that produced it and it molded it. Beginning all this historical survey, the Theoretical Reference whose estimated beddings and had given support to the research; after all, as well as a teacher conducts an orchestra searching harmony between its integrant ones, the theoretical reference served as guide maker for the success of the set.
Avaliação da velocidade de cisalhamento média em biorreator convencional tipo tanque agitado e aerado
(Universidade Federal de São Carlos, 2007-03-12) Campesi, Alexandre; Badino Júnior, Alberto Colli; https://lattes.cnpq.br/1087619912727132
In biochemical processes, shear rate ( γ&) in the system is an important variable on design and operation of bioreactors. Shear can result in damage to the cells and the microorganisms, taking to the viability loss and even to the cellular breaking and the microbial death. In the present work was proposed a methodology to quantify average shear rate ( av γ & ) in stirred bioreactor with a 4 L working volume, through volumetric oxygen transfer coefficient (kLa), varying the operating conditions, as the impeller rotational speed (N: 600, 700, 800, 900 and 1000 rpm) and the specific air flow rate (Φar: 0.50 and 1.00 vvm). Five different glycerol solutions and distilled water were utilized as Newtonian fluids and six different xantham gum solutions were utilized as non-Newtonian fluids. Dynamic viscosity (µ) of the glycerol solutions and rheological parameters (K, n) for the xantham gum solutions, were determined at 28ºC from rheograms using a digital concentric-cylinders rheometer. Based on the obtained results, a correlation for average shear rate ( av γ & ) as function of the impeller rotational speed (N), rheological parameters (K, n) and volumetric oxygen transfer coefficient (kLa) was proposed. The correlation obtained for the average shear rate ( av γ & ) showed appropriate to estimate av γ & , because the estimated values approximated of others values described in literature for another correlations. In a second stage, four cultivations of Streptomyces clavuligerus ATCC 27064 was realized in a stirred bioreactor, aerated 0.50 vvm and agitated in 700, 800, 900 and 1000 rpm. Process variable values, as consistency index (K), flow index (n), cellular concentration (Cx), glicerol concentration (CGlic) and 2 CO n& produced ag of the cultivations were evaluated. It was observed that the consistency index (K), flow index (n) and cellular concentration (Cx) varied due to shear conditions imposed to the cultivations. Finally, based on experimental literature results, average shear rate ( av γ & ) was determined in function of the time for cultivation of S. clavuligerus in stirred bioreactor for 600, 800 and 1000 rpm and specific air flow rate (Φar) of 0.50 vvm, using the proposed methodology, the obtained values were more consistent, because the experimental values of kLa were obtained by gaseous balance.