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Uso de métodos clássicos e bayesianos em modelos de regressão beta
(Universidade Federal de São Carlos, 2007-05-18) Reitman, Diomedes Pael; Diniz, Carlos Alberto Ribeiro; https://lattes.cnpq.br/3277371897783194; https://lattes.cnpq.br/0290791444723891
This work involves a study of a regression model appropriated for situations which the response variable is measured in a continuous scale in the (0, 1) interval, as, for instance, taxes or proportions. The developed inferences were based on the Classic and Bayesian methodology. A discussion about the application of the beta regression model is presented.
Estudo do mecanismo eletroforético de coleta na filtração de aerossóis
(Universidade Federal de São Carlos, 2007-05-18) Mello, Rafael Lopes Seabra de; Gonçalves, José Antônio Silveira; https://lattes.cnpq.br/0337997526924402; https://lattes.cnpq.br/8445153978573450
Previous works have shown that the presence of electrostatic forces in particles significantly affect the performance of a filter, both increasing collection efficiency and reducing pressure drop. Recently, in the Environmental Control research group of the Chemical Engineering Department of UFSCar, Rodrigues (2005) have studied the filtration of electric charged phosphate rock particles in polypropylene filter, observing the influence of the charge acquired by the particles in collection efficiency and pressure drop. The aim of the present work is to analyze the particle trajectory during filtration and the contribution level of each collect mechanism present in the process, in order to theoretically detail the results obtained by Rodrigues (2005) and propose a model for the electrophoretic mechanism of collection that better fit in experimental data.
Síntese de ácidos anacárdicos e análogos, candidatos a inibidores da enzima gliceraldeido-3-fosfato desidrogenase glicossomal de Trypanosoma cruzi
(Universidade Federal de São Carlos, 2007-05-18) Pereira, Junia Motta; Corrêa, Arlene Gonçalves; https://lattes.cnpq.br/7425467156776144; https://lattes.cnpq.br/6882588789482791
Chagas disease, caused by Trypanosoma cruzi, is endemic in 15 countries in Latin America, including Brazil, and it is estimated that about 16 million people are infected by this protozoan. The enzyme glyceraldehyde-3- phosphato-dehydrogenase (gGAPDH) is one of the nine enzymes involved in the T. cruzi glycolysis and experimentally it was proved that inhibition of this metabolic pathway causes the elimination of trypanosomes in the bloodstream. Among several natural products that have presented interesting inhibitory activity against this enzyme are the anacardic acids, isolated from cashew-nut shells. Many biologic and/or pharmacologic properties have been described for this class of compounds. In this work a serie of anacardic acids and analogues were synthetized and their biological activity evaluated . In total, 23 compounds were prepared and evaluated against T. cruzi gGAPDH and Schistossoma mansoni purine nucleoside phosphorylase (PNP) enzymes. In both cases the most active compound was 6-n-decylsalicylic acid with IC50 of 55 and 30 M respectively. Through the analysis of the experimental results together with the molecular dock studies, it was possible to observe that the size and substituents of alkyl side chain in these compounds can influence the inhibitory activity and the free hydroxyl groups in the ring are essential for the activity.