Navegando por Data de Publicação, começando com "2012-09-04"

Filtrar resultados por ano ou mês

Agora exibindo 1 - 2 de 2

Avaliação pancreática de animais submetidos à dieta hiperlipídica
(Universidade Federal de São Carlos, 2012-09-04) Pisani, Graziéle Fernanda Deriggi; Leal, Ângela Merice de Oliveira; https://lattes.cnpq.br/7202663545989206; https://lattes.cnpq.br/4835384433555310
The pathogenesis of type 2 diabetes mellitus (DM2) is associated with insulin resistance (IR) and pancreatic β cells (β cells) defect. Adipose tissue modulates metabolism by releasing free fatty acids (FFA), glycerol, pro-inflammatory cytokines, chemokines and hormones. The increased production of most of these factors compromises insulin action in target organs, leading to IR. The lack of β cell adaptation to IR leads to hyperglycemia and DM2. The mechanisms of β cell adaptation are not well established. The objective of the present study was to evaluate the morforlogical and functional patterns of the progression of IR and DM2 development in an animal model of obesity and DM2. Swiss mice were divided into two groups: control (C), received standard diet; HFD group, received high-fat diet. Glucose (GTT) and insulin (ITT) tolerance tests were performed tests at 3, 7, 11 and 15 weeks of diet regimen. Animals of both groups were sacrificed by decaptation at 4, 8 and 16 weeks of diet regimen and pancreatic tissue was analysed. Fasting glycemia and GTT and ITT responses were significantly different in HFD from C group. Immunohistochemical analysis showed that islets area increased and insulin expression decreased in islets of HFD group compared with C group. The expression of the anti-apoptotic factor, Bcl-2, and the concentration of the citokines, TNF-α (factor tumor necrosis factor-α) and IL-1β (interleukin-1β) determinated in pancreatic homogenate by ELISA were not different in the groups. The results indicate that high-fat diet regimen induces pancreatic morphological and functional derangements associated with the development of DM2 in swiss mice. The study also suggests that TNF-α, IL-1β and Bcl-2 are not involved in the pathogenesis of DM2 in this model.
A regulação social do trabalho em sistemas ERP
(Universidade Federal de São Carlos, 2012-09-04) Ponce, Ana Maria Carlos; Camarotto, João Alberto; https://lattes.cnpq.br/1427853773681255; https://lattes.cnpq.br/2391828882949322
The ERP - Enterprise Resource Planning is considered one of the most important strategies for organizations in a business scenario that reconfigures itself permanently. Most researches on this subject follows a pragmatic-interventionist orientation, predominantly, with an approach oriented to identify practices that could improve the results of ERP implementations for a series of organizational actors and few attentions has been directed to aspects of the regulation of work in the ERP environment. In this perspective, this work aims to verify how the regulation of activity by agents that interact directly with the ERP system occurs. The study was developed with the presupposition of the Theory of Organizational Act of Maggi, on three core issues: the transformation of task, coordination and cooperation. Other issues relevant to the study were addressed as the Ergonomics of the Activity. We performed a qualitative, descriptive research. For the stated purpose it was defined as a technical procedure of research the study of multiple cases. The choice of the companies fell upon those companies that adopted ERP system in the area of Planning and Production Scheduling, in different sectors of activities and that expressed a willingness to participate. With respect to data collection it were used multiple techniques: documentary, interviews and observation. The results showed that the ERP system does not include the variability of the production system and that the agents regulate the activity through the use of other tools.