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O trabalho nas cozinhas de unidades escolares: impactos sobre a saúde das merendeiras em escola municipal de São Carlos
(Universidade Federal de São Carlos, 2013-09-14) Coimbra, Fabiano Bueno; Camarotto, João Alberto; https://lattes.cnpq.br/1427853773681255; https://lattes.cnpq.br/5183162360533455
This work aims to understand the activity of people who work in food preparation at school from an understanding of the factors that influence and determine that work. The need arose from the demand of the city of São Carlos, which identified several problems faced by employees who perform the function of cook staff, problems that resulted in several complaints and absenteeism due to health problems in developing the activities and productivity. As a working methodology a case study was used through a set of data collected from a municipal school unit of São Carlos, and using methodological fundamentals of Ergonomic Work Analysis, the presented work situation was analyzed based on the fundamentals of ergonomics and situated criteria workplaces. The results are expected to generate a set of inferences and knowledge in order to serve as a basis for designing and dimensioning units of food and nutrition in public schools.
Síntese e avaliação da atividade biológica de alcaloides e derivados n-heterociclos
(Universidade Federal de São Carlos, 2013-09-14) Duarte, Patricia Domingos; Corrêa, Arlene Gonçalves; https://lattes.cnpq.br/7425467156776144; https://lattes.cnpq.br/7086364518205814
4-Quinolinone derivatives and hydantoins are important classes of cyclic nitrogen compounds which have very interesting biological activity against a variety of biological targets. Phytochemical studies of plants of the genus Dictyoloma, guided by in vitro bioassays, led to the isolation of three new 4-quinolinone alkaloids, the dictyolomides A and B and 6- methoxydictyolomide, which showed good activity against Leishmania. The absolute configuration of the natural dictyolomides is still unkown. This work aimed the asymmetric synthesis of these alkaloids. In order to introduce the enantiomeric enriched side chains in the 4-quinolinone core, some synthetic routes have been tested employing organometallic chemistry, among other techniques. A series of 4-quinolinone derivatives was also synthesized, using methods described in the literature, especially the one described by Ding et al., in which it uses microwave irradiation. The study of the synthesis of hydantoin derivatives was also performed using microwave irradiation as a source of energy. New organocatalysts were tested in order to obtain new amino acid derivatives which would be employed as starting materials in the synthesis of hydantoins. The synthesized compounds were submitted to bioassays focus on antiparasitic activity and enzyme inhibition. The result obtained with 4- quinolinone derivatives against proliferation of Leishmania amazonensis promastigotes and epimastigotes of Trypanosoma cruzi showed that the compounds possess in general better leishmanicidal than trypanocidal activity. Nevertheless, two of the synthesized compounds showed an excellent trypanocidal activity, even better than the standard, benznidazole. The 4- quinolinones have also shown good inhibitory activity against cathepsin L and V enzymes.