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Evolução molecular das luciferases das lanternas da fase adulta e larval de elaterídeos luminescentes e filogenia molecular de Elateroidea
(Universidade Federal de São Carlos, 2014-10-01) Amaral, Danilo Trabuco do; Viviani, Vadim; https://lattes.cnpq.br/3942043373510668; https://lattes.cnpq.br/1962677068147121
The origin and evolution of Elateridae bioluminescence is uncertain, especially the evolution of the luciferases of different phases and lanterns of Elateridae, the relationship between structure and bioluminescence spectra and the phylogeny of neotropical species. In this study, the cDNA containing the genes of Fulgeochlisus bruchi and Pyrophorus angustus luciferases, which presente different kinetic characteristics, such as high pH optimum and a high affinity for ATP and Luciferin, were cloned. Analyses of Elateridae luciferases suggest that, regardless of the stage of life or organ (dorsal or ventral lanterns), these luciferases displayed a higher identity degree to the luciferases that present closer bioluminescence spectra, probably, due to intergenetic recombination effects. The luciferase primary sequences alignments and site-directed mutagenesis studies suggested important residues to modulate color in Elateridae, such as S247. Our phylogenetic analyzes indicated a closer relationship between Elateridae and Phengodidae, however there are diverngence between the markers used. The sequencing of mitochondrial genomes showed that the Phengodidae genomes displayed several rearrangements and gene duplication, indicating the need for further studies on this family. Our data also suggest that bioluminescence arised at least three times independently in Elateoridea from ancestors similar enzymes.
Biotecnologia, bioética, biodireito, biossegurança e biodefesa no contexto DQBRNE: atualidade, perspectivas e desafios
(Universidade Federal de São Carlos, 2014-10-01) Petrucelli, Marcos Roberto; Moreira, Fernando Manuel Araújo; https://lattes.cnpq.br/1809254923092721
The proposed work for this research, entitled Biotechnology, bioethics, biolaw,biosecurity and biodefense in the DCBRNE context: actuality, challenges and perspectives is considered controversial, and in the language of national defense, it is a sensitive issue because it is related to the different interface controversial fields of legal, military, political and religious content within the scientific-technological context of biotechnology, biosafety, bioethics and biolaw. This dissertation is intended in particular to reflect the related issues and their applicability in the Brazilian legal system, as well as in the relationship between public agencies in their conduct, in order to elucidate the best possible way some of the many questions of Biotechnology trinomial bioethics-biolaw when applied to areas of biodefense and biosecurity in the context of defense CBRNE (Chemical, Biological, Radiological, Nuclear and Explosives). There is no doubt that in this universe of areas, biotechnology plays probably the main role. The present study is based on digital, booklets, handbooks, journals and medicalscientific publications and research knowledge gained in the course of the profession of Military State Police as a Lieutenant of that force, having several courses of area as well as in civil training of Bachelor of Law with as a member of the Order of Lawyers of Brazil. Among other conclusions, it appears the lack of disclosure over actions against CBRNE incidents, operations centers to assume coordination of events and training, and training materials for this type of threats especially those conducting the first calls (responsiveness), not to mention the health situation in the hospitals and medical care, which also unaware of how to individualize the onset of diseases, which are very similar. Throughout the realization of this project, it was possible to verify that all the material gathered here, analyzed and discussed there, as far as we know, does not exist neither in Portuguese nor English. Thus, we believe that it will become an important reference material and consultation mainly by the various agencies that deal with public safety and national defense, in particular, those related to CBRNE defense.
Uma abordagem de otimização multicritério para o problema integrado de distribuição e estoque
(Universidade Federal de São Carlos, 2014-10-01) Soto de La Vega, Diego Armando; Vieira, José Geraldo Vidal; https://lattes.cnpq.br/2068340476477363; https://lattes.cnpq.br/0870329113007005
Povos indígenas na universidade: ação afirmativa e a geopolítica do conhecimento
(Universidade Federal de São Carlos, 2014-10-01) Mattioli, Érica Aparecida Kawakami; Silvério, Valter Roberto; https://lattes.cnpq.br/3215917572806088
The selectivity concerning the access of indigenous students to Brazilian higher education have been due to the practices formed racially and the understanding of the political strategy of the education for the recognition of the otherness has appeased the definition of public policies of Affirmative Actions (AA) for groups historically considered subaltern. Affirmative action is often conceptualized as strategic mechanism when both racial tension and socio-economic inequality exist in order to counter the effects of a colonial history of discrimination and disadvantaging that has left huge silences and deformations in the historical narratives about indigenous people and their knowledge, philosophies, bodies and cultures. Therefore, we also can think about affirmative action in its epistemological dimension. A post-colonial reading of affirmative action policies in Brazilian universities focused on indigenous people provided the basis for our analysis. We argue that AA policies have a potential force to produce epistemological disruptions in university contexts. The goal of this research is both to analyze and to describe sociologically the experiences of indigenous students from different ethnic groups in the context of Affirmative Action Policies Program at Federal University of São Carlos. This study ends presenting discussions on how we can epistemologically rethink AA policies in Brazilian universities, especially regarding to indigenous people.