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A política do multilinguismo na contemporaneidade vista pela ótica das instituições supranacionais
(Universidade Federal de São Carlos, 2015-03-23)
Silva, Tânia Mara da
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Silva, Soeli Maria Schreiber da
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https://lattes.cnpq.br/8794598988783452
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https://lattes.cnpq.br/5809579658012683
The work in question aims to examine how languages are distributed and divided into the supranational institutions, to this end, observe that run in two institutions that share this trait, which are the Southern Common Market (MERCOSUR) and the European Union (EU). Our observation point will be guiding the appointment of languages in enunciation spaces of these organs, seeking to demonstrate how this division sets new categorizations for languages at the supranational enunciation space. Our theoretical and methodological apparatus will be based on the concepts and definitions of semantics enunciative, more specifically, from the semantics of the theory of Festivals developed mainly by Guimarães (2002), seeking to understand the meaning production through practices that the mean man a symbolic. Our corpus consists of official documents of MERCOSUR and the European Union, which dissertem on language policies anchored to the strategic planning of multilingualism, as adopted by these institutions. These documents will be analyzed as text, in other words, as a unit of meaning that integrates listed in enunciation event. Appointments about languages circulating in supranational enunciation space will be observed as a declarative event such as a difference in their own order, that hierarchical positions of the legal and social range of languages circulating in their territory (enunciation space). Through language policies, the languages are named and take positions according to their social status, political and economic. In order to substantiate such a claim, this study will seek to understand and define the categorization and prioritization of languages of supranational institutions, based on the language of appointments work, procedural language, regional language, languages devoid of territory, official language, history and language minority language, etc. And in the meantime, try to understand how these languages relate to each other, and how they emerge in the midst of language policies on the scope of multilingualism.
Recomendação semântica de documentos de texto mediante a personalização de agregações OLAP.
(Universidade Federal de São Carlos, 2015-03-23)
Berbel, Talita dos Reis Lopes
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Gonzalez, Sahudy Montenegro
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https://lattes.cnpq.br/9826346918182685
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https://lattes.cnpq.br/5079756785405008
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Oikawa, Marcio Katsumi
With the rapid growth of unstructured data, such as text documents, it becomes more and more interesting and necessary to extract such information to support decision making in business intelligence systems. Recommendations can be used in the OLAP process, because they allow users to have a particular experience in exploiting data. The process of recommendation, together with the possibility of query personalisation, allows recommendations to be increasingly relevant. The main contribution of this work is to propose an effective solution for semantic recommendation of documents through personalisation of OLAP aggregation queries in a data warehousing environment. In order to aggregate and recommend documents, we propose the use of semantic similarity. Domain ontology and the statistical measure of frequency are used in order to verify the similarity between documents. The threshold of similarity between documents in the recommendation process is adjustable and this is the personalisation that provides to the user an interactive way to improve the relevance of the results. The proposed case study is based on articles from PubMed and its domain ontology in order to create a prototype using real data. The results of the experiments are presented and discussed, showing that good recommendations and aggregations are possible with the suggested approach. The results are discussed on the basis of evaluation measures: precision, recall and F1-measure.
Caracterização morfológica, molecular e reprodutiva de híbridos interespecíficos de Arachis na busca de resistência a pragas do amendoim
(Universidade Federal de São Carlos, 2015-03-23)
Paula, Ailton Ferreira de
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Vigna, Bianca Baccili Zanotto
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https://lattes.cnpq.br/1663784979286725
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Fávero, Alessandra Pereira
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https://lattes.cnpq.br/4329892306148506
The peanut (Arachis hypogaea) is, worldwide, an important source of protein and oil. Pests and foliar diseases are among the factors that limit the economically sustainable production of peanuts in Brazil. Among the pests, thrips and the rednecked peanutworm are considered important pests in São Paulo State. To decrease the cost of production on the management of these pests, genetic improvement to obtain resistant varieties from wild plants is a viable alternative. The main obstacle in the genetic improvement is that the vast majority of wild species of Arachis is diploid, while the cultivated species is allotetraploid. For the barrier of ploidy between the wild and the cultivated peanut to be broken, it is necessary to obtain interspecific hybrids genome AB. Such hybrids should be treated with colchicine to induce polyploidy and get fertile hybrids with two distinct complete genomes (amphidiploid), which can be crossed with A. hypogaea to get the same or similar genomic constitution of the cultivated species. The aim of the research were to identify hybrids derived from crosses made between wild species with A, B or K genome that are resistant to thrips and the rednecked peanutworm and hybrids from one amphidiploid and A. hypogaea, characterize the hybrids and their parents 1) by microsatellite molecular markers, 2) by pollen viability and 3) by their morphology. The molecular markers were genotyped in polyacrylamide gel with standard 10 base pairs. The viability of pollen grains was used to analyze the data of analysis of variance and mean Tukey test, and morphological data were analyzed by Principal Component Analysis. Six polymorphic microsatellite loci were analyzed in 25 F1 plants, 18 of them result of selfing and six of hybridization with a total of three different hybrid combinations plus four hybrid plants from across between the amphidiploid An 13 and A. hypogaea. The pollen viability data corroborated the molecular analysis in the identification of hybrids, noting that An 13 had high viability of pollen grains and interspecific hybrids had low values when compared to their parents and selfed individuals of progeny. From the 63 morphological descriptors measured the ones from the main axis expressed the most morphological variation observed. Pollen viability of F1 hybrid plants obtained by cross among A. hypogaea and the amphidiploid An 13 was above 76%, showing the possibility of new interesting genes introgression in A. hypogaea
Modelo de compartilhamento de localização em redes sociais móveis com garantias de privacidade
(Universidade Federal de São Carlos, 2015-03-23)
Rosa, Tiago Antônio
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Zorzo, Sérgio Donizetti
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https://lattes.cnpq.br/2523715806470871
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https://lattes.cnpq.br/4805808810910503
Mobile social networks are characterized by the sharing of user context information, such as the location of one’s mobile device, with one’s friends and groups of friends. The location information in a social network enables providers to offer products and services based on geographical area, which is considered either a personal gain or an invasion of privacy by the users who receive these offers. A user sharing location information with a particular friend or group of friends, without social network providers having access to this information, ensures the safety and privacy of the information. This paper presents a model of mobile social networking with privacy guarantees regarding sharing the location of members with groups of friends; it allows users to configure rules that determine to whom, when and where location information can be made available. The model provides three levels of privacy, chosen by the user, using techniques of anonymity and diffusion, which adjust the location to ensure the concealment of the information before it is made available on the social network. The proof of concept of the proposed model, called RSM Privacy, was developed for the Android platform. Performance tests showed that delays generated by the use of RSM Privacy are proportional to and justifiable for the privacy levels desired and chosen by users. A group of 50 users evaluated the model proof of concept, RSMPrivacy, with respect to usability and verified the efficiency of the techniques included in the proposed model.
Catalisadores de Co e Pt suportados em La2O3 e SiO2 aplicados na reforma a vapor do etanol
(Universidade Federal de São Carlos, 2015-03-24)
Baldoino, Marília Gabriela Branquinho
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Assaf, José Mansur
;
https://lattes.cnpq.br/9563312407691130
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https://lattes.cnpq.br/0292961252771980
In intense search best environmental conditions, it is necessary to invest in renewable fuels, affordable and low polluting. With the aim to participate in this effort, this work was undertaken to study the steam reforming of ethanol. Cobalt catalysts supported on SiO2 were studied using mass loading of lanthanum 10, 20 and 30% mass content, and 0,5% platinum as additives in order to check their influences on the initial catalyst to reduce carbon formation on the catalyst surface, enhancing the activity, stability and selectivity for H2. All catalysts were prepared by impregnation method. Were characterized by temperature programmed reduction in H2, Hydrogen Chemisorption, surface area by BET, X ray diffraction method, thermo gravimetric analysis and chemical analysis. Subsequently, the reaction RVE catalysts, which was analyzed in conversion and selectivity were applied. The TPR and XRD analyzes observed the formation of Co3O4 which espinélia phase is reduced to CoO and Co°, respectively. Subsequently, the catalysts were used for ethanol steam reforming reaction, where the conversion, selectivity, and stability was analyzed. In XRD analysis and RTP observed the formation of Co3O4 that espinélia phase and reduces CoO and Co°, respectively. Also, it was identified diffraction peaks relating to La2O3 and La(OH)3; platinum, and a broad peak was assigned to the SiO2 structure, which has low crystallinity. There was a decrease in coking catalysts, effect obtained by forming lanthanum oxicarbonate, which was also identified by XRD. The increased lanthanum loading also influence the decrease in particle size, thereby increasing the dispersion of the catalysts. During the 24-hour stability test, the catalyst is not desactivated. It was identified that the impregnation method used and the utilized treating conditions were adequate to obtain the desired compounds for reform to ethanol vapor. The CoLa2SiO2 catalyst showed promise for ethanol steam reforming, with better selectivity to hydrogen, with little formation of undesirable products. The addition of 0.5% by mass Pt content in the cobalt catalyst has not led to a significant increase in product formation and conversion. The monometallic Pt catalyst (0.5% w / w) proved active and with good hydrogen selectivity even with a small amount of active phase. This behavior can be related to the presence of highly dispersed platinum metal on the surface. The best performing catalysts did not show the formation of CO, which can be related to the addition of lanthanum.
Contribuições à noção de ato na filosofia de Henri Bergson : à luz do Essai sur les données immédiates de la conscience (1889)
(Universidade Federal de São Carlos, 2015-03-24)
Proença, Luiz Fernando de Oliveira
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Pinto, Débora Cristina Morato
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https://lattes.cnpq.br/1311151012002541
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https://lattes.cnpq.br/1850373959106777
The aim of this paper is to highlight a particular notion in Bergson’s thought, namely the activity of the mind. Even though this inquiry does not intend to deal with the entire bergsonian corpus, as its subtitle indicates, highlighting the aforementioned notion, together with other structuring conceptual aspects, such as synthesis, continuity, indivisibility, might – as we hope – bring about different outlooks to the reading of Bergson’s works. These concepts are supposed to justify the inquiry inasmuch as they are supposed to demonstrate that the duration of consciousness, the very object of An Essay on the immediate data of consciousness, is a psychic, mind process, and an activity. A fourfold division was established, corresponding to each of the four chapters that compose this paper, in order to achieve our goal. The first three chapters are dedicated to analyzing each of the three chapters in the Essay, aiming at demonstrating in what way those notions happen to be fundamental in the development of that particular work, the means of their respective genesis and unfoldings. Thus, the opening inquiries into the intensity of psychological states focus on the distinction between the quality and the quantity of psychic data, by means of the concept of intensity. Next, the plurality of such data shall be examined by means of the distinction between the concepts of numerical multiplicity and non-numerical multiplicity. Finally, in the third chapter an analysis shall be undertaken of the organization of such data of consciousness, in order to conclude the description of the psychological subject in the previous chapters and, most importantly, in order to demonstrate that the duration of such subject is synthetic, active, indivisible, while at times producing free activity. The final considerations merely reiterate what has been divided throughout the previous chapters, besides giving a brief mention on the extension of the notion of activity in both of Bergson’s following works: Matter and memory and The Creative Evolution.
Avaliação da sensibilidade dolorosa em idosos hipertensos: estudos de casos e controles
(Universidade Federal de São Carlos, 2015-03-24)
Rebelatto, Marcelo Nascimento
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Salvini, Tânia de Fátima
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https://lattes.cnpq.br/4391969032505723
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https://lattes.cnpq.br/7204785489008565
Background: Hypoalgesia related to hypertension has been described and studied by many authors over the last few decades, but little is known about how it behaves in the elderly. Therefore the aim of this study was to establish whether there are differences in pain sensitivity between hypertensive and normotensive older adults. For this, we selected seventy-two elderly of which 36 were normotensive and 36 were hypertensive and the pressure pain threshold (PPT) was assessed on seven points bilaterally in both groups by means of pressure algometry. Two-factor analysis of variance (ANOVA) group and gender was performed, and the effect size was calculated using Cohen s index. Results: The PPT values were higher in the group of hypertensive older adults compared to the normotensive ones; that difference was significant (P < 0.05) for the following points: right and left trochanters, left trapezium, left L3/L4 and left anterior tibialis muscle. The correlations exhibited by the PPTs were stronger in the group of hypertensive older adults; hypoalgesia was more generalized among the hypertensive adults compared to the normotensive ones. Gender did not influence that difference, although the magnitude of the difference was greater among males compared to females. Conclusion: Hypoalgesia, as assessed by means of PPT, exhibited a relationship with arterial hypertension in older adults. The influence of gender on hypoalgesia exhibited by hypertensive individuals is controversial.
Okinawanos e não-okinawanos em Campo Grande: relações de parentesco e famílias
(Universidade Federal de São Carlos, 2015-03-24)
Kubota, Nádia Fujiko Luna
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Machado, Igor José de Renó
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https://lattes.cnpq.br/4705450652848752
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https://lattes.cnpq.br/8216228858672384
Japan has been permeated by the myth of ethnic homogeneity. The idea that homogeneity is present even in countries receiving "nikkeys" immigrants, as is the case in Brazil. However, a few decades it has been possible to note that the multiplicity and diversity are also part of the japanese reality. This diversity makes the group think of themselves and others to think as opposites. Thus, Campo Grande becomes field investigation of this heterogeneity, since it possesses two distinct groups - Okinawans and "naichi" (japanese) - in an opposition movement and aggregation throughout history. When thinking of a "Japanese unit" is over for not paying attention to details that make up the relations between the groups involved (Okinawans, non-Okinawans and non-western). The purpose of this research is therefore to understand how notions of family and belonging can build the oppositions and differences between Japanese immigrants and their descendants.
Avaliação de parâmetros globais de desempenho de biorreatores pneumáticos através de fluidodinâmica computacional
(Universidade Federal de São Carlos, 2015-03-25)
Rodriguez, Guilherme Youssef
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Béttega, Rodrigo
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https://lattes.cnpq.br/1379682125857376
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Badino Júnior, Alberto Colli
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https://lattes.cnpq.br/6244428434217018
Pneumatic bioreactors are devices free of moving parts which have the purpose of converting raw materials in bio-products of commercial interest by the action of enzymes or cells. They are promising in the biochemical industry, ensuring good oxygen transfer and consuming less energy. Global performance parameters such as global gas hold up and the volumetric oxygen transfer coefficient are important criteria in the design and selection among different geometries of the mentioned devices. In the present work it was carried out modeling and simulation of pneumatic bioreactors based on Computational Fluid Dynamics (CFD) in order to estimate the global gas hold up and the volumetric oxygen transfer coefficient in three different geometries of pneumatic bioreactors: bubble column, concentric tube airlift and split tube airlift. The simulated results of each performance parameter were verified by comparison with the experimental values reported by Thomasi et al. (2010) and Mendes and Badino (2015) for the fluids distilled water, glycerol solution 10 cP and xanthan gum solution 0.2% w/v (weight/volume) in a wide range of specific air flow rate (0 to 5 min- 1). Application suite ANSYS® 14.5 was used for numerical simulations in CFD. Important parameters such as the bubble diameter played a great influence on results of the volumetric oxygen transfer coefficient. It can be observed by the experimental and simulated results that the concentric tube airlift bioreactor was the best alternative to the global gas hold up and the volumetric oxygen transfer coefficient (reaching 14% and 0.06 s-1 for distilled water, respectively). It was found that the results obtained via the CFD agreed with the majority trend of experimental data, capturing the most important hydrodynamic phenomena and mass transfer characteristics, showing that the modeling of different systems with different fluids fulfilled the main objective of obtaining reliable models design and performance of other geometries of pneumatic bioreactors.
Estudo da estrutura de complexos de polieletrólitos sobre as propriedades de transporte de água e sais
(Universidade Federal de São Carlos, 2015-03-25)
Vale, Rayane da Silva
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Silva, Caio Marcio Paranhos da
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https://lattes.cnpq.br/7793686262868668
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https://lattes.cnpq.br/9352007529619570
Polyelectrolytes complexes (PECs) are defined as materials formed by combining oppositely charged polyelectrolytes together via ionic interaction. PECs have some unique physical properties such as non-solubility in common organic solvents, high surface hydrophilicity, tunable surface charge, and stable structures. A new type of PEC based on chitosan (CS) and sulfonate poly(ethylene terephthalate) (SPET) were synthesized in two different media, buffer solution and salt solution acidified with acetic acid. Fourier transform infrared spectroscopy (FTIR), zeta potencial, X-ray diffraction, thermal gravity analysis and differential scanning calorimetry were used to characterize the chemical structure, particle charge, crystallinity and thermal stability. To assess how the internal structure of the PEC and the subsequent membrane formation can affect water and salts transport capacity of microporous polycarbonate membrane, PECs solutions were spread via casting in commercial membranes with pore size of 5 μm. These membranes were characterized by Scanning Electron Microscopy (SEM), Water Vapor Flux, Resistance to Ion Migration and Membrane Potential. FTIR results indicated the electrostatic interaction of polyelectrolyte to form the polyelectrolyte complex. From the results of zeta potential it was found that the surfaces of CS/SPET nanoparticles have positive charges of about 25 to 44 mV. TGA curves showed that the PECs were more stable than their polyelectrolytes. The deposition of the PEC on the membranes was confirmed by SEM images and the increase of water vapor flux of membranes indicated that the presence of the complex significantly alter the hydrophilic profile of the polycarbonate matrix. The microfiltration of Saccharomyces cerevisiae cells demonstrated that membranes modified with PECs retained more of these organisms than the commercial membrane without modification.
A experiência estética no Cerrado para a formação de valores estéticos e éticos na educação ambiental
(Universidade Federal de São Carlos, 2015-03-26)
Iared, Valéria Ghisloti
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Oliveira, Haydée Torres de
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https://lattes.cnpq.br/5458113597909705
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https://lattes.cnpq.br/1273203310250467
Our world views are based on principles, feelings, emotions that go through a dimension of human life which involve ethical and aesthetic values. However, the formation of values is a less explicit dimension of environmental education compared to the appropriation of knowledge. Some studies confirm the relative silence of aesthetic considerations in the literature and curriculum, so this topic has the potential to be further explored in research and in environmental education practice. Based on an interpretative perspective, we assume as aesthetic experience the possibility of our bodies engaged in the world to realize and create meanings of all forms of existence. From this, this study aims to understand the nature of aesthetic experience in the Cerrado, due to its history of occupation and degradation. In this research, we transition between the modern and post-modern paradigm in order to deeply understand the meaning of aesthetic experience. This transition is the result of our study pathway which was willing to seek for approaches and methods to answer the research question. Therefore, our data collection was carried out using two techniques: 17 semistructured interviews (understood in a modern paradigm, but interpreted together with the research participants) and a walking ethnography in the Cerrado (located as a post- modern methodology), which 08 participants who had already been interviewed were present, and 04 out of 08 were part of the data collection The participants were invited following the criteria of a life story related to the Cerrado, reflecting on a love involvement regarding this environment.The results indicated that the informal and spontaneous experiences in nature, moments of conflict and dialogue were significant for the development of an affective bond and an ethical stance towards the Cerrado. The walking ethnography put the prospect of analyzing the aesthetic experience of the participants moving in the Cerrado and the researcher was also engaged in the aesthetic experience of the Cerrado along with the participants. Instead of being a dialogical and verbal action, this activity is embodied and the focus is the multisensorial experience which involves multi-dimensions of corporality and connections with the materialities of the more than human world. The data that emerged during the walk in the Cerrado supplemented the interviews. In addition, we identified that the participants of this study had an ethical position in relation to the Cerrado, which we attributed to be from the dialogue among participants and family, friends, coworkers and text readings. However, this relationship can not be considered the same in other groups of people, situations and contexts. Therefore, new research questions that continue investigating the relations between aesthetic experience and ethics are necessary.
Tradução das Diretrizes Curriculares Nacionais dos cursos de Medicina de 2001: análise do projeto pedagógico das universidades federais da região sudeste do Brasil
(Universidade Federal de São Carlos, 2015-03-26)
Arruda, Fernando Teles de
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Pereira, Sissi Marilia dos Santos Forghieri
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https://lattes.cnpq.br/8136814539282369
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Lima, Valéria Vernaschi
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https://lattes.cnpq.br/7945420582384290
The numerous changes in health care, is creating the need for revaluations and adjustments in vocational training policies. The health graduation, particularly medical training, has been challenged in this regard. In Brazil, the National Curriculum Guidelines, adopted in 2001 to guide the Pedagogical Project Course (PPC) health degree, are considered a major milestone in training, promoting the fight against health conditions of the population, expressed in health needs through a critical and reflective formation. Fourteen years after the publication of the DCN- 2001, the goal of this research was to analyze the translation of these guidelines in PPC's. the medical graduation projects of Federal Institutions in Southeastern Brazil were analyzed. The sample was composed of 12 institutions, after applying the inclusion and exclusion criteria. For the analysis of PPC's was built / validated an evaluation matrix. two axes were analyzed (i) curriculum and (ii) professional profile, according to the constituent elements of DCN. The analysis of PPC's identified the category "general profile egress" as the one closest to the Policy and Health Management category as the more distanced. The simple publication of the guidelines, as well as its translation in PPC's do not guarantee their applicability, but are an important indicator of educational Instituição. This research points to the need to create the PPC's discussion environments, stimulating sharing experiences, achievements and challenges, respecting the uniqueness of each institution, but stimulating the advancement towards the guidelines.
Depressão e ansiedade em população com quadros reumatológicos
(Universidade Federal de São Carlos, 2015-03-26)
Jaoude, Thaísa de Carvalho
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Reis, Maria de Jesus Dutra dos
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https://lattes.cnpq.br/4273980531985019
Rheumatic diseases have been defined as those relating to musculoskeletal and connective tissues. Through the analysis of the literature it is observed a significant prevalence among patients with these pathologies, and both depression and anxiety. The present study investigated, in two different studies, the relations between rheumatic diseases and mental disorders. The Study 1 presents a literature reviews organized in the form of article. The manuscript presents the product of a literature review in brazilian and foreign databases, in the last 25 years, examining the results on the prevalence of mental disorders in rheumatic diagnoses patients, particularly anxiety and depression. The review was organized to systematize the principal addressed rheumatologic diseases, the countries where the investigations were implemented, the populations investigated in these studies, and the prevalence observed between depression and anxiety in each case. In Study 2 indicators of depression and anxiety in users of rheumatology ambulatory are described, in a health and teaching unit, with exclusive service to users of the Social Health System. It was evaluated 85 patients, 76 women and 9 men, aged between 41 and 70 years. In the evaluation, the following instruments were used: 1) The questionnaire for survey of general information; 2) Beck Depression Inventory (BDI); 3) Beck Anxiety Inventory (BAI); 4) Inventory of Stress Symptoms of Lipp (ISSL); and; 5) Brazilian Economic Criteria of the ABEP. The results showed that 51.8% of the sample had a education equal or less to complete primary, and 31.8% are retired or removed by social security provision. In addition, 68.2% of them were identified as inserted into economic classes with power consumption equal or less than to Class C1; 37,6% of users had two or more diagnosis of rheumatic diseases. Indicators showed that 43.5% of users were under medical treatment with at least one psychotropic substance, with treatment duration ranging from 2 to 21 years. Users under psychotropic drug prescription had significantly higher scores of depression (Mann-Whitney: z = 6.513, p <0.000), anxiety (Mann- Whitney: z = 6.083, p <0.000) and stress (Mann-Whitney: z = 6.119; p <0.000). The rheumatics diseases most frequently found in the population were Fibromyalgia (n = 33), Osteoarthritis (n = 33) and Rheumatoid arthritis (n = 24). In the general population, there was a prevalence of 43.5% of depression, 57% anxiety and 31.4% of stress. Considering the prevalence of depression in the Fibromyalgia, Osteoarthritis and Rheumatoid Arthritis were observed respectively values of 87.9%, 60.6% and 37.5%. Anxiety showed a prevalence of 72.7% in Fibromyalgia, 36.4% in Osteoarthritis, and 29.2% in Rheumatoid Arthritis. It was discussed the importance of evaluation and multidisciplinary intervention, in particular the psychologist role, for the care of rheumatic diseases.
Search for enzyme inhibitors in cerrado plants as strategy for the discovery of prototype drugs against neglected tropical diseases
(Universidade Federal de São Carlos, 2015-03-26)
Sousa, Lorena Ramos Freitas de
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Vieira, Paulo Cezar
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https://lattes.cnpq.br/8923844563320377
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https://lattes.cnpq.br/3468067160878475
A primeira etapa deste trabalho de pesquisa envolveu uma triagem de extratos de plantas do cerrado paulista através de ensaios frente à arginase (ARG) de Leishmania amazonensis. Os resultados de inibição enzimática da ARG apresentados pelos extratos, levaram ao fracionamento biodirecionado dos extratos de acetato de etila (folhas e galhos) de Byrsonima coccolobifolia Kunth. (Malpighiaceae). Alguns compostos bioativos foram isolados (flavonóides, ácido galoilquínicos, uma lignana, uma fenatrenona e uma ortoquinona) o que indicou que estes compostos seriam os responsáveis pela diminuição da atividade enzimática da ARG observada nos extratos de B. coccolobifolia. Os flavonoides e os ácidos galoilquínicos apresentaram modo de inibição do tipo não-competitivo da ARG, com atividade inibitórias significativas (IC50 = 0,13 à 4,8 μM) e com forte afinidade (valores de Ki variando entre 0,10 à 3,80 μM). Os estudos de relação entrutura atividade (SAR) revelaram que o grupo catecol dos flavonóides, tanto como a unidade galoila das estruturas dos ácidos galoilquínicos, forneceram importantes características em relação as interações ARG inibidor. Na segunda parte deste trabalho, experimentos subsequentes foram realizados para investigar os produtos naturais frente a proteases, as quais possuem funções importantes na patogenicidade de virus e parasitas, tais como: as serino proteases NS2B-NS3 dos vírus da dengue serotipos 2 e 3 (dengue), a rodesaína de Trypanosoma brucei rhodesiense (tripanossomíase africana), a cruzaina de Trypanosoma cruzi (doença de chagas), a catepsina L de Leishmania mexicana (leishmaniose) e a falcipaina-2 de Plasmodium falciparum (malária). Através destes estudos foram descobertos alguns inibidores das proteases NS2B- NS3 dos vírus da dengue (tipo 2 e 3) e da catepsina L (r-CPB2.8) de L. mexicana. Os flavonóides agatisflavona, miricetina, e quercetina (Ki = 11,1; 4,7; e 20,7 μM; respectivamente) mostraram inibição do tipo não-competitiva frente à NS2B-NS3. Também foram realizados, um experimento de termoforese em microescala (MST) (ensaio livre de substrato) e um estudo in silico, de forma a obter maiores informações sobre as interações biomoleculares envolvidas. Os metabólitos secundários, agatisflavona e ácido 3-oxo-urs-12-en- 28-óico, foram determinados serem inibidores do tipo não-competitivo parcial da catepsina L do tipo r-CPB2.8, e a tetrahidrorobustaflavona como um inibidor incompetitivo desta catepsina L (r-CPB2.8), com valores de Ki na faixa de micromolar (Ki = 0,14−1,26 μM).
Ação da vitrocerâmica bioativa (Biosilicato®) no processo de reparação óssea em ratos
(Universidade Federal de São Carlos, 2015-03-26)
Kido, Hueliton Wilian
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Anibal, Fernanda de Freitas
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https://lattes.cnpq.br/4918261968772806
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Bossini, Paulo Sérgio
;
http://lattes.cnpq.br/1256982144741336
The present study aimed to evaluate the effect of two different Biosilicate® (P2O5-Na2O-CaO-SiO2 system) presentations - highly porous scaffold and composite material – on a tibial bone defect model in rats. Two studies were performed; the first one aimed at evaluating the effect of highly porous scaffolds on bone regeneration using histopathological analysis, immunohistochemistry and immunoenzymatic assay. In this study, 80 male Wistar rats (12 weeks old and body weight of approximately 300 g) were divided in two groups (control and Biosilicate®) and euthanized after 3, 7, 14 and 21 days post-surgery. The histopathological evaluation revealed that both groups presented similar inflammatory responses after 3 and 7 days. At all time points, the scaffold degradation was observed, mainly in the border of the material, allowing the ingrowth of newly formed bone. The immunohistochemical analysis showed that the Biosilicate® scaffolds induced the synthesis of (i) ciclooxigenase 2 (COX-2), (ii) vascular endothelial growth factor (VEGF) and (iii) runt-related transcription factor 2 (RUNX-2). Additionally, the immunoenzymatic assay indicated that the Biosilicate® group did not presented significant statistical difference in the levels of tumor necrosis factor alpha (TNF-α) in all evaluated periods compared to the control group. In addition, the Biosilicate® group presented a higher concentration of interleukin 4 (IL-4) at day 14 and a lower concentration of interleukin 10 (IL-10) 21 days after the surgery when compared to the control group. The second study aimed at investigating the effects of Biosilicate®/poly lactic-co-glycolic acid (PLGA) composites on the process of bone repair using histopathological, morphometric, immunohistochemical and gene expression (Real-Time PCR, qRT-PCR) analyses. In this study, 80 male Wistar rats were distributed in two groups (Biosilicate® and Biosilicate®/PLGA) and euthanized 3, 7, 14 and 21 days after the material implantation. The main findings showed that the incorporation of PLGA into the Biosilicate® had a significant effect in the material morphological structure, leading to a pH decrease and accelerating the mass loss upon incubation in phosphate buffered saline (PBS). Moreover, the histological evaluation revealed that the Biosilicate®/PLGA group presented a higher material degradation accompanied by a higher bone formation when compared to the plain Biosilicate® after 21 days. The immunohistochemical analysis did not show any difference in the immunolabeling for Runx2, RANKL and OPG between Biosilicate® and Biosilicate®/PLGA. In addition, the qRT-PCR indicated that the Biosilicate®/PLGA induced the osteogenic gene expressions (bone morphogenetic protein 4, Runtrelated transcription factor 2 and osteocalcin) at 21 day after surgery. The results evidenced by the present studies suggest that both materials (highly porous Biosilicate® scaffolds and Biosilicate®/PLGA composites) were effective in inducing the repair of tibial bone defects in rats, demonstrating that these materials are promising alternatives for treating bone fractures.
Tafonomia e morfologia de cingulados quaternários da Gruta da Lapinha, Iramaia-BA
(Universidade Federal de São Carlos, 2015-03-26)
Jesus, Jorge Felipe Moura de
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Fernandes, Marcelo Adorna
;
https://lattes.cnpq.br/6709493251686592
;
https://lattes.cnpq.br/4277988664353633
Gruta da Lapinha is one of the largest limestone caves in Bahia state, located in Municipality of Iramaia. In the year 2012 speleologists of Grupo Pierre Martin de Espeleologia (GPME Pierre Martin Speleology Group), discovered a complete skeleton of Holmesina major. In 2014, in a joint expedition between researchers of Federal University of São Carlos and GPME, three more specimens were found and glyptodonts remains. In a taphonomic analysis it was concluded that due to the integrality of the bones, the sedimentation patterns and the lack of some marks, those animals entered alive in the cave probably in search of resources and posteriorly dead locally, however, the deposition of the glyptodont material happened asynchronously to the pampathere ones. And all of the fossils collected in this cave were of cingulates. Cingulata is the order of xenarthrans that has the largest number of species and the widest geographical distribution in the present time; however, it is only reduced to the Family Dasypodidae. During the Pleistocene there were more than one Family; Pampatheriidae was one among them. In that Family, the species H. major was distributed from Northeast to South of Brazil through the eastern regions. Most of what is known about the geographical distribution of those animals is due to their osteoderms that has been found; nevertheless, few specimens with an almost complete skeleton had been found. This paper makes a literature review about phylogenetic relationships and paleoecology of pampatheres; describes two well-preserved new specimens of H. major found in Bahia state, detailing new structures of Pampatheriidae, such as pelvis and xenarthrous vertebrae; compares the specimens, analyzing inter- and intraspecific variations; and concludes that H. major treats being a clade distinct from H. paulacoutoi.
Conceito de letramento: desafios e implicações no processo de aprendizado da língua materna - perspectiva bibliográfica
(Universidade Federal de São Carlos, 2015-03-26)
Ohde, Halide de Quadros
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Reyes, Cláudia Raimundo
;
https://lattes.cnpq.br/9917860612494529
This dissertation falls within the research area of School Education: Pedagogical Theories and Practices. Its central theme is the concept of literacy within the initial learning of the mother tongue of schoolchildren. The origin of the dissertation is the results of previous research which conducted a survey of the occurrence of the concept of literacy. That particular study identified that the theoretical approaches used to support the concept of literacy were stable, with no major variations, and that they were encapsulated in the dichotomised view of the initial learning of the mother tongue and literacy. From that starting point, this MA dissertation set out to research the theoretical foundations of literacy used in PhD theses that have studied the process of learning the mother tongue, and to check if there has been progress in relation to the theoretical bases of those theses. Our hypothesis was that we would find in these theses greater reflection and new perspectives on the topic, which would go beyond the dichotomous view of the initial learning of the mother tongue and literacy. Consequently, this dissertation is characterised as a meta-search, which aimed to identify the theoretical foundations of literacy concepts, and to verify possible advances in academic discussions on this topic, within the PhD theses completed in 2002 2013, and which were available in the database of the Digital Library of Theses and Dissertations. For our analysis we used a theoretical framework based on studies on the subject by Geraldi, Kleiman, Tfouni, Soares, Ferreiro, Bakhtin, Freire and others. Our methodological approach was inspired by the perspective of content analysis, with the work of Laurence Bardin as a theoretical reference, since we chose to perform a study that categorised by data, developing a qualitative and quantitative analysis. The results point to the existence of academic research at the doctoral level involving the theme, and indicate a possible stabilisation of the theoretical bases of the initial learning of the mother tongue and literacy, indicating the dichotomy between both topics, as well as evidence of advances in relation to the idealist and humanist conception of literacy.
Caracterização e composição química do material particulado grosso (MP10) no centro da cidade de São Carlos (SP)
(Universidade Federal de São Carlos, 2015-03-27)
Alexandrina, Eduardo Carlos
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Aguiar, Mônica Lopes
;
https://lattes.cnpq.br/0431688649128529
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Gonçalves, José Antônio Silveira
;
https://lattes.cnpq.br/0337997526924402
Coarse particulate matter with aerodynamic diameter smaller than 10μm (PM10) have long been considered as air pollutants associated with health issues. They penetrate into the upper respiratory tract, causing respiratory problems such as worsening of asthma. The aim of this study was to determine and quantify the distribution of chemical elements in the PM10 particulate matter present in the atmosphere of the city of Sao Carlos (Sao Paulo). Samples were collected daily for a period of 23h and 30 minutes, from April 16, 2014 to April 16, 2015. A high-volume sampler (AGV-PM10) with micro quartz and fiber glass filters were used. The filters were subjected to gravimetric analysis to obtain the mass of PM10 and were then analyzed by energy dispersive X-ray fluorescence and Laser Induced Breakdown Spectroscopy to identify and quantify the chemical composition of the samples. The highest average concentration during twelve-month period was 70.41μg/m³ (August, 2014) and the smallest was 22.59μg/m³ (January, 2015). The annual arithmetic average found for the twelve months period was 42.71μg/m³. If compared with annual arithmetic average limit of 40μg/m³, established by CETESB, the value is slightly above and below 50 μg/m³ (CONAMA). If we consider the limit established by the World Health Organization (WHO), which is 20μg/m³, this value is much higher than recommended. The chemicals elements found were characteristic of urban areas
Aplicações da espectroscopia Raman ao estudo dos efeitos de temperatura e de pressão hidrostática em cristais orgânicos: 2-amino-1,3,4- tiadiazol, 2-amino-5-fenil-1,3,4-tiadiazol e 2-amino-5-(4-deciloxi-fenil)-1,3,4- tiadiazol
(Universidade Federal de São Carlos, 2015-03-27)
Toledo, Thiago Andrade de
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Pizani, Paulo Sérgio
;
https://lattes.cnpq.br/1038437165007849
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https://lattes.cnpq.br/5138069407379918
Molecular organic crystals are a promising class of materials because of their excellent physical, chemical and biological properties. Among them, Thiadiazole and its derivatives have been investigated in the last years due their versatility to build new materials as well as their potential use in pharmaceuticals and organic electronic devices. For this reason, the temperature and hydrostatic pressure dependence on Raman spectra of the 2- amino-1,3,4-thiadiazol (ATD), 2-amino-5-phenyl-1,3,4-thiadiazol (APTD) and 2-amino-5-(4- decyloxy-phenyl)-1,3,4-thiadiazol (ADPTD) are investigated. In addition, complementary studies using FT-IR, thermal analysis as experimental technique and density functional theory (DFT) are also given in order to support the Raman analysis. Decreasing temperature, it can be observed the reduction of band line width and blue-shift (from 290 to 10 K), which allow a better identification of some vibrational modes, in special, in lattice mode region. In contrast, the temperature induces phase transition in the select molecular crystal above 373 K, in accordance with thermal analysis. Furthermore, pressure induces a molecular conformation changes at 0.8, 2 and 2.5 GPa in ADPTD characterized by appearance and disappearance of Raman bands. On the other hand, ATD and APTD show only anharmonic effects contribution.
Tópicos sobre funções de várias variáveis complexas
(Universidade Federal de São Carlos, 2015-03-27)
Coacalle, Joel Rogelio Portada
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Hounie, Jorge Guillermo
;
https://lattes.cnpq.br/7302904386484949
;
https://lattes.cnpq.br/4153627834860786
This work shows classical results of analysis of holomorphic functions of both one and several complex variables. Are treated as main topics results on integral representations of holomorphic functions, approximation by holomomorfas functions, the Cauchy-Riemman operator and its homogeneous and non homogeneous equation associated, results on func- tions subharmonics, and the problem of analytic continuation. As the integral representa- tion of holomorphic functions present the Cauchy Integral Formula well as the immediate results of this as are the representation in series of powers, estimates of Cauchy and the most important of the principle for holomorphic functions, these results as much as for one and several complex variables. As the approach we present here the Runge theorem, as well as those resulting from its application in the context of meromorphic functions that are Mittag-Leffler's theorem and the Weierstrass theorem. Subharmonic functions are handled here putting out two main properties and some others that can be seen even in a generalized sense. As for analytic continuation of problems discussed here in the context of several complex variables Hartog the Extension Theorem, some geometric pro- perties of holomorphy domains where we prove a special case where analytical extension called Bochner's theorem, the special case of a domain named Domain Reinhardt, and some properties on the concepts of plurisubharmonicidade and pseudoconvexidade.