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A transformação vetorial de Ribaucour para subvariedades de curvatura constante
(Universidade Federal de São Carlos, 2015-06-09)
Guimarães, Daniel da Silveira
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Figueiredo Junior, Ruy Tojeiro de
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https://lattes.cnpq.br/9930999514347198
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https://lattes.cnpq.br/3520357439188664
In this work we obtain a reduction of the vectorial Ribaucour transformation that preserves the class of submanifolds with constant sectional curvature of space forms. As a consequence, a process is derived to generate a new family of such submanifolds starting from a given one. We prove a decomposition theorem for this transformation, from which the classical permutability theorem for the Ribaucour transformation of submanifolds with constant sectional curvature follows. Given k scalar Ribaucour transforms of a submanifold with constant sectional curvature, we prove the existence of a Bianchi k-cube all of whose vertices are submanifolds with the same constant sectional curvature, each of which is given by means of explicit algebraic formulas. A further reduction of the transformation is shown to preserve the class of Lagrangian submanifolds of dimension n and constant sectional curvature c of complex space forms of complex dimension n and constant holomorphic sectional curvature 4c. In particular, explicit parametrizations in terms of elementary functions of examples with arbitrary dimension and curvature are provided. A decomposition theorem and a version of the Bianchi cube for this transformation are also obtained.
A agroecologia e os serviços ecossistêmicos : um estudo de caso nos assentamentos do município de Iperó/SP
(Universidade Federal de São Carlos, 2015-06-10)
Buquera, Rodrigo Brezolin
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Franco, Fernando Silveira
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https://lattes.cnpq.br/3218633711361955
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https://lattes.cnpq.br/2208143183411783
The human being interacts constantly with ecosystems and uses various goods and services from them. These goods and services are called "Ecosystem Services" (ES) and the benefits from these services are called "constituents of well-being." The agroecosystems are modified so that there is greater provision of certain ES, such as food, raw materials and fuels. However, to provide these ES, the agroecosystems need others ES to suits their needs, thus maintaining its production capacity. In agroecosystems, farmers are the main managers of natural resources, influencing the management directly. Therefore, understanding how farmers perceive and interact with natural resources is of great importance. This study aims to evaluate the perception of farmers on the ES, through semi-structured interviews. Analyzing ES perceived by farmers, their relationship with the agricultural practices used, with the impacts caused by agriculture and socioeconomic factors. The farmers interviewed were all in agroecological transition process and belong to settlements Ipanema and Horto Bela Vista, in the municipality of Iperó, near Ipanema National Forest. Within the results, it was observed greater perception of the production ES in relation to regulatory and cultural ES. As well the relevance of the educational level in the perception of ES. Increased awareness of the ES by farmers is of great importance, since it may well assist in agroecological transition.
Análise da variabilidade genética e parentesco de Lycalopex vetulus (LUND, 1842), de uma região de cerrado do norte de Minas Gerais e sudeste de Goiás – Brasil
(Universidade Federal de São Carlos, 2015-06-10)
Silva, André Pereira da
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Galetti Júnior, Pedro Manoel
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https://lattes.cnpq.br/7398754661670478
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https://lattes.cnpq.br/9681455918779067
This study describes the genetic diversity of a population of Hoary foxes (Lycalopex vetulus), animal whose habitat is in the physiognomy of Cerrado, one of the most fragmented and disturbed areas of Brazil. To this end, 33 individuals were captured in a region of cattle ranches in northern Minas Gerais and southeast of Goiás. We amplified 10 microsatellite loci. Our data reveal that these loci are useful in the study of genetic conservation. The genetic diversity present in individuals captured in this study, can be considered high, despite the high degree of fragmentation in the area. The effective population size calculated in this study shows that the genetic diversity supported by the animals studied is representative of a population of approximately 1,300 individuals. We conducted kinship estimates using three methods, one by reading the genotype by software, another through information obtained by field observation studies and a final one, used only when the first two were at odds, based on par visual analysis to analyze all alleles of all loci. With the aid of GPS, the distance between related individuals, paying attention to possible gender’s variation. We conclude that the fox is able to move long distances (over thirty kilometers) and that apparently there is no difference in the male and female dispersal capacity.
MultiFlow: uma solução para distribuição de subfluxos MPTCP em Redes OpenFlow
(Universidade Federal de São Carlos, 2015-06-10)
Sandri, Marcus
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Verdi, Fábio Luciano
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https://lattes.cnpq.br/9143186843657940
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https://lattes.cnpq.br/4217700777543613
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Venturini, Yeda Regina
This Master s thesis shows a solution for splitting MPTCP subflows in an Openflow network. MPTCP is a network protocol designed to branch a single TCP connection into many subflows. The main idea is to forward subflows th- rough disjointed paths. Commonly, ECMP protocol is adopted together to split flows through distinct paths. Nevertheless, there are many issues that shows that ECMP is not pareto-optimal, such as: ECMP can easily set two subflows from the same TCP connection on the same path and/or set a distinct forward and back forward route to the same subflow. To solve these issues, it is designed MultiFlow, a module which uses a controller for guarantee multipath routing by setting subflows from the same MPTCP connection so that such subflows are forwarded through distinct paths. MultiFlow is evaluated in experimentation where is analyzed throughput and resilience comparing it with Spanning-Tree (STP) and ECMP. The experiments were done by using Mininet: An OpenFlow emulator for experimenting with a set of topologies.
Uma abordagem sobre a relação entre funções e áreas para o ensino fundamental
(Universidade Federal de São Carlos, 2015-06-11)
Deangelis, Fernanda Maria Gomes
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Barbosa, Grazielle Feliciani
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https://lattes.cnpq.br/5368292206467565
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https://lattes.cnpq.br/1401159743620548
This work presents a didactic proposal for the classes of affine and quadratic functions in elementary school. From our experiences in the teaching profession, we noted that the study of this content requires experimentation and contextualized activities. The study of affine and quadratic functions in basic education is of great importance for abstraction capacity development, solving practical problems and helps to get skills of comparing results, recognizing the characteristics of these functions. Our work is not intended to define affine and quadratic function, but to develop the perception ability of the results that leads to graphs and charts building and can be confirmed using the GeoGebra software. This activity was implemented in two classes of the ninth year of elementary school at Colégio Batista Brasileiro in Bauru. To do this we need four classes of 100 minutes and 1 class of 50 minutes. This is a didactic sequence that requires the use of computers and of the GeoGebra software
Representação de soluções homogêneas contínuas de campos vetoriais no plano
(Universidade Federal de São Carlos, 2015-06-11)
Menis, Alexandra Cristina
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Hounie, Jorge Guillermo
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https://lattes.cnpq.br/7302904386484949
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https://lattes.cnpq.br/3928582698221236
In this work we study conditions for the validity of the analogue of Mergelyan’s theorem for continuous solutions of a type of locally integrable vector field. On a domain in the plane, we consider a vector field L that has a first integral on of the form Z(x, t) = x + i'(x, t), where '(x, t) is a smooth, realvalued function. Given a continuous solution u of Lu = 0 on , our first objective was to find conditions on and Z for the validity of the factorization u = U Z, where U 2 C0(Z ()) \ H(int{Z ()}). We will next study this factorization on the closure of . We assume that u 2 C0( ) and that the boundary of is real analytic, then we show in which cases the condition Z(p1) = Z(p2) implies that u(p1) = u(p2), for p1, p2 2 . The cases are divided according to the geometry of the boundary in the points p1 and p2. When is a compact set and u = U Z on , we obtain that u is uniformly approximated by polynomials of Z on .
Envelhecimento e gestão pública : o “estado da arte” na produção científica brasileira
(Universidade Federal de São Carlos, 2015-06-11)
Padula, Giovana de Oliveira
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Pedro, Wilson José Alves
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https://lattes.cnpq.br/8135701448186851
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https://lattes.cnpq.br/5404257329698570
Nowadays the aging phenomenon has been studied by many researchers because of the characteristics and relevance of the demographic transition and the impact on public policy. Because of this phenomenon, it is considered extremely relevant to the broad scientific production developed view, and in this study we chose to focus on what has been produced in federal universities. This study aims to analyze the Brazilian scientific literature on the topic aging and administration / public management, from scientific publications (qualis A1 and A2 of interdisciplinary and administration areas) and on the registered research groups in groups Directory Research CNPq Brazil (biological areas, health, human and applied sciences). It is a social and exploratory and descriptive study of document analysis and public information. The results suggest that the thematic management / public administration and aging are not being developed directly as both magazines surveyed in the research groups of federal universities. It was decided, therefore, to present a characterization of what both study objects present on the topic aging. Accordingly, it was found that the aging subject is being exploited in different areas of knowledge in an interdisciplinary approach. It was observed that most groups (n = 180) are concentrated in the area of health sciences, with predominant area of medicine (n = 39). As for scientific journals, it was observed that interdisciplinary journals with qualis A2 has a higher number of publications on human aging (n = 262). In this study, further reflection on population aging in the context of public administration studies have concluded that it is necessary, and also points to the need for more studies on aging and public administration.
Considerações para o controle tecnológico de obras em alvenaria estrutural
(Universidade Federal de São Carlos, 2015-06-12)
Canato, Ricardo Luiz
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Parsekian, Guilherme Aris
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https://lattes.cnpq.br/7798651726059215
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https://lattes.cnpq.br/3822906451253321
Masonry is known as a building structure for thousands of years. Cases where masonry elements (several units laided together bonded or not with mortar and grouting) support the building structure are widely found. Until mid-19th century, almost all structures had masonry part of its structural elements, although not all historic construction can be called structural masonry the way we understand it today with high strength blocks. The great expansion on the use of structural masonry occurred after the development of specific techniques and equipment. Moreover, technological development has enabled the production of higher strength blocks, dimensional precision and uniformity. To certify the design specified quality, there is the need of construction technologic control. This is the guarantee of minimum structural performance. Quality control is necessary to receive (or acceptance) the materials and components, including blocks, concrete, grout and the mortar, and finally the acceptance of masonry. This paper presents an assessment of the masonry quality control. Two parts has focus in different topics. In the first, field study cases in São Carlos city are assessed. The cases include concrete and ceramic blocks masonry building, and the quality control plan of each case were checked. The other part, focus on evaluating the several quality control tests on prisms compressive strength. From an extensive database, simulations concerning on the calculation of the characteristic value and coefficients of variation of samples, are assessed and weighted. As a conclusion, we can point that the quality control as required by Brazilian standards are not always followed in practice. About the prism test, we suggest considering to evaluate standard sample size specified today. It may be possible to reduce the number of specimens in each sample.
Impactos da duplicação de rodovias : variação da mortalidade de fauna na BR 101 Sul
(Universidade Federal de São Carlos, 2015-06-12)
Dornelles, Sidnei da Silva
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Kindel, Andreas
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https://lattes.cnpq.br/8762190723929036
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Pires, José Salatiel Rodrigues
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https://lattes.cnpq.br/3412204514901170
Roadkill and isolation of populations due to the barrier effect can be considered the main direct impacts of roads on wildlife. Mammals by behavioral, size and charisma features are one of the groups of vertebrates that require mitigation for mortality, as they are also among the most seriously injured on roads. An important approach to effectively mitigate roadkill on highways is to locate the points where roadkill are concentrated. The objective of this study was to evaluate the variation in mortality of mammals due to the duplication of the BR 101 highway south. In addition to the K Ripley aggregation analysis, were generated habitat suitability models (MAH) to identify favorable locations roadkill species, using the model functional groups for prediction of highway stretches with more chances to roadkill. It was recorded 21 taxa of mammals get hit, being the most abundant gender Didelphis (n = 721), followed by Cerdocyon thous (n = 108). The abundance of carcasses decreases between before and after the duplication (F 18.04 p = <0.001). Hotspots were not overlapped between the periods analyzed, indicating that some explanatory factor has changed over the work. Observing the variables that contributed most to the models for each functional group, we noted that there were differences in the most influential variables for each functional group in different periods. Of the nine generated models, we note that six variables contributed more than 20% in different models. There were differences between the periods before, during and after the duplication of the variables that contributed most or contribution value in functional groups. These differences may reflect the change in the distribution of roadkill among highway doubling periods. Both approaches demonstrated that there have been changes in the magnitude and distribution of roadkill in the period prior to the period after duplication. So a highway with two paviments differ from a highway with four paviments about how the mammals react in terms of movement and relationship to landscape.
Diversidade e estrutura genética de Pilosocereus aureispinus: uma espécie de cactácea vulnerável e microendêmica
(Universidade Federal de São Carlos, 2015-06-12)
Ribeiro, Paulianny de Moura
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Moraes, Evandro Marsola de
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https://lattes.cnpq.br/3100796431732251
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https://lattes.cnpq.br/5203536984295113
Pilosocereus aureispinus (Buining & Brederoo) F. Ritter is a narrow endemic columnar cactus of eastern Brazil, occurring at Ibotirama and Oliveira dos Brejinhos, Bahia. In this work the genetic diversity and population structure were assessed for eight microsatellite loci in four P. aureispinus localities of occurrence, covering its known distribution. Genetic diversity levels were relatively high (A = 4,2 e HE = 0,451) comparing with closely related species and other narrowly distributed plant species. Significant Hardy-Weinberg Equilibrium departures and linkage disequilibrium were not detected. Private alleles in low frequencies and low levels of genetic structure (FST =0,071 e G”ST = 0,132) were detected. STRUCTURE software analysis did not identified structure, showing that samples from four analyzed localities represent a unique genetic group (K=1). These results pointed to high level of ongoing gene flow among sampled localities, which may counteract differentiation effects and genetic diversity loss. Despite P. aureispinus is not suffering genetic variability erosion due its narrow distribution, the species should be classified as endangered (EN) at IUCN Red List of Threatened Species due existent anthropogenic disturbs in regions where it occurs.
Padrão de especialização do comércio internacional brasileiro: uma análise das vantagens comparativas
(Universidade Federal de São Carlos, 2015-06-12)
Andriotta, Amanda de Brito
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Cruz Júnior, José César
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https://lattes.cnpq.br/0086426315229286
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https://lattes.cnpq.br/1063048735368930
During the most recent decades the Brazilian foreign trade has shown significant changes regarding its pattern of trade specialization. These changes suggest that the country is undergoing into a process of exports reprimarization, caused mainly by the increase of the Chinese demand for commodities. The increase of the share of commodities in trade transactions between Brazil and the rest of the world has happened at the same time that manufactures have lost importance in the nations’ total trade. The new composition of the Brazilian foreign trade transactions indicates the country is following a new pattern in the international market. In addition, not only the country’s exports composition has changed over the last years, but we can also verify changes in the main exports destinations rank list. In this paper, our goal is to investigate the dynamics of changes in the Brazilian foreign trade transactions, focusing on exports, during the period of 1997 and 2003. We divided our analysis in different sectors, destination markets, and different periods to have a better understand of how changes happened. Our main hypothesis is that the reveled comparative advantages in international trade have led the country to the reprimarization process of its exports. Moreover, fewer sectors have shown high competitive levels over the last years, indicating a poor dynamics of Brazilian exports. In order to test our hypothesis, we first calculated revealed symmetric comparative advantages indexes, and then used Markov chains to calculate their probability distributions in different periods. We combined the two methodologies to identify the sectors and groups of technology where the country has higher competitiveness. We could also test for changes in exports composition, identifying which were the sectors and technology groups with higher trade competitiveness, in each period. Our results show that Brazil has been using its comparative advantages in the international trade, and its exports are becoming more dependent of commodities, since this is the group of products with higher revealed comparative advantages index. We also found a general loss of competitiveness in the non-commodity sectors during the analyzed period, which clearly shows that the country is facing a process of export reprimarization. The analysis of trade regarding different groups of countries shows that, even though with different intensities, commodity exports are becoming more relevant to all exports destinations (BRICS, European Union, MERCOSUL, and NAFTA), and it has happened more intensively during the third reporting period (2007- 2011). In addition, we also found that there is an indication that, in the future (ceteris paribus), there will be a possible convergence of exports in sectors with lower levels of comparative advantage. Our findings indicate that Brazil has been losing competitiveness in international trade, even with those products that the country has more comparative advantages in trade.
Avaliação de uso, apropriação e integração urbana de técnicas compensatórias para o manejo de águas pluviais: estudos de caso em Ribeirão Preto
(Universidade Federal de São Carlos, 2015-06-12)
Vicente, Tiago Zanetti de
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Gonçalves, Luciana Márcia
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https://lattes.cnpq.br/9491069760631962
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Barbassa, Ademir Paceli
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https://lattes.cnpq.br/2979012440240781
Increasing urbanization has impacted in various ways in the environment, such as changes in the hydrological cycle, increased flooding and pollution of rain origin. Soil sealing and removal of vegetation reduce infiltration and increase the volume and speed of runoff. With the questioning of the hygienists paradigms based on rapid evacuation of runoff, alternative drainage systems seek temporal rearrangement of the flow from the use of Best Management Practices and forms of rainwater management integrated with urbanization. Some Brazilian cities have public policies to encourage the deployment of alternative drainage systems, as is the case of Ribeirão Preto, a city in the state of São Paulo with a long history of problems related to the management of storm water, as floods and maintenance its source to the underground water consumption. With the inclusion of flow control requirements in the legislation, multiplied by the city storm control structures. The objective of this study is to analyze the implementation of these BMPs in urban subdivisions, from the point of view of the ownership and use of these spaces and their integration with the surroundings. From the survey of legislation and storm control structures performed in the city, were selected two installments, the Allotment Parque dos Servidores and the Condominium Quinta do Golfe, for characterization and analysis of the conditions of pre-occupation, urban design and drainage and finally, the space for BMPs. The results highlights the neglect of the management of these spaces where maintenance is precarious and the interference of the population could compromise its hydrological functions. We conclude therefore that the technical implementation of compensatory policy is an ongoing process, not just boils down to its implementation, its success is linked to urban-landscape qualification, frequent maintenance, as well as community education and involvement in the management of these spaces
Influência de compostos xenobiontes na densidade, diversidade e função ecológica bacteriana de degradação do agrotóxico fipronil
(Universidade Federal de São Carlos, 2015-06-15)
Pacheco, Zaryf Araji Dahroug
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Seleghim, Mirna Helena Regali
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https://lattes.cnpq.br/5998337634888263
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https://lattes.cnpq.br/2053875175175770
The actual agricultural production system requires the use of chemicals such as pesticides and antimicrobials. These compounds, when reach aquatic environments, can cause serious environmental problems and affect target and non-target organisms such as microorganisms, that play key ecological functions to the ecosystem functioning. So, the objectives of this study were: (i) to evaluate the bactericidal action of oxytetracycline (OTC) and fungicide imazalil (IMZ) on bacterial ecological function of pesticide fipronil degradation; (II) evaluate the effect of oxytetracycline on density and aquatic bacterial diversity; (III) to monitor changes in bacterial dynamics in the presence of fipronil. Water was sampled in Beija-Flor Reservoir for mounting the experiments. Microcosms were prepared in triplicates for six different treatments: water; water and OTC; water and IMZ; water and fipronil; water, fipronil and OTC; water, fipronil and IMZ. The microcosms were kept in the dark at 21oC. Samples were collected at 1, 5, 10, 20, 45 and 70 days of incubation. It was determined the water pH, the dissolved organic carbon (DOC), total nitrogen (TN), OTC and fipronil concentrations. Water samples from the microcosms were also used for bacterial density analysis by epifluorescence microscopy and diversity by DGGE band profiles analysis. The presence of OTC alone and especially mixed with IMZ affects bacterial diversity, but does not cause significant effect on fipronil degradation, suggesting the existence of functional redundancy among the individuals that formed the bacterial community. The oxytetracycline, at certain concentrations, promotes a bacterial density decrease and diversity increase, probably by mediating the coexistence of species as a result of the growth control of the best competitive bacteria. Fipronil may cause bacterial density increase but, concerning its diversity, initially in the experiment, it was reduced, comparing with the control samples. However, after 70 days, the diversity was similar, suggesting that the community was reestablished, leading us to consider that the community was resilient to the impact caused by fipronil.
Avaliação de habilidades sociais de adolescentes em conflito com a lei em interações com familiares e amigos : uma análise de metacontingências
(Universidade Federal de São Carlos, 2015-06-15)
Fogaça, Fabiane Ferraz Silveira
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Benvenuti, Marcelo Frota Lobato
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https://lattes.cnpq.br/5625607708848040
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Del Prette, Almir
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https://lattes.cnpq.br/2191226494887247
The study of juvenile offender’s interactions with mother, brother, and friend indicates which categories of social skills (assertiveness, self-control, conversation, and empathy) are established by shaping and modeling processes. Furthermore, it produces more evidences to the relationship between prosocial and antisocial behavior. This study aimed to describe a set of interlocking behavioral contingencies (IBCs) comprised by categories of social skills, which in turn contribute to legal measures outcomes. This study is made up by three independent chapters. The chapter 1. “Social skills of young offenders and at risk adolescents” discussed the social skills repertories as one of multiple factors of evaluation and intervention with adolescents. In summary, the outcomes indicated improvement on social skills categories, specially presented in home settings, the decrease of offending persistence, and lower evidences of the impact of social skills improvements on other adults and peers relationships. The chapter 2, named “Contributions of conceptual, descriptive and experimental metacontingencies studies to family interactions”, explored the metacontingency unit of analysis. Specifically, it discussed the interpersonal relationship patterns as behavioral products transmitted along family members. The last chapter, named “Identifying social skills repertoires in juvenile offenders´ interactions with relatives and friends: a metacontingencies analysis” aimed to describe IBCs that contribute to legal measures results. The participants were three families composed by a mother, a juvenile offender, and a brother without a history of delinquency. Self-reports instruments and interviews were used. The data analysis procedures were as follows: the development of IBCs coding system, establishing relationship between categories of IBCs and categories of social skills, and establishing relationship between categories of IBCs and categories of aggregate products. The results suggested that the participants, who achieved better scores on socials skills categories, also got engaged in conversation, support, negotiation, cooperation, and rules establishment interactions. Also they achieved some of the goals of legal measures (aggregate products).
We will hold the line: o fandom como forma de participação dos fãs no desenvolvimento do universo transmidiático do jogo mass effect
(Universidade Federal de São Carlos, 2015-06-15)
Palomino, Paula Toledo
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Andrade, Leonardo Antônio de
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https://lattes.cnpq.br/3921612856948891
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https://lattes.cnpq.br/8123777210874634
The advent and popularization of the Internet has enabled the cultural convergence movement, creating numerous online communities as well as the consolidation of collective intelligence. Without being blocked by geographical barriers that once separated them, fans of today are much more active, organized and eager for content. Their voices can now be heard by the companies holding the canonicity of the stories on the internet, through protests on social networks and unofficial content building (fandom culture). Their reactions can influence and even change the original plots. This work aimed to study this phenomenon from the fans perspective and their participation in the evolution of the transmedia universe of Mass Effect games (2007-2012), from Bioware, through its unofficial productions such as fanfiction, specific actions through crowdfunding platforms and interactions via social networking communities like Facebook, in response to the end of game trilogy, which generated great dissatisfaction due to an expectation not fulfilled (from the perspective of those fans). It analyzed the narrative complexity of the work, and how this aspect influenced the relationship with the fans, culminating in this highly organized protest action against the ending, forcing the company holding the canon content to retract and change the ending of its work.
A formação de padres na diocese de São Carlos
(Universidade Federal de São Carlos, 2015-06-16)
Rossi, Renan
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Souza, André Ricardo de
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https://lattes.cnpq.br/7016915324466152
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https://lattes.cnpq.br/5742451767849892
Trying to understand a process through which individuals are raised in certain skills and dispositions, "physical and moral states" that are required by society as a whole, but also by specified groups to which one belongs, I conducted a research about the formation of Catholic priests process. I tried to understand from the experience of the diocese of São Carlos / SP, which dynamic, actors and situations were involved in this process of socialization, through which are cultivated in seminarians a number of provisions that in the future will contribute to the exercise of their priestly ministry. This set of provisions that I call priestly habitus is unconsciously and sometimes deliberately instrumentalized by these social actors, both in the daily performance of their social roles and in the maintenance activity or achievement of social positions in the Catholic Church or even in other fields such as the academic one. The dynamics of such priestly habitus cultivation takes place in a broad context, larger than the boundaries of a seminary, covering a range of training situations arranged through an institutionalized itinerary experiences that culminates in ordination. Such a priestly itinerary - equipped with native significance through a structured vocational speech that reduces the importance of profane motivations in the admission at the seminary provides the trajectories of these actors with a purity of inclination that omits the possibility of other interests (less transcendental ones). Finally, I discuss how to some members of the Catholic clergy, to be a priest not as regarded in the official speeches, but in the daily practices is less of an inescapable fixed identity than a contingency identification activity, which is evoked or omitted by these social actors according to the nature of relations at stake.
Modelagem por homologia da tubulina do Plasmodium falciparum e o estudo de lignanas ariltetralônicas antimaláricas por docking molecular
(Universidade Federal de São Carlos, 2015-06-16)
Corrêa, Denis da Silva
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Schpector, Julio Zukerman
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https://lattes.cnpq.br/4252331837170383
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Caracelli, Ignez
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https://lattes.cnpq.br/8956527354576143
Malaria is an acute febrile disease caused by protozoan parasites of the genus Plasmodium, being the species P. falciparum responsible for the most severe forms and deaths caused by the disease. These parasites have developed resistance to commonly used drugs and therefore there is a need to develop new antimalarial agents. Aryltetralone lignans are compounds that show antiplasmodial activity in vitro against P. falciparum, but its mechanism of action is still not fully understood. In this work, we postulate a plausible mode of action of some aryltetralone lignans and according to the obtained results we suggest modifications to the ligands for a better biological activity. In order to achieve our objectives we first performed a search for similar chemical compounds, for which their macromolecular targets were known. From the results obtained, P. falciparum tubulin was selected as a potential target for these lignans. Since there is no experimentally determined three-dimensional structure for this protein, we performed a molecular homology modeling of P. falciparum tubulin and the structure of bovine tubulin complexed with colchicine was selected as template. The analysis of the obtained model showed that the three dimensional structure of Plasmodium tubulin is conserved in relation to the bovine tubulin with some important substitutions occurring in the colchicine binding site region: Ala250B by Ser248B, Ala316B by Cys314B and Ile318B by Met316B. Then, molecular docking of the aryltetralone lignans, colchicine and podophyllotoxin was performed in the modeled P. falciparum tubulin. The docking calculations results allowed to conclude firstly that, although the amino acid substitutions in the binding site, the colchicine binding mode in the P. falciparum tubulin is exactly the same as that already described in the literature for bovine tubulin. As for podophyllotoxin, a different binding mode from that described in the literature for bovine tubulin was obtained due to the replacement of Ala250B by Ser248B and the Val318B by Met316B. For the aryltetralone lignans studied, three different binding modes were obtained: one exhibited by compounds 1, 2 and 3, another by 4 and 6, and a third one by 5. The lignans 1, 2 and 3 are oriented in a way so that the C ring containing the dimethoxy or methylenedioxy group is positioned in the same region obtained for the ring containing the trimethoxy group in the case of colchicine and podophyllotoxin, performing a C-H...π interaction with Leu246B. Lignans 4 and 6 orient themselves with the aromatic ring C between Ala180A and Leu246B and being held in this position by C-H...π interactions. Lignan 5 is oriented with the aromatic ring C between Leu246B and Leu253B, performing C-H...π interactions with these residues, in a similar way to what was obtained with colchicine in this site. So the likely mechanism of action of the aryltetralone lignans studied here would be their binding to the same colchicine binding site in the tubulin protein of P. falciparum and thereby interrupting the divisions and other cellular functions.
Avaliação de abordagens de gestão do conhecimento aplicadas a um processo de teste de software enxuto
(Universidade Federal de São Carlos, 2015-06-16)
Silva, Ana Eliza Pedroso da
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Ferrari, Fabiano Cutigi
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https://lattes.cnpq.br/3154345471250570
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https://lattes.cnpq.br/3444162625104967
Context: A well-defined testing process is necessary to ensure that the required activities are conducted effectively, supported by maturity models such as TMMi. Even so, for this activities results have real impact on the quality and reliability of the produced artefacts, is fundamental manage the knowledge belonging to the involved individuals. In this context, Knowledge Management (KM) is essential to help software testing professionals acquire and disseminate individual and group expertise. However, existing KM approaches for software testing are still incipient and are driven by different key concepts, such as feedback, lessons learned and knowledge documents. Objective: This work investigates the applicability degree of KM approaches in a streamlined software testing process, from the point of view of professionals with experience in leadership and testing team management in Brazilian companies. Method: A literature search allowed us to identify three KM frameworks for software testing processes. Based on them, we devised their underlying KM processes, upon which we performed two evaluations by means of a critical, in-depth analysis and a survey. An additional investigation explored the combination of the three KM key concepts in a single KM approach for software testing. All evaluations relied on the opinion of experienced software testing professionals. Results: Our results indicate the most applicable KM process, among to the three addressed in our study, to support testing teams in their activities. Such process relies on the concept of feedback provided throughout the software testing lifecycle. Conclusion: Different key concepts applied in KM process leads to diverging opinions regarding their applicability, in the particular scenario of software testing. Combining such concepts into a single KM process may not yield a better solution, possibly due to the augmented complexity and required effort to manage knowledge within testing teams.
Temporalidade e constituição : uma investigação acerca do acesso metodológico à esfera da consciência constitutiva do tempo na fenomenologia husserliana
(Universidade Federal de São Carlos, 2015-06-16)
Thomé, Scheila Cristiane
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Ferraz Neto, Bento Prado de Almeida
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https://lattes.cnpq.br/0084436724293824
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https://lattes.cnpq.br/1334137965142207
The aim of this work is to analyze the possibility and the apparent limit of the reflective-descriptive methodological access to the deepest layer of the constitution of time in Edmund Husserl’s phenomenology. If on one side, reflection presents a real possibility of the phenomenological description of consciousness by seeing and capturing in an objectifying way the acts and objects of consciousness, on the other hand, there seems to be at first glance a certain limit concerning the grasp of reflection because reflection can not capture the deepest sphere of the constitution of time as it picks up objects and acts of consciousness, so this original constituent sphere can never become an object. The price paid for making this ultimate constitutive sphere of time an object is falling into a return to infinity. The examination of this methodological issue will be conducted based on the analysis of three periods in which Husserl investigates this question, namely, in On the Phenomenology of the Consciousness of Internal Time (1893-1917); Bernau Manuscripts (1917-1918) and Manuscripts C (1929 to 1934). The thesis that is being defended here is that ever since his early writings about the theme of temporality, Husserl seeks to prepare an answer to the question concerning the methodological access to the deepest realm of time constitution; but it is particularly in his afterthought by formulating the notion of transzendentalphänomenologisierende Ich that Husserl dissolves once and for all the apparent "limit" or "puzzle" about the reflective-descriptive access to the ultimate sphere of time constitution. This resolution becomes possible because the phänomenologisierende Ich is here understood as the Ego which constitutes the time as well as the Ego that observes itself retrospectively in their ways of constituting, so that in this retrospective and constituent movement the transcendental life of consciousness is accessed and can then be captured descriptively in their deepest constituents layers.
Distribuição espacial da tuberculose em um município do interior do estado de São Paulo entre 2008 - 2013
(Universidade Federal de São Carlos, 2015-06-17)
Fusco, Alcione Pereira Biffi
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Protti-Zanatta, Simone Teresinha
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https://lattes.cnpq.br/6772128930979370
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https://lattes.cnpq.br/3860615184602053
Objective : To analyze the spatial distribution of tuberculosis cases in São Carlos / SP. Method : descriptive and ecological study of tuberculosis cases registered in the tb-web information system, between the years 2008 and 2013. Results: We identified 315 cases (addresses), and, of this total, 290 cases were geocoded, which corresponds to 92%. Most of these cases were male (n = 224; 70.89%), median age of 40 years and with the pulmonary clinical presentation predominant (n = 257; 81.33%). The distribution was not random or heterogeneous, representing specific areas of the municipality in epidemiological terms. Conclusion: The study showed that the city needs improvement with regard to aspects related to the management and planning of health services, strengthening the decentralization actions in relation to primary health care. In this sense, it is essential to increase the early detection and prevention actions, stimulating treatment adherence and active pursuit, contributing, consequently, to the improvement of tuberculosis patient’s care and their social environment.