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Visualização gráfica dos fundamentos da lógica matemática por meio de diagramas de conjuntos
(Universidade Federal de São Carlos, 2017-05-05)
Peach, Glen
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Moura, Renato José de
;
https://lattes.cnpq.br/5227908949297904
The purpose of this work is to propose a method that allow to bring the fundamentals of mathematical logic to high school through the use of set theory, however making the whole approach of the subject through diagrams, making it possible to avoid, for the demonstrations and understanding necessary to the development of the subject, the rigors of writing used in mathematical logic, which, in a first contact, tend to discourage the interest of beginning students.
Estudo das propriedades estruturais, elétricas e ópticas de filmes finos de Niobato de Sódio e Potássio (KNN), fabricados por deposição a laser pulsado (PLD)
(Universidade Federal de São Carlos, 2017-05-05)
Burgos Gavelán, Ricky Nelson
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Zambrano, Michel Venet
;
https://lattes.cnpq.br/1830376229286038
;
Moreira, Fernando Manuel Araújo
;
https://lattes.cnpq.br/1809254923092721
Environmental problems arising from lead toxicity in materials, such as those in lead zirconate titanate (PZT) have stimulate the search for new lead-free ferroelectrics materials with ferroelectric and piezoelectric characteristics comparable to those of PZT. Potassium sodium niobate (KNN) based materials are possible candidates to replace PZT materials in several applications because their high Curie temperature and high piezoelectric coefficients. Development of microelectronics and optoelectronics requires materials with multifunctional properties and low dimensionality, therefore studies in ferroelectric thin films with applications in ferroelectric memories, ferroelectric transistors, photovoltaic devices, electronic modulators, infrared detectors and varistors are necessary. The main object of this thesis, is the synthesis and characterization of morphological, electrical and optical properties of ferroelectric KNN and samarium doped KNN (KNN:Sm3+) thin films, deposited on three diferents substrates SrTiO3, MgO e Si/SiO2) by pulsed laser deposition method (PLD), in addition, a conductive layer of LaNiO3 was deposited on SrTiO3 substrate before deposition of the ferroelectric films for using as electrode and perform electrical characterizations including current leakage, which limits applications of ferroelectric thin films. Finally, photoluminescence measurements of samarium doped films were performed in order to investigate the interaction of this element with crystal structure of KNN, which provides information about possible multifunctional applications.
Made in China / produzido no polo industrial da zona franca de Manaus : o trabalho nas fábricas chinesas
(Universidade Federal de São Carlos, 2017-05-05)
Brito, Cleiton Ferreira Maciel
;
Lima, Jacob Carlos
;
https://lattes.cnpq.br/9244132532446607
;
https://lattes.cnpq.br/5852813705553258
This research analyses the Chinese production in the Industrial Cluster of Manaus Free Zone, focusing on the production pattern and work management. In recent years, significant changes have been operating within the global production chain as a result of the massive displacement of Chinese capital towards the various regions of the globe. Brazil and, more specifically, the Amazon has been one of the main destinations of these Chinese investments. An empirical proof of these metamorphoses of global capital is the arrival of a set of Chinese factories at the Industrial Cluster of Manaus (PIM) from the beginning of the year 2000. In order to understand the meaning of this on the organization of local work, especially in relation to the process of productive restructuring developed in the last years, this research sought to organizationally map out four Chinese factories. Quantitative and qualitative data were produced and gathered together from workers, managers, managers of public and private institutions, and Chinese expatriates. The research findings show that the Chinese, on the one hand, incorporated the local production pattern but, on the other hand, reshaped labour management. Such remodelling I called "taylorization with Chinese characteristics", which operates under the duality of being, at the same time, Made in China, but Produced at the Industrial Cluster of Manaus. As a fundamental element of this process, it was observed that strong socio-productive linkages between parent-subsidiary generate fragile socio-productive links in the Industrial Cluster of Manaus, implying high control of the Manauara workforce and Chinese expatriates. In spite of this, there has been a process of "appropriateness / injunction" that causes some "Chinese characteristics" to be deepened while others have to undergo transformations.
Análise do desempenho do leito vibrofluidizado na secagem de pasta
(Universidade Federal de São Carlos, 2017-05-05)
Costa, Ariany Binda Silva
;
Freire, Fábio Bentes
;
https://lattes.cnpq.br/8937961078558996
;
Freire, José Teixeira
;
https://lattes.cnpq.br/2270677706718167
The agitation promoted by the vibrofluidized bed allows the incorporation of several unitary operations such as granulation, coating of particle, drying of grains, and the drying of pasty materials. However, it is necessary more studies about the drying of paste in this equipment, since according to the work of Daleffe (2005) and Meili (2009) it was verified that a same dimensionless vibration number (Γ) presented different dynamics behaviors and influenced in distinct ways in the process. To understand more about the interference that the vibrational parameters may exert in this type of operation, that the goal of this present work was to develop a more detailed study on the drying of skimmed milk in vibrofluidized bed, varying the intensities of agitation imposed to the bed, two Amplitude (A) from 0.003m and 0.015m combined at frequencies (f) ranging from 100 to 1100 RPM. Thus, firstly, it was analyzed the influence that the vibrational parameters exercised on the characteristic curves of the pressure drop and the standard deviation of pressure drop in function of the superficial velocity of the fluid (Us), when the bed was constituted with glass beads with the diameters of 0.00119m, 0.00219m, and 0.00319m. Thereafter, water evaporation tests were performed to determine the size of the inert material and the experimental conditions that would be used in the paste drying trials. For the drying of the skimmed milk has been used glass beads with 0.00319m of average diameter, air temperature of 100 ° C, surface velocity of 20% higher than minimum fluidization velocity (Umf), different agitation intensities and different paste feed rates. During the experiments, the influence of agitation on the dimensionless pressure drop, air temperature at the bed outlet, relative air humidity at the bed outlet, powder moisture content, powder production rates and powder accumulation rates were analyzed. Analyzing the obtained results, it may be verified in the two amplitudes that the increase of the agitation intensity, through the increase of the frequency, allowed the use of higher maximum feeds rates of skimmed milk in the equipment. It was also observed, for the values of Γ almost constant with different combinations of A and f, that the agitation with amplitude of 0.015m resulted in the greatest variations of pressure drop during the process, in the lower relative humidity levels, in the higher powder production rate and higher powder accumulation rates at the exit of the cyclone. In this way emphasizing the importance to inform A and f to characterize the implemented vibration in the vibrofuidized bed. From these experimental data was designed a hybrid CST / Neural to describe the heat and mass transfer phenomena that occurred during the drying of skim milk. The results showed that the proposed model presented a great agreement with the experimental data, assuming that the vibrofluidized bed behaved as a perfectly stirred tank.
Eleição de líder com qualidade de serviço para o modelo falha-e-recuperação
(Universidade Federal de São Carlos, 2017-05-05)
Reis, Vinícius Angiolucci
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Vieira, Gustavo Maciel Dias
;
https://lattes.cnpq.br/9020007815886406
;
https://lattes.cnpq.br/1535333547015731
A distributed system is a set of processes and links that is desgined to provide computing power and data persistency, even on the presence of failures. To encapsulate the abstraction of time and to determine which processes have currently failed, these distributed systems are based on unreliable failure detectors, which in its turn are used as a leader election service. Many works are dedicated to analyze the quality of service (QoS) of failure detectors, but a few of them has analyzed the QoS of a leader election algorithm. In this work, we present the NFD-L leader election algorithm, designed to work on crash-recovery distributed systems and to follow the QoS specification defined by Chen, Toueg e Aguilera (2002). We used NFD-L to elect Paxos coordinators for a replication framework and compared the observed QoS for NFD-L with the behavior of the framework native leader election algorithm that is not designed to explicitly meet any QoS requirement.
Avaliação do potencial antimicrobiano e leishmanicida de materiais orgânicos derivados da base de Schiff N,N-bis’(Salicilideno)-1,2-fenilenodiamina
(Universidade Federal de São Carlos, 2017-05-05)
Soriano, Bianca
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Sousa, Cristina Paiva de
;
https://lattes.cnpq.br/9002619114161319
;
https://lattes.cnpq.br/6431092009628550
Bacteria and fungi are the main etiological agents potentially causing health care-related infections and the fourth leading cause of death, according to the WHO. Parasitic agents such as Leishmania infantum chagasi, the causative agent of leishmaniasis, neglected and endemic disease, have treatments that are not always eﬀective and have serious side eﬀects. Resistance to antibiotics, antimycotics and leishmanicides, has increasingly induced bioprospecting and synthesis of new substances with pharmacological properties. The Schiﬀ bases, especially those derived from the N, N’-bis (salylcilidene) -1,2-phenylenediamine linker, also known as Salofen, have been studied in order to demonstrate the physical, chemical and biological properties due to Variety of potential technological applications. The objective of this work was to evaluate the biotechnological potential of the Schiﬀ N, N’-bis (salylcilidene) -1,2-phenylenediamine (Salofen) base derivative in relation to the antimicrobial and leishmanicidal activity. Agar diﬀusion techniques and microdilution assays were used for bacterial and yeast studies, and the colorimetric method with Alamar Blue® for Leishmania tests at 24 and 48 hours. Inhibition halos were observed for all microorganisms tested, with the highest mean halos (30 mm) for Candida albicans. Dilution assays have shown promising results, with inhibition rates above 90%, emphasizing better Gram-negative efciency. The leishmanicidal eﬀect was also observed with IC50 at 1.06 mg.mL−1 at 24 hours and 0.66 mg.mL−1 at 48 hours. Thus, the data collected suggest that the Schiﬀ base tested has an antimicrobial and leishmanicidal potential of the compound studied, suggesting a biotechnological application.
Relações entre infância, escola e religião : etnografia dos Baniwa do médio Içana
(Universidade Federal de São Carlos, 2017-05-05)
Marqui, Amanda Rodrigues
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Cohn, Clarice
;
https://lattes.cnpq.br/1714080901123094
;
https://lattes.cnpq.br/1696584969032916
This dissertation is about the relations of childhood, school and evangelical religion of the Baniwa people, who live in the Upper Rio Negro, northwest Amazon. From ethnographic experience in communities of the Middle Rio Içana aspects of Baniwa sociality in the formation of their children are addressed in this dissertation, considering the school and the evangelical religion contexts. The school context is one of the common threads of the ethnographic narrative since the entry into the field happened after an invitation received from the Moliweni school in Vista Alegre community located in the Cuiari River within the scope of the UFSCar Observatory of Indigenous School Education. The religious and school events in Baniwa communities of the Middle Içana demonstrate the importance of religion in its social organization as well as its influence in the debates regarding differentiated Baniwa school education. Thus, this ethnography describes the formativa process of children anf young in their communities in school and religious spaces to understand the meaning of good living in the Baniwa communites of the Middle Içana
Uma análise do universo ficcional de Doctor Who e de seus arquétipos centrais
(Universidade Federal de São Carlos, 2017-05-05)
Contartesi, Felipe
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Andrade, Leonardo Antônio de
;
https://lattes.cnpq.br/3921612856948891
;
https://lattes.cnpq.br/1092242500436134
Doctor Who, a British series created and produced by the BBC since 1963 has been devoted as one of the oldest and most successful series of fiction for television. The series has set its course and achieved cult status, becoming the success it is today with an extensive amount of episodes and seasons and a large expansion of its narrative universe to other media such as movies, comics, literature, digital and analog games. The expansion of a work brings a series of obstacles, a vast narrative maintained for so long and in so many media, undergoes several changes with the passage of time, the fans can also change or have different expectations. Nevertheless some series like Doctor Who, manage to remain firm and coherent over time. These series can find and construct a solid identity that is interesting and acceptable to its fans, this identity is related to the archetypes of the fictional universe of the series and is what often guides the narrative direction and the migration of this narrative to other media, this study aimed to analyze and punctuate the elements that define this identity of Doctor Who and how this can contribute to the production and study of vast transmedia narratives.
Modificações da técnica de corrida : aspectos biomecânicos e clínicos em corredores com e sem dor patelofemoral
(Universidade Federal de São Carlos, 2017-05-05)
Santos, Ana Flávia dos
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Nakagawa, Theresa Helissa
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https://lattes.cnpq.br/3020771286419217
;
Serrão, Fábio Viadanna
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https://lattes.cnpq.br/8137335642635433
Every year, up to 70% of recreational runners reported some musculoskeletal injury. Patellofemoral pain (PFP) is one of the most common injuries in these athletes. It has been reported that gait retraining may have a beneficial effect on the lower limb biomechanics and consequently may reduce the patellofemoral joint overload. However, the information regarding biomechanical and clinical effects after a training protocol in PFP runners and, the comparison between different techniques in a same cohort in order to identify the most effective are sparse. Therefore, the objectives of this thesis were: to evaluate the immediate and long-term effects of gait retraining of kinematic, electromyography, pain and function in PFP runners and; to verify the effectiveness of three running techniques on the patelofemoral joint stress in healthy runners. The three running techniques were: forefoot landing, step rate increase by 10% and forward trunk lean. Kinematic, kinetic and electromyography analysis were done. To assess pain and function, the visual analog scale and two self-reported questionnaires were used. The results showed that the three running techniques reduce pain intensity and improve function in PFP runners after 2 weeks of a supervised gait retraining and, these improvements are maintained 6 months after the intervention. The gait retraining increased the muscle pre-activation before the initial contact. Forefoot landing technique was the most effective condition for reducing patellofemoral joint loading.
Efeitos de um derivado semissintético do [6]-gingerol na autofagia e apoptose em células de câncer de mama
(Universidade Federal de São Carlos, 2017-05-09)
Dulcey, Liany Johanna Luna
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Cominetti, Márcia Regina
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https://lattes.cnpq.br/3725318894555272
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https://lattes.cnpq.br/1841833705087719
In this work, we describe a semisynthetic derivative of [6]-gingerol called SSi6, which induces cytotoxic effects on the MDA-MB-231 breast tumor, showing a greater selectivity for these cells when compared to the non-tumor MCF-10A , In addition, the substance was determined to induce autophagy and apoptosis in tumor cells, with less pronounced effects on non-tumor cells. The coexistence of both events (autophagy and apoptosis) was demonstrated by flow cytometry, which evidenced an increase in the percentage of apoptotic cells after 24 hours of treatment, these results were also confirmed by the analysis of the gene and protein expression of caspase-3 using Real-time PCR and western blotting respectively. Induction of autophagy in SSi6-treated cells has been demonstrated through acid vesicle organelle (AVOs) detection assays and the expression of genes encoding the LC3-I and II microtubule-associated proteins to quantify the abundance of autophagosomes in MDA-MB-231 cells. Thus, these results indicate that SSi6 has the potential to induce autophagy and apoptosis, as well as antitumor and antimetastatic properties in MDA-MB-231 breast tumor cells.
Regressão não linear quantílica para classificação de sítio em povoamentos de Eucalyptus sp.
(Universidade Federal de São Carlos, 2017-05-09)
Santos, Carlos Juliano
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Thiersch, Cláudio Roberto
;
https://lattes.cnpq.br/8791966697254106
;
https://lattes.cnpq.br/6499460352099237
The productive capacity is conventionally estimated by anamorphic or polymorphic calculated site curves; however, these curves have some limitations. Due to these limitations, the objective of this work was to evaluate the creation of growth curves for site classification by the nonlinear quantile regression method and to compare them with the curves generated by the algebraic difference method. The database was collected in two mesoregions of the state of São Paulo (Paulista and Bauru Metropolitan Macro), with 460 measurements in 98 plots with distinct periods in Eucalyptus sp. The site curves were adjusted according to the Chapman-Richards model using the algebraic difference method for anamorphic and polymorphic curves and nonlinear quantum regression (RNLQ). The results of this work allowed to conclude that the site curves adjusted by the RNLQ method are superior to the curves generated by the algebraic difference method by graphical analysis of the residuals with smaller ranged of the errors and greater homogeneity and residual standard error with lower values in the classes in general.
Propostas de pagamento no estudo de matemática financeira : análise de uma abordagem prática
(Universidade Federal de São Carlos, 2017-05-09)
Francisco, Marcelo Sabbadini
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Malagutti, Pedro Luiz Aparecido
;
https://lattes.cnpq.br/5462523657624050
;
https://lattes.cnpq.br/9478680093249519
The objective of the project and research was to apply and conjecture about a practical approach to the study of payment methods, using commercial proposals of students' daily routine of a technical course in the management area. Assessing the historical and conceptual aspects, as well as associating them to students' daily life, in order to assist the student and the technical future in their future commercial transactions, whether private or professional, and enable them to conceptually and critically evaluate the methods of payment offered in the acquisition of a property, were the main strands developed in the application of the research proposal, as recommended by various scholars in the area of financial education, among them GRANDO and SCHNEIDER (2011). The work was developed, according to the theoretical presuppositions of didactic engineering, in stages, among them the study of conceptual and historical aspects of the amortization system, analysis of everyday situations and the application of questionnaires. The researcher professor conducted the study in the 1st module of technical course in finances at a state technical school in Jaú city. The results obtained in the questionnaires from the students finances course were compared with the results from the students in the first module of the management technical course. However in the management class the content was developed by exposing the theory and solving problem situations. The guiding question for our research was: “Does a practical approach to the study of financing systems help the student by comparing the methods of payment opt for the most economical option?” The analysis of the results presented a favorable framework for the proposal of a practical approach, prioritizing the use of everyday situations, to the study of payment methods besides it offered a more critical learning to the detriment of a reproductive bias normally observed in the teaching of financial mathematics.
Transformação e permanência : regionalismo e representação da mulher em Faca, de Ronaldo Correia de Brito
(Universidade Federal de São Carlos, 2017-05-10)
Santos, Élide Mendonça dos
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Pellegrini, Tânia
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https://lattes.cnpq.br/0280434883580627
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https://lattes.cnpq.br/1860491964988052
This work aims the investigation of the permanence of a contemporary Brazilian regionalism tradition, based on some tales of the book Faca, published in 2003 by the cearense writer Ronaldo Correia de Brito. These tales are: “A espera da volante”, “Faca”, “Redemoinho”, “A escolha”, “Mentira de Amor” e “Cícera Candoia”. It is proposed to line a possible trajectory for a women’s representation in different kinds of regionalism that comes out in different moments in our literary panorama, basing on canonical works about this subject. Our own work is also based on the critical theory studies to comprovate our hypotheses and objectives. Our choice for this work is justified by the fact that the feminine characters, established in the author’s universe, revisit and reiterate some tradicional codes about genre, but also include new codes that are related with the present time. It reaffirms, in this way, the own survival of the recent regionalism, once that the characters assumed contravention roles, different from that is verified in ulterior phases, engendering the turn of the XIX century. Besides, our hypothesis is the effect of transgression, subversion and punishment, always present in stories and characters in the regionalism expression; it has coming a bit of consuming in the contemporary, to indict, in a certain way, the sociocultural transformations lived in our time.
Mecanismos linguísticos e relações intersubjetivas na produção de textos : atividades enunciativas na prática de ensino
(Universidade Federal de São Carlos, 2017-05-11)
Barros, Solange Christiane Gonzalez
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Valentim, Helena Topa
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Onofre, Marilia Blundi
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https://lattes.cnpq.br/4908382415301882
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https://lattes.cnpq.br/3171777102805120
In this study called Linguistic mechanisms and intersubjective relations in textual production: enunciative activities in the teaching practice, the aim is to recall questions from the Master’s degree, such as the difficulty that students have to insert notions of qualification as explicit marks of intersubjective regulation (commented world) in their textual productions. Analysing, now, a practical work to be done in school contexts and considering the difficulties observed in the students’ textual production, we have the objective to i. explore more deeply the process of constitution of enunciative plans which involve linguistic mechanisms as marks of intersubjective regulation, especially the appreciative modality, which marks the enunciator’s point of view – favourable or unfavourable – about a content that is constructed linguistically; ii. determine and analyse the use of the appreciative modality in a corpus constituted of narrative texts, especially fables; iii. propose linguistic practices to be applied in the exercise of textual production aiming to explore, in the language teaching, the language process which can promote the students’ linguistic-cognitive development. It is used in this work the Theory of Predicative and Enunciative Operations proposed by the French linguist Antoine Culioli.
Seletividade de herbicidas aplicados em pré-emergência e pós-emergência sobre Crotalaria ochroleuca, Cajanus cajan e Raphanus sativus
(Universidade Federal de São Carlos, 2017-05-12)
Pereira, Laís Molinari
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Monquero, Patricia Andrea
;
https://lattes.cnpq.br/2766526793830455
;
https://lattes.cnpq.br/9612469769486531
Green manure has been widely diffused because of the benefits it brings to the chemical, physical and biological characteristics of the soil. However, the adoption of this practice by farmers depends on the definition of management strategies that allow the full development of these crops in the field. Among the strategies, the definition of selective herbicides is a fundamental point in helping the development of the crop. The objective of this work was to evaluate in the greenhouse if pre-emergence and post emergence herbicides are selective for the three green manure species: forage turnip (Raphanus sativus L. cv. CATI AL 1000), dwarf pigeon pea (Cajanus Cajan (L) Millsp cv. IAPAR 43) and crotalaria (Crotalaria ochroleuca L. comun cv.). In the field evaluate if the herbicides defined as selective in greenhouse will damage crops, in relation to phytomass production. The herbicides applied in greenhouses in pre-emergence were atrazine, saflufenacil, sulfentrazone and metribuzin. Separately, post-emergence bentazon, fluazifop-p-butyl, fomesafem, chlorimuron ethyl, mesotrione, imazethapyr, nicosulfuron, clomazone and imazapique. The doses were 0.5, 0.75, 1 and 1.25 of the commercial dose. The three species of green manure were planted in cups with a capacity of 0.5 L. The application of pre-emergence herbicides was performed one day after sowing, and the post-emergence herbicides were applied when the plants had 2 to 3 Pairs of definitive leaves. Phytotoxicity evaluations were performed at 7, 14, 21 and 28 days post-emergence (DAE) for pre-emergent herbicides and 7, 14, 21 and 28 days after application (DAA) for post-emergence herbicides. At 28 DAE / DAA the aerial part of the plants were collected to determine the dry biomass. In greenhouse the herbicides considered selective for Cajanus cajan were fluazifop-p-butyl, bentazon, imazethapyr, clomazone, imazapique, mesotrione and nicosulfuron. For Crotalaria ochroleuca: fluazifop-p-butyl, imazethapyr, bentazon, clomazone, fomesafem and mesotrione. No herbicide was selective for Raphanus sativus. In the field experiment were used the herbicides that were selective in the greenhouse, in the case only for the crotalaria and dwarf pigeon pea. The experimental design was a randomized block design with 4 replicates for treatments and controls. When the crotalaria plants were with up to 3 pairs of true leaves were sprayed with the herbicides bentazon, fluazifopp-butyl, fomesafem, mesotrione, clomazone and imazethapyr. The application in pigeon pea occurred at the same phenological stage with the herbicides bentazon, fluazifop-p-butyl, mesotrione, imazethapyr, nicosulfuron, clomazone and imazapique. Phytotoxicity of the crops was evaluated weekly until flowering corresponding to 42 DAA for pigeon pea and 56 DAA for sunflower. In the field only the mesotrione in the crotalaria crop caused 100% of phytotoxicity, in the other treatments all herbicides selected in greenhouse were also selective in the field, allowing the complete cycle of the crop and producing significant biomass
Práticas de Produção Mais Limpa e sua relação com o desempenho financeiro das empresas de manufatura listadas na BM&FBOVESPA
(Universidade Federal de São Carlos, 2017-05-12)
Silva, Thiago Lopes da
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Mergulhão, Ricardo Coser
;
https://lattes.cnpq.br/0598720328915137
;
https://lattes.cnpq.br/2516968651757684
Sustainable development raises at present days a number of challenges to manufacturing, precisely in order to make production more sustainable, equating economic and financial issues with environmental and social issues. Cleaner Production represents one of the approaches which can be used by manufacturing companies in the attempt to achieve this purpose, rightfully represent this a strategy oriented to the reduction of negative impacts arising from production processes in all its extension. As a direct result of the implementation of cleaner production practices, enhances the efficiency of the production process, thus increasing competitiveness of enterprises, whether in terms of increases in manufacturing capacity, both in terms of better prospects of generating financial results. However, in the case of the Brazilian context, are relatively sparse theoretical-empirical evidence that greater intensity as the implementation of cleaner production practices on the part of corporations effectively shown able to influence your financial performance. Under such circumstances, the objective of the present study is to assess whether the greater or less intensity about the implementation of cleaner production practices by manufacturing companies listed on the BM&FBOVESPA shown effectively able to provide significant differences in terms of financial performance. To this end, a survey research was undertaken by the manufacturing companies listed on the BM&FBOVESPA, whose research instrument was constituted in the questionnaire. The collected data were subjected to statistical analysis by means of appropriate software to such purpose, by use of Multivariate Statistical technique called multiple Linear Regression. Finally, the survey results point to the perception that some of the cleaner production practices seem to influence corporate financial performance, profitability, and profitability, than be seen to be viable your implementation under the economic-financial point of view.
Newsminer: um sistema de data warehouse baseado em texto de notícias
(Universidade Federal de São Carlos, 2017-05-12)
Nogueira, Rodrigo Ramos
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Gonzalez, Sahudy Montenegro
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https://lattes.cnpq.br/9826346918182685
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https://lattes.cnpq.br/0327974399448757
Data and text mining applications managing Web data have been the subject of recent research. In every case, data mining tasks need to work on clean, consistent, and integrated data for obtaining the best results. Thus, Data Warehouse environments are a valuable source of clean, integrated data for data mining applications. Data Warehouse technology has evolved to retrieve and process data from the Web. In particular, news websites are rich sources that can compose a linguistic corpus. By inserting corpus into a Data Warehousing environment, applications can take advantage of the flexibility that a multidimensional model and OLAP operations provide. Among the benefits are the navigation through the data, the selection of the part of the data considered relevant, data analysis at different levels of abstraction, and aggregation, disaggregation, rotation and filtering over any set of data. This paper presents Newsminer, a data warehouse environment, which provides a consistent and clean set of texts in the form of a multidimensional corpus for consumption by external applications and users. The proposal includes an architecture that integrates the gathering of news in real time, a semantic enrichment module as part of the ETL stage, which adds semantic properties to the data such as news category and POS-tagging annotation and the access to data cubes for consumption by applications and users. Two experiments were performed. The first experiment selects the best news classifier for the semantic enrichment module. The statistical analysis of the results indicated that the Perceptron classifier achieved the best results of F-measure, with a good result of computational time. The second experiment collected data to evaluate real-time news preprocessing. For the data set collected, the results indicated that it is possible to achieve online processing time.
Avaliação dos efeitos antitumorais do complexo de rutênio [Ru(GA)(dppe)2]PF6 em células não-tumorais e tumorais de mama cultivadas in vitro
(Universidade Federal de São Carlos, 2017-05-12)
Naves, Marina Araújo
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Cominetti, Márcia Regina
;
https://lattes.cnpq.br/3725318894555272
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https://lattes.cnpq.br/6398544243407478
Cancers have become an increasingly relevant problem of public health in the last decades. Within neoplastic diseases, breast cancer is one of the most incidental in female population and related to a high mortality rate. Within types of breast cancer, triple-negative is the most aggressive one and prone to form metastasis to lung and brain. Because they do not express hormone receptors, triple-negative tumors do not have an auxiliary target therapy, thus, treatment is hampered and chemotherapy is the only option of treatment remaining for metastatic cases of this tumor type. However, chemotherapy drugs currently used, in some cases are not selective to tumor cells, acting only on the proportion of cells exposed to treatment or cells that are at certain stages of the cell cycle. Thus, non-tumor cells are affected and some neoplastic cells remain intact, characterizing tumor recurrences and resistance to treatment. Rosenberg and colleagues, in 1964, were responsible for the discovery of cisplatin, a metal and antiproliferative compound still widely used in therapies against various types of tumors, but despite its effectiveness, it has several side effects. Therefore, the search for more selective antitumor drugs for neoplastic cells and with fewer adverse effects is critical to advances in the treatment of cancer. With the limitations of cisplatin, new researches have been developed with ruthenium complexes. Ruthenium has properties that may justify its antitumor potential and selectivity for tumor cells; within them, the ability to imitate iron binding to many biomolecules, including transferrin and albumin. Previous studies have suggested the antitumor effects of ruthenium both in vitro and in vivo. Therefore, the aim of this study was to evaluate the chemosensitizing ability of the ruthenium complex [Ru(GA)(dppe)2]PF6, which we called Ru(GA), as well as its antitumor activity on triple-negative breast cancer cells (TNBC). In addition, differences between the in vitro behavior of cells treated with the compound and untreated cells were verified, as well as differences between the activity on tumor and non-tumor cells used in this study. The results demonstrated that the complex Ru(GA) was more efficient in inhibiting the proliferation of triple negative breast cancer cells MDA-MB-231, compared with the non-tumor cell line MCF-10A, which was more resistant to the complex. Furthermore, the compound was able to reduce the number and size of colonies, to modify the cytoskeleton and act inhibiting the migration ability of tumor cells. The complex also induced apoptosis by increasing the expression of pro-apoptotic genes such as Bax, Caspase-9, Caspase-3 and decreasing anti-apoptotic genes Bcl-2 in TNBC cells. Moreover, Ru(GA) was able to increase the expression of apoptotic proteins and sub-G1 phase distribution on tumor cells. Interaction assays with Ru(GA) and transferrin showed that this protein has a strong participation in the contact between ruthenium complexes and tumor cells, increasing their effectiveness. These results show that the complex Ru(GA) has antitumor potential against breast tumor cells and it might be a good alternative drug for the treatment of cancer.
Participação de pequenos grupos neurais seletivamente ativados do córtex pré-límbico na reinstalação da autoadministração de etanol induzida pelo contexto
(Universidade Federal de São Carlos, 2017-05-12)
Palombo, Paola
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Cruz, Fábio Cardoso
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https://lattes.cnpq.br/4804337113083801
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Planeta, Cleopatra da Silva
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https://lattes.cnpq.br/2514762545280942
Context-induced reinstatement of drug seeking is an animal model for assessing the neural mechanisms underlying context-induced drug relapse, a major factor in human drug addiction. Neural activity in prelimbic cortex has been implicated in context-induced reinstatement drug seeking. Here, we report a new and feasible training procedure for context-induced reinstatement of alcohol seeking to explore the role of prelimbic cortex in context-induced relapse to alcohol seeking. Long-Evans rats were first given home-cage access to 10% ethanol. Using a saccharin fading technique, rats were first trained to self-administer 10% ethanol in one context. Next, lever pressing in the presence of the discrete cue was extinguished in a different context. Subsequently, context-induced reinstatement of drug seeking was assessed by re-exposing rats to the drug-associated or extinction context under extinction conditions. Re-exposure to the alcohol-associated context reinstated alcohol seeking and increased expression of the neural activity marker Fos in the prelimbic prefrontal cortex. The percentage of neural activation in this brain region was 3.4 % in extinction context and 7.7 % in drug associated context. Reversible inactivation of neural activity in prelimbic prefrontal cortex using GABA agonists muscimol and baclofen attenuated context-induced reinstatement. Based on previous findings of the literature that Fos-expressing neurons play a critical role in conditioned drug effects, we assessed whether context-induced reinstatement was associated with molecular alterations selectively induced within context-activated Fos-expressing neurons. We used fluorescence-activated cell sorting to isolate reinstatement-activated Fos-positive neurons from Fos-negative neurons in prelimbic cortex and used quantitative PCR to assess gene expression within these two populations of neurons. Context-induced reinstatement was associated with increased expression of the GABAα5 gene and decrease in the AMPA receptor subunit genes GluR1 and GluR2 in only Fos-positive neurons. Our results demonstrate an important role of prelimbic cortex in context-induced reinstatement of alcohol seeking and that this reinstatement is associated with unique gene alterations in Fos-expressing neurons.
Relacionamento entre estrutura e função muscular periférica, inflamação sistêmica e regulação autonômica na capacidade funcional de adultos obesos com ou sem distúrbios metabólicos
(Universidade Federal de São Carlos, 2017-05-15)
Carvalho, Lívia Pinheiro
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Mendes, Renata Gonçalves
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https://lattes.cnpq.br/9634590922242052
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Silva, Audrey Borghi
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https://lattes.cnpq.br/4855616925791895
Obesity is considered a worldwide epidemic, exerting great impact on cardiometabolic morbidity and mortality. Obese individuals often present poor cardiorespiratory fitness (CRF), altered cardiac autonomic modulation (CAM) and muscle functioning and, therefore a higher risk of developing physical disabilities and life-threatening events later in life. However, a subpopulation, the so-called "metabolically healthy obese," appears to be less likely to develop such impairments because of a more favorable metabolic profile, despite excessive body fat. In this context, we proposed the accomplishment of three observational and cross-sectional studies that could contribute to the comprehension of the global capacity and physiological responses in young adults aged 20 to 45 years when submitted to different exercise tests, including the cardiopulmonary exercise testing (CPX), the gold standard method for evaluating CRF, and field functional tests, which are less costly and interesting because they mimic usual activities of daily living, such as the six-minute step test (6MST) (Study I) an the six-minute walking test (Study II). Thereafter (Studies II and III), we aimed to investigate whether there would be an influence of the metabolic profile, namely the association with Metabolic Syndrome (MetS), insulin resistance (IR) and systemic inflammation, in such clinical outcomes. The first study evaluated a sample composed only of sedentary normal-weight (NW) and obese (OB) women (n=31) to investigate the agreement between cardiorespiratory responses from the 6MST and CPX; to develop a predictive equation from the 6MST to estimate the maximal aerobic capacity (VO2peak in the CPX); and to investigate whether aerobic/functional capacities are related to muscle strength and power (knee extensor peak isokinetic/isometric torque, power and total work). We found that CRF, functional capacity (6MST), relative muscle strength and power were lower in OB than in NW women. We demonstrated that body mass index (BMI), age and performance (up-and-down cycles) in the 6MST explain 83% of maximal VO2peak total variance, and it was possible to elaborate the predictive equation. Moderate to strong correlations were found between CRF, functional capacity (6MST) and muscular strength and power. Study II (n=66) aimed at evaluating cardiorespiratory responses to exercise and CAM (at rest and during the submaximal six-minute walking test [6MWT] and 6MST) by linear and nonlinear indices of heart rate variability (HRV), and their associations with IR and systemic in NW and OB men and women, with or without MetS. We found that cardiorespiratory responses to exercise are affected by obesity per se and do not reflect the influence of MetS in obese patients. However, MetS seems to affect CAM at rest and in response to exercise, since we observed reduced parasympathetic modulation and overall HRV at rest as well as an altered complexity in response to exercise in the OB group with MetS. IR was associated with altered CRF, but not with HRV, and serum levels of IL-10 and TNF-α were associated with HRV. Finally, we demonstrated that the 6MST induces greater cardiovascular stress than the 6MWT, and may be applicable for MAC evaluation in clinical practice. Study III (n=61) aimed to compare the metabolic and inflammatory profile, especially the role of specific biomarkers (leptin, LP, adiponectin, ADP and myostatin, MSTN) and muscle function, energy expenditure and CRF between the same groups. The last group, however, was characterized by the association of MetS with IR. We concluded from this study that high levels of MSTN and LP-to-ADP ratio are associated with MetS and IR, low-grade chronic inflammation and low muscle mass. LP/ADP is associated with parameters of obesity alone and with CRF, and neither LP/ADP nor MSTN are associated with energy expenditure and muscle function, as suggested in previous studies in animal models.