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Banco Central e os sentidos sociais da ação em política monetária : as justificações morais distintas dos usos sociais do dinheiro
(Universidade Federal de São Carlos, 2017-07-31) Silva, Márcio Rogério; Grün, Roberto; https://lattes.cnpq.br/6028266827740491; https://lattes.cnpq.br/6859176963189141
It is a study about the social meanings emerging from the monetary policy action of the Central Bank of Brazil (BCB) between 1995 and 2016, using comparisons with agents of the Federal Reserve (Fed), European Central Bank ( ECB) and pressure groups inserted in a broader social space, aiming to understand the social meanings of decision making on such a policy, based on structural and moral inheritances throughout the historical process of the role of the Central Banks. Under the sociology of Boltanski and Thevenot's critical capacity, supported by the prosopography, narrative, content, and financial statements methods, by reference to situational disputes over interest rates, it was possible to demonstrate that there are moments in which there is convergence between the position and the Position at the BCB, while at other times they influence more public-economic-financial coalitions or the performative pressure of groups outside of power, especially in cultural disputes that open up larger areas of opposition, opposing Hawkish practices to practices Dovish (monetary easing), emerging moral senses of accusation and defense. Finally, it was concluded that the monetary counter-performance between 2011 and 2014, contrary to the equivalence agreements in monetary policy, was one of the important variables for the establishment of a political crisis, along with other multisectorial factors. To this end, this tension has indicated a meta-heuristic operator of interest and debt which anchors high interest in technical-moral justifications, as justification in the "sacrifice" and "just reward" to financiers and as "punishment" to the "irresponsible".
Avaliação in vivo da inativação fotodinâmica para tratamento de pneumonia
(Universidade Federal de São Carlos, 2017-07-31) Geralde, Mariana Carreira; Kurachi, Cristina; https://lattes.cnpq.br/0194007981724312; Bagnato, Vanderlei Salvador; https://lattes.cnpq.br/4947860249518663; https://lattes.cnpq.br/5271980848300405
Infectious pneumonia is a major cause of morbidity/mortality, mainly due to the increasing rate of microorganisms resistant to antibiotics. Photodynamic Inactivation (PDI) is emerging as a promising approach, as effects are based on oxidative stress, preventing the emergence of resistant microorganism strains. In previous studies, the in vitro inactivation of Streptococcus pneumoniae using indocyanine green (ICG) and infrared light source was successful, and achieved reduction of 5 log10 colony-forming units (CFU/mL) with concentration as low as 10 μM ICG. In the present study, a proof-of-principle protocol was designed to treat lung infections by PDI using extracorporeal illumination with a 780 nm laser device and ICG as photosensitizer. In a first row of experiments, hairless mice were infected with S. pneumoniae and PDI was performed two days after infection. For control groups, CFU recovery ranged between 103-104 CFU/mL/mouse. For PDT group, however, no bacteria were recovered in 80% of the animals. Animal survival was evaluated separately over 50 days. No deaths occurred in PDT group, whereas 60% of the control did not survive. Lung injury analyses were performed in BALB/c mice, the bacteria reduction were 2 and 4 log10 in 2 mice (5 in total) and the wet-to-dry ratio showed that PDI did not increase the edema in lungs. The bronchoalveolar lavage data indicated a larger absolute number of cells (mononuclear and polymorphonuclear) in the PDI group in contrast to control group, meaning that the technique could increase the immune system response. In vitro results showed the irradiated ICG could generate aggregates or photoproducts that help PDI to inactivate the bacteria. Our results indicate that extracorporeal PDI has potential for pneumonia treatment, and pulmonary decontamination with PDI may be used as a single therapy or as an antibiotics adjuvant.