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Isolamento e caracterização de cepas termotolerantes de Saccharomyces cerevisiae e análise da expressão de genes possivelmente envolvidos com a termotolerância
(Universidade Federal de São Carlos, 2018-03-28)
Souza, Jonas Paulino de
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Cunha, Anderson Ferreira da
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https://lattes.cnpq.br/0329741640375661
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https://lattes.cnpq.br/8998062189801580
Brazil is the world’s second largest producer of ethanol, which is produced, in our country, from the fermentation of sugarcane sucrose by Saccharomyces cerevisiae yeast. Despite having a high capacity for ethanol production, the industrial yeasts act in a narrow band of temperature between 30 and 35ºC. In order to maintain this band of temperature, chillers are used, which results in cost increase and water consumption. Besides the temperature, other stress factors, such as high sugar and ethanol concentrations and contamination by microorganisms, also affect the yields of production. In this sense, the present research aimed at isolating and characterizing thermotolerant S. cerevisiae yeast strains from the industrial fermentative process. In addition, the expression of the genes OLE-1, YHR087W and HSP26, which are correlated in literature to different stress factors, was evaluated in these strains. A total of 157 yeasts was analyzed for growth capacity at 40ºC. Eight S. cerevisiae strains, which were identified through the ITS 18S region, were able to grow in this condition. Among the eight strains, four showed excellent glucose consumption at 30 and 40ºC. After 27 fermentative cycles at 40ºC, the four strains showed a preference for growth at this temperature and indicated to be possibly thermotolerant. Previous analyses showed that these strains have a higher capacity for cellular growth, high ethanol concentration and resistance to osmotic stress and acid treatment. Fermentative analyses evidenced that thermotolerant yeasts produced similar quantities of ethanol at 30 and 40ºC. The expression of the genes HSP26 and YHR087W was positively regulated during the fermentation at high temperatures, while the gene OLE-1 reduced the expression at the same condition. The application of thermotolerant yeast strains in fermentations at high temperatures can contribute to increase ethanol production, which is an important strategy to optimize the production of ethanol in Brazil. In addition, the identification of S. cerevisiae genes that were differently expressed under high temperature conditions can contribute to a better understanding of molecular mechanisms that lead to the activation of metabolic pathways responsible for thermotolerance.
O conceito de História em Voltaire
(Universidade Federal de São Carlos, 2018-03-28)
Zaninetti, Priscila Aragão
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Baioni, José Eduardo Marques
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https://lattes.cnpq.br/9613180348313909
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https://lattes.cnpq.br/5633660296578965
The purpose of this dissertation is to study the concept of history in Voltaire. Therefore the research embraces the conception of historical narration, the methodological resources established to verify them, and also the discipline that entitles the work that, here, will be central, The Philosophy of History. It covers such areas, however, with a specific question that would interweave them, namely the possible conservation of contents from the historical conception of Antiquity and the elaboration of contents concerning the historical conception of Modernity by the Voltairean concept of history. Thus narrativity, linked to the adoption of the principle of verisimilitude, and conviction in the instructive utility of history, would therefore be contents that would refer back to the old sense of the concept of history. However, in Voltaire, the separation between the true historical account and the fable aims not only at the education of princes, but above all the progress of the human spirit. Moreover, the Voltairean concept of history seems structured by the specifically historical temporality, capable of encompassing the multiplicity of human manifestations and, therefore, the development of customs by various peoples throughout the centuries. Under these terms, such a concept would also contain contents elaborated by the historiography of Modernity, at which time the philosopher had belonged and for which he had contributed much to the elaboration of his intellectual apparatus. That said, the hypothesis of this dissertation is to understand the supposed ambivalence of the Voltairean concept of history, placing it between the meanings of the historical conceptions of Antiquity and Modernity, as the intersection between inheritance and acquisition, as the perfection of the corpus of thought bequeathed by tradition for a rationality that would experience the social, political, economic and cultural changes of Modernity, thus constituting its own historical thought.
Educação musical e letramento emergente: possibilidades para crianças do primeiro ano da educação básica
(Universidade Federal de São Carlos, 2018-03-28)
Fantini, Renata Franco Severo
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Rose, Tânia Maria Santana de
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https://lattes.cnpq.br/3726292298571344
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https://lattes.cnpq.br/9611195121776675
Based on the studies of Ainscow, Rodrigues and Mantoan, and considering the decisive role of emerging literacy based on the studies of Semeghini-Siqueira and Sulzby and Teale and the importance of this in our society for scholar inclusion to occur in fact, this study seeks to investigate in a way the musical education, inspired by the contributions of musical educators working in the Brazilian scenario, such as Koellreutter, Kater, Brito, Feres, Joly, Parejo, among others, can dialogue with the emerging literacy experiences of children of six years in the context of Elementary School. The purpose of this study was to explore new possibilities and implications of music education in partnership with emerging literacy aspects. The study presents a qualitative approach to data, and they were collected in twelve music lessons for children enrolled in the first year of a public school in the interior of the state of São Paulo, Brazil. The classes were based on the programs of music and literacy proposed by Standley and Hughes (1997) and Register, Hughes and Standley (2012) and had their activities inspired by the contributions of Brazilian musical educators. The data were analyzed qualitatively in eight categories that emerged from the organization of musical activities in the encounters experienced: reception, hello and goodbye songs, activities with voice and language, listening, instruments, movement and body expression, graphics and symbols. The results indicated that when they experienced a set of interdisciplinary musical activities to the emergent literacy, the children progressed in their musical experiences and had opportunities to strengthen aspects of the literacy process itself.
Entre céu e terra: socio-espacialidade dos Mebengôkré-Xikrin. Terra indígena Trincheira Bacajá (T.I.T.B) (Pará, Brasil)
(Universidade Federal de São Carlos, 2018-03-28)
Tselouiko, Stéphanie Anastasia
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Surrallés, Alexandre
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Cohn, Clarice
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https://lattes.cnpq.br/1714080901123094
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https://lattes.cnpq.br/3202788572576556
The Mebengôkré-Xikrin of the Trincheira Bacajá Indigenous Land (Pará, Brazil) have recently undergone unprecedented political, economic and ecological transformations. These are caused, among other things, by the establishment of the Belo Monte hydroelectric dam and by the compensation projects that accompany it. Among the impacts, the reduction of the hydric regime of their Bacajá river, resulting in an erosion of thebiodiversity and an infringement of their mobility and autonomy in their relationship to the Others. In this context, this thesis aims to analyse how the Xikrin conceive and practice their territoriality as they assert themselves and reproduce as Mebengôkré, and this, in a historical depth allowed by the literature and the speeches of the Ancients. At the crossroads between social anthropology and anthropology of the environment, this research is a continuation of recent work on socio-spatiality that has begun a revision of the idea of closure attributed to the Jê societies and to the Mebengôkré in particular. The hypothesis is that the conceptions and practices of the space lived by the Xikrin are guided by the relation to the Other: the Kuben (the Whites), the Mẽkarõ (the dead) and the animals and plants populating the extra and intra villagers. The thesis is structured according to a three-scale analysis, from the widest to the narrowest: from the region between Central Brazil and the Volta Grande do Xingu to the village, passing through the explored places of the Trincheira Bacajá Indigenous Land. The proposed analysis permits to understand how the Xikrin emerged as a collective apart from the other Mebengôkré, by appropriating the space that today constitutes their territory, in their migration and dispersion through the successive splits since their settlement. This thesis finally shows that the Xikrin, originated from a savanna ecosystem, have not only developed a singular relationship with the city but also with the forest and the rivers of a tropical region. Thus, the conclusions put into question the concentric dual representation of the Xikrin socio-spatiality, allowing to consider the extra villagers spaces and their inhabitants not as simply asocial and potentially socializable but, on the contrary, as being socializing, that is to say also having a role in the (re)production of Mebengôkré people and Xikrin sociality, in particular by learning and appropriating elements of these spaces. ABES
Durabilidade de argamassas submetidas ao ataque de sulfatos : efeito da adição da nanosílica
(Universidade Federal de São Carlos, 2018-03-28)
Schmalz, Rosana
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Quarcioni, Valdecir Angelo
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https://lattes.cnpq.br/9443243894564249
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Ferreira, Fernanda Giannotti da Silva
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https://lattes.cnpq.br/0329487394818763
Durability is one of the characteristics to be considered in design and projects of concrete structures as it is related to the useful life of buildings. Among the aggressive agents most damaging to the concrete are sulfate ions, both internal and external, that when in contact with the cement hydration products, cause expansion and cracking of the cementitious matrix. The purpose of this work was to produce more durable cementitious materials against the sulfate attack, with the use of nanosilica, a mineral addition with a lower particle size than the silica fume, which reacts chemically and physically in the hydration reactions of the cement. For this purpose, 1: 3.20 (cement: sand) mortar specimens were tested, two water/binder ratios (0.40 and 0.50) and three colloidal nanosilica contents (1, 5 and 10%). In addition, its effect was evaluated in combination with the silica fume. The mortars mechanical and physical properties were evaluated by means of mechanical strength tests and water absorption by capillarity, and their durability against the sulfate attack by means of dimensional variation tests, chemical and microscopic analyzes. Sulfate attacks were carried out externally, by immersing the test specimens in sodium sulfate solution (10%), and internally by using a sulfate-containing mixing water (3%). In addition, some mortars were subjected to heat cure at 85ºC, in order to verify the occurrence of an internal sulfate attack, due to high temperatures. In general, the results indicated that the nanosilica contributed to the increase of the compressive strength and, mainly, to the reduction of the capillary absorption coefficients of the mortars, due to its filler and pozzolanic effects. Regarding the durability against sulfate attack, both external and internal, it was not possible to verify the positive effects of nanosilica on mortars subjected to wet curing, since during the 91 days of the experiment no evidence of expansion was observed. As for mortars subjected to heat curing, the 10% nanosilica addition was efficient in mitigating delayed ettringite formation (DEF), preventing expansion and cracking. Finally, it was concluded that the nanosilica addition results in positive effects on the cementitious matrix microstructure, reducing its permeability and, consequently, increasing its durability against aggressive agents.
Efeitos agudos e crônicos dos fármacos paracetamol e propranolol em diferentes biomarcadores de uma espécie de peixe neotropical
(Universidade Federal de São Carlos, 2018-03-28)
Pereira, Beatriz Vieira Ramos
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Nunes, Bruno
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https://lattes.cnpq.br/6801060474640624
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Silva-Zacarin, Elaine Cristina Mathias da
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https://lattes.cnpq.br/3993998796939609
Aquatic environments contamination has emerged mainly as a consequence of human activities. The presence of xenobiotics in water bodies can drastically affect the ecosystem, as well as to cause deleterious effects to the species. Production, consumption and inappropriate disposal of pharmaceuticals and personal care products (PCPs) have important contribution for such contamination. Despite existing ecotoxicological studies, there is still a lack of data and studies with native species from neotropical regions and the effects of such substances on non-target species. Taking this into consideration, the present study aimed to assess the effects of two pharmaceuticals, paracetamol and propranolol, on the neotropical fish species Phalloceros harpagos, which genus is native to Brazil and Paraguay, through the analysis of biochemical and cellular markers. Paracetamol is an analgesic and antipyretic drug used to treat pain and fever; propranolol is a non-selective β-blocker. The evaluation of toxicological effects of the described drugs was conducted through analysis of biochemical markers that indicate oxidative stress and neurotoxicity, namely catalase (CAT) in the liver, glutathione-s-transferases (GSTs) in the gills and cholinesterases (ChEs) in the head. The test organism was exposed to 5 different concentrations of each drugs under acute (96h) and chronic regimes (28d). For the acute exposure, besides the control (without drug), the concentrations used were 8, 80, 800, 8000, 80000 µg L-1 for paracetamol and 0.1, 1, 10, 100, 1000 µg L-1 for propranolol. For the chronic exposure the concentrations, apart from the control (without drug), were 5, 10, 20, 40, 80 μg L-1 for paracetamol and 0.0625, 0.125, 0.25, 0.5, 1 µg L-1 for propranolol. Acute exposure results showed increased GSTs activity for most concentrations of paracetamol (80, 800, 8000 and 80000 μg L-1) and propranolol (1, 10, 100 and 1000 μg L-1). ChEs had significant increase in activity for acute exposure to paracetamol (80 µg L-1). In the chronic exposure GSTs activity was significantly increased for propranolol (0.25 and 0.5 μg L-1). For the cellular stress biochemical marker, a protein that belongs to the HSP70 family, an increase in the level of immunolabeling was detected after the acute exposure to both paracetamol (8, 80, 800, 8000 e 80000 µg. L-1) and propranolol (1, 10, e 1000 µg L-1). On the other hand, after the chronic exposure a reduction in the level of HSP70 staining was detected after exposure to paracetamol (5, 10, 15, 20, 40, 80 µg L-1) and an increase after the exposure to propranolol (0,0625, 0,125, 0,25 e 0,5 µg L-1). The results obtained in this research indicate an effort of the organism towards recovering its homeostasis after being exposed to the compounds, whether that is through the attempt of getting rid of the xenobiotics and its metabolites (GSTs activity) or even through cellular protection (immunolabiling of HSP70). Thus, under the experimental condition adopted the fish P. harpagos presented alterations on both biochemical and cellular levels, indicating the organism’s primary response after exposure to these pharmaceuticals.
Poda e raleio da pimenteira para produção e qualidade de frutos
(Universidade Federal de São Carlos, 2018-03-28)
Marchi, Luana Ferreira
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Sala, Fernando César
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https://lattes.cnpq.br/6771975466075202
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https://lattes.cnpq.br/3977174572516802
Peppers are an important fruit vegetable, valued by farmers for their profitability and by consumers for their sensorial characteristics. Its production can be influenced by the management of the plant, through the number of stems and thinning of the fruits, aiming at quality and value aggregation. In this sense, the objective of this work was to evaluate the production, productivity and biometry of the fruits of the CCA 37701 strain of non-pungent (sweet) pepper cultivated in a protected environment through pruning of stems and fruit thinning. The experiment was carried out at the Agricultural Sciences Center of UFSCar-Araras-SP under a randomized block design, with four replications in a 2 x 2 pruning scheme (without pruning and pruning of the stems) and thinning (without thinning and thinning) of fruits). Four plants of each experimental plot were evaluated over eight harvests. The evaluated characteristics were: total number of fruits, total fruit mass, total average fruit mass, total productivity, number of commercial fruits, number of defective fruits, commercial fruit mass, average commercial fruit mass, percentage of commercial fruits , fresh mass of 10 fruits, dry mass of 10 fruits, percentage of dry mass, length, diameter, length / diameter ratio, fruit pulp thickness, number of loci, soluble solids content, pH, titratable total acidity and maturation. The data collected were submitted to analysis of variance and the means compared by the Tukey test. There was a significant interaction between the treatments for mean mass of total fruits, commercial fruit mass, average commercial fruit mass, percentage of fruit dry mass, average diameter, length / diameter ratio, titratable total acidity and maturation index. The treatments conducted with pruning, regardless of whether the fruits were thinned, provided higher total mass and diameter, but reduced the commercial mass. Therefore, pruning management is recommended to increase the average fruit mass and the diameter, and it can be used for the commercialization of fresh fruits.
Reflexões sobre o habitus escolar de alunos do ensino fundamental I em seu processo de escolarização
(Universidade Federal de São Carlos, 2018-03-28)
Martins, Daniela Gimenez Faustino
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Fernandes, Maria Cristina da Silveira Galan
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https://lattes.cnpq.br/5786385589553214
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https://lattes.cnpq.br/0148341594001271
This study aims to study the school habitus of elementary school students in a municipal school. The research is inserted in the discussions about the schooling process, more specifically, in the relation that is established between the school habitus, the practices of teachers and the family of students. The research problem investigates the contribution of the homework mediated by the family and school in the constitution of the school habitus of elementary school students and their contribution for the students' schooling process? The general objective of this research is therefore to analyze the school habitus of elementary school students in a municipal school in the outskirts of the city Serrana – SP, in order to understand their family and school relations with the students' schooling process. It is intended to identify in the routines, in the relations between the family and school institution, the strategies and practices that contribute to the dynamic consolidation of the school habitus. It seeks to identify and reflect on the possible existence of discipline, routines and arrangements for student studies within and outside the school environment and whether families and teachers enable practices that teach these students to study, promoting a school habitus and cultural capital school profitable. The research is based on the concept of habitus of the sociological theory of Pierre Bourdieu. For the collection of data, semi-structured interviews were conducted with teachers, parents or guardians of students and with students enrolled in a municipal elementary school. A total of 14 participants were interviewed. The data of the interviews were submitted to the content analysis and the results show that most of the students have dispositions for the studies, doing with certain frequency the activities inside and outside the school environment, but the routines and discipline established by the families are presented basically by through the development of homework, proposed by the teacher, with some family practices that teach them to study. However, despite their limitations on the possibility of school aid to children, families demonstrate the importance of these practices in the formation of their children / grandchildren. The data also indicate that the teachers believe that these dispositions, discipline and routines for the studies that make up the school habitus have an impact on the students' school performance, and present strategies in their pedagogical practices aiming at the consolidation of this habitus that has been demonstrated related to the students' profitability.
Análise da estrutura relacional das patentes: o caso domínio tecnológico no seguimento dos veículos elétricos e híbridos
(Universidade Federal de São Carlos, 2018-03-29)
Assis, Filippo Savoi de
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Sacomano Neto, Mário
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https://lattes.cnpq.br/0000793038362058
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https://lattes.cnpq.br/1108520989581683
This work aimed to analyze the relational structure of patents in the automotive sector, especially for electric vehicles. More specifically, the objective was to: identify relevant patents and emerging technologies in the automotive sector; to establish the profile of deposit of patents of the main depositors, referring to the emerging technologies; identify patent relational structure; quantitatively investigate the patents of the major automobile manufacturers; to study the economic relations and patents of the great automakers and to study the technological relations and patents of the great automakers. In this research the network approach was used in conjunction with patent analysis to show the existing relationships within this industry in the construction of innovation, observing the patents deposited by these companies and the cooperation agreements made between them. Data collection was carried out through the analysis of patents of high commercial value in the automotive sector, collected through the Derwent database, collecting 111,094 patents of international patent code (CIP) B60 which refers to vehicles. The data were processed using Vatange Point software for the preparation of lists and data matrices related to specific fields of patents. By compiling the data of lists, matrices and combinations it was possible to create indicators in graphic form or in tables that were built with the help of software Microsoft Excel 2016 and the software Origin. The graphs representing the networks were obtained with the help of Gephi software. From the results, it is emphasized that the theme of electric and hybrid vehicles has become predominant in the sector, with Toyota, Bosch and Nissan companies dominate the total number of patents, and are organized in groups that gravitate around them sharing patents only with companies with strong business links, especially cross-shareholding, formal strategic alliances or joint ventures. Companies like Volkswagen and Honda have a high number of patents, but no technological partnership between automakers. Others, such as Fiat, Ford and General Motors have no patents, but seek to position themselves within cooperative networks in order to remain competitive in the marketplace. There are still companies like Hyundai, which has no patents in the sample analyzed and at the same time does not establish technological alliances. Thus, it was sought to understand how part of the technological capital is distributed by the automotive sector, in order to collaborate for a better understanding of the sector.
Rede de atenção à saúde de pessoas com doenças crônicas não transmissíveis sob a perspectiva de seus articuladores
(Universidade Federal de São Carlos, 2018-03-29)
Martins, Ana Carolina Bertini
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Machado, Maria Lúcia Teixeira
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https://lattes.cnpq.br/5703683100332513
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https://lattes.cnpq.br/7855160897682091
The Health Care Networks (HCN) in Brazil are essential for the coordination and integration of services, aiming the integrality and qualification of care, expanding strategies for health promotion, disease prevention and its complications. Between 2011 and 2012, five themes were agreed for these networks and one of them is the Attention to Non-Communicable Chronic Diseases (NCCD), which aims to provide fully attention to the health care for people with these diseases, which are associated with several causes. These diseases have a prognosis of long duration, they may also manifest disfigurement and generate disabilities. The basic care (BC) is a strategy of the Networks and the São Paulo State Department of Health created the program of articulators of basic care, which has the role of supporting, advising and developing actions for their qualification. The work becomes relevant because of the epidemiological picture of these diseases and their serious consequences for the affected individuals and their relatives, the increasement of the demand for care of these diseases in the health units and, consequently, a high cost for the country and municipalities. This work aimed to analyze the Network of Attention for People’s Health with Non-Communicable Chronic Diseases from the perspective of its articulators. The methodological approach was qualitative, with the use of a semi-structured script for interviews conducted in October 2017 with the four articulators working in the NCCD Network in two municipalities of medium size in the countryside of São Paulo State, with subsequent entirety transcription of the interviews and thematic categorical analysis , in which the goal is to identify, in the people’s speech, the meaning and values in relation to the object of study, taking into account the theoretical and methodological framework. The results found indicate weaknesses in the communication among the levels of attention, fragmentation of the care network, non-articulation of care lines and the need for more investments in basic care. The lack of human and financial resources has a direct impact on the implementation and functioning of this HCN. It is important to create strategies to sensitize the managers and shared management that best develop health actions, optimizing the work process, quality of care and life, both users and health workers.
Detecção automática de alterações estruturais hipocampais em imagens de ressonância magnética para auxílio ao diagnóstico da doença de Alzheimer
(Universidade Federal de São Carlos, 2018-03-29)
Poloni, Katia Maria
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Ferrari, Ricardo José
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https://lattes.cnpq.br/8460861175344306
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https://lattes.cnpq.br/8456178776986505
Alzheimer's disease (AD) is the most common form of dementia in world population, accounting for around 60% of all dementia cases and affecting nearly 20% of the population above the age of 80 years. It is an irreversible degenerative disease that causes loss of mental function due to deterioration of brain tissue. This disease is able to develop itself in different ways and its symptoms usually show up gradually. The most common prognostics include the inability to mentally record new information, some degree of difficulty to solve simple problems and to complete familiar tasks at home, confusion about current time and place and trouble to understand visual images. Currently, hippocampus reduction is considered one of the most important, and commonly used AD biomarker. However, despite its clinical use, hippocampal volume reduction is involved not only in AD but also in other dementias and even in healthy aging. In this context, this research aims to create an automatic computational technique capable of detecting and classify structural changes in magnetic ressonance (MR) images that differ from AD when compared to cognitively normal (CN) patients. For this, a probabilistic atlas of 3D salient points was built using a dataset of healthy brain images. 3D salient points were detected in the training dataset with CN and mild-AD brain images and used to label each atlas points. Then, the 3D salient points detected in each training dataset image were "matched" against the labeled points in the atlas, and their descriptors vectors were used to train two classifiers, K-NN and SVM-RBF. After that, 3D salient points were detected for each image from the test dataset, and its respective descriptor was used to find equivalent salient points in the atlas. Their descriptors were inserted and classified in K-NN and SVM-RBF classifiers. Finally, each image was labeled accordingly to the majority of points classified in the corresponding class. This technique was tested in different age groups of the ADNI database (with a total of 551 MR images) and the results were evaluated using ROC curve and 10-fold cross-validation. The highest accuracy value achieved by this technique was 85% (up to 82.59% sensitivity and 88.50% specificity) for the 70-89 age group and the highest AUC was 0.9227.
Descrição dos diferentes estágios do desenvolvimento embrionário de aves das ordens Anseriformes, Galliformes e Psittaciformes e sua aplicação no embriodiagnóstico de espécies selvagens
(Universidade Federal de São Carlos, 2018-03-29)
Guida, Fernanda Junqueira Vaz
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Pereira, Ricardo José Garcia
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https://lattes.cnpq.br/3125092985361893
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https://lattes.cnpq.br/1302967676407620
Although the artificial incubation of wild-bird eggs has progressed in the last decades, this tool is still rudimentary when compared to the technology applied in the poultry industry, which presented considerable advances in order to maximize eggs hatchability. To wild species, parameters such as temperature and humidity of the incubator are often determined by trial and error, taking into account only the hatching rate of the incubated eggs. In this sense, the information generated by embryodiagnosis is of great value in the incubation of unconventional eggs because they offer a greater detail on the causes of birth failure (egg infertility, transport, storage, age and reproductive nutrition, etc.). Thus, the present study aimed to describe the different stages of the embryonic development of representatives of the Anseriformes, Galliformes and Psittaciformes orders of the species Cygnus atratus, Pavo cristatus and Nymphicus hollandicus, respectively. The eggs were incubated at a standard temperature and humidity for each species and, to describe the development, embryos with less than 50% of the incubation period were euthanized by hyportemia and, above this period, by anesthetic overdose using the Halothane 100% inhalant liquid. In total, 238 eggs were incubated, but due to the natural deaths during the incubation process, 67 embryos were described so far, with the final two thirds of the incubation period prioritized. Due to the difficulty in acquiring viable eggs and the reduced number of embryos per day of incubation, the development picture presented gaps, so the research will continue. We believe the continuity of this study will provide subsidies for the improvement of techniques of artificial incubation of eggs, an indispensable instrument in programs of conservation of several species of wild birds.
Cuidado à família enlutada: intervenções realizadas em um hospital público do interior do Estado de São Paulo
(Universidade Federal de São Carlos, 2018-03-29)
Bérgamo, Daniela Carvalho
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Silva, Geovani Gurgel Aciole da
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https://lattes.cnpq.br/6146469366214279
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https://lattes.cnpq.br/9448832786547504
Introduction: the experience of the mourning process is unique and it will develop according to the characteristics of the bereaved and the circumstances of death, which has been occurring more and more in hospitals due to the technological advances in health. Studies show the importance of caring for the bereaved who are experiencing difficulties in drawing up the loss in order to avoid the establishment of complicated mourning. From the implantation of the National Policy of Humanization, changes in health care models were proposed aiming the integral care and redefinition of the hospital's function in the health system, opening space to reformulate the performance according to the characteristics of the service and patient´s need, allowing for a rethinking of care practices including the social support network involved. Objective: this research aimed to understand the repercussions of the interventions performed by a public hospital in the interior of the state of São Paulo in the process of elaboration mourning families of patients who died in the institution and promoting a discussion about grief assistance and the accomplishment of these things by hospitals. Method: this is a qualitative research used was a comprehensive approach based on the sociological phenomenology described by Minayo (2014), the instrument used was the semi-structured interview with bereaved relatives who attended the Grief Reception Group and the analysis of the material was collected through the content analysis of Bardin (1977). Results: the bereaved relatives expressed suffering to face the bereavement even of a predictable death and the need for a bereavement to be heard and to be understood in the face of the feelings and difficulties experienced that goes beyond the loss. They identified as favorable the interventions performed by the hospital, for being reminded, not to feel alone and to the possibility to exchange these experiences with other pelople who are experiencing similar situation, to understand the natural reactions and finding comfort and support to face the mourning. Final considerations: the research shows many possibilities of mourning interventions that can be performed in several places. It also showed the benefit of bereavement care being performed in hospitals because of the the bond already established previously and the comfort felt by the family in contact with the health team after the patient´s death. The mourning of deaths understood as natural and expected, despite bringing suffering to families is neglected. There is then a need to rethink the health practices of institutions, including hospitals, to change the current reality of carelessness in mourning.
Múltiplas soluções em certas classes de problemas elípticos não homogêneos e não locais
(Universidade Federal de São Carlos, 2018-03-29)
Nunes, Amanda Angélica Feltrin
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Madeira, Gustavo Ferron
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https://lattes.cnpq.br/1540196066117667
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https://lattes.cnpq.br/2298201351246179
This work concerns multiplicity of solutions to some nonhomogeneous and nonlocal elliptic problems. The nonlocal term on the operator is of Kirchhoff type and it may be degenerated or not, continuous or discontinouos at the origin. The operator herein includes several examples appearing in the applications like p-laplace, (p,q)-Laplace, generalized p-mean curvature among others. The source terms include concave-convex terms, sublinear or superlinear term which can be local or nonlocal, pertubation of those, and functions satisfying a nonquadraticity condition at infinity. The results proved in this work assure the existence of infinitely many negative energy solutions, infinitely many positive energy solutions whose energy divergs to +\infty and, in some cases, multiplicity of positive solutions.
Mídium e gestão da paratopia criadora: o trabalho inscricional do Clube Atlético Passarinheiro
(Universidade Federal de São Carlos, 2018-03-29)
Pinto, Pedro Alberto Ribeiro
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Salgado, Luciana Salazar
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https://lattes.cnpq.br/5206927424265495
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https://lattes.cnpq.br/4781565686926861
By subscribing to a certain tradition of Discourse Analysis derived from the works of Dominique Maingueneau (2006) in an interface with the studies of the literary and cultural materialities, this work searchs for an understanding of the author's identities of the group of poets Club Atlético Passarinheiro and its members Luiza Romão, Ni Brisant and Victor Rodrigues, understanding the concept of authorship as a discursive place to which texts refer, both in their ways of circulation and in their textual mesh (SALGADO, 2016a). With this objective in mind, this dissertation focuses mainly on the aspects of the Club's inscriptional work, turning to a wider archive that circumscribes the phenomenon of poetry slams, poetic battles whose increasing consolidation in Brazil and in the world has acted as base for different discursivizations of the body, voice and poetry. As a specific corpus, it takes certain materialities related to the first practices of the collective when it emerges, investigating the relations established between the configuration of the constitutive instances of its creative paratopia (MAINGUENEAU, 2006, 134) and the mediological functioning of its practices - the particular way in which the technical vectors and institutional vectors cross one another in these discursive processes.
Comparação da capacidade de formulações medicamentosas de diferentes quimioterápicos em induzir morte celular em células da linhagem MB49 de tumor de bexiga murino
(Universidade Federal de São Carlos, 2018-03-29)
Trevisoli, Pablo Gil Mortol
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Borra, Ricardo Carneiro
;
https://lattes.cnpq.br/5655362515357840
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https://lattes.cnpq.br/2545013323954327
Despite recent advances in cancer prevention and treatment, bladder urothelial carcinoma continues to be one of the most common types of malignant neoplasms in the world, with a 20% mortality rate. The cells and molecules of the immune system are fundamental components of the tumor microenvironment. Probably the fact that the neoplastic cell shares antigens with normal cells, have high growth rate and suffer edition, contributes to its resistance to the antitumor immune response. Even with these obstacles, the immune response remains one of the best bets in the malignant neoplasms treatment. In the past, homeostatic cell death, which often occurs through apoptosis, was irrelevant to the antitumor immune response since it was unable to stimulate the immune system. However, in recent years, it has been observed that certain types of apoptosis were able to induce immune response against dead cell antigens, particularly when they were derived from malignant neoplasms. This type of phenomenon was called immunogenic cell death (ICD). Despite advances in the discovery of the mechanisms involved in cell death associated with various tumor lines, no work to date has evaluated its efficacy in the model of bladder cancer induced by chemotherapeutics commonly used in the treatment of this disease.Therefore, the aim of the present study was to evaluate the action of cisplatin, mitoxantrone, daunorubicin, doxorubicin and epirubicin on the viability of MB49 lineage cellsand to identify the best dose with apoptotic activity of cisplatin, mitoxantrone, daunorubicin and doxorubicin. The results showed that chemotherapeutics agents, in their pharmaceutical formulation, performed well against MB49 cells in vitro. Cisplatin and mitoxantrone proved to be efficient in producing apoptosis, but only in vivo tests could confirm their immunogenic effect on these cells. In addition, this work showed that the effects of viability may be quite divergent depending on the dose and time evaluated and the need for a follow-up of viability after treatment withdrawal. In addition, this work showed that the effects of viability might be quite divergent depending on the dose and time evaluated and the need to observe viability after treatment withdrawal. It is concluded that the drug formulations of daunorubicin, epirubicin, doxorubicin and mitoxantrone produced varying degrees of apoptotic death in vitro, depending on exposure time and drug concentration.
Estudo de embriões de zeólitas como catalisadores básicos na condensação de Knoevenagel
(Universidade Federal de São Carlos, 2018-03-29)
Vicente, João Guilherme Pereira
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Cardoso, Dilson
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https://lattes.cnpq.br/2462847535959232
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https://lattes.cnpq.br/6538029003571409
The accessibility to the catalytic sites is one of the main objectives involving the development of heterogeneous catalysts. In this context, several researches seek the reduction of crystal diameters or the creation of mesopores in zeolites. The present work presents a new way of increasing the accessibility to the sites through the synthesis of embryonic zeolites. This method consists of obtaining structures that have a short range order, which improves mass transfer and leads to better catalytic results, especially in the processing of larger molecules. For this, the study of formation of FAU, LTA and SOD structures was carried out, associated with the catalytic evaluation of Knoevenagel condensation between benzaldehyde and ethyl cyanoacetate. The synthesis of the microporous sieves was performed under various times at 60 °C and all materials obtained (with and without crystallinity) were evaluated as catalysts. The highest conversions of the condensation reagents were always achieved by the zeolite embryos, regardless of the structure that originated. This higher activity is related to the secondary units of construction of the zeolite structure, as observed by Raman spectroscopy, these units are formed during the induction period. While the zeolite structure is in formation all the catalytic sites are accessible to the reactants, as the crystallization process is initiated, some of the sites become inaccessible and consequently a reduction in catalytic activity is due. By means of the CO2 TPD technique, zeolites with high crystallinity have a higher number of sites compared to their homologues containing only the embryos, but the catalytic activity does not reflect this trend. That is, as verified by N2 physisorption, embryonic zeolites have no micro- or mesoporosity and hence bulky molecules of reagents have access to all sites. The presence of aluminum with tetrahedral coordination in all embryonic zeolites was evidenced by NMR technique. The zeolite embryos that gave rise to the LTA structure prove to be the most active catalyst of their FAU and SOD homologues. This higher activity is related to the fact that this catalyst has a higher content of aluminum in its network, that is, a larger number of basic sites. When performing XPS measurements and calculating activity by site (TOF0), it was found that the catalytic activity of the zeolite embryos is mainly dependent on the number of sites.
Desejo de branqueamento: uma análise da questão étnico-racial em Anjo negro de Nelson Rodrigues
(Universidade Federal de São Carlos, 2018-03-29)
Sepúlveda, Estefanía
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Alves-Bezerra, Wilson
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https://lattes.cnpq.br/1602719736498812
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https://lattes.cnpq.br/1012989424899648
Este trabajo sobre Anjo negro (1946) de Nelson Rodrigues (1912-1980) comienza con la contextualización del teatro rodriguiano en relación al teatro brasileño anterior a los años 40 década en que el autor hace su aparición generando una renovación en el género. Luego se presentarán las características de este teatro dando énfasis en lotrágico, en lo desagradable y en lo moderno de las primeras obras permitiendo llegar a la cuestión étnico-racial como tema central y transversal de nuestro objeto de estudio. Con respecto a este último punto se incursionará en el mito que apoyado por el psicoanálisis y la tragedia servirá en la interpretación de la problemática racial que la obra expone, resaltando el cuestionamiento que se levanta en Anjo negro con respecto a la “democracia racial”, aspecto esencial en la construcción de la sociedad brasileña y en relación al “blanqueamiento”, presentado en la obra como deseo y alienación del sujeto negro.
Envolvimento da neurotransmissão nitrérgica do núcleo leito da estria terminal (NLET) nas respostas cardiovasculares ao estresse em ratos: interação com mecanismos glutamatérgicos e noradrenérgicos locais
(Universidade Federal de São Carlos, 2018-04-02)
Barretto-de-Souza, Lucas
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Crestani, Carlos Cesar
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https://lattes.cnpq.br/1117432571971568
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https://lattes.cnpq.br/5795792232582121
The aim of the present study was to assess an interaction between nitrergic neurotransmission within the bed nucleus of the stria terminalis (BNST) with local glutamatergic and noradrenergic neurotransmissions in control of cardiovascular responses evoked by an acute session of restraint stress in rats. For this, all animals were subjected to surgical procedures for implant of bilateral guide cannulas into the BNST and a catheter into the femoral artery. Bilateral microinjection of NMDA into the BNST increased the restraint-evoked tachycardia, but whithout affecting the pressor response and the drop in tail skin temperature. Changes on blood pressure, heart rate and tail skin temperature evoked by restraint stress were recorded. The acute 30 min session of restraint stress was performed five minutes following BNST pharmacological treatments. Bilateral microinjection of NMDA into the BNST enhanced the tachycardia to restraint, but without affecting the pressor response and the drop in tail skin temperature. The effect of NMDA on restraint-evoked tachycardia was completely inhibited in animals pretreated with the selective nNOS inhibitor Nω-Propyl-L-arginine (NPLA) into the BNST. Bilateral microinjection of NOC-9 decreased the heart rate and blood pressure increases evoked by restraint stress. The effect of NOC-9 on HR, but not on blood pressure, was inhibited by BNST pretreatment with WB4101. Besides, microinjection of NPLA in animals pretreated with WB4101 into the BNST decreased the HR and blood pressure increases to restraint. Taken together, these results indicate that the inhibitory control of cardiovascular responses to stress by BNST nitrergic neurotransmission is mediated by a facilitation of local noradrenergic neurotransmission. Also, present data provide evidence of an involvement of local nNOS in facilitatory control of the NMDA receptor within the BNST.
Extensão de uma álgebra ER para execução de consultas em bancos de dados NoSQL orientados a documentos
(Universidade Federal de São Carlos, 2018-04-02)
Noguera, Viviana Elizabeth Romero
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Lucrédio, Daniel
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https://lattes.cnpq.br/9090396559596221
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https://lattes.cnpq.br/2452374458203874
Non-relational databases, also called as NoSQL (``Not Only SQL''), have emerged from the need for new mechanisms for storing, retrieving and processing for large amounts of data produced mainly from the coming of Web 2.0 applications. There are different models of non-relational data, each with its own characteristics and applicability. There are also hundreds of non-relational database management systems, each with a different query language,and its own API. Due to the lack of a standard for data manipulation languages (DML) in this type of database, it is a challenge for the Software Engineer to deal with the learning and development of queries.In addition, by prioritizing performance, non-relational databases often adopt denormalized schemas, generating a large diversity in stored data structures, which also makes it difficult to develop and reuse queries. Faced with these two challenges, this work aimed to define a generic approach to queries, independent of the database type and also independent of the schema in which the data is stored. For this, extended an existent algebra, based on Entities and Relationships for data manipulation, with an operational semantics driven by models (Model-Driven Engineering - MDE). More specifically, metamodels have been developed so that the Software Engineer can: (i) model the persistent entities (Entity-Relationship); (ii) model queries about the entities and relationships according to the algebra being used; and (iii) model the mapping between the entities and the types of documents stored. Based on these specifications, an algorithm was implemented that automatically generates JavaScript queries to be executed in the MongoDB database, according to the mapping model. If the database schema needs to be modified throughout the lifecycle, only the mapping model (model ``iii'') needs to be modified. The conceptual model and the queries (``i'' and ``ii'' models) remain completely independent of the storage schema and can be developed and reused more easily. Two evaluations were carried out, using an example of an academic system and a real system, trying to exhaustively test the different possibilities of mapping between entities and documents. The results obtained with these systems show that it is possible that the generated queries always return the same results, independent of the mapping, thus reaching the objective of this work.