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Hidrogéis magneto-reponsivos para liberação estimulada de fármacos
(Universidade Federal de São Carlos, 2018-05-08)
Bortolin, Adriel
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Oliveira, Cauê Ribeiro de
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https://lattes.cnpq.br/5321313558714462
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https://lattes.cnpq.br/6389000762427080
Nanocomposite hydrogels modified with polysaccharides, minerals clay and magnetic nanoparticles of iron oxide functionalized with polymeric material were developed, allowing higher interaction between the nanoparticles and the hydrogel matrix. The nanocomposites were synthesized with small amounts of magnetic nanoparticles (0.5 - 2.0% w/w) and in all proportions magnetic properties were observed, as visibly by interaction with a magnet and experimentally through VSM analysis. The materials were subjected to several characterizations applying constant magnetic field of 0.23 Tesla. The magnetic field influenced directly all the properties of the nanocomposite materials, increasing the rate of water absorption and release of the active principle present in the structure (streptomycin), up to 5 times faster than the active material without application of magnetic field. Release tests on bacterial cultures also showed the bactericidal efficiency of the hydrogels loaded with streptomycin, where with the application of the magnetic field there was an average increase of 16.4 % in the inhibition radius of the bacteria studied. The release mechanism for hydrogels follows a pseudo-2nd order model, indicating the interaction between the active and specific sites of the hydrogel, and rearrangements may occur in the release mechanism. Magnetic hydrogels presented a pulsatile release behavior with the application of the field whose intensity was directly related to the concentration of nanoparticles used in the synthesis of hydrogels. Thus, the obtained hydrogels present characteristics that make possible the application in responsive systems of drugs release.
Corpo e espírito: representações da homossexualidade no espiritismo
(Universidade Federal de São Carlos, 2018-05-09)
Guimarães, Fernando Augusto de Souza
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Souza, André Ricardo de
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https://lattes.cnpq.br/7016915324466152
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https://lattes.cnpq.br/9081757614929729
The aim of this research was analyzed the way which spiritist theory, by the belief in reincarnation and immortality of the spirit, explain a sexual diversity. The analysis took by goal the specificity which the homosexuality is understood. Therefore, it was compared the representations on the homosexuality in two dimensions of the spiritism: institutional level and the religious base. The consideration on institutional dimension it was from some literary works concerned with this topic and, mainly, at the discourse of Andrei Moreira, ex-president of the Associação Médico-Espírita de Minas Gerais (AME-MG), in his book: A homossexualidade sob a ótica do espírito imortal. Subsequently, the research became turned to the way which members of two spiritist centers in the state of São Paulo, Centro Espírita Amor e Caridade e Centro Espírita Casa do Caminho, precisely in the cities of Bauru and São Carlos, deal with the question about sexuality. Starting from the hypothesis of great majority of brasilians, incluing spiritists, aren’t receptive to individuals LGBT (lesbians, gays, bisexuals and transgenders), this research has as its core the approach the contrast between the acceptance discourse in the institutional level which the limited degree of real acceptance of this sexualities in the context of the interior state of São Paulo. Based on the foundations of Michel Foucault and the proposals of queer studies, were taken as a basis of spiritist discourse about sexuality, further then Andrei Moreira’s book, the following ones: Homossexualidade, reencarnação e vida mental by Walter Barcelos; Vida e Sexo by Francisco Cândido Xavier saying by Emanuel spirit and Além do azul e do rosa – recortes terapêuticos sobre a homossexualidade à luz da doutrina espírita, wrote by Gibson Bastos and Sexo e Consciência, wrote by Divaldo Franco, Encontro com a paz e a saúde e Constelação familiar, by Divaldo Franco saying by Joanna Ângelis spirit, and last Sexo e sexualidade de Regis de Moraes. After that, semi-structured interviews were conduct with some national and international spiritist leaders. This data were cross-referenced with the results through semi-structured interviews with representatives of both centers with data collected in field work. Finally, in terms of conclusion, this work introduce the way which the believes in reincarnation and immortality of spirit enable the comprehension of homosexuality as natural and normal, in addition it was possible contribute which a greater understanding of the dynamics of functioning of the spiritist movement
Narrativas, “espaço” e dádivas. A conformação de um Movimento de luta por moradia
(Universidade Federal de São Carlos, 2018-05-09)
Bologna, Paula Cristina Corrêa
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Lanna, Marcos Pazzanese Duarte
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https://lattes.cnpq.br/8355559441138016
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https://lattes.cnpq.br/7860333851637419
The reflections presented in this work are the result of two years of ethnographic research realized with the Movimento de Moradia da Região Centro (MMRC) or the Housing Movement of the Centre Region. The MMRC is a social movement compound for low-income families, which claim for the right of decent houses in the city centre of São Paulo, thought their insertion in public policy programmes. The problematic of the lack of decent housing for low-income populations is the background of this work, but it is not on this specific issue that its treats. This work is about the multiple relations which produce a housing social movement, the above mentioned MMRC. To approach such relations, I have highlighted three aspects: i) the use of narratives of the leadership trajectories, and how these narratives are mobilised to build connections between militants and Movement, as much as the narratives are also feeding for political and life resistance to the militants. ii) The relations of the everyday in the Mauá Occupation show that the term "space" used by them to name the place of dwelling within the Occupation, cannot be assumed as a synonym for “house.” On the contrary, “space” is a term that has its own meaning and temporality, as well as being a locus to produce other sociabilities for occupants. iii) The exchange regime in which the relations between the MMRC and the São Paulo City Hall are established, can also be understood as mediated by mechanisms of gifts, including those of the agonistic type.
Para un barroco sin nombre: aproximações à estética onettiana em Cuando ya no importe (1993)
(Universidade Federal de São Carlos, 2018-05-09)
Guethi, Amanda Fanny
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Alves-Bezerra, Wilson
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https://lattes.cnpq.br/1602719736498812
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https://lattes.cnpq.br/2763020556963242
Since at least the 1950s, the fictional work of the Uruguayan writer Juan Carlos Onetti (1909-1994) has been read by a portion of specialized criticism from a supposed Baroque aesthetic: for others, Onetti's work would be baroque , for other non-baroque, both positions being understood as valuing depending on the objective of the critical appreciation and the conception regarding the literary that sustains such positions. This can be noticed, on the one hand, in the significant number of critical texts that approximate Onetti's literature to the Baroque, and, on the other, in the establishment of a set of elements that specify the Onethean style, but which functions both to affirm it as typically baroque - and exalting him for it - as if to deny it - which, too, earned him praise. From a reading i) that organizes the critical reception of the work of Juan Carlos Onetti, apprehending, in it, the discussions about the baroque, namely: criticism of observation (subdivided in criticism of negation, critic of drama and critical enthusiasm) and criticism of conceptualization (latent baroque, baroque fiction, open work and Cervantine heritage); ii) and who rescues the assumptions of his poetry in the set of his journalistic chronicles published in the Semanario Marcha (1939-1941) and his letters to his friend Julio Payró, this dissertation aims to analyze the latest Onetti novel, When (1993) as a novel-testament, with which the author closes the history of the city of Santa María and resumes, concluding, the process of his literary work, in the form of a diary that, as a genre, holds the narration of facts and comments on the narration act. In this analysis, the concepts of literary chronotope (BAKHTIN, 1990), of absurd subject and work (CAMUS, 1995) and of modern fiction (COSTA LIMA, 1986) are mobilized because, together, they allow to articulate the structural and thematic significance of the diary to the artistic presuppositions of the Uruguayan writer, emphasizing that the mentioned elements corroborate the substitution of the baroque adjective for cervantino.
¿De qué hablan? discursos editorialistas en Centroamérica
(Universidade Federal de São Carlos, 2018-05-09)
López, Edi Efrain Bámaca
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Miotello, Valdemir
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https://lattes.cnpq.br/9131819326282708
The objective of the present work is to analyze the editorial discourse of written media in Guatemala (Prensa Libre), Salvador (La Prensa Gráfica), Honduras (La Tribuna) and Nicaragua (La Prensa) and determine the importance of discourse on climate change. In response, 168 editorials were analyzed from the technique of constructing weeks, which consists of choosing one week per month, with days not repeated. They are analyzed under a Bakhtinian look; which emphasizes the compositional form and thematic unity. It is denoted that the majority’s editorial emphasis is on subjects related to politics, economics, and violence, especially. Despite the cause of the increasing climatic change, is of anthropic origin, the speech is null. There is no assertive speech about it.
Dinâmica da comunidade de macroinvertebrados bentônicos no baixo rio Xingu durante a fase inicial de operação da Usina Hidrelétrica (UHE) de Belo Monte
(Universidade Federal de São Carlos, 2018-05-10)
Assis, João Vitor de Mello
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Tundisi, José Galizia
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https://lattes.cnpq.br/5730659239785432
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https://lattes.cnpq.br/7318310325575455
The Belo Monte Hydroelectric Power Plant started operations in 2016 in the lower Xingu River basin. Dams in the Amazon have many social and environmental impacts and there is a prerspective of changes in river hydrological regimes due to climate change. In this contexto, benthic macroinvertebrates are important organisms in the functioning of freshwater ecosystems and are also widely used in water quality monitoring. In the present study, 11 sampling points were selected in different basin environments to evaluate the parameters of surface water and sediment, benthic community dynamics and application of a biological index (BMWP) to classify water quality during the initial phase of hydroelectric operation. Surface water and sediment analyses did not indicate impacts directly associated with damming, but the dynamics of benthic macroinvertebrates and BMWP indicated changes in the ecosystem. In the year 2016 a severe drought occurred and its combination with the modifications in the basin negatively affected the benthic community. The natural pulses at the water level along the hydrological cycle in the Xingu River are a force function that drives density and richness of benthic macroinvertebrates and their own characteristics in the composition of that community are associated with the discordant result of the BMWP. An alternative in monitoring would be the use of diversity indexes related to the natural dynamics of the community. The minimum flow in the river should be maintained and there should exist protection around water bodies throughout the basin.
Ceifando a cana... Tecendo a vida. Um estudo sobre o pós/trabalho nos canaviais
(Universidade Federal de São Carlos, 2018-05-10)
Reis de Souza, Tainá
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Silva, Maria Aparecida de Moraes
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https://lattes.cnpq.br/6792025643983370
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https://lattes.cnpq.br/3601577908568788
The goal of this research was to understand the post/work of unhealthy retired sugarcane cutters that is the new sociability network, where they are embraced. We employed qualitative methods with direct and unsystematic observations, semi-structured script interviews, photodocumentation and field research. Cane cutters are mostly migrants; when they get sick, they often return to their hometown. Therefore, the empirical field of this research is a place of origin of these workers, Araçuaí city in Jequitinhonha Vale/MG, where exist an intense migratory flow to the sugarcane plantations of São Paulo state. Unhealthy cane cutters were interviewed, such as their relatives and professionals who work with these persons – medical doctors, social workers and psychologists of the Social Security services and Brazilian health system (SUS). Cutting cane is a physically and emotionally exhausting job that could cause disease. They are discharged by the agro-ethanol industry, because their bodies and minds cannot support the work anymore, since their labor capacity is affected by the disease symptoms. If, according to the Marxian interpretation, the work organizes sociability of the subjects, their capitalist expression - the sale of the labor force - establishes estranged relations, even more so in a situation of overexploitation. What, then, does the illness produce? The subject does not have the labor force to exchange, but remains immersed in estranged relations. In the post/work the estrangement intensifies, because the restrained relations remain, the workers are understood as a discarded commodity. Discarding generates a sense of shame shared among the subjects. The unhealthy sugarcane cutters seek in the State the means to ensure their reproduction. State institutions play the regulatory role in biopolitics, expressing “to make live and let die”. Discarded sugar cane cutters do not fit the labor norm, that is, they cannot execute the function that they were become docile: that of labor power. They establish a new sociability with social workers, physicians and psychologists from social security and welfare agencies. The State acts permit that one to believe that discarded persons of the cane are left to die - not only physical but social death – since their lives are not more managed and controlled. The family is impacted in this process, not only by the loss of a significant income in the budget, but also because it has repercussions on the results of deep estrangement. Women - wives and mothers - become in charge of caring for these sick men, dealing with the difficulties this role entails. In a patriarchal society, women are given care, which in the case of the wives and mothers of sugarcane cutters is intensified, inasmuch as they must also take care of this sick person. Men, on the other hand, are attributed to masculinity, virility and strength, naturalization that fractures with illness. Gender relations reorganize, but not with the inversion of the poles of power. The subjects do not passively experience any of these processes, producing different strategies of resistance, lines of escape to the imposed impositions. The cane cutter - expropriated migrant, overexploited labor force, split generic being - establishes new relationships of sociability in post/work by disease. In this way, we can affirm that capitalist sociability extends out of space-time of work. For the Sociology of Work, specifically those who study rural work, it is possible, from the present reflection, to broaden the field of studies. The end of the work relations constitutes, as seen in the case of the discarded cane cutters, another sociability related exactly to the space-time of work, inaugurates the post/work, theme not different, but belonging to the Sociology of Work.
Otimização por colônia de formigas para o problema de programação job-shop flexível multiobjetivo
(Universidade Federal de São Carlos, 2018-05-10)
Souza, Cleverson Moreira de
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Kato, Edilson Reis Rodrigues
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https://lattes.cnpq.br/8517698122676145
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https://lattes.cnpq.br/1133011281219931
The job-shop production scheduling activity is at the most detailed and complex level of a production planning and control system. The Flexible Job-shop Scheduling Problem (FJSP) is an extension of the job-shop scheduling problem (JSP) and plays an important role in because of its combinatorial nature that allows an operation to be processed in more than one alternative machine of the set of available resources. Problems of job-shop programming belong to the class of NP-complete problems due to the difficulty in obtaining an optimal solution by traditional approaches. The metaheuristic Ant Colony Optimization (ACO) has proved to be efficient in solving combinatorial optimization problems. The ACO consists of an algorithm inspired by the behavior of the ant colonies, which functions as a probabilistic method and constructs solutions through collective intelligence. In this way, it uses the experience gained during the search process adaptively. In this work an Ant System (AS) is presented along with the Shortest Processing Time (SPT) rule for multiobjective FJSP resolution. Traditionally, allocation and scheduling decisions are made separately in production management. Thus, the proposed approach employs the SPT rule for resource allocation and the AS algorithm for the sequencing of assigned operations, where each ant constructs a viable scheduling according to the constraints that apply to the problem. The objective of this research is to find optimal solutions for the FJSP, considering minimization of completion time, minimization of the most critical machine load and minimization of the total load of all machines as optimization criteria. The combination of several optimization criteria induces additional complexity and new problems. However, the results of the comparative study with other approaches in instances known in the literature have shown that the proposed algorithm is feasible and effective for solving multiobjective FJSP, especially in large scale problems.
Leitura e escrita como ato responsável: uma experiência de ensino/aprendizagem à luz da filosofia da linguagem do Círculo de Bakhtin
(Universidade Federal de São Carlos, 2018-05-11)
Anna, Telma Gomes Novato Sant
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Moura, Maria Isabel de
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https://lattes.cnpq.br/7089011529083708
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https://lattes.cnpq.br/2263321059248030
The present PhD research aims to investigate the reading of literary texts and the writing of texts as an active-responsive understanding of the texts read in the daily school life. The work was developed in a narrative and autobiographical approach, based on the theoretical contributions of the Bakhtin studies. In the professional narrative of the researcher the forms of seeing and conceiving the language during its 32 years of teaching are evident. The conceptions of language defined the way of being a student and teacher of Portuguese Language. By going through the three ways of conceiving language: Language is the expression of thought; Language is an instrument of communication and Language is a form or process of interaction and its methodological implications in the teaching / learning of Portuguese language, the researcher brings reflections on the teaching / learning of Portuguese Language in each mode. Only in the last decade, the researcher positions herself consciously when proposing a teaching / learning experience of reading a literary text: Romance genre for students of the ninth grade of Elementary School in a public school of a large municipality in the interior of the state of São Paulo with the intention of bringing a reflection on why work with literary texts in school everyday and what benefits can bring to improve the practice of reading literary texts and written as counterwords in the classroom, anchored in Bakhtinian interactionism. The experiment generated a significant number of documents from which the survey data was collected. These data were analyzed from the narrative methodology based on the Bakhtinian contributions, which places in the center the subject of language, the conditions of production of discourse, the social, the relations of meaning constructed between the interlocutors, dialogia, argumentation, exotopia and the importance of the presence of the textoliterary in the classroom.
Como se escolhe um candidato? uma etnografia das estratégias pré-eleitorais para as eleições de 2016
(Universidade Federal de São Carlos, 2018-05-11)
Santos, Caroline Mendes dos
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Villela, Jorge Luiz Mattar
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https://lattes.cnpq.br/8301325600502054
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https://lattes.cnpq.br/6965626522411638
This research is based in the analysis of anthropology of politcs and, through fieldr research, I was able to produce an ethnography of the formation of alliances around the choices of candidates for the 2016 municipal elections in a small municipality in the state of São Paulo. The data were obtained from the monitoring of one of the political groups formed in the municipality for those elections. Thus, this ethnography is a result of the analysis of the choices for candidates, based on a series of social attributes that legitimize the choice of some to the detriment of other pre-candidates. In addition to legal issues, I observed the importance of political inheritance and political capital, relations of kinship and friendship and belonging to certain political groups, the fact of being known and having a life course considered exemplary are also fundamental for those who aim the politics of votes. Therefore, I present what would be these attributes of the pre-candidatures to the executive and municipal legislature, and the close relation with the pre-candidatures of the executive and the state legislature.
Reconhecimento de línguas de sinais e educação de surdos no Brasil e na Suécia
(Universidade Federal de São Carlos, 2018-05-11)
Montes, Aline Lucia Baggio
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Lacerda, Cristina Broglia Feitosa de
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https://lattes.cnpq.br/9468232016416725
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https://lattes.cnpq.br/3961195090677393
The objective of this work is to investigate, in a comparative perspective, the documents that recognize sign languages in Brazil and Sweden and to analyze if their respective acknowledgments contributed to the educational process of the deaf in both countries. This is a documentary study, with content analysis as the main approach. In the midst of a broader discussion of linguistic rights and the right to use minority languages, advances in the education of deaf people - from a legal point of view - are beginning to be more explicit in the 1990s, marked by deaf and debates about the negative reflexes of the clinical-therapeutic model. The deaf community is then represented at the core of the political strategy of the multiculturalist movement, and studies on this aspect begin to strengthen in the international context, as well as discussions on the officialisation of sign languages. Sweden, the first country to give language status to a sign language, as well as the "Swedish model" of bilingual education, arouses great interest. The analysis lines were: type of recognition, analyzes of the texts of the Law Libras (nº 10.436 / 2002) and Law of the Swedish Language (SFS 2009: 600) and contributions of the documents for the education of the deaf. The methodology of comparative education studies showed important aspects. In Sweden, the right to acquire and use the Swedish language of signs as a mother tongue is provided for by law, and the country effectively contributes to the creation of real conditions for acquisition by the deaf community; linguistic policies govern the entire process of linguistic law and the right of language acquisition to the deaf. In Brazil, the right to purchase is not provided for by law and, thus, the paths to be covered by deaf children who seek acquisition of their language are not defined; the debates on Libras have always been closely linked to the debates on the rights of persons with disabilities, with the double categorization of the deaf being evident: persons with disabilities and members of minority groups. Therefore, the recognition of Libras did not guarantee the deaf people of Brazil the right to acquire sign language; and also did not promote the guarantee of a bilingual education. In Sweden, in view of the scenario studied, the law only reaffirmed the practice carried out over many years: sign language education throughout school age.
Fluxo e acesso assistencial: mecanismos da regulação em saúde entre a atenção básica e a especializada
(Universidade Federal de São Carlos, 2018-05-14)
Tangerino, Lariana Cássia Pereira
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Feliciano, Adriana Barbieri
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https://lattes.cnpq.br/9398810638733882
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https://lattes.cnpq.br/0870498096542954
The health like right in Brazil, guided by equal terms have been affected by the current situation of the country due to its diversity and magnitude of both territorial and regional features. The Single Health System and some its policies (Basic Attention National Policy, Health Attention Systems, National Regulation Policy) seek for guaranteeing care integrality, promoting accessibility with continuous assistance and rational operation of the existing resources. The aim of this study was to analyze the performance of a municipal regulation system within the scope of the relations among Basic Attention, Specialist Assistence and Regulation Center, in order to provide a reflection about both the potential and the improvement opportunities in the services of scheduling medical appointments and exams. The conduct of this research was based on the qualitative approach assumption. The chosen city for the research development was Araraquara (SP). For data collection method, there were meetings to hold focus groups. The participants were the administrative agents, nurses and doctors of Basic Attention from a predetermined area, people responsible for scheduling appointments and the servants of Regulation Center, a total of 31 people. Data was examined from the point of view of the subject content analysis. The 31 participants were: 5 nurses, 14 doctors, 11 administrative agents and 1 licensed practical nurse. After the exhausting reading of the recorded and transcribed answers, it was possible to group them according to the contexts they referred to, in main topics and their categories. The main catalogued issues were: “The Health Care Attention System”, “The City Scheduling System”, “The use of protocols for Clinical Evaluation” and “The Permanent Education in health”. Through this data, it was possible to identify that the already established actions to review the scheduling system in such city have provided significant improvements in the employments’ work routine and also facilitated patients’ access to health. However, these mechanisms, have also brought some challenges that require confrontation by management and workers in order to solve communication problems, information systems, document records, employee improvement and qualification of their professionals.It is suggested to the municipality to face these challenges, adjustments in the use of protocols for clinical evaluation, provide systematized training for all categories of Basic Attention, have matrix support and use of only one information system.
Estratégias de invasão de Hedychium coronarium J. König (Zingiberaceae)
(Universidade Federal de São Carlos, 2018-05-14)
Costa, Rosane Oliveira
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Guaratini, Maria Tereza Grombone
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https://lattes.cnpq.br/5774910805378453
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Matos, Dalva Maria da Silva
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https://lattes.cnpq.br/4728734263109138
The invasion of natural ecosystems by exotic species threats world biodiversity, causing competitive exclusion of native species and loss of ecological interactions, compromising ecosystem functions and services. Invasive species often resist to environmental variations and are capable to develop strategies that increase their competitive ability. Hedychium coronarium J. König (Zingiberaceae) is an herbaceous macrophyte native from Himalaya, considered an aggressive invader on Americas. We investigated its dominance mechanisms and the effects on associated terrestrial and aquatic communities. We evaluated 1) the effect of intraspecific competition (rhizomes density) on sprouting and growth of aerial and subterraneous parts of H. coronarium on different light conditions; 2) the interspecific competition, by estimating the seedling growth of a native tree species (Anadenanthera macrocarpa) on the presence/absence of the invader; 3) the phytotoxicity of the essential oil from H. coronarium rhizomes on the germination of native riparian tree species; and 4) the toxicity of aqueous extract of H. coronarium rhizomes on aquatic organisms (algae, macrophyte, cladoceran, insect and fish). H. coronarium showed similar performance and occupation capacity on opened and shaded environments, suggesting the existence of a compensation mechanism of resource allocation on different light and density conditions. The presence of H. coronarium harmed the growth of A. macrocarpa seedlings independently of the removal of aerial part of the invader. The secondary compounds of essential oil of H. coronarium rhizomes affected the germination of native riparian tree species. The aqueous extract was toxic for all tested aquatic organisms, indicating possible alterations on trophic chain dynamic of invaded aquatic ecosystems. Our results suggest that H. coronarium use different invasion strategies and impose multiple negative effects on native communities, highlighting their high invasion potential and capacity of promote ecosystem changes.
Avaliação da influência da fonte de carbono sobre a expressão de genes associados à degradação da biomassa vegetal durante o cultivo do fungo Trichoderma Harzianum P49P11 em reator
(Universidade Federal de São Carlos, 2018-05-15)
Braga, Cleiton Márcio Pinto
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Pradella, José Geraldo da Cruz
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https://lattes.cnpq.br/4428559309561977
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Farinas, Cristiane Sanchez
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https://lattes.cnpq.br/9933650905615452
Plant biomass is a renewable resource with great potential for obtaining a variety of products with different applications. The production of biofuels from vegetable biomass is an alternative to increase ethanol supply and thus meet the growing demand in the world. The lignocellulosic material, which makes up the biomass, consists mainly of cellulose, hemicellulose, pectin and lignin, which are arranged in a complex way, reflecting in the difficulty of material degradation. Several groups of enzymes need to be employed so that the complex carbohydrates are converted into fermentable sugars, which can then be transformed into interest products. However, the production costs of these biocatalysts are an obstacle to economic viability of the plant biomass biochemical conversion path. One of the mechanisms to reduce costs is the improvement of producing strains, for example, by the deletion of repressor genes and overexpression of activators related to cellulase production. For the fungus Trichoderma reesei, many works have identified such regulators as the activators xyr1, ace2, ace3 and lae1 and cre1 and ace1 repressors. But, the fungus T. harzianum lacks studies of this category, considering that it is pointed out as a good producer of cellulolytic enzymes. In order to better understand the dynamics of the genes associated with them, initially the profiles of these enzyme production and of regulatory genes (xyr1, ace1, ace2, cre1 and lae1) and hydrolases encoders expression were evaluated, along the bioreactor cultivation using different carbon sources. Expression was found to be significantly higher on cellulosic substrates, which also provided higher levels of enzymatic activity. In addition, a hydrolysis assay suggested that enzyme complex produced by the fungus was specific to the substrate that induced it. Finally, a strategy was set up for the fungus genetic improvement by means of a point mutation in the β-glucosidase cel1a gene.
Entre a liberdade e a virtude: pensamento social e político de Michael Oakeshott
(Universidade Federal de São Carlos, 2018-05-15)
Cardoso, Felipe Gava
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Ribeiro, Pedro José Floriano
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https://lattes.cnpq.br/6336151484882362
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https://lattes.cnpq.br/4033086190529398
The thesis investigates Oakeshott's complete work and aims to analyze the nature of his conservative "disposition", taking into account his skeptical postulate and its theoretical roots, its contribution to social and political thought and its relation to the intellectual production of liberals and conservatives. The review of his arguments allows us to observe qualities and weaknesses in his approach to topics such as the epistemological foundations of knowledge, the attributes of individual consciousness, modes of conduct and civil society, the role of conversation in human fulfillment, the ideological fields and their patterns, the function and framework of the state, among others. These include concepts such as "conservative disposition", "reflexive consciousness", "conversation", "civil association", and "politics of faith". This appraisal evidences that Oakeshott transits on the edge of conservative and liberal thinking in a permanent tension. The comparison with liberal authors reveals a thinker that is constantly concerned with the preservation and use of the valuable habits of Western heritage. On the other hand, dialogue with conservatives highlights his emphasis on the role of individual freedom in the conduct of their own existence. Those are the sources of his originality and vulnerability.
Elaboração e validação de um questionário para avaliar conhecimentos, atitudes e práticas de médicos e enfermeiros da atenção básica em relação ao cuidado de mulheres com diabetes mellitus gestacional
(Universidade Federal de São Carlos, 2018-05-16)
Rezende, Anisia Aparecida Oliveira
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Callegari, Fernanda Vieira Rodovalho
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https://lattes.cnpq.br/6123189460389930
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Carbol, Maristela
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https://lattes.cnpq.br/9852217198710064
Gestational Diabetes Mellitus (GDM) is one of the most common complications of pregnancy, being considered a public health problem due to the high rates of maternal and neonatal morbidity and mortality and it remains a challenge to scientific community. High qualified and resolute care prenatal can contribute to reduce rates significantly and promote safe motherhood. The purpose of this work was elaborated and validated the knowledge, attitudes and practices of primary care physicians and nurses in relation to the care of women with GDM. It is a study of the elaboration and validation of a questionnaire for Knowledge, Attitude and Practice (CAP) studies. An instrument was used as a self-administered questionnaire containing open and closed questions. Participants who perform prenatal care in primary care were randomly chosen from the municipalities belonging to the Alta Mogiana and Alta Anhanguera colleges of the Regional Health Department VIII of the city of Franca / SP. Six phisicians and six nurses took part in the study. In the knowledge section, participants identified that there were questions with more than one possible answer about the diagnosis of diabetes in pregnancy. To cover the points of interest in this research, participants pointed out the need to add questions about prenatal care, growth assessment and fetal well-being. The indexes of correct answers in the Knowledge section and the indexes of positivity in the answers in the Attitudes and Practices sections were high, contributing to ensure that the questions of the CAP questionnaire were coherent with the object of this research. It was concluded that the validation process allowed the elaboration of a CAP questionnaire validated as an adequate instrument for future studies.
Análise do efeito da liderança sobre a cultura organizacional das agências do INSS da região administrativa de Araraquara/SP
(Universidade Federal de São Carlos, 2018-05-17)
Somenzari, Marcel Sigrist
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Ganga, Gilberto Miller Devós
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https://lattes.cnpq.br/9062191157466610
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Sacomano Neto, Mário
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https://lattes.cnpq.br/0000793038362058
The present research discusses the relations between leadership and organizational culture in the Brazilian public sector. The objective of the study was evaluate the effect of leadership on the organizational culture of thirteen agencies of the Instituto Nacional do Seguro Social (INSS) of the Araraquara administrative region, located in the interior of the State of São Paulo. The work was carried out through a survey, namely, a data collection for the accomplishment of a correlational study. For this purpose, two models of survey questionnaires for quantitative analysis were used: the Multifactor Leadership Questionnaire, developed by Bass and Avolio (1990), and the Competing Values Framework, produced by Cameron and Quinn (2006). The assertions of the questionnaires were adapted to the 5-point Likert scale. The questionnaires were applied to the organizational individuals of the agencies under study, obtaining a valid sample of 166 respondents, being 13 managers and 153 employees of the agencies teams surveyed. For the treatment of the data collected in the survey, descriptive and exploratory analyzes were carried out, using the partial least squares approach of the structural equation modeling method (HAIR; RINGLE; SARSTEDT, 2011). It was possible to validate the relationships identified between the leadership and organizational culture constructs in the INSS agencies of the Araraquara administrative region. The results demonstrate the predominance of the transformational leadership style (BURNS, 1978; BASS; AVOLIO, 1993) and the type of clan culture (CAMERON; QUINN, 2006), as well as the correlation between these two constructs as the one that most stood out among the several correlations present between leadership and organizational culture in the INSS agencies surveyed. Finally, it was possible to conclude that, in the perception of the respondents, leadership influences the culture of a public organization, through a positive correlation of high statistical significance (COHEN, 1992).
Quantificação em problemas com mudança de domínio
(Universidade Federal de São Carlos, 2018-05-17)
Vaz, Afonso Fernandes
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Izbicki, Rafael
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https://lattes.cnpq.br/9991192137633896
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https://lattes.cnpq.br/5022046007587066
Several machine learning applications use classifiers as a way of quantifying the prevalence of positive class labels in a target dataset, a task named quantification. For instance, a naive way of determining what proportion of positive reviews about given product in the Facebook with no labeled reviews is to (i) train a classifier based on Google Shopping reviews to predict whether a user likes a product given its review, and then (ii) apply this classifier to Facebook posts about that product. Unfortunately, it is well known that such a two-step approach, named Classify and Count, fails because of data set shift, and thus several improvements have been recently proposed under an assumption named prior shift. However, these methods only explore the relationship between the covariates and the response via classifiers and none of them take advantage of the fact that one often has access to a few labeled samples in the target set. Moreover, the literature lacks in approaches that can handle a target population that varies with another covariate; for instance: How to accurately estimate how the proportion of new posts or new webpages in favor of a political candidate varies in time? We propose novel methods that fill these important gaps and compare them using both real and artificial datasets. Finally, we provide a theoretical analysis of the methods.
Registros dos processos participativos sob a ótica do mapeamento: o caso do zoneamento ecológico-econômico no Vale do Ribeira
(Universidade Federal de São Carlos, 2018-05-17)
Parada, Isadora Le Senechal
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Toppa, Rogério Hartung
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https://lattes.cnpq.br/0673898572494729
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https://lattes.cnpq.br/6997735186305357
The Ecological-Economic Zoning (EEZ) formulation must, necessarily, be a participatory process, comprising the methodological adaptations according to the regional peculiarities. This research aimed to study, from the perspective of the participatory mapping, in three failed attempts of the Vale do Ribeira EEZ to formalize this legal instrument (1st period: from 1980 to 1998; 2nd period: from 1999 to 2005; 3rd period: from 2010 to 2014). The methodology was based on case study and content analysis, from four data sources: Geographic Database (GDB), Minutes of Meetings, Processed Documents and Interviews. Only documents and interventions directly related to the map were analyzed, discarding the conceptual and theoretical character ones. In the three periods, it was noted the existence of social participation strategies. In the first two periods, there was a predominance of participatory mapping based on cartographic (on paper), while in the third period, there was also participatory mapping with GIS Desktop. The minutes of 122 meetings and registrations of 191 geographical interventions were analyzed, most of them from the third period. A low processing of documents was observed, with a majority (65%) sent by the coordinating body of the EEZ. Regarding the records in the BDG, of the 1,495 existing polygons, 65.2% presented some description or justification of the framework. The approach of key actors with geotechnical tools is also important to evaluate the process as a whole, and not just the results. The evaluation showed that all forms of registration (meeting minutes, GDB and documentation) complement each other in the understanding of the process dynamics. Minutes of meetings are fundamental to record the conceptual discussions and details of the arguments that led to the decision making by the group, but they also make it difficult to retrieve the discussions in future meetings and to do the direct correlation with the map. On the other hand, the direct insertion in the attribute table during the discussion, proves to be effective both for the agility of the registry and for the subsequent rescue of the discussion. This study sought to demonstrate that there has been progress in the development of participatory techniques, but also to highlight the needs to improve the debate about these works’ methodologies and criteria. The approach of the stakeholders with geotechnology is also be seen as a positive result, since it brings empowerment and greater knowledge about the work. The use of GDB as a complementary method for the registration of participatory processes deserves to be improved, with the development of new techniques that allow the storage of the history of modifications made on the map.
Adição de Michael de α,α-Diciano-Olefinas a Chalconas via organocatálise assimétrica empregando solvente derivado de biomassa
(Universidade Federal de São Carlos, 2018-05-18)
Martelli, Lorena Suelen Ribeiro
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Corrêa, Arlene Gonçalves
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https://lattes.cnpq.br/7425467156776144
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https://lattes.cnpq.br/0303515313359935
In recent years, organocatalysed reactions have become an important field in asymmetric synthesis. Particularly, Michael addition reactions using various donors and acceptors have been explored to generate substrates that can be used as building blocks in other transformations. Chalcones, for example, are widely used as Michael acceptors not only because of their privileged reactivity but also due to their biological activities already reported. On the other hand, the α,α-dicyanoolefins proved to be a very versatile reagent, capable of acting as Michael acceptors as well as vinylogous nucleophiles in organocatalysed reactions. However, to date, the addition of α,α-dicyanoolefins to chalcones has not yet been explored. Considering the potential biological activity of the products, in this study, we report the use of a bifunctional catalyst derived from the alkaloid cinchona to perform the enantioselective addition of α,α-dicyanoolefins to chalcones. Based on preliminary results obtained in our research group, the Michael addition reaction was optimized by investigating time, acid additive, temperature, catalyst loading and solvent. Looking for more environmentally sustainable conditions, we have tested a series of greener solvents and the bio-derivative 2-MeTHF at 15 mol% of catalyst proved to be the best for this transformation. Having established the best reaction condition for this reaction, we investigated the scope and limitations of the developed protocol, where 17 new compounds were synthesized with yields in the range of 28-66% and 71-98% enantiomeric excesses. With the goal to increase the structural diversity, attempts to cyclize the Michael adducts were performed using different bases and acids.