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Efeitos da fotobiomodulação a laser (660nm) associada às células tronco mesenquimais em queimaduras de espessura total: estudo in vitro e in vivo
(Universidade Federal de São Carlos, 2019-12-03)
Andrade, Ana Laura Martins de
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Brassolatti, Patricia
;
https://lattes.cnpq.br/8403640648196148
;
Parizotto, Nivaldo Antonio
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https://lattes.cnpq.br/5527703735628408
Burning, a traumatic lesion of thermal origin affects organ tissues and may be classified according to the layers of affected tissue. The complexity of the tissue repair process has always made burning treatment a challenge, not only due to its severity but also due to its multiple complications. Photobiomodulation (PBM) therapy for burning, especially in the initial phases of the process, promotes better healing and shorter repair time. The use of stem cells is an area of cutaneous lesion treatment that has been greatly explored and has shown progress in the field of tissue engineering, especially with mesenchymal stem cells. The association of both therapies is believed to accelerate the burned tissue repair process, stimulating cell proliferation and aiding the growth of a tissue of quality. Thus, this study aimed to evaluate the laser PBM therapy (660nm) action on the mesenchymal stem cells (MSC) proliferation; identify the biological mechanisms involved in the laser PBM action; establish a efficient experimental model for full thickness burn; and investigate the association of the techniques (PBM and MSCs) on the treatment of full thickness burns. Thus, we performed fours studies, two in vitro and two in vivo. The in vitro studies were performed with two (2D) and tri (3D) dimensional cultures, using mesenchymal stem cells derived from adipose tissue (hASCs) and lase PBM with three different energies (1J, 2J and 6J), with four groups for 2D cultures and four groups for 3D cultures. The 3D culture used a gellan gum spongy-like hydrogel. In both cultures we evaluated the viability, cell proliferation, reactive oxygen species (ROSs) and the inflammatory mediator interleukin-8 (IL-8). The in vivo studies concluded that laser PBM stimulates hASCs proliferation, in addition to maintaining their viability, depending on the energy used in both cultures; in addition to contributing directly to the stimulation of the ROSs and acting in the IL-8 modulation in the 3D culture. The in vivo studies utilized 114 Wistar mice, 18 for the first and 96 for the seconds study. The first study was performed with the soldering iron burn method, with temperature of 150 ºC. The animals were randomized in three groups, G5: burned with 5 seconds of contact with the soldering iron; G10: burned with 10 seconds of contact with the soldering iron; and G20: burning with 20 seconds of contact with the soldering iron. Histopathologial analysis concluded that all groups resulted in full thickness burn, regardless of the time of application. For the second in vivo study, the animals were randomly distributed in four groups: CG: control group, LG: animals treated with lase PBM (660 nm) and 2 J of energy, TCG: animals treated with MSCs and GLCT: animals treated with laser PBM (660 nm and 2J of energy) plus MSCs). The groups treated with laser PBM received irradiations three times a week, in alternated days, for 21 days. The groups treated with MSCs received ten applications of cells in a total volume of 600 μL right after the burning. We performed photographic monitoring in the periods of 3, 7, 14 and 21 days after the beginning of the experiment to evaluate the lesion contraction. Animals were euthanized in four distinct periods (3, 7 , 14 and 21 days after the experimental procedure) and we collected blood and tissue for further histological, immunohistochemistry, immunoenzyme and birefringence analyses. We conclude that the association of MSCs and laser PBM was an efficient method to accelerate the repair process and formation of cutaneous tissue of quality.
Habilidades sociais educativas parentais de mães sobre relacionamentos afetivo-sexuais dos filhos com deficiência visual
(Universidade Federal de São Carlos, 2019-12-03)
Theodoro, Helen Cristiane da Silva
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Costa, Carolina Severino Lopes da
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https://lattes.cnpq.br/0303439637261272
;
https://lattes.cnpq.br/0154240998811428
The development of human beings largely depends on the family context and, during adolescence, issues arise that can often make parents feel unprepared to address, as is the case with affective and sexual development, even more so when the child presents any disability. For this reason, the objective of this study is to analyze the Social Educational Skills of parents in relation to their visually impaired children, with regard to the establishment of affective and/or sexual interpersonal relationships with their children. Seven mothers of teenagers with visual impairment participated in the research, with the teenagers being between 12 and 17 years old, with low vision or blindness. Participants responded to a Semi-structured Interview Guide, containing 23 questions. Subsequently, the interviews were transcribed and the data analyzed qualitatively, using 18 categories and subcategories of Parental Educational Social Skills. The results showed that the participants have a deficit in relation to Parental Educational Social Skills, given that they have overprotective attitudes, which interferes with the development of their children's autonomy and independence. Another factor found is that mothers do not allow many social interactions to be carried out by their children and, despite reporting that they have the freedom to talk about all subjects, when asked about sexuality and affective-sexual relationships, the majority of them were uncomfortable or uncomfortable. reported that they did not address these matters. The concept of sexuality proved to be a great taboo and interferes directly when linked to issues involving a person with a disability.
Um estudo sobre o movimento lógico-histórico do conceito de continuidade
(Universidade Federal de São Carlos, 2019-12-03)
Silva, Rafael Siqueira
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Sousa, Maria do Carmo de
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https://lattes.cnpq.br/6637658562543505
;
https://lattes.cnpq.br/1573729723278166
The aim of this paper is to investigate the logical-historical movement of the concept of Continuity through a historical-epistemological analysis, with a view to determining the essential relations that can be configured as conceptual nexus. Assuming the theoretical contributions of the Historical-Cultural theory, the conceptual nexus are understood as the synthesis of the internal and external relations of a concept, whose determination is realized through the logical-historical movement. Thus, it is established as a guiding question: What are the relations established in the logical-historical movement of the concept of Continuity that can be configured as conceptual nexus from the realization of a historical-epistemological analysis? The research methodology is based on the principles of historical-dialectical materialism and is constituted by the realization of the State of the Art of research on Continuity teaching and the historical-epistemological analysis of historiographical sources that address essential aspects on the development of this concept. The results point to the determination of conceptual connections in the commensurable-incommensurable, discrete-continuous, infinite-infinitesimal, permanence-fluency, punctual-general and rigor-intuition dialectical pairs. Reflections on the results indicate the resignification of the curriculum structure of Continuity in the fields of basic and higher education. In addition, it also discusses the need for the realization of teaching organization of Continuity based on conceptual nexus and conceptual appropriation by students.
Recursos para o acesso aos conteúdos da disciplina de ciências da natureza por estudantes com cegueira
(Universidade Federal de São Carlos, 2019-12-03)
Silva, Janaina Francieli Ferreira da
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Paulino, Vanessa Cristina
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https://lattes.cnpq.br/5235654050505504
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Costa, Carolina Severino Lopes da
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https://lattes.cnpq.br/0303439637261272
The inclusion of students with visual impairments in regular education is still a challenge, especially with regard to access to Braille textbooks. Therefore, this research aimed to analyze the access of blind students to Natural Sciences curricular content, and the teaching strategies used by the teacher. To this end, a qualitative case study was conducted, with two blind students and their teachers from the Natural Sciences discipline, as well as Special Education, as participants. Data collection took place on the premises of a state public school, located in a medium-sized city in the interior of São Paulo. To achieve the proposed objectives, semi-structured interviews were carried out with blind students and questionnaires were administered to Natural Sciences and Special Education teachers, based on previously prepared scripts, covering the following themes: student-teacher relationship; knowledge of Braille; possible difficulties regarding the book; opinion about the book. Furthermore, observations were carried out, when it was possible to ascertain that students in regular classes do not have access to Braille – in written form or for reading, even due to the lack of a textbook for the subject in Braille. The results showed that the resources used by the Natural Sciences teacher cannot yet be considered inclusive, because it was found that the participation of blind students in the classroom was practically zero. The same can be said about collaborative planning between teachers, showing that there is a lot to be done so that the school inclusion of students with blindness is truly achieved.
Influência do tipo de solo na densidade de madeira e IMA de dois clones comerciais de eucalipto
(Universidade Federal de São Carlos, 2019-12-03)
Silva, Gustavo Torres Galvão da
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Martins, Karina
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https://lattes.cnpq.br/9367637840430435
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https://lattes.cnpq.br/4751362739288223
In forest plantations, the productive potential of a given site is the result of the interaction between genetic materials and environmental conditions. Both are fundamental factors for the wood quality and the average annual increment. Knowing the performance of different Eucalyptus urophylla commercial clones under different soil conditions is important for forest planning. Our objective is to evaluate the influence of soil types on wood basic density and Average Annual Increment (AAI) in two E. urpophylla clones. We analyzed the wood basic density in trees at 5-6 years of age and the AAI of the two clones grown in four soil types in 14 localities of São Paulo state. ANOVA and Tukey test at 5% probability were performed to test the effect of soil type in the basic wood density and the AAI. Linear and exponential regression equations were performed between AAI x wood basic density and between AAI x Clay Content, respectively. In general, some soils showed significant differences in wood basic density, which may be due to climatic variation among sites. Also, the AAI increased exponentially with the increase of soil clay content (up to about 25 to 35% of clay), but there was no correlation between AAI and wood density.
Privacy Everywhere: mecanismo para tomada de decisões e garantia da privacidade em ambientes IoT
(Universidade Federal de São Carlos, 2019-12-03)
Andrade, Leandro Prado de
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Zorzo, Sérgio Donizetti
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https://lattes.cnpq.br/2523715806470871
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https://lattes.cnpq.br/6280032570953598
Through technological advances, society has moved toward the "always connected" paradigm. Growing varieties of devices are becoming able to connect to a network, capture information around them, and send and receive information. On the other hand, increasing in number of Internet of Things (IoT) devices, the ability to integrate IoT devices with IoT cloud services, and the diversity of forms of interaction can make it tiring to ask the user to make a privacy decision whenever it contacts a new IoT device. Due to sensitivity of many of information captured by IoT devices and because IoT cloud services do not focus on preserving user privacy, it is necessary that data captured by IoT devices be processed before being sent to cloud services. IoT environments can have a large number of data collection devices that often go unnoticed by users. Informing the user about the presence of each one of these devices and asking the user to make privacy decisions about data collection from these devices may be impracticable. This work presents the Privacy Everywhere mechanism for decision making and user privacy assurance in IoT environments. The proposed mechanism addresses user privacy issues and makes use of trained neural networks with data collected from a pre-established community. This minimizes user consultation at the time of data collection by the device that is part of an IoT environment. In validation of the mechanism, accuracy check of the Allow/Deny and Privacy Action neural networks that make up the mechanism presented an accuracy of 88.02% and 86.67%, respectively. Privacy Everywhere mechanism is able to help users preserve the privacy of their data in IoT environments.
Sistemas baseados em cartão: revisão da literatura de novos sistemas e proposta de uma lista de fatores soft para a implementação desses sistemas
(Universidade Federal de São Carlos, 2019-12-03)
Bagni, Gustavo
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Godinho Filho, Moacir
;
https://lattes.cnpq.br/6136685270563354
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https://lattes.cnpq.br/0315166757122262
Although Production Control Systems are considered a mature topic in literature, up to now, the focus of literature has been on optimizing the operating parameters of each system, assigning little importance to factors related to human influence (soft factors). Implementation, however, remains a complex problem. This paper aims to reduce this gap by proposing, through a combination of research methods, a list of soft factors critical to success in implementing card-based systems, which which are the most studied and implemented and which share as a characteristic a strong human influence on their functioning. However, to achieve this goal, it was initially necessary to identify which systems are based on cards. Although for systems such as Kanban and CONWIP there is a large literature available, systems developed after POLCA proposal in 1998 were little explored. Therefore, this dissertation initially performs a systematic literature review identifying 13 systems developed between 1999 and 2018, such as COBACABANA, DDMRP, Redutex, B-CONWIP, BK-CONWIP, among others. Briefly, it presents how each system works, its characteristics, current research stage and environments in which it has been proved to be useful, aiming to increase researches about them. The systems are also compared in relation to six variables defined in the literature, identifying that many of the new systems are card-based. The soft factors proposed for the implementation of card-based systems are based on the analysis of problems cited in the literature as well as difficulties identified through a longitudinal case study. This list was validated by experts as well as a group of employees from the focus company that participated in the implementation of kanban. This dissertation also proposes a soft factor house for the implementation of card-based systems, in which the factors are classified as exclusive to this theme or classic management factors, as well as in relation to the organizational level in which it operates (organization, implementation group, or individual). This house aims to assist managers in implementing card-based systems, increasing success rates in this process. In addition, by reviewing recent production control systems, this dissertation aims to increase the repertoire of managers on existing systems, enabling the implementation of more appropriate options for the productive environment in which they are located.
A cadeia produtiva da carne e a política de subsídios via Banco Nacional de Desenvolvimento Econômico e Social (BNDES): uma análise de resultados financeiros das grandes empresas beneficiadas e efeitos para produtores e consumidores
(Universidade Federal de São Carlos, 2019-12-03)
Silva, Joice Carla da
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Santos, Leandro de Lima
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https://lattes.cnpq.br/2750978055015275
;
https://orcid.org/0000-0001-8413-5372
This research sought to identify and analyze the reflections of BNDES subsidy policy for the meat production chain (from 2006 to 2016) and its alignment with the expected formal results, based on the financial ratios of three national meatpackers and, under the premise that the government encourages in accordance with the constitutional foundation articles 174 and 192 to promote the development of the country. The justifications of this work are based on the importance of meat, both for the economy and as a source of food, in the fact that the segment is one of the most subsidized by the government and possible contributions from this study to the improvement of government policy aimed at the sector. As a research method, information was collected from the Productive Development Policy (PDP), legislative documents, historical series of the price of beef and meat sold to the final consumer and a comparative analysis of dry liquidity indexes, inventory turnover. , equity evolution, changes in equity interests and other pertinent valuations through the statements of the meatpacking plants. It was found that the companies' financial results improved significantly with the incentives (mainly in terms of growth in equity, net operating income, cash and fixed assets) and the segment increased in the foreign market as PDP aimed, but clear benefits to the Bank and society were not observed. Therefore, it is concluded that there is a misalignment between the effects of the policy and the expected results for the incentive.
Seleção de sistemas de isolamento térmico multi-componentes para fornos de altas temperaturas baseada no desempenho térmico
(Universidade Federal de São Carlos, 2019-12-04)
Santos, Denis Prado
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Mello, Rodrigo Fernandes de
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https://lattes.cnpq.br/6840478133476887
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Pandolfelli, Victor Carlos
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https://lattes.cnpq.br/7369376873984839
Controlled heating through furnace development has allowed the humankind to mold the matter to obtain various products for several different purposes. However, some of them require high-temperature processes so that the necessary physical and chemical reactions can occur, leading to local temperature increase and high energy consumption. Refractory ceramic materials are used for lining the walls of furnaces, in order to reduce the heat dissipation from the heating chamber, and thus minimizing the required thermal energy for keeping its high temperatures. Nevertheless, there is a huge number of commercial insulating materials available, with several properties ranges, that could be used for furnace design, making the selection of the optimal combination of materials a difficult task. This work explores the possibility of using computational tools for the modeling and optimization, providing data-driven recommendations for furnace designers to choose suitable insulating systems. Thus, an evolutionary screening procedure (ESP), based on finite element method and stochastic optimization by multi-objective genetic algorithms, was developed and evaluated on a case-study related to an electric resistance furnace operating up to 1600$^o$C. The ESP has shown to be very efficient, requiring computations on a very small fraction of the total insulating systems possibilities, 3.8\%, in order to recommend a set of optimized combinations of refractory ceramics materials. The obtained results also allowed further analysis of the optimized set, which highlighted important aspects of furnace designing and insulating product costs and benefits. Additionally, three hyperparameters of the proposed algorithm were optimized such that its search effectiveness was improved while reducing execution time.
Necessidades formativas de professores que atuam nos espaços de privação de liberdade em Cuiabá e Várzea Grande-MT
(Universidade Federal de São Carlos, 2019-12-04)
Moraes, Luciana Ferreira da Silva
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Onofre, Elenice Maria Cammarosano
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https://lattes.cnpq.br/9391211432183878
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https://lattes.cnpq.br/1220555321388195
The educational actions developed by professionals of Basic Education of the state schools of Mato Grosso take place in the school spaces through a study project elaborated “from a situational diagnosis with the use of techniques and resources that point out the potentialities, needs and difficulties of students within learning and teaching process” (SEDUC, 2018, p. 2).Whereas this context, this study aims to analyze the teacher education needs who work in classrooms in the prison unities of Cuiabá and Várzea Grande-MT. In order to achieve the proposed objective, this study seeks to answer the following question: Which educational needs emerge in the processes of experiences and in the teachers’ sayings who work in classrooms in the prison unities of Cuiabá and Várzea Grande-MT? This is a qualitative approach study, developed based on field research. For data collection, the following techniques were used: participant observation in the weekly educational meetings of the Teacher Education Program at School and also conducting narrative interviews. The treatment of the obtained data was done through the content analysis proposed by Bardin (2016).The study collaborators are: the teacher educator responsible for accompaniment to educational meetings of Teacher Education Program at School and the teachers involved in this educational event. With this study, based on Paulo Freire’s Liberating Pedagogy, it was found that teachers present collective, contextual and individual educational needs. The collective educational needs, at mostly, come from the context where it was developed the educational practice. From this, it emerges the main challenge and, in the same time, it was arranged as a collective educational need: articulation between theory and practice. In addition, there are contextual educational needs where come from spaces of deprivation of liberty, an environment marked by rules, disciplines and apart students, for a period of time, from social interaction. Lastly, the analysis of the set of data showed that teachers are in stages of distinct career, have a variety of academic education, singular histories of personal and professional life and these aspects point to individual educational needs referred to their education, work and concerned area. The variety of educational needs identified demonstrate the relevance of (re)thinking about Continuing Educational of these teachers who work on education at prison.
Resíduos de cama de frango para fabricação de biochar
(Universidade Federal de São Carlos, 2019-12-04)
Pereira, Moisés Edevaldo
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Varanda, Luciano Donizeti
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https://lattes.cnpq.br/9095009636880827
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Yamaji, Fábio Minoru
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https://lattes.cnpq.br/4787449634914831
Brazil has a large generation of poultry litter, as a result of its worldwide prominence in the production of broiler chicken. The poultry litter biomass generates considerable environmental impacts according to its volume produced. Thus, the general objective of this work was to characterize the poultry litter biomass to verify the possibility of using as a raw material for biochar manufacture. To characterize the poultry litter, was analyzed samples of sawdust pine, poultry litter with 1 and 2 lots of broiler chicken. Were performed immediate analyze, moisture, thermogravimetric analysis (TGA), scanning electron microscopy (MEV), dispersive energy spectroscopy (EDS) and macro and micronutrient analysis were performed only with poultry litter with 1 and 2 lots of broiler chicken (chapter 2). For the manufacture of biochar, were used 5 treatments with the following residence times: 0.5, 1, 2, 4 and 6 hours. The biochar produced were subjected to immediate analysis, moisture, gravimetric yield, scanning electron microscopy (MEV), dispersive energy spectroscopy (EDS) and higher heating value (HHV), shown in chapter 3. The results showed that poultry litter biomass has great potential for biochar manufacture, with expressive values of phosphorus, potassium, calcium and others, and pH of 8.4, important characteristics for biochar with soil use. The results showed that the best conditions for biochar manufacture are with pyrolysis temperature of 450 °C and residence time of 0.5 hour, with high gravimetric yield of 37.21%. The studies also concluded that use of both biomass and biochar are not indicated for use in energy due to characteristics such as moisture, ash content and higher heating value.
Altas habilidades/superdotação em liderança: identificação e suplementação para o ensino fundamental I
(Universidade Federal de São Carlos, 2019-12-05)
Lima, Clairen Angélica Santiago
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Rangni, Rosemeire de Araújo
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https://lattes.cnpq.br/6399149504309769
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https://lattes.cnpq.br/3918587725545579
LIMA, C. A. S. High Skills/Leadership Giftedness: identification and supplementation for elementary school I. Master’s dissertation. Post-Graduation Programo of Special Education. Federal University of São Carlos, 2019. High Ability /Giftedness (HA/G) students demonstrate high potential in any of this areas isolated or combined: intellectual, academic, leadership, psychomotor and arts, furthermore showing great creativity, involvement in learning and performing tasks in areas of interest, according to the law. Although Leadership is one of the areas in HA/G, few studies are found in Brazil on this context, and even less in the school context. The school has an academic bias that difficult the identification on plans for potential development of students with leadership indicators. It was thought in identification in students with leadership profile at school, specifically in elementary school and how it would be this procedure for evaluation. This way it was decided to split this work into two independent studies that interweave themselves: Step 1 – High Ability/Giftedness in Leadership: Initial referral of the elementary school students and Step 2 – Enrichment of students with leadership characteristics in elementary school. The step 1 aimed to indicate gifted leadership students in a municipal public school, in the inland city of São Paulo. The draw of the research was descriptive and field study. A hundred ninety (190) students, and fifteen (15) teachers took part of the research. The instruments used were questionnaires for the teacher description; Indicator ckecklist (LIVIAHSD); Questionnaires to high ability/giftedness indication (QIIAHSD-PR); Appointment leadership list (CNL). The results pointed to seven (7) students with leadership characteristics and considered the instruments effective for identifying. The Step 2 objectives were: to plan and to accomplish a curriculum enrichment project to students with high ability/giftedness with leadership characteristics at the multifunctional resource room enrolled in an elementary school in the municipal public school in the city of São Paulo. The research was characterized in descriptive study and action research. The seven students indicated (Step 1) took part to the curriculum enrichment project (step 2) at the multifunctional resource room in the specialized educational service. The enrichments were performed type I and II with chosen themes by the students. It happened at the school in opposite time of the classes. The students could experience diversified activities and the results were positive due to the involvement of all students with the activities. Key words: High Ability/Giftedness. Leadership. Identification. Enrichments.
O mundo Panará em criação
(Universidade Federal de São Carlos, 2019-12-05)
Werneck-Regina, Adriana
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Peggion, Edmundo Antonio
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https://lattes.cnpq.br/9849805103860827
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https://lattes.cnpq.br/3050098696837860
The aim of this thesis is to outline ways of conceiving growth, marriage and death among the Panará, people speaking the Gê language that inhabits the Panará Indigenous Land, covering the north of Mato Grosso and southern Pará. At the same time, the contours of social relations that are configured as creation are traced, exploring how they connect to the perceptions of the growing body, the marrying body and even the body that changes when it dies. It is observed that the creation focuses on contexts of action related to the nutrition of the bodies and the relations practiced by them, involving the participation of the dead. It is discussed how the latter become constituent parts of socius. In discussing creation as a social model, it is considered how its articulation with mutual care is unstably configured, since the conflict is unveiled as inherent to the condition of existing. At the same time, it reverberates in the notion of person, indicated in it that being good and bad are powers of existences.
Development of seminconductor nanowire materials for electronic and photonics applications
(Universidade Federal de São Carlos, 2019-12-05)
Piton, Marcelo Rizzo
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Guina, Mircea
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Gobato, Yara Galvão
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https://lattes.cnpq.br/7558531056409406
;
https://lattes.cnpq.br/2913665013211219
The thesis is concerned with study of GaAs nanowires fabricated on Si substrate. The possibility of growing III-V semiconductor materials directly on silicon in the form of nanowires is an attractive route to the integration of microelectronic, photonic and optoelectronic technologies. To this end, development of functional heterostructure require effective and controllable doping but the dopant incorporation mechanisms involved in nanowire growth can be quite different from the well-established semiconductors thin film technology. The interplay of the different dopant incorporation mechanisms and the competition between axial and radial growth can result in dopant concentration gradients in the nanowires. As a key technology development enabling the study of transport properties in nanowires, a method for fabricating electrical contacts on single NWs using electron- beam lithography is reported. On the other hand, the reduced dimensions and the quasi one-dimensional nanowire geometry are challenging factors for the fabrication of electrical contacts in the correct geometry for Hall effect measurement, which is traditionally used in planar film to determine the dopant concentration and carriers mobility. Therefore, alternative techniques were employed to gain an understanding of the dopant incorporation mechanisms. To this end, Raman spectroscopy and current-voltage analysis on single-nanowire were used to estimate the spatial distribution of the Be and Te dopants along the axial direction of GaAs nanowires. The study reveals that the dopant incorporation mechanisms are strongly affected by the growth conditions for both p-type and n-type GaAs nanowires, resulting in gradients of dopant concentration along the nanowires. Besides the carrier transport properties, the waveguide properties of semiconductor nanowires were explored in the area of chiral sensing and emission of circularly polarized light. By fabricating asymmetric gold layers deposited on the nanowires sidewalls and under the adequate experimental conditions an extrinsic optical chirality configuration is achieved. The results show a strong chiral behavior in both absorption and emission of the partially Au-coated nanowires, and paves the way for applications such as chiral sensing and emitting devices.
Métodos de estimação em modelos de efeitos mistos não lineares de caudas pesadas
(Universidade Federal de São Carlos, 2019-12-05)
Gomes, José Clelto Barros
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Novelli, Cibele Maria Russo
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https://lattes.cnpq.br/1011098065426388
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https://lattes.cnpq.br/7522100387675610
Parameter estimation in nonlinear mixed-effects models is often challenging. In this thesis, a comparison of estimation methods for these models is proposed under a frequentist approach. In the first study, a comparison of maximum likelihood estimates under an exact method via Monte Carlo expectation-maximization (MCEM) and an approximate method based on a Taylor expansion, frequently used in the literature, is provided. In a second study, a restricted maximum likelihood estimation method is proposed, aiming to decrease the bias for the variance components estimates, based on the integration of the likelihood function on the fixed-effects, also in an exact likelihood context. These estimates are compared to the maximum likelihood ones. For the latter comparison, stochastic approximation of expectation-maximization (SAEM) algorithms are considered. The random effects and errors are assumed to follow multivariate symmetric distributions, namely the scale mixture of normal distributions, which include the normal, t and slash distributions. Finally, a general nonlinear mixed-effects model is proposed, where no linear relation is assumed in the random effects structure. In all the proposals, real data sets and simulation studies are used to illustrate the estimates’ properties.
Caracterização e avaliação biológica do colágeno marinho de esponjas incorporado na hidroxiapatita para a engenharia do tecido ósseo
(Universidade Federal de São Carlos, 2019-12-05)
Parisi, Julia Risso
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Tim, Carla Roberta
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https://lattes.cnpq.br/7999144275569009
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Renno, Ana Claudia Muniz
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https://lattes.cnpq.br/4106611304688552
Fractures cause non-union and delay in bone consolidation, those problems are associated with a substantial physical incapacity and high socioeconomic costs and it’s considered an important clinical challenge. In this context, some biomaterials have been investigated to accelerate the consolidation of fractures and to be effective for bone grafting. One of the most promising strategies to improve the biological performance of bone grafts is the combination of different biomaterials. In this context, the aim of this work was to evaluate through in vitro assay (study I) and in vivo study (study II) the effects of the incorporation of marine spongin (SPG) from Aplysina fulva into Hydroxyapatite (HA) for bone tissue engineering proposals. In the study I, SPG and HA scaffolds with different proportions (HA/SPG 90/10 and HA/SPG 70/30) were produced. For this, the following procedures were evaluated: scaffolds mass loss after incubation, pH, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and in vitro cell viability. Regarding study II, HA and HA/SPG 70/30 scaffolds were produced and SEM analysis was performed to characterize the samples. Also, in order to evaluate the in vivo tissue response, samples were implanted into a tibial bone defect in rats. Histopathological, immunohistochemistry and biomechanical analyzes were performed after 2 and 6 weeks of implantation to investigate the effects of the material on bone repair. The results of study I showed that pH measurements presented no statistical difference between the groups. Moreover, a higher mass loss was observed for HA/SPG70/30 compared to the other groups for all experimental periods. Moreover, SEM representative micrographs showed the degradation of the samples. FTIR analysis demonstrated the absorption peaks of the materials. A higher L929 cell viability for HA/SPG 70/30 was observed compared to HA and HA/SPG 90/10 on days 7 of culture. Furthermore, HA/SPG 70/30 showed a significant lower MC3T3 cell viability compared to HA and HA/SPG 90/10 on day 1. After 3 days the HA group showed lower cell viability when compared to the control group and HA/SPG 70/30. In the study II, it was possible to observe through the SEM results that SPG were successfully inserted in the HA, forming a homogeneous scaffold. The histological analysis demonstrated that the HA/SPG (70/30) group presented an accelerated material degradation and enhanced newly bone formation compared to the HA group. Additionally, histomorphometry analysis showed higher values of %BV/TV and N.Ob/T.Ar for HA/SPG (70/30) compared to the HA. Immunohistochemical analyzes, the Runx-2 immunolabelling was observed in granulation tissue and newly formed bone for all experimental groups. Furthermore, HA/SPG (70/30) showed an increase of immunolabelling compared to the other groups. Moreover, the VEGF immunolabelling was observed in granulation tissue for all experimental groups however, no difference was found. The biomechanical analysis demonstrated similar values for all groups. Considering the results of the two studies it is concluded that SPG can be used as an additive in HA, especially the one mimicking the composition of bone (with 70% of HA and 30% of SPG), providing an improvement in biological performance for bone regeneration applications. However, further long-term studies should be carried out to provide additional information regarding the material degradation and bone regeneration.
Prática segura na administração de medicamentos injetáveis para prevenção de infecção relacionada à assistência à saúde: elaboração e validação de instrumento
(Universidade Federal de São Carlos, 2019-12-05)
Fittipaldi, Thais Roberto Magalhães
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Figueiredo, Rosely Moralez de
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https://lattes.cnpq.br/2597491235073085
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https://lattes.cnpq.br/6565148052129714
Introduction: Injectable medications are often used in health services, the knowledge of the professionals and adherence to good practices are essential for safety during their preparation and administration, which minimizes the risks of existing infection. Objective: To develop and to validate an instrument to measure the knowledge of nursing professionals about infection prevention in the administration of injectable medications. Method: Methodological study of quantitative approach. The conceptual structure of the instrument was guided on the situational diagnosis made with nursing professionals from the State of São Paulo, on national and international publications and guides about the subject. The evaluation was by face recognition and valuable content. To select the judges, the criteria used was: minimum professional experience of two years in assistance, experience in infection control or to be a researcher in the department of nursing in infection control department. For the assessment of each department an agreement rate above 80% was considered appropriate, for the items assessment, were considered valid those with Content Validity Index ≥ 0,8. After, the pre-test was performed with nursing professionals by snowball technique. Results: Final instrument consisting of 24 items, divided into four domains: preparation of the workplace, preparation of injectable medications, administration of injectable medications and disposal of sharps. Eleven judges validated the instrument, three domains obtained an agreement rate below 80% in relation to the inclusion of items, and that´s what were added three items, one item for each domain. In spite of all items reached a CVI> 0,80, twelve items had changed on the essay by suggestion of the judges. The pre-test was performed with 34 nursing professionals, and nine items had changed on the essay as suggested by the target audience. Conclusion: Tool developed by face validation and content, available to measure the knowledge of nursing professionals about infection prevention in the administration of injectable medications.
Segregação Socioespacial em Sorocaba (1980 – 2018): o processo de territorialização nos condomínios Residencial Ipatinga e Parque dos Eucaliptos
(Universidade Federal de São Carlos, 2019-12-05)
Costa, Vinícius Felipe da
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Melo, Ismail Barra Nova de
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https://lattes.cnpq.br/3576937472687059
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Lana, Rita de Cássia
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https://lattes.cnpq.br/1816504631940006
Based on the understanding that socio-spatial segregation occurs as a strategy for the real estate sector and for the State, preventing portions of the population from having access to decent housing, we sought to problematize the issue by analyzing the process of territorialization of groups of residents living in condominiums in a situation of land tenure irregularity in the western periphery of Sorocaba-SP. The cut of the Residencial Ipatinga and Parque dos Eucaliptos condominiums serves as an empirical basis to support this problem. For this, the historical process of housing financing and the periphery of housing in the city was analyzed in order to apprehend the production of socio-spatial segregation. Then it was verified how some social groups adapted or overcome this condition of exclusion. The practices present in these places reveal strategies for adapting to the conditions imposed by the hegemonic agents, constituting norms created locally, but which are connected to different scales and levels of reality. In this way, a theoretical exercise was carried out brought the global context of the place closer, exposing the nexus between the hegemonic use of the territory taken as a resource, and the hegemonized use of a territory built as a shelter.
Roda de conversa: (re)pensando o processo de ensino de alunos com deficiências no ensino fundamental II
(Universidade Federal de São Carlos, 2019-12-06)
Aporta, Ana Paula
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Denari, Fátima Elisabeth
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https://lattes.cnpq.br/5575213011914394
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https://lattes.cnpq.br/3865029215782402
Research that aims to investigate the reality of the inclusive process of people with disabilities in the common school system points out several components that still represent a barrier to their effective quality. One of the most frequently portrayed components in the literature refers to the methodological issues contained in the teaching process of these students and the lack of training of teachers to work with this population in school. Thus, this research aimed to develop a continuing education with professionals responsible for Elementary School II, about curriculum adaptations to meet the student with disabilities included in their classroom. Thus, a qualitative research was conducted, of nature descriptive and outlined by action research. 23 professionals from the school community participated in the research, including: elementary school teachers; Brazilian Sign Language Interpreters - LIBRAS; speech therapist; pedagogical assistant; and instructors of children with disabilities in a School Unit in the interior of São Paulo State. As training and research procedure, formative conversations, observations of classroom activities and teachers' discourse analysis were carried out. Considering the applied nature of the research focus theme, observations were made from three classes of 6th grade teachers and records of activity adaptation practices before, during and after the conversation wheels. Wheel recordings were analyzed to identify the core components contained in teachers' statements that influence their practice. The results obtained in the first observations and then in the first two rounds of conversation, it was found that the teachers had difficulties to teach students with disabilities. Also, it was observed that teachers did not perform curricular adaptations in the activities aimed at teaching these students. After the first two rounds, teachers began to rework their own identities, and with that, they thought about activities options tailored for students with disabilities. Thus, it was observed that teachers had actions with the purpose of offering curricular learning considering the potentialities of students with disabilities. Moreover, at the end of the research, it was found that the conversation wheels contributed to adaptive actions for students with disabilities. With the observations of the teachers' classes after the wheels, it can be verified that they prepared and performed different activities based on the student's characteristics. Thus, this research states that the conversation wheel can be an effective teacher training strategy for changing the practice of teaching students with disabilities.
Uma avaliação qualitativa da presença de micotoxinas e micro-organismos toxigênicos em insumos e em cervejas artesanais
(Universidade Federal de São Carlos, 2019-12-06)
Paix, Murilo D`Abruzzo
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Rodrigues-Filho, Edson
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https://lattes.cnpq.br/3667941735597178
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https://lattes.cnpq.br/7248460348326502
Consisting primarily of water, hops, malted and non-malted cereals as well as yeast, beer is one of the most consumed alcoholic fermented beverages in the world. Although there are risk laws that compromise product quality, some pathogens such as fungi can contaminate the raw material used in beer production with secondary metabolites. For example, mycotoxins which are compounds produced by filamentous fungi, which in certain amounts can cause disease in animals and humans. Thus, we studied some fungi of the species of the genus Fusarium spp. and Aspergillus flavus to identify which mycotoxins could produce when grown in vitro under favorable input conditions (barley, maize and rice) used by microbreweries for the production of craft beers. These microorganisms when cultivated under favorable conditions, it was possible to find in their fungal extract that fungi of the genus Fusarium spp., Produced mycotoxins such as Zearalenone, α-Zearalenol and β-Zearalenol, Nivalenol, Fumonisin B1, in relation to the extract. obtained from the cultivation of the fungus Aspergillus flavus, it was possible to observe the production of mycotoxin Aflatoxin B1. Six craft beers were produced on a laboratory scale using the same previous inputs without contamination with the fungi in different proportions of barley, corn and rice, in which these samples when subjected to liquid chromatography coupled with mass spectrometry, but were not found. In addition, a study was carried out under which fungi could be isolated from barley grains used by microbreweries, where it was possible to isolate seven fungi. And with micro-cultivation and MALDI-TOF experiments, two fungi may belong to the genus Fusarium sp. and the genus Mucor sp.. Several bacteria were also found when isolating microorganisms, which were also submitted to experiments using MALDI-TOF, many of which have a very similar proteomic profile.