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Um jogo de tabuleiro envolvendo conceitos de mineralogia no ensino de química
(Universidade Federal de São Carlos, 2021-03-23) Santos, Karen Ouverney; Benedetti Filho, Edemar; https://lattes.cnpq.br/5963704923612696; https://lattes.cnpq.br/3809541916156428
This paper describes the development and application of the board game "Minerals", aiming at teaching concepts of mineralogy in High School. Once concluded the artistic conception, assembly of pieces, boards and rules definition, the game was submitted to a team of undergraduate students in Chemistry, in order to assess its pedagogical potential, as well as its playfulness, dynamics and playability. Subsequently, the game was introduced to high school students from a state public school, in order to analyze its applicability and effectiveness in the teaching of concepts generally unexplored at this school level. Results showed an excellent acceptance of the game by the students, as well as its contribution to the learning of concepts on an important theme, which is very little explored in Basic Education. Furthermore, the work involved undergraduate students in Chemistry, whom had the opportunity of experiencing the development and application of a playful teaching tool.
Desenvolvimento de dispersões sólidas e membranas baseadas em praziquantel-poli(álcool vinílico) na terapêutica de esquistossomose
(Universidade Federal de São Carlos, 2021-03-23) Silva, Vanessa Bezerra da; Silva, Caio Marcio Paranhos da; https://lattes.cnpq.br/7793686262868668; https://lattes.cnpq.br/1145646563114694
Schistosomosis is a parasitic disease considered neglected and endemic in 75 countries. It is estimated that 240 million people are infected and 700 to 800 million people are at risk. Despite that, there is no effective vaccine. Therefore, oral medications continue to be used a lot. Praziquantel (PZQ) is the drug mostly used in this case, however it has low solubility in water and is extremely bitter, making it difficult for children between 3 months and 6 years keep the treatment. Solid dispersion (SD) is a very useful pharmaceutical technology to increase dissolution, absorption, bioavailability and, consequently, the efficiency of a drug and also mask flavors. In order to study the interactions between praziquantel (PZQ) and poly(vinyl alcohol) (PVA), SDs and membranes were prepared and characterized in terms of their microstructure, swelling, release and dissolution. The results show that the crystalline structure is not modified with freeze-thaw cycles and the drug is an obstacle to crystals formation. The swelling measurements show that, for membranes, the amount of PZQ does not influence the sample’s swelling. The XRD shows that the position of PZQ’s peaks is in accordance with the diffraction patterns of the racemic form and that the drugs’ peaks overlap the PVA bands. The infrared spectroscopy shows that for membranes it is clear that the more PZQ in the sample, the smaller is the C–H ring bonds movement, suggesting that the interaction between the polymeric matrix and the drug is given through interactions within the rings in addition to the hydrogen bonds. For the DSs, however, the change between the polymer-drug proportions analyzed is not clear. As for the release, the DS with the highest release for all tested pHs is the sample with a 1:2 ratio (PZQ: PVA) and placed in the Turrax at 20,000 rpm, showing that the processing is important.