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Otimização da sensibilidade de detecção de sensores óticos baseados em moléculas fotônicas
(Universidade Federal de São Carlos, 2021-05-21)
Junior, Valnir Carlos da Silva
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Barea, Luis Alberto Mijam
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https://lattes.cnpq.br/7929868663210908
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https://lattes.cnpq.br/4925370507459259
The integrated photonics has been consolidated in the last years in part by the ability to meet the recent demand for the miniaturization of photonic devices. Waveguides and optical microcavities stand out among the main components used in integrated photonics. Waveguides consist of structures capable of guiding electromagnetic waves between their starting and endpoints, based on the difference in the refractive indices of two or more materials to keep light confined by guiding them inside the chip. The optical microcavities are simple photonic structures, mostly in the form of disks or rings, which allow the photons to be strongly confined in a tiny volume. Several integrated photonic devices take advantage of the optical characteristics of these structures, which combined, guarantee the design of integrated photonic chips, fabricated in laboratories of universities, companies, and foundries. One of the largest applications of integrated photonic chips is in optical sensors, called lab-on-a-chip, which allows several lab functions on a single chip in order to achieve high-performance automation and screening. In particular, sensors based on photonic molecules (PMs), which are combinations of optical microcavities coupled with each other, use a detection method linked to the variation of resonances of the microcavities in the presence of a change in the refractive index of the environment around the microcavities. The resolution of these sensors is highly dependent on the dimensions of the transverse session of the waveguide where the light is confined. One of the main challenges of this type of sensor is the optimization of its sensitivity, without there being major changes in the fabrication methods to obtain them once they are well established in the industry. In this sense, the focus of this project was to investigate methods to increase the sensitivity of integrated sensors based on PMs from the optimization of the dimensions of the components that constitute them to the implementation of strangulation in the waveguide that forms the detection rings. This strangulation will ensure an increase in the evanescence of the propagating modes in these cavities, responsible for the detection of the sensors, increasing significantly its sensitivities.
A leitura nos anos iniciais do ensino fundamental: uma análise do manual do professor do livro didático da coleção Novo Pitanguá
(Universidade Federal de São Carlos, 2021-05-21)
Carvalho, Beatriz Mendes de
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Souza, Geraldo Tadeu
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https://lattes.cnpq.br/3516168011612531
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https://lattes.cnpq.br/4950930245413416
This course conclusion work aims to analyze reading proposals present in a unit of the textbook teacher manual approved by PNLD 2019 of the Novo Pitanguá - Língua Portuguesa collection (BURANELLO, 2017) of the second year of elementary school. It is a documentary and bibliographic research that takes into consideration, mainly, the different fields of action of the Reading/Listening axis present in the curricular component Portuguese Language of the Common National Curricular Base (BNCC) and the Digital Guide of the National Book and Didactic Material Program (PNLD) of 2019. Sections and subsections of the aforementioned textbook are analyzed to understand the space given to reading and the relationship with the reading competences proposed by BNCC. It seeks to enable a reflection on the importance of knowing the public educational policies and the didactic materials derived from these so the didactic proposals are used in a meaningful way by the researcher professor. The results show that the unit of the book corresponds to what is presented in its review of the PNLD Digital Guide 2019, contemplates the skills and abilities present in the BNCC, is concerned with the multiliteracies, the respect for cultural diversity and considers the reading capacities of second year students without underestimating them.
Utilização de grãos secos de destilaria (DDG) como substituto de farelo de soja na fase de terminação de novilhas Nelore
(Universidade Federal de São Carlos, 2021-05-21)
Forcin, Tales Monteiro
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Stipp, Danilo Tancler
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https://lattes.cnpq.br/2930975168886154
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https://lattes.cnpq.br/4404135116350937
Brazil presented in 2019 the world’s largest beef cattle herd, but still has great potential for development of this productive chain. Beef cattle supplementation is one of the tools for optimizing the meat production in the country. Accordingly, the use of high rumen undegradable protein (RUP) supplements like soybean meal (SM) and dried distiller’s grains (DDG) on meat production becomes interesting. Thereat, the objective of that study is evaluating the replacement of SM by DDG in terms of productive efficiency during finishing phase beef cattle. Sixty Nellore heifers were used to evaluate their performance submitted 3 different treatments of concentrate supplementation: T1 - conventional SM as protein source; T2 - supplement with 50% replacing SM protein source by DDG, and T3 - supplement with 100% replacement of SM protein source by DDG. During dry season, the finishing developed in grazing system, during 30 days (first moment), which were maintained in Bracchiaria grass pasture, receiving supplementation. Then the last 63 days (second and third moment) were maintained in corn silage, in additional to the same supplementation. In between every moment of 30 days and in the last day of the experiment were collected weight and body condition score (BCS), then animals were slaughtered and collected carcass weight and carcass yield. It was concluded that DDG can partially replace SM in feedlot diets without changing animal performance. The total replacement of SM by DDG, without being accompanied by ingredients that provide a better rumen degradable protein RDP / RUP ratio, can change performance.
Nanopartículas de ouro funcionalizadas com flavina adenina dinucleotídeo para detecção eletroquímica de dopamina
(Universidade Federal de São Carlos, 2021-05-21)
Medrades, Jennifer de Pontes
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Ferreira, Marystela
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https://lattes.cnpq.br/4714185516263478
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https://lattes.cnpq.br/7324777155217947
Dopamine (DA) is a neurotransmitter with multiple roles in the central nervous system, and alterations in its level in the organism result in Parkinson’s and schizophrenia diseases. Therefore, DA levels monitoring in the body is of medical interest. Hence, a novel electrochemical biosensor was designed on a gold substrate with a self-assembled 11-Mua monolayer, a cationic polyelectrolyte (PEI) layer, and a layer of gold nanoparticles stabilized with glutathione and functionalized with flavin adenine dinucleotide (FAD). FAD, a cofactor found in the active site of monoamine oxidase enzymes, was added to this biosensor to make it selective. The developed biosensor was characterized by UV-Visible spectroscopy, FTIR, atomic force microscopy (AFM), and cyclic voltammetry (CV), confirming a successful development process. Differential pulse voltammetry (DPV) data for detection assays using 0.1 mol L-1 (pH 7.4) PBS buffer demonstrated no interference of uric acid, ascorbic acid, serotonin, and urea. The biosensor was stable for 20 days, presenting a linear detection ranging from de 0.8 to 8.0 µmol L-1, 1.25 µA/µmol L-1 cm-2 of sensitivity, and 0.525 µmol L-1 and 1.75 µmol L-1 for calculated limits of detection and quantification, respectively. Human urine was used as a real sample, and the values of recovery ranged from 85 to 90%. In summary, the developed biosensor demonstrated perspectives for being applied in complex sample analyses.
Design of high entropy alloys for hydrogen storage: study of the Mg-V-Al-Cr-Ni, Mg-Al-Ti-Mn-Nb and Ti-V-Nb-Cr systems
(Universidade Federal de São Carlos, 2021-05-21)
Strozi, Renato Belli
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Zepon, Guilherme
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https://lattes.cnpq.br/7924187202036614
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Leiva, Daniel Rodrigo
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https://lattes.cnpq.br/6576844591900987
The advent of high entropy alloys (HEA) has brought new opportunities and challenges to metallurgy. Due to extensive compositional field of HEAs, the possibility of controlling properties in a composition-driven approach becomes evident. However, this vast compositional field demands enormous efforts to select promising alloys for a given application. Up to now, an accurate model to effectively designing HEAs for hydrogen storage is still lacking. Thus, this thesis is dedicated to investigating the effects of the chemical composition on the structural and hydrogen storage properties of body-centered cubic (BCC) HEAs for hydrogen storage applications. Firstly, a set of lightweight HEAs of the Mg-V-Al-Cr-Ni system was produced by high-energy ball milling (HEBM). The experimental results indicate that a single-phase solid solution was only obtained for the equiatomic composition. The investigated alloys exhibited poor hydrogen storage properties. This behavior brought to light the importance of balancing hydride- and non-hydride-forming elements to tune the alloy’s hydrogen affinity, specially considering the mean enthalpy of hydrogen solution of the alloying elements. In a second step, a semi-empirical design method was employed to screen a single-phase BCC alloy with high hydrogen affinity from the Mg-Al-Ti-Mn-Nb system. Through the calculation of four composition-dependent parameters (φ, VEC, mean enthalpy of hydrogen solution and mean mean enthalpy ), the Mg12Al11Ti33Mn11Nb33 alloy was designed. When produced by HEBM, this alloy exhibited a single-phase BCC structure and interesting hydrogen storage properties, indicating that the design approach can be successfully applied to find interesting compositional regions for a multicomponent system, decreasing the number of experiments needed to find alloys with appropriate properties for hydrogen storage. In the third part of this study, the effects of adding a non-hydride-forming element in a multicomponent system composed only of hydride-forming elements was investigated. The CALPHAD method was applied to find a suitable alloy system. The (TiVNb)100-xCrx alloy system was selected, with x = 15, 25, and 35 at.%. In this range of composition, the CALPHAD method indicates the formation of single-phase BCC during solidification for the three alloys, which was confirmed experimentally. The hydrogen storage performance was evaluated, and it was verified that increasing the Cr/(TiVNb) ratio leads to significant increase in the equilibrium plateau pressure of the (TiVNb)100-xCrx alloys, without significant loss of maximum hydrogen storage capacity. It was demonstrated that the proportion of a non-hydride forming element can be used to tune the hydrogen storage properties of the HEAs.
Participação social em educação e dominação: uma análise sobre o campo e as implicações do trabalho parrésico
(Universidade Federal de São Carlos, 2021-05-21)
Batista, José Ricardo
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Silva, Flávio Caetano da
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https://lattes.cnpq.br/7889803676083470
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https://lattes.cnpq.br/7671024971334446
The discourse about the democracy participation in education asks educators, for instance. This paper on the assumption that the policies actives take on important in all human life, especially, from the participative democracy model. Therefore, we seek to investigate how the mechanisms of social participation in educational public policies have been developed, purposing to understand the resignifies and establish regimes of truths grounded by the speeches. We used dice from official documents, laws among others. In addition to treating parrhesic work as a possibility for the present day, from the perspective of resistance to the governmentalized state. Besed on a theoretical basis in Michel Foucault, we sought to understand the dynamics established by the governmentality that uses institutions, as well as the structures proper to the Democratic State to constitute a homogeneous group that reinforce and expand its Power. One of the sides, which is the parrhesic represent the rupture of that order. It suggesting think that we have ethical experiences that overcome all harassment of normalizing devices. The, we rake up some implications of Foucault's analysis are evaluated to rethink the dilemmas of educational theorization and the role of teachers and education professionals as intellectuals to specific rationality developed today. Consciousness and this practice originated by the antiquity, implies a virtue, a quality and a duty that in the political and educational show as a technique of your own direction. Because of that, this paper examined official documents and some bibliographic references to understand how this transition takes place between intellectual discussion and the formation of a set of laws, projects, opinions, theses and pedagogical / legislative proposals with the scope of unifying thought and that provides the improvement of governmentality. Freedom is a fundamental principle of democracy. For that reason, any form of limitation, restraint and weakening must be repelled by anyone. The centralization at the state level represents a serious threat to freedom. In our reality, we can note a strong centralization. This can make easy the implementation of totalitarianism. Only the strengthening of the individual as an autonomous being can represent a way of resisting governmentality. In the end, we’d like to talk about the role of education in this scheme that we will try to situate in this characteristic game of modernity.
O professor de educação especial nos institutos federais
(Universidade Federal de São Carlos, 2021-05-21)
Guimarães, Luciana Carlena Correia Velasco
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Vilaronga, Carla Ariela Rios
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https://lattes.cnpq.br/6536774151778096
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https://lattes.cnpq.br/2385112302119235
Special Education is transversal and is foreseen at all levels and teaching modalities, therefore, the presence of the special education teacher must be ensured as one of the actors of this modality. Once, the role of the school and its educators in the schooling of the target audience of Special Education is to effect accessibility, integrally, as school autonomy of diversity in all its manifestations. This research aims to analyze the role of Special Education teachers in Federal Institutes. Specifically: a) Outline the profile of the initial and continuing education of Special Education teachers; b) Describe the possibilities and challenges of the practice of Special Education teachers in research, extension and teaching; c) Describe the functionality and organization of the Specialized Educational Service; d) Analyze the conceptions about the institutional policy in the accessibility actions of the campus. This work consisted of an investigation of a descriptive character, following a qualitative approach, of the field study type, and had as participants 20 teachers in the area of Special Education from 11 Federal Institutes. Based on ethical procedures for research with human beings, the research was authorized under CAAE number: 3.927.464 by the Research Ethics Committee of the Federal University of São Carlos. For data collection, two instruments were used, a questionnaire and a script that was used for the interview, both carried out online. The registered data were treated and analyzed in light of the content analysis approach, and discussed with the scientific literature in the field of Education, Special Education, Political and Social Sciences. As a result, we found that the majority of respondents are graduates in Pedagogy with a postgraduate degree in Stricto Sensu in Education or Special Education programs. The employment relationship has a greater number of effective vacancies. The challenges in working with teaching, research and extension are the organization of the workload in the Individual Work Plan and the lack of human and material resources. Specialized Educational Service is prioritized in teaching, but it is not restricted to teaching activities, with the exception of three Special Education teachers. The completion of this study allowed describing the role of the Special Education teacher at Federal Institutes.
Obtenção de fibras cerâmicas ultrafinas à base de Nb₂O₅ para a fotoconversão gasosa de dióxido de carbono
(Universidade Federal de São Carlos, 2021-05-21)
Prado, Ana Carolina Figueiredo
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Paris, Elaine Cristina
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https://lattes.cnpq.br/8475640212486290
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Luz, Ana Paula da
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https://lattes.cnpq.br/3470395641242374
The increase in global warming rates is worrisome due to the harmful effects on different ecosystems. However, there is a need to reconcile these figures with the demand of industrial society for food, health, leisure, and energy production, which directly/ indirectly contribute to the increase in greenhouse gas emissions. Pollutants such as NOx, CO2, CH4, and others, significantly affect the lives of beings as a whole. One way to minimize these effects is to remove and reuse these pollutants from photocatalytic processes. In this sense, one of the promising materials for application in conversion is Nb2O5, due to its photocatalytic properties, abundance in Brazil, and low cost compared to usual catalysts. The present work aimed to develop a photocatalyst system based on ultrafine Nb2O5 fibers to convert CO2. To obtain the ceramic fibers, the electrospinning method was used, followed by heat treatment. The concentrations of the polymeric solutions and the heat treatment conditions were optimized. For the evaluation of the photocatalytic activity of Nb2O5 fibers in the conversion of CO2, a reactor monitored by gas chromatography was used to quantify the products generated. At the end, the stability of the system was evaluated in view of the number of reuse cycles. Furthermore, when varying the calcination temperature, it was observed that the temperature of 600°C for 2 h was the condition that made it possible to obtain homogeneous nanofibers with average diameters of 84 nm. It was confirmed that the Nb2O5 nanofibers converted CO2 mostly into CO and CH4 at less ratio, with values close to 8.5 μmol g-1 and 0.55 μmol g-1, respectively. In reuse tests, a decrease in CO production was identified until the end of the 4th cycle, whereas for methane these concentrations were not observed. Consequently, photocatalyst nanofibers based on Nb2O5 were obtained, which enabled the CO2 converting process to added value products CO and CH4.
Estado, mercado e a defesa concorrencial: uma análise sociológica das configurações do CADE
(Universidade Federal de São Carlos, 2021-05-21)
Casagrande, Diego José
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Candido, Silvio Eduardo Alvarez
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https://lattes.cnpq.br/0194644249955417
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https://lattes.cnpq.br/4156550100749294
The aim of this work is analize the remakings in the CADE´s directors and presidents profile, between 1994 and 2020. It searchs to understand how and what level of intensity the social trajectories of these agentes influenced, directly or indirectly, the agency´s decisions in the sector of Brazilian economic regulation. The research purpose is ruled in the theoretical discussions about the joints that exists between State, market and competitive defense. Historically, when assuming a mediation paper next to the economic field, specially through acting regulatory agencies, the State has became inseparable to the market. From the perspective of economic sociology, therefore, State and market can´t be characterized as antagonistic elements, in view of social, political and legal relationships established between both. In the face of this context, a qualitative research was realized containing the data survey about the trajectories of 62 advisers who acted in CADE in th focused period. In order to achieve the proposed central objective, it was used as a base the sociology concepts of Pierre Bourdieu. These data were analized for the production of descriptive statistics and through Multiple Correspondence Analysis (MCA). So, this study demonstrated, in theirs results, that CADE postions in the Brazilian competitive sphere are not ruled only in the legal and political aspects that encompass the organ, but essencially in the settings that envolve the social, cultural and symbolic constructions of agents that are inserted in it, making possible, thus, the articulation of its functional dynamics.
Modelagem e análise numérica da estabilidade lateral com distorção de vigas mistas de aço e concreto
(Universidade Federal de São Carlos, 2021-05-21)
Rossi, Alexandre
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Martins, Carlos Humberto
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https://lattes.cnpq.br/1665294496138141
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Souza, Alex Sander Clemente de
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https://lattes.cnpq.br/3572504605209699
The most rational behavior of steel-concrete composite beams occurs in the case of simply supported elements, in which the concrete is in compression and the steel profile in tension. However, in the continuous and semi-continuous composite beams, in regions close to supports, negative bending moment arise. In this condition, the concrete is in tension, requiring additional reinforcement, and the steel section in compression, being subject to stability phenomena. The most common stability mode in steel-concrete composite beams is Lateral Distortional Buckling (LDB). The current standard procedures verify the LDB starting from the elastic critical moment determination. And, subsequently, they use design curves, such as those derived from the SSRC (Structural Stability Research Council) or ECCS (European Convention for Constructional Steelwork), to determine the LDB strength of steel-concrete composite beams. However, the technical literature shows that the procedures used to determine the LDB elastic critical moment are limited. In addition, it appears that the use of design curves (SSRC and ECCS) proposed for the analysis of stability phenomena in steel elements, are flawed when applied to steel-concrete composite beams. Therefore, in this work, studies about the LDB behavior of steel-concrete composite beams were developed. The investigations were carried out based on the development of a numerical model using the ABAQUS software. With the numerical model properly validated, the following parameters were investigated: I-section, span under negative moment, influence of thickness and slab type, longitudinal reinforcement in the concrete slab, transversal stiffeners in the I-section web and, different distribution of negative moment. With the development of buckling analyses, the LDB elastic critical moment was analyzed, and with the development of post-buckling analyses, the LDB ultimate moment was analyzed. The results showed that the analytical procedures for determining the LDB elastic critical moment, in majority, are conservative. The same behavior was verified in relation to standard and analytical procedures about to the values of the LDB ultimate moment. Finally, with the database obtained in the numerical study, it was proposed, by means of artificial neural networks and multiple regression, analytical procedures to determine the LDB ultimate moment.
Endothelial function provides early prognostic information in patients with COVID-19: a cohort study
(Universidade Federal de São Carlos, 2021-05-23)
Oliveira, Murilo Rezende
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Back, Guilherme Dionir
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Goulart, Cássia da Luz
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Domingos, Bianca Cristina
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Arena, Ross
Engenharia de reservatórios com temperaturas efetivas arbitrárias e máquinas térmicas quânticas para sistemas de spins nucleares
(Universidade Federal de São Carlos, 2021-05-24)
Mendonça, Taysa Mendes de
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Villas-Bôas, Celso Jorge
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https://lattes.cnpq.br/5700887540085418
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https://lattes.cnpq.br/7097528602412625
In this work we show how to engineer reservoirs with different effective temperatures for a single qubit (quantum bit) system. To that end, we built an appropriate interaction between a qubit, that is, a 13C nuclear spin, and a reservoir, in our case, a large number of nuclear hydrogen spins that act as a spin bath. For this study, we used the carbon-hydrogen structure present in the polycrystalline sample of adamantane. The interaction we seek is built by applying a sequence of specific radiofrequency pulses using the technique of nuclear magnetic resonance (NMR). The temperature of the entire system can be controlled by preparing the initial state of the nuclear hydrogen spins and, thus, we show how to build reservoirs with arbitrary temperatures, including negative effective ones. As an application of these artificial reservoirs, we investigated the implementation of quantum thermal machines. First, we performed an experiment in which a quantum thermal machine works under two reservoirs, one at a positive and the other at an effective negative spin temperature. We use the liquid chloroform molecule to simulate the qubit system. We show that the efficiency of this thermal machine can be greater than the case when the two reservoirs are at positive temperatures. We also demonstrate a counterintuitive result, in which the efficiency of the Otto cycle can be surpassed and when the quantum thermal machine operates in a finite time, that is, in a non-adiabatic manner. Finally, we implemented a quantum thermal machine that operates in a single reservoir at an effective negative temperature whose efficiency is always 100%, regardless of the unitary transformation carried out on the qubit, as long as its final state is different from its initial one. In this experiment we again use the carbon-hydrogen structure present in the polycrystalline sample of adamantane. As far as we know, this is the simplest and most efficient quantum thermal machine ever built. For all steps, we show that the theoretically predicted results are in very good agreement with the experimental data.
Propriedades físicas e mecânicas da madeira de Angelim SP obtidas de árvores provenientes de regiões distintas do país
(Universidade Federal de São Carlos, 2021-05-24)
Teixeira, Julia Naves
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Christoforo, André Luis
;
https://lattes.cnpq.br/7623383075429186
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https://lattes.cnpq.br/2235732843292318
In Brazil, the use of wood in civil construction structures is regulated by the technical standard NBR-7190 "Wood Structures Project", of the Brazilian Association of Technical Standards (ABNT, 1997), which does not establish the possibility of influence of extraction regions in the wood properties. The aim of this research was to investigate the influence of different regions of wood extraction from Angelim Pedra on its physical and mechanical properties. In this research, it was also evaluated, with the help of ANOVA of the regression models, the possibility of being able to estimate the strength properties and some physical properties of the wood as a function of the apparent density. It was concluded that lots from all regions had a high equivalence index; the Bonfim region showed full equivalence and Mucajaí and Claudia showed an equivalence index equal to 93% in both analyses. As for the estimation of properties by bulk density, it was observed that it was impossible to estimate properties by regression models. The characteristic value relationships, used in the simplified characterization of the wood found in this research, were superior to the values established in the Brazilian Standard ABNT NBR 7190; demonstrates that the results obtained in this study can be used, in a new revision of the Standard on the relationships used, for the simplified characterization of wood.
Papel da proteína Fbxo7 no perfil de citocinas produzidas em linhagem celular monocítica humana (THP-1) estimulada por lipopolissacarídeo
(Universidade Federal de São Carlos, 2021-05-24)
Martins, Isabela Fernanda Morales
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Teixeira, Felipe Roberti
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https://lattes.cnpq.br/3568850159381693
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https://lattes.cnpq.br/8976622007212196
The canonical function of SCF E3 ubiquitin ligase complexes is the ubiquitination of their substrates, directing them to proteasomal degradation or modulation of function. From these complexes, F-box protein class is the most important component due to their substrate recognition, which ensures the specificity of the complex. In 2012, it was described that Fbxo7 acts as a negative regulator in the nuclear transcription factor kappa B (NF-kB) signaling pathway in human osteosarcoma cell line (U2OS). This pathway is regulated by several ubiquitination events, thus being responsible for regulating inflammation via activation of genes involved in the immune response, including cytokines. So far it has not been evaluated whether Fbxo7 can regulate the cytokine profile through NF-kB. Therefore, the aim of this work was to investigate the role of Fbxo7 in cytokine production using THP-1 cells stimulated by lipopolysaccharide (LPS). Since macrophages help to direct the standard immune response through cytokines, we used the differentiated THP-1 lineage for this study. We performed FBXO7 knockdown by specific siRNA in these cells and stimulated the NF-kB pathway with LPS, followed by the evaluation of 36 cytokines through an array containing capture antibodies for each cytokine. We verified a reduction in the amount of CCL1, CCL3, IL-10 and IL-1β in FBXO7 knockdown cells when compared to the control. Considering that IL-1β is a potent pro-inflammatory cytokine and is produced mostly by macrophages, we also evaluated the expression of the IL-1β gene by RT-qPCR. We noticed that, although there was a reduction in the protein level of IL-1β, there was an increase in transcription of this gene, which may suggest that cells are trying to compensate the reduction in protein levels by increasing gene expression. In addition, we did not find any change in the transcription of NF-kB after the knockdown of FBXO7. Considering that IL-1β is post-translationally regulated, we suggest a regulatory mechanism of Fbxo7 for IL-1β secretion by LPS-stimulated, differentiated THP-1 cells. Thus, this work contributed for the understanding of the role of another F-box protein in the immune response.
Efeito citotóxico e pró-apoptótico do composto [6]-Shogaol contra células de câncer de bexiga (MB49), in vitro
(Universidade Federal de São Carlos, 2021-05-24)
Nina, Diana Gabriela Nina
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Anibal, Fernanda de Freitas
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https://lattes.cnpq.br/4918261968772806
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https://lattes.cnpq.br/4687877693840586
Bladder cancer is considered one of the most aggressive malignancies due to its profile of recurrence and progression, and even with the improvement in methods of diagnosis and treatment, the mortality rate has not shown a declining trend in recent decades worldwide. In this perspective, the search and development of more effective and safer therapeutic alternatives is necessary. Phytochemicals are excellent sources of active ingredients with therapeutic potential, which have been used for centuries for therapeutic and culinary purposes. [6]-Shogaol is a phenolic compound extracted from the rhizome of ginger (Zingiber officinale Roscoe) that has shown antiproliferative and anti-tumor effects in a wide variety of cancer models, both in vitro and in vivo. However, there are no records of studies reporting an antitumor effect in cell models of bladder cancer. Thus, this study aimed to investigate the in vitro cytotoxic and pro-apoptotic potential of [6]-Shogaol against murine bladder cancer urothelial cells (MB49), in relation to non-tumor murine fibroblasts (L929). Through the in vitro study, the cytotoxic and pro-apoptotic effect was evaluated, through the analysis of the reduction of the metabolic activity, observation of morphological alterations associated with cellular damage, identification of alterations in the process of colony formation, evaluation of the level of reactive species of intracellular oxygen, evaluation of alterations in the nuclear structure, identification of apoptosis events and assessment of anti-migratory potential. Based on the results, it was shown that [6]-Shogaol was able to induce cytotoxic effects that compromised cell viability, exhibiting an inhibitory concentration of 50% of cells (IC50) of 135,5 µM for tumor cells MB49 and 205,3 µM for L929 non tumor fibroblasts, in addition to inhibiting and altering the proliferative processes of colony formation, showed pro-apoptotic activity identified by the observation of apoptotic phenotypes, mediated by nuclear fragmentation. In summary, our study suggests that [6]-Shogaol causes cytotoxic damage that compromises the viability of MB49 murine bladder tumor cells in a concentration-dependent manner. It can be suggested that [6]-Shogaol is promising for delineation in more in-depth studies to understand its antitumor properties, as it is a strong phytotherapeutic candidate in the treatment of bladder cancer.
Implementação do Consultório na Rua em um município do interior de São Paulo
(Universidade Federal de São Carlos, 2021-05-24)
Pereira, Caroline dos Santos
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Protti-Zanatta, Simone Teresinha
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https://lattes.cnpq.br/6772128930979370
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https://lattes.cnpq.br/1169849134084413
This dissertation aims to analyze the process of implementing the Street Clinic in a city in the interior of São Paulo. This is a descriptive-exploratory study with a qualitative approach. Five respondents participated in the study, with the inclusion criterion working or having worked providing services directly or indirectly to the homeless population by the Municipal Department of Citizenship and Social Assistance or Municipal Health Department. Professional exclusion criteria under the age of 4 years at the Municipal Secretariat of Citizenship and Social Assistance or Municipal Health Secretariat. The municipality has a Consultancy team on street of modality 1, implemented in 2017. Semi-structured interviews were carried out by Google Meet with professionals from the Citizenship and Assistance Secretariat Social and Health for data collection. As a result, two categories emerged: Street Clinic: condition of eternal constrution and Challenges of the intrasectoral and intersectoral network. We concluded that the Street Clinic in the municipality of the study represents an advance in the health issues of people living on the streets, the difficulties of access, prejudices and attempts to articulate with the intra and intersectoral network.
Contribuição ao conhecimento dos Agathidinae (Hymenoptera, Braconidae) da fauna brasileira
(Universidade Federal de São Carlos, 2021-05-25)
Campos, Giulia Yurie Iza de
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Dias, Angélica Maria Penteado Martins
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https://lattes.cnpq.br/8637344058859147
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https://lattes.cnpq.br/1063811977704671
The order Hymenoptera is one of the most numerous and diverse among the insects’ group and is represented by ants, wasps, and bees. The parasitoid wasps present ecological importance for being top predators, biological control agents and bioindicators of preserved areas as well as economic importance for attack Lepidoptera larvae, many of which, with agricultural relevance. The subfamily Agathidinae is a moderately large group of the family Braconidae, presenting 26 New World genera. In order to analyze diversity of these wasps in the Coleção Taxonômica do Departamento de Ecologia e Biologia Evolutiva da UFSCar (DCBU), it was conducted a study that identified 1033 Agathidines from 13 genera: Aerophilus Szépligetti, Agathis Latreille (first record for Brazil); Alabagrus Enderlein, Amputoearinus Sharkey, Cremnops Förster, Earinus Wesmael, Hemichoma Enderlein (first record for Brazil), Lytopylus Förster, Sesioctonus Viereck (first record for Brazil), Therophilus Wesmael, Trachagathis Viereck, Zamicrodus Viereck, and Zelomorpha Ashmead. Through the results it was possible to elaborate location maps for each genera and charts relating the percentage of individuals with the seasons and biomes in which they were collected. The study allowed to: (1) contribute to the knowledge of Brazilian Braconidae; (2) register three unprecedent Agathidinae genera in the country; (3) identify new species and (4) register the collection methods, seasons, and collection sites of the material studied.
Estudo de genótipos para características de milho verde sob diferentes níveis de nitrogênio, em Buri - SP
(Universidade Federal de São Carlos, 2021-05-25)
Ferreira, Maria Eduarda de Oliveira
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Afférri, Flávio Sérgio
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https://lattes.cnpq.br/4868650342029685
The objective of this study was to study genotypes from open populations and non-transgenic commercial corn genotypes (Zea mays L.), in the search to know the most efficient populations for nitrogen use under conditions of low and high N supply in cover (30 and 160 kg ha1 of N) in the production of green corn, at experimental area of the Federal University of São Carlos - Lagoa do Sino Campus, located at municipality of Buri- SP, in the 2019 crop. The experimental design used was randomized block design, with three repetitions and two doses. Variables of agronomic and commercial interest for green corn production were evaluated: plant height, first ear insertion height, length and diameter of ear without straw, and green mass of ear without straw. Analyses of variance and Scott-Knott test were performed for all characteristics. There was no statistically significant difference for any characteristic in relation to nitrogen doses. All variables showed significant differences in relation to the genotype, showing its importance for this study, being possible to notice that in the F3 generation (open population genotypes) showed good performance for green corn, when compared to commercial genotypes
Tecnologia espacial, risco e política: o caso INPE
(Universidade Federal de São Carlos, 2021-05-25)
Gonçalves, Murilo Aparecido
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Marzochi, Samira Feldman
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https://lattes.cnpq.br/6466778428443375
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https://lattes.cnpq.br/2027810048936374
This work produces a sociological investigation about the political disputes involving INPE (National Institute for Space Research) and President Jair Messias Bolsonaro. Applying concepts of “risk” and “risk society” by Ulrich Beck, the study established a relationship from a sociological perspective with a focus on the environmental issue, as well as on the potential of new resources linked to space and computer sciences, especially satellites and databases. With these technological resources, a complex data mining system is articulated, where data is collected and converted into valuable information. Thus, having these systems means keeping under control, for example, images of the Earth's surface of various technological qualities and forms of use. It is institutes linked to States or even private companies that most have them; it is worth emphasizing, therefore, that there is a certain exclusivity of access. In the Brazilian case, INPE is the one who concentrates all the elements presented, whether its technical dimension or its political dimension. The path of institutionalization of Space Sciences in Brazil, especially linked to INPE, represents paradigmatic technological advances in this sector. However, the tradition of publishing its databases openly on its website generated, in the current government, a strong reaction, for highlighting the environmental crisis caused by deforestation. In view of the institute's experience consolidating itself in the midst of the military dictatorship, recent events raise the alert of a past that has come back to haunt. Therefore, the theme of risk refers to ongoing processes involving the suffocation of scientific horizons when pushed to this imposing political arena, putting the autonomy of research institutes in check, as well as the interests of civil society. This allows us to see the political dimension of these technical artifacts, especially when specific interests seek to incorporate these databases into power projects. In view of a sociologically produced field, the aim is to contribute to an interdisciplinary debate that demonstrates the political dimension, in addition to the environmental dimension, of Ulrich Beck's notion of risk.
Efeitos da exposição a estímulos aversivos imediatos sobre a catalepsia induzida por haloperidol: possível modelo animal para cinesia paradóxica
(Universidade Federal de São Carlos, 2021-05-25)
Waku, Isabelle
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Oliveira, Amanda Ribeiro de
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https://lattes.cnpq.br/4993675879410961
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https://lattes.cnpq.br/0851895403197213
Haloperidol – a dopaminergic D2 antagonist – acts on the nigrostriatal pathway inducing catalepsy, a state of immobility similar to the bradykinesia of Parkinsons disease (PD). Therefore, haloperidol-induced catalepsy in rodents is used as a model for the study of PD motor impairments. The bradykinesia in PD appears to be related to the patients emotional state, for example, immobile patients capable of performing sudden movements when exposed to aversive stimuli, a phenomenon known as paradoxical kinesia. Thus, it is of great interest to study the relationship between catalepsy and emotional states in rats. In this sense, in a previous study, we started to assess the effects of the presentation of aversive stimuli at the exact moment of exposure of rats to the catalepsy test, with results pointing to a possible attenuation of the cataleptic state. The present study continued this evaluation. In the first stage, we conducted a study of systematic literature review in order to identify publications that report the use of haloperidol-induced catalepsy as an animal model for parkinsonism, and to explore the methodological characteristics and the main issues addressed in these studies. In the second stage, in an experimental study, we investigated the effects of unconditioned and conditioned aversive stimuli on haloperidol-induced catalepsy. For this, 162 male Wistar rats received intraperitoneal administration of saline or haloperidol (1 or 2 mg/kg) and were evaluated in the catalepsy test. Three experiments were carried out in order to: I. Assess the intensity of the cataleptic state induced by the different doses of haloperidol over time; II.Evaluate the effects of three types of unconditioned aversive stimuli - 75 dB noise (1 and 20 s of duration), 100 lux light (1 and 20 s), or 0.6 mA footshocks (1 s) - on the catalepsy; III. Evaluate the effects of light and sound conditioned aversive stimuli (previously paired with shocks) on catalepsy. Catalepsy was the main effect produced by haloperidol and observed in the two doses used. Exposure to unconditioned sound or light stimuli did not cause significant effects on catalepsy compared to the group itself before receiving the stimulus (baseline) or compared to the non-stimulated group. On the other hand, exposure to shock caused a significant reduction in the latency to remove the paws during the catalepsy test compared to the group itself before receiving the stimulus. Exposure to fear conditioned using sound did not alter catalepsy. Exposure to fear conditioned using light significantly reduced catalepsy, both for the group that received light and shocks in a paired and non-paired manner during training. The results suggest that the effect on haloperidol-induced catalepsy is dependent on the modality/intensity of the aversive stimuli used. Exposure, during the catalepsy test, to shocks or lights previously associated with shocks is capable of disrupting the cataleptic state, pointing to a model with face validity for the study of paradoxical kinesia.