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Caracterização das Metaloproteinases de Matriz- 2 e -9 circulantes com o nível de atividade física e os efeitos do treino aeróbio em indivíduos pós-acidente vascular cerebral em fase crônica
(Universidade Federal de São Carlos, 2022-02-07) Garcia-Salazar, Luisa Fernanda; Pereira, Natalia Duarte; https://lattes.cnpq.br/3408152349657748; Russo, Thiago Luiz de; https://lattes.cnpq.br/2755480908047791; https://lattes.cnpq.br/5857467388927483
High concentrations of matrix metalloproteinases-2 (MMP-2) and -9 (MMP-9) are associated with inflammation shortly after stroke and functional prognosis. It is proposed that during the chronic phase, post-stroke individuals exhibit a systemic inflammatory state that may be related to comorbidities. On the other hand, the muscular characteristics of this population are associated with the release of some cytokines that may enhance systemic inflammation, such as interleukin-6 and -10. The inclusion of aerobic exercises (AE) in the rehabilitation programs of these individuals has been suggested as an important strategy for recovery. AE improves mobility, cardiopulmonary conditions, cognition, regulates cardiovascular risk factors in these individuals, and has been associated with neuroplasticity, therefore motor recovery due to the increased concentration of Brain Derived Neurotrophic Factor (BDNF) mediated by the myokine Irisin. In this context, two studies were developed in this thesis, the first one aimed to quantify the serum activity of MMP-2 and MMP-9 in chronic post-stroke individuals and correlate these gelatinases with variables of physical activity level, body composition, functional capacity, and walking test, as well as with metabolic and inflammatory biomarkers. In addition, the activity of these gelatinases was characterized according to the motor impairment of these individuals. The second study, evaluated the changes in gelatinases activity in serum samples from chronic post-stroke subjects who received an intervention protocol for two-week, consisting of one session of high-intensity interval EA before the modified constraint-induced movement therapy (mCIMT). We also correlated the gelatinases with BDNF and Irisin concentrations, and with changes in manual dexterity and functional capacity. It was demonstrated with these studies that chronic post-stroke individuals have increased MMP-9 activity when compared to healthy individuals. Positive correlations were observed with time and steps at low cadence and negative correlations with medium cadence and peak activity index. According to motor impairment, MMP-2 activity is increased in the mild-moderate group compared to the control group. Furthermore, it was observed that the intervention protocol with the inclusion of AE, produces an acute response in MMP-9 increasing its activity. This increase was not correlated with manual dexterity nor with the functional capacity of these individuals, and there was also no relationship with BDNF and Irisin concentration. In conclusion, chronic post-stroke individuals present altered MMP-2 and -9 activity indicating a possible systemic inflammation, associated with the cardiovascular conditions of these individuals. In addition to showing, before an acute intervention, an increase in MMP-9 activity indicates a possible adaptive process prior to the modifications of vessels and muscle tissue to the AE. For long-term modifications in cardiovascular and/or muscular conditions, a change in the physical activity level of these individuals or the execution of longer duration intervention programs would be necessary.
Avaliação do presenteísmo em mulheres com e sem dismenorreia
(Universidade Federal de São Carlos, 2022-02-07) Godoy, Amanda Garcia de; Avila, Mariana Arias; https://lattes.cnpq.br/5905617922199364; https://lattes.cnpq.br/2779049250342505
Objectives: The objective of the present study was to evaluate presenteeism due to dysmenorrhea in adult women. Methods: Our primary endpoints were presenteeism, assessed with the Stanford Presenteeism Scale-6 (SPS-6), and dysmenorrhea-related pain intensity was assessed with the Numerical Pain Scale. Our secondary outcome was absenteeism due to dysmenorrhea in the last three months. The collection was carried out online with adult women. For statistical analysis, the Kolmogorov-Smirnov, Mann-Whitney U, Spearman correlation, chi-square tests and binary logistic regression with backward insertion method were used. A p<0.05 was considered for significance. Results: A total of 408 women were included in the analysis, of which 228 reported menstrual cramps. Of the women who reported dysmenorrhea, 58.3% also reported presenteeism due to the condition (p<0.001). There was a negative correlation between the SPS-6 score and the intensity of pain related to dysmenorrhea. The score of the SPS-6 avoid distraction subdimension showed a moderate negative correlation with the intensity of pain related to dysmenorrhea, and the finish work subdomain showed a weak negative correlation with the same variable. Higher pain intensity and practice of absenteeism in the last three months increase the chances of presenteeism (0.73 and 0.58 times, respectively). We found a moderate negative correlation between the SPS-6 score and absenteeism. Conclusion: The occurrence of presenteeism was higher in women with dysmenorrhea, and presenteeism is higher according to the intensity of perceived pain related to dysmenorrhea. Greater pain intensity related to dysmenorrhea and absenteeism in the last three months increase the chances of presenteeism among women with dysmenorrhea.
Perfil funcional e repertório ocupacional de crianças típicas e crianças diagnosticadas com transtorno do espectro autista
(Universidade Federal de São Carlos, 2022-02-07) Faustino, Gabriela Fernanda; Figueiredo, Mirela de Oliveira; https://lattes.cnpq.br/3660487766535040; https://lattes.cnpq.br/1258168914802546
As in other life cycles, childhood is also characterized by specific occupations. It is through the performance of occupations that children constitute their occupational repertoire. Considering that delays or functional losses are factors that can hinder the performance of an occupation, neurodevelopmental disorders influence the composition of the occupational repertoire to the extent that they interfere with functionality. Although Autism Spectrum Disorder (ASD) is the most common neurodevelopmental disorder today, there are no studies in Brazil on the development of the occupational repertoire of this population. Therefore, the present study aimed to investigate the functional profile and occupational repertoire of children between 2 and 12 years of age, both with typical development and diagnosed with Autism Spectrum Disorder (ASD) through the following instruments: Pediatric Disability Assessment Inventory - Testing Adaptive Computing (PEDI-CAT) and Occupational Repertoire Development Measure – Parent (ORDM-P). This is a cross-sectional and descriptive study with a quantitative approach. The sample consisted of 40 mothers of children between 2 and 12 years of age, from and residing in the state of São Paulo. Of these, 20 were mothers of typically developing children, and 20 were mothers of children diagnosed with ASD. The children were evaluated using the PEDI-CAT to identify their functional profile and the ORDM-P to characterize their occupational repertoire. As for the functional profile of children with typical development, the results obtained by the PEDI-CAT, indicated that of the 20 children who composed the Typical Group, all obtained normative scores within a normal range for their age group in the four areas evaluated by the instrument. In contrast, in the ASD Group, 10 of the 20 children had normative scores below expectations in at least one of the areas. The development of the occupational repertoire of children in the Typical Group showed similarities in the composition and acquisition of activities according to age groups, varying in relation to the predominance of some occupations in the children's repertoire. In the ASD Group, however, no similarity was observed in relation to the composition and acquisition of occupations in the repertoire considering the age of the children. The study made it possible to infer that functional impairment in some areas of development does not prevent children from engaging and participating in meaningful occupations.