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Música e vida: olhares sensíveis de jovens estudantes de instrumentos musicais
(Universidade Federal de São Carlos, 2022-02-10) Pires, Jorge César de Araujo; Joly, Ilza Zenker Leme; https://lattes.cnpq.br/5569335876343450; https://lattes.cnpq.br/7919070291982987
We believe it is possible to teach a musical instrument aimed at human formation, to make instrumentalists more critical, sensitive and amorous people aware of their human role in society. In this research, the learning of the musical instrument is understood as a social practice and music as a language and a form of artistic expression. As an educational process, learning a musical instrument can be a practice full of oppressive relationships, power disputes and colonialities. On the other hand, it can also be a coexistence with availability, with respect for learning, with understanding and appreciation of the other's knowledge, attitudes and worldviews. It can be an educational process inserted in social practices that consider each person as an active participant in the process, understanding the involvement of all subjects in the construction of knowledge. The aim of this study was to understand the perceptions of students about the human relationships that are established from the learning of musical instruments. The 6 research participants were, at the time of the study, aged between 15 and 17 years and lived in two different regions of our country: South and Southeast. We started from preliminary questions that later generated a research question. The first questions were: are these students interested in the general formation of the human being when learning a musical instrument? Are students, when looking for musical instrument classes, interested in other elements besides instrumental technique? How do students perceive interactions with teachers and the development of sensitivity, creativity, expression and affection? From these three questions, we arrived at a research question: What elements of human and musical development do students perceive when participating in the educational process of learning musical instruments? The qualitative research began in 2018 with theoretical studies, but data collection took place in the midst of the Covid 19 pandemic, in 2020. An online questionnaire was carried out as the first contact with the participants and later individual conversations were held and a virtual conversation circle. From the transcripts of the conversations, in the analysis of the data, two thematic units emerged: elements of human development and elements of musical development. From these elements, we can see the perceptions that the students participating in the research have of their learning as an instrumentalist and also as a human person. It was possible to perceive that the practice and learning of a musical instrument promoted the awareness of the students participating in the research on issues related to motivation, affection, relationship, sensitivity and subsistence. It was also possible to perceive how the practice and learning of a musical instrument is influenced and can influence the social context of those who practice it and their families.
Identificação de ligantes e substratos do complexo E3 ubiquitina-ligase SCF(FBXL17)
(Universidade Federal de São Carlos, 2022-02-10) Passos, Patrícia Maria Siqueira dos; Teixeira, Felipe Roberti; https://lattes.cnpq.br/3568850159381693; https://lattes.cnpq.br/2396407697900589
Fbxl17 is one of the 69 F-box (Fbx) proteins in humans capable of interaction with SKP1, Cullin 1 and Rbx1 to form the E3 ubiquitin ligase complex SCF(Fbxl17). The SCF(Fbxl17) complex is the major class of human E3 ubiquitin-ligases and acts ubiquitylating its substrates leading them either to proteasome degradation or function modulation. The Fbxls proteins have a F-box domain that interacts with SKP1 and a LRR domain (Leucine Rich Repeat domain) for substrate interaction. This LRR domain gives specificity to the SCF(Fbxl17) complex. In the METABRIC project (Molecular Taxonomy of Breast Cancer International Consortium) mutations in FBXL17 were found leading to depletion in the LRR domain of Fbxl17 protein. Those mutations were identified in 135 out of 1992 patient’s samples. Moreover, it was performed a CGH-array (Comparative Genomic Hybridization) of 746 cancer cell lines. As a result, they identified breaks in the FBXL17 gene in 3 cell lines of breast cancer (BT-474, HCC38 and HCC1395) and in 1 cell line of esophageal/gastric cardia adenocarcinoma (OE-19). Those breaks led to the generation of Fbxl17 protein with LRR domain truncation, among those mutants there is a protein entitled Fbxl17-Δ3LRR. Since there are no study relating Fbxl17 to tumorigenicity, we aimed to identify potential substrates for Fbxl17. It was performed an immunoprecipitation assay to purify SCF(Fbxl17), SCF(Fbxl17-Δ3LRR) and Fbxl17-ΔF-box from HEK293T cells. The eluates were submitted to a large-scale in vitro ubiquitination assay (Protoarray). We were able to identify 194 possible substrates positive for SCF(Fbxl17) excluding the ones that were detected in the Fbxl17-ΔF-box slide, and 92 targets that were positive only for SCF(Fbxl17) subtracting the ones that were positive for SCF(Fbxl17-Δ3LRR) and Fbxl17-ΔF-box. With those data, a functional enrichment analysis was performed using REACTOME and DAVID databases. The data showed most targets were related to RNA metabolism regulation and several of them were associated to splicing processing. Therefore, a functional assay was performed to evaluate whether Fbxl17 plays role in pre-mRNA splicing. It was used a splicing reporter minigene called E1A in two different cell lines (HEK293 and MCF7). Afterwards, several targets were selected to go through substrate validation analysis. After performing interaction and ubiquitylation assay in cell, it was observed that DDB1, SNRPB2, and SRS9 interact with Fbxl17. Moreover, among those binders our data indicate that DDB1 is ubiquitylated by SCF(Fbxl17) in cells. Hence, this study identified three new binders to Fbxl17 and one novel substrate. The functional characterization and the relationship of those binders to tumor development are going to be evaluated in subsequent study.
"Suburbanas, Irreverentes e Mana-moças": uma pesquisa sociológica sobre a prostituição feminina de rua em um bairro da elite moçambicana, na cidade de Maputo
(Universidade Federal de São Carlos, 2022-02-10) Muchanga, José Luís Magaço; Leite Júnior, Jorge; https://lattes.cnpq.br/7253561448346772; https://lattes.cnpq.br/8850182612566846
This research explored the phenomenon of female street prostitution in Maputo City. Problematizing the current framework of sociological productions referring to the matter of street prostitution in Mozambique, the objective of this work was to understand the social dynamics that circumscribe the occurrence and reproduction of the referred phenomenon, in a neighborhood of the Mozambican elite (Sommerschield), in a context of stigma relegate to the activity. Based on a qualitative research methodology, and the adoption of field research and post-colonial theories, the main results of this work pointed to the fact that female street prostitution occurs in the Sommerschield neighborhood thanks to direct or indirect consent given to street prostitutes, by residents and other important stakeholders in the neighborhood. In fact, the research sought to broaden the reflection on the subject in question here, in the Mozambican urban context, aiming at greater knowledge management about the ways of life, interfaces and conflicts arising from the activity, in a social context marked by relationships of social inequalities, but also by intense negotiations, creativity and resistence.
Financiamento climático: eficácia institucional do Fundo Nacional sobre Mudança do Clima do Brasil
(Universidade Federal de São Carlos, 2022-02-10) Lopes, Ariane Cristina Cordeiro Gazzi; Albuquerque, Andrei Aparecido de; https://lattes.cnpq.br/9667573506903226; https://lattes.cnpq.br/7520920430908906
There is consensus among climate researchers that global warming is caused by human actions, including population size, economic activity, lifestyle, energy use, land use patterns, technology and climate policy, and that continued greenhouse gas (GHG) emissions could further increase the temperature of the Earth's atmosphere, with the possibility of severe and irreversible impacts for all beings. Aiming to stimulate resilience to climate change, public and private organizations have intensified climate mitigation and adaptation actions, creating policies and institutional arrangements to implement climate finance. To manage the flow of climate finance some countries have already created National Climate Funds (NCFs), responsible for channelling and coordinating the various sources of resources (national, private, bilateral, multilateral and donations) and priority actions. In 2009, the National Fund on Climate Change (FNMC) was created in Brazil as a climate finance intermediary, with the purpose of guaranteeing resources to support projects, studies and undertakings aimed at mitigating and adapting to climate change and its effects. Although research on climate change and climate finance has increased, especially in 2021, there are still few empirical studies documenting experiences with climate finance funds. In order to contribute to this gap, this research verifies the challenges for the institutional effectiveness of the FNMC, through the qualitative analysis of 80 documents, considering 21 indicators divided into 05 categories: Legal and Regulatory Framework; Resource Mobilization and Sustainability; Governance and Resource Allocation; Monitoring and Evaluation; and Accountability and Transparency. The results revealed that its institutional effectiveness is critical, since none of the categories meets 100% of its indicators, with Resource Mobilization and Sustainability being its weakest point. This research does not give a definitive answer on the institutional effectiveness of the FNMC, but provides a better view of the problems and facilities related to its organizational capacity.
Time trend of overweight and obesity in adults from Rio Branco, Acre, Western Brazilian Amazon (2006–2020)
(Universidade Federal de São Carlos, 2022-02-10) Dias, Flávia Santos Batista; Lima, Yara de Moura Magalhães; Martins, Fernanda Andrade; Silva-Nunes, Mônica da; Andrade, Andréia Moreira de; Ramalho, Alanderson Alves; https://lattes.cnpq.br/8240520191833512; https://lattes.cnpq.br/3049892650659963; https://lattes.cnpq.br/2201737214355619; https://lattes.cnpq.br/5180108615629613; https://lattes.cnpq.br/9813124176068905; https://lattes.cnpq.br/1173989709557324
Abstract: This study aimed to analyze overweight trend and obesity in adults from Rio Branco, Acre, Western Brazilian Amazon, from 2006 to 2020. This is a time series study, with data from Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey (VIGITEL). To estimate annual percentage change (APC) and 95% confidence intervals, the software Jointpoint Regression Analysis v.4.6.0.0., was used. In Rio Branco, overweight prevalence ranged from 44.0% in 2006 to 58.9% in 2020, with a bigger frequency among men than that among women. Obesity prevalence has increased from 12.5% in 2006 to 21.4% in 2020, similar between both sexes. From 2006 to 2020, overweight APC was 5.2% (95% CI: 1.4; 9.1) by 2010, and decreased to 1.3% by 2020. Public policies to control obesity and its risks must be both, implemented as strengthen