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Parametrização de ligantes em reações catalisadas por metais de transição
(Universidade Federal de São Carlos, 2023-04-24) Barboza, Amanda Aline; Ferreira, Marco Antonio Barbosa; https://lattes.cnpq.br/6874055640224407; https://lattes.cnpq.br/4255739684342248; https://orcid.org/0000-0001-5606-911X
The approach of statistical methods capable of accurately predicting the relationship between catalyst structure and reactivity represents a major impact on reaction development, since both reactivity and selectivity of the catalyst employed in organic reactions are directly related to its structural aspects. In the case of transition metal catalysis, this parameterization provides quick information and relevant estimates about the structure and respective activity of new ligands that are briefly identified in structural descriptors that influence the desired activity. Here we list key results obtained in the development and use of ligand parameterization to guide, predict and explain the discovery and development of new catalysts and methodologies. In the context of nucleopalladation reactions, we highlight Wacker-type reactions that employ carbonylation reactions of double bonds not activated by CO capture in a palladium-catalyzed process. We present a new methodology to obtain pyrazoline ester derivatives tolerant to different substitutions at strategic positions in the starting material as demonstrated by the scope study. By statistical studies, it was possible to observe that the molecular softness (ƞ) of the pyridine has a direct relationship with the yield - except for the bulkiest pyridines. For monophosphine ligands, the reactivity threshold analysis revealed that bulkier ligands are associated with the worst results. When bisphosphines are involved, the angle between the phosphorus substituents in the complex with PdCl2 indicates an important role, which can be interpreted in terms of flexibility of the ligand. In summary, the parameterization analysis of phosphine ligands and pyridine bases in general revealed dominant influences of steric effects that may imply the formation of bis-ligated palladium species and a detrimental role of pyridine coordination in active catalysts. In sequence, we report our efforts to integrate data science and computational chemistry tools to guide, predict, and explain synthetic catalyst development in the context of ruthenium-catalyzed crossmetathesis in the synthesis of trisubstituted olefins. To investigate the reactivity of substrate versus catalysts, we performed reactions with 3 methylenecyclohexane derivatives (challenging substrates), cis-1,4-diacetoxy-2-butene and 28 Ru-based catalysts. These experimental results were integrated with molecular steric and electronic descriptors obtained for the Ru complexes to parameterize the catalyst structure in relation to the reaction yield. Our results indicate that although the overall structure of ruthenium-based olefin metathesis precatalysts is highly modular, the use of carbenes as one of the neutral ligands has the greatest impact on the performance of these reactions. The variation in the substitution pattern of the aromatic ring bonded to the NHC nitrogens comprises the greatest variability in results for the challenging substrates, still, no clear correlation could be observed. However, through catalyst parameterization we found correlations and univariate and multivariate models to predict the outcome of new structures to broaden the scope of the catalyst used in these important reactions.
Pesquisar COM como potência de aprendizagem social: uma experiência nas ciências ambientais junto a uma escola do campo
(Universidade Federal de São Carlos, 2023-04-24) Oliveira, Maria Paula Pires de; Figueiredo, Rodolfo Antônio de; Valdanha Neto, Diógenes; https://lattes.cnpq.br/9925430852423901; https://lattes.cnpq.br/0854609216769461; https://lattes.cnpq.br/8853958256665125; https://orcid.org/0000-0003-4834-7954; https://orcid.org/0000-0002-8481-1008; https://orcid.org/0000-0002-8170-0484
O objetivo deste artigo é apresentar uma pesquisa-intervenção realizada no campo das ciências ambientais junto a uma escola do campo e analisar a possibilidade desse pesquisar COM como potência de aprendizagem social. A escola situa-se no Território Portal da Amazônia (norte de Mato Grosso) e a intervenção visou à definição, validação, aplicação e análise de indicadores estabelecidos para compreender o papel de práticas escolares na resiliência socioecológica de comunidades rurais, assim como uma análise conjunta dos resultados e do processo participativo. Foram realizados encontros dialogados e dinâmicas com a comunidade escolar para se alcançar os objetivos pretendidos. Para além dos resultados dos indicadores em si, uma análise do próprio processo evidenciou que este constituiu um exercício de aprendizagem social, o qual possibilitou o desenvolvimento de diferentes habilidades e valores.
Vamos pedir um delivery? Meio técnico-científico-informacional e a precarização do trabalho dos entregadores de plataforma na cidade de Sorocaba
(Universidade Federal de São Carlos, 2023-04-24) Benegas, Diego Morais; Tozi, Fabio; https://lattes.cnpq.br/1239744709191702; https://orcid.org/0000-0003-1448-8353; Silva, Carlos Henrique Costa da; https://lattes.cnpq.br/5444248390841543; https://orcid.org/0000-0003-2910-6602; https://lattes.cnpq.br/4201098730156741
Esta disertación se centrará en tratar de comprender cómo el concepto de entorno tecno-científico-informativo y el surgimiento de la Industria 4.0 están relacionados con la precariedad del trabajo de los repartidores de plataformas de entrega en Sorocaba. Para llevar a cabo la investigación se seleccionaron repartidores que conforman una categoría denominada shopper, la cual conforma una categoría diferenciada de repartidores de alimentos, caracterizados por seleccionar productos de los anaqueles de los supermercados, pagar los artículos y luego entregarlos. Las entrevistas permitieron comprender cómo el proceso de globalización es fundamental para que las plataformas de delivery utilicen el territorio para generar valor. En ese sentido, la lectura de Ludmila Costhek Abilio del trabajo de plataforma que relaciona la informalidad, el trabajo a pedido y los mecanismos de control en línea con la teoría del valor desarrollada por Ricardo Antunes fue fundamental para esclarecer la precariedad del trabajo de los repartidores de plataforma en Sorocaba. El aporte teórico de estos pensadores permitió comprender cómo se manifiesta la expansión del sector servicios en el territorio, además de constituir una nueva etapa en el concepto de entorno técnico-científico-informativo idealizado por el geógrafo Milton Santos.