• português (Brasil)
    • English
    • español
  • English 
    • português (Brasil)
    • English
    • español
  • Login
About
  • Policies
  • Instructions to authors
  • Contact
    • Policies
    • Instructions to authors
    • Contact
View Item 
  •   Home
  • Centro de Ciências Biológicas e da Saúde - CCBS
  • Programas de Pós-Graduação
  • Interinstitucional em Ciências Fisiológicas - PIPGCF
  • Teses e dissertações
  • View Item
  •   Home
  • Centro de Ciências Biológicas e da Saúde - CCBS
  • Programas de Pós-Graduação
  • Interinstitucional em Ciências Fisiológicas - PIPGCF
  • Teses e dissertações
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsAdvisorTitlesSubjectsCNPq SubjectsGraduate ProgramDocument TypeThis CollectionBy Issue DateAuthorsAdvisorTitlesSubjectsCNPq SubjectsGraduate ProgramDocument Type

My Account

Login

Importância do núcleo parabraquial lateral no controle do equilíbrio hidromineral em modelo animal de hipertensão essencial

Thumbnail
View/Open
GUILLEN_Camila_2018.pdf (828.9Kb)
Date
2018-07-05
Author
Guillen, Camilla Dias
Metadata
Show full item record
Abstract
Excessive salt intake has been associated with the development or worsening of chronic diseases such as hypertension. Spontaneously hypertensive rats (SHR) have a typical increased sodium preference. The lateral parabrachial nucleus (LPBN) acts as an important inhibitory mechanism for sodium intake control, besides its involvement in cardiovascular control in normotensive rats. However, the involvement of LPBN in cardiovascular control and sodium appetite is still unknown in SHR. The aim for the present study was to evaluate cardiovascular responses and 0.3 M NaCl intake after α2-adrenergic receptors activation in LPBN in this model of essential hypertension. In SHR, bilateral injections of moxonidine (α2-adrenergic/imidazolinereceptors agonist) in LPBN increased 0.3 M NaCl intake induced by water deprivation – partial rehydration protocol (WD-PR), without changes in water intake. However, LPBN moxonidine injections did not significantly change 0.3 M NaCl or water intake induced by WD-RP in normotensive Holtzman rats. In normohydrated SHR moxonidine injections into the LPBN did not change 0.3 M NaCl and water intake, mean arterial pressure (MAP), heart rate (HR) and baroreflex responses. The WD-PR protocol did not change baseline values of MAP and HR in SHR, neither after LPBN moxonidine injections. It was also observed that LPBN moxonidine injections in SHR resulted in a positive sodium balance, characterized by increased 0.3 M NaCl intake during the sodium appetite test followed by increased renal sodium excretion and urinary volume at the end of the experiment. Therefore, present results show thatα2-adrenergic/imidazolinereceptors activation in the LPBN increases WD-PR-induced sodium appetite in SHR. This effectis not related to changes in arterial pressure. Therefore, we can conclude that LPBN inhibitory mechanisms contribute to limit sodium intake also in Spontaneously Hypertensive Rats.
URI
https://repositorio.ufscar.br/handle/ufscar/10361
Collections
  • Teses e dissertações

UFSCar
Universidade Federal de São Carlos - UFSCar
Send Feedback

UFSCar

IBICT
 

 


UFSCar
Universidade Federal de São Carlos - UFSCar
Send Feedback

UFSCar

IBICT