Estudo de degradação forçada dos agroquimicos azoxistrobim, amicarbazona e picloram, procedendo-se a elucidação estrutural dos produtos gerados pela técnica de RMN

Abstract

The growing consumerism of food by the population, both in Brazil and worldwide, leads to the intensified use of agrochemicals in large and small farms. In Brazil, according to Law 7802/1989, agrochemicals are materials resulting from physical, chemical or biological processes intended for use in the production, storage and processing of agricultural products. Among the main problems involving agrochemicals, the lack of knowledge about its polluting potential and harmful effects on human health and the environment are the most worrisome, besides the effects caused by the impurities of these compounds. Therefore, this work aims to show the formation and identification of the impurities formed - by exposing the product to several factors such as UV radiation, humidity, temperature, soil pH and seasonality of the application region - from the agrochemicals containing the active principles of Azoxistrobim, Amicarbazona and Picloram, from studies of forced degradation recommended by ANVISA in DRC 045 / 2012. After a preliminary study, the best degradation conditions, the incubation time-out, and the factorial design of the experiments were set up. Triplicate of each degrading condition was also performed, as well as triplicate of collection times. The impurities formed were isolated, dried by rotoevaporation and analyzed by chromatographic (LC and LC-MS) and nuclear magnetic resonance (1D and 2D) techniques. For Azoxistrobim and Amicarbazona, two impurities were generated; to Picloram five. These results show that the formation of impurities in the degradation of agrochemicals is something that can occur frequently, demanding greater attention in its use, application and stud.