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Efeito do pré-condicionamento físico na hipertensão induzida pela dexametasona: papel do sistema renina angiotensina
(Universidade Federal de São Carlos, 2014-03-28)
Dexamethasone (DEX) is widely used to treat inflammation and allergies, but its chronic use determines several side effects such as hyperglycemia, muscle atrophy and hypertension (H). The renin-angiotensin system (RAS) is ...
Efeitos do treinamento físico combinado na rigidez arterial de ratos tratados com dexametasona
(Universidade Federal de São Carlos, 2019-03-26)
Arterial stiffness, determined by pulse wave velocity (PWV) has been considered an important cardiovascular risk predictor. It has been shown that high arterial stiffness contributes to develop hypertension (HT) and may ...
Bloqueio da integrina αvβ3 inibe apoptose e induz autofagia em células tumorais de cancêr de mama
(Universidade Federal de São Carlos, 2018-12-17)
Integrins are key receptors that mediate cell adhesion to the extracellular matrix (ECM) and regulate cell behavior including cell migration. Particularly, αvβ3 integrin, the vitronectin receptor, plays a key role in both ...
Efeito do treinamento intervalado de alta intensidade na composição corporal, na regulação do processo inflamatório e do metabolismo de ratos Wistar alimentados com dieta hiperlipídica
(Universidade Federal de São Carlos, 2017-09-04)
This study aims to analyze the behavior of Omentin and Vaspin in relation to a high intensity interval training protocol (HIIT) in rats fed a hyperlipidic diet. To this end, male Wistar rats, divided into 4 groups, received ...
Participação dos receptores purinérgicos P2 no núcleo do trato solitário sobre as respostas cardiorrespiratórias induzidas por hipóxia
(Universidade Federal de São Carlos, 2015-09-18)
Cardiorespiratory responses to hypoxia are controlled by brainstem areas including the nucleus of the solitary tract (NTS). In the present study, we investigated the effects of suramin (a non-selective purinergic receptor ...
Efeitos do surfactante nonilfenol etoxilado em peixes : função cardiorrespiratória e histopatologia em Tilápia-do-Nilo, Oreochromis niloticus, em condições de normóxia e hipóxia aquáticas
(Universidade Federal de São Carlos, 2018-01-26)
Nonylphenol ethoxylate (NPE) is a nonionic surfactant component of many chemical formulations. Investigations on the effects of nonylphenol ethoxylate toxicity and its derivatives on fish mostly focus on endocrine disruption, ...
Participação do sistema purinérgico no locus coeruleus (LC) no controle cardiorrespiratório e térmico em normocapnia e hipercapnia em ratos não anestesiados
(Universidade Federal de São Carlos, 2011-12-14)
Locus coeruleus (LC) is considered as a chemosensitive region to CO2/pH in mammals and amphibians, mainly its noradrenergic neurons. The LC purinergic neuromodulation is of particular interest since adenosine 5′-triphosphate ...
Importância do núcleo parabraquial lateral no controle do equilíbrio hidromineral em modelo animal de hipertensão essencial
(Universidade Federal de São Carlos, 2018-07-05)
Excessive salt intake has been associated with the development or worsening of chronic diseases such as hypertension. Spontaneously hypertensive rats (SHR) have a typical increased sodium preference. The lateral parabrachial ...
Envolvimento de receptores muscarínicos centrais no controle da ingestão de sódio
(Universidade Federal de São Carlos, 2017-07-10)
Water and sodium intake are fundamental behaviors for body fluid homeostasis. These behaviors are controlled by a neural circuitry involving facilitatory and inhibitory mechanisms, which are modulated by signals activated ...
Efeitos de um derivado semissintético do [6]-gingerol na autofagia e apoptose em células de câncer de mama
(Universidade Federal de São Carlos, 2017-05-09)
In this work, we describe a semisynthetic derivative of [6]-gingerol called SSi6, which induces cytotoxic effects on the MDA-MB-231 breast tumor, showing a greater selectivity for these cells when compared to the non-tumor ...