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Respostas cardiorrespiratórias promovidas pela ativação de receptores glutamatérgicos e purinérgicos no núcleo do trato solitário
(Universidade Federal de São Carlos, 2012-03-02)
The central nervous system (CNS) has an important role in maintaining the composition and volume of body fluids for the appropriate tissue perfusion. An important area of the CNS that receives cardiorespiratory afferents ...
Efeitos de um derivado semissintético do [6]-gingerol na autofagia e apoptose em células de câncer de mama
(Universidade Federal de São Carlos, 2017-05-09)
In this work, we describe a semisynthetic derivative of [6]-gingerol called SSi6, which induces cytotoxic effects on the MDA-MB-231 breast tumor, showing a greater selectivity for these cells when compared to the non-tumor ...
Expressão da Miostatina e ActRIIB em ratos submetidos a dieta hiperlipídica e exercício
(Universidade Federal de São Carlos, 2009-07-31)
Myostatin (MSTN) is a secreted growth factor expressed in skeletal muscle and negatively regulates skeletal muscle mass. MSTN is also expressed in adipose tissue. Recent data suggest that MSTN regulates adipogenesis and ...
Avaliação dos efeitos antitumorais do complexo de rutênio [Ru(GA)(dppe)2]PF6 em células não-tumorais e tumorais de mama cultivadas in vitro
(Universidade Federal de São Carlos, 2017-05-12)
Cancers have become an increasingly relevant problem of public health in the last decades. Within neoplastic diseases, breast cancer is one of the most incidental in female population and related to a high mortality rate. ...
Papel do cortex pré-frontal medial no comportamento defensivo de camundongos : avaliação farmacológica da lateralização funcional
(Universidade Federal de São Carlos, 2017-04-13)
Stressful situations are risk factors to the development of neuropsychiatric diseases, as anxiety disorders. However, not everyone who experiences stressful events develops stress-related illness. That is due to the existence ...
Participação dos receptores gabaérgicos, serotoninérgicos e adrenérgicos do núcleo do trato solitário na ingestão de água e sódio induzida por diferentes tipos de desidratação
(Universidade Federal de São Carlos, 2016-12-20)
The nucleus of the solitary tract (NTS), the primary site of peripheral osmoreceptor and cardiovascular afferences, is suggested to receive important inhibitory signals involved in the control of water and sodium intake. ...
Treinamento resistido e restrição calórica : fatores de proteção cardiovascular em ratas ovariectomizadas
(Universidade Federal de São Carlos, 2017-06-29)
Introduction: Hypertension is an important risk factor for menopausal cardiovascular disease. Resistance training (RT) when associated with the caloric restriction diet (CR) has been shown to have important effects on blood ...
Envolvimento da serotonina no controle respiratório durante o desenvolvimento pós-natal
(Universidade Federal de São Carlos, 2017-04-07)
Serotonin (5-HT) is a neurotransmitter involved in nervous system development, being an important modulator of respiratory rhythm via activation of diverse receptors on respiratory neurons. Selective serotonin reuptake ...
Avaliação do papel da amídala na antinocicepção induzida pelo medo : análises comportamental, imunoistoquímica e farmacológica
(Universidade Federal de São Carlos, 2017-05-30)
Exposure of rodents to an open elevated plus maze (oEPM, an EPM with all four open arms) elicits antinociceptive responses, high level of plasma corticosterone and defensive behaviors. However, very little is known about ...
Fator inibitório da migração de macrófagos : envolvimento na regulação cardiovascular em ratos com hipertensão renal
(Universidade Federal de São Carlos, 2015-08-31)
The high blood pressure levels reach about 22% of the world population, increasing the risk factors for coronary disease, heart attack and heart failure. Many studies have tried to understand the causes of hypertension and ...