• português (Brasil)
    • English
    • español
  • English 
    • português (Brasil)
    • English
    • español
  • Login
About
  • Policies
  • Instructions to authors
  • Contact
    • Policies
    • Instructions to authors
    • Contact
View Item 
  •   Home
  • Centro de Ciências Biológicas e da Saúde - CCBS
  • Programas de Pós-Graduação
  • Interinstitucional em Ciências Fisiológicas - PIPGCF
  • Teses e dissertações
  • View Item
  •   Home
  • Centro de Ciências Biológicas e da Saúde - CCBS
  • Programas de Pós-Graduação
  • Interinstitucional em Ciências Fisiológicas - PIPGCF
  • Teses e dissertações
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsAdvisorTitlesSubjectsCNPq SubjectsGraduate ProgramDocument TypeThis CollectionBy Issue DateAuthorsAdvisorTitlesSubjectsCNPq SubjectsGraduate ProgramDocument Type

My Account

Login

Efeitos da administração crônica de nanopartículas de óxido de ferro magnético em ratos adultos jovens

Thumbnail
View/Open
3661.pdf (3.297Mb)
Date
2010-12-17
Author
Wang, Charles Chenwei
Metadata
Show full item record
Abstract
The fast development of the nanotechnology, and the use of this technology to develop new products to help in diagnosis diseases, drugs and treatments for many diseases is increasing. Some authors have been warning about the nanoparticles use, because the real affect, toxic or not, still unknown. Iron oxide nanoparticles have been used in contrast liquid for magnetic resonance imaging, cancer treatment, among others. The aim of this work was to analyze the possible effects of chronic treatment with these nanoparticles in adults rats. The animals were distributed in 3 groups: Control (saline 0.9% - 0.1 mL/100 of body weight), nFe 0.3 (magnetic iron oxide nanoparticles 0.3 mg/kg BW) and nFe 0.6 (magnetic iron oxide nanoparticles 0.6 mg/kg BW). The animals were treated by gastric gavage during 8 weeks, 5 days per week. The body weight of the animals from the nFe 0.6 group decreased when compared to animals from the control group, and the BW of the animals from nFe 0.3 group was not different from the control group. The animals from the nFe 0.6 group showed the higher blood levels of cholesterol, although the levels of glucose, urea, creatinine, AST, ALT and alkaline phosphatase, plus hematology were not different from the animals of control group. Moreover, the seminal gland and ventral prostate of the animals of nFe 0.6 were atrophied. All those parameters of animals from nFe 0.3 group were not different compared to control group. The bone (femur and vertebra) biometric, biomechanical and biophysical parameters were similar in the animals from the different experimental groups. These results showed that high concentrations of magnetic iron oxide nanoparticles could be toxic and dangerous to the rats when take daily, but in low concentration it could be safe.
URI
https://repositorio.ufscar.br/handle/ufscar/1227
Collections
  • Teses e dissertações

UFSCar
Universidade Federal de São Carlos - UFSCar
Send Feedback

UFSCar

IBICT
 

 


UFSCar
Universidade Federal de São Carlos - UFSCar
Send Feedback

UFSCar

IBICT