Borracha natural modificada com ácido hialurônico para aplicações em lesões cutâneas
Resumo
Skin lesions are considered a public health problem, because in addition to
compromising and impairing the quality of life of individuals, they can generate high costs for
the health system. In this context, the search for biomaterials that can treat and recover damaged
tissues is growing. Studies show that Natural Rubber (NR), extracted from Hevea brasiliensis
rubber trees, is a biocompatible biopolymer that has properties that help in the tissue repair
process. However, for biomedical applications, it has certain limitations related to the presence
of allergenic proteins, hydrophobicity and unsaturated bonds, which limiting its application. In
order to overcome these limitations and contribute to the development of new biomaterials, this
study aims to deproteinize, epoxidize and graft NR with hyaluronic acid (HA), which is
extremely widespread in the medical field due to its bioactive properties. The study also aimed
to evaluate the behavior of the new material as a release system for active compounds. For this
purpose, the release profile of dry chamomile flower extract (CHAM) was tested due to its
therapeutic properties. Therefore, the 1st stage of this work investigated two different
methodologies to obtain the proposed material, which were called 1st and 2nd route. Both
materials were analyzed by Fourier Transform Infrared Spectroscopy (FTIR), which allowed
us to observe signs of deproteinization and esterification grafting between the epoxidized NR
and HA molecules. Hydrogen Nuclear Magnetic Resonance Spectroscopy (1H NMR) analysis
corroborated the results obtained by FTIR. Thermogravimetry (TG) and Differential Scanning
Calorimetry (DSC) thermal analyzes showed that the grafted sample had a lower degradation
rate and a higher glass transition temperature (Tg), indicating strong intermolecular
interactions. In the 2nd stage, it was found by FTIR that the interaction between the grafted
material and CHAM is merely physical. The TG showed that the incorporation of CAM to the
modified material is capable of causing a decrease in its thermal stability. The DSC showed
that the addition of CHAM can cause a slight increase in the flexibility of the material. Finally,
the release profile showed that the grafted material is capable of acting in the CHAM release
process, which makes the material promising to be applied in the future in the treatment of skin
lesions.
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