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Estudos sobre a síntese de ftalocianinas anfifílicas com baixa agregação em solução
(Universidade Federal de São Carlos, 2013-01-16)
The present dissertation describe the studies conducted on the synthesis and photophysical properties of phthalocyanine dyes. The main propose of this work was to produce amphiphilic structures with low aggregation in ...
Síntese de clorinas anfifílicas com potenciais aplicações em terapia fotodinâmica
(Universidade Federal de São Carlos, 2012-10-26)
The main objective of this work was to construct amphiphilic chlorins with low aggregation in a physiological environment. The synthesis and structural characterization of the target compounds were carried out, and preliminary ...
Estudo fitoquímico de Conchocarpus marginatus (Rutaceae), e avaliação do potencial biológico dos compostos isolados
(Universidade Federal de São Carlos, 2013-03-27)
The specie Conchocarpus marginatus is native from Espírito Santo. This plant, that was recently reclassified by PIRANI e KALLUNKI, does not show chemical or biological data in literature yet. In this way, the phytochemical ...
Estudo da atividade biológica do motivo ECD do domínio tipo-desintegrina da botropasina
(Universidade Federal de São Carlos, 2011-05-10)
Integrins are cell surface receptors that mediate cell adhesion and platelet aggregation, although they do part of important physiological processes in the organism, are also related pathologies such as tumorigenesis, ...
Emprego da organocatálise como uma ferramenta da química verde em reações de adição conjugada : estudos visando a síntese de anéis indólicos
(Universidade Federal de São Carlos, 2012-03-30)
Organocatalysis has emerged as a powerful synthetic paradigm and has accelerated the development of new methods to make diverse chiral molecules. In addition, the small chiral organic molecules used to accelerate asymmetric ...
Planejamento de inibidores da cruzaína baseado em fragmentos
(Universidade Federal de São Carlos, 2011-07-27)
The Chagas disease, described in 1909 by the Brazilian sanitary physician, scientist and bacteriologist Dr. Carlos Chagas, is caused by the Trypanosomatid parasite Trypanosoma cruzi. Current treatments involve the use of ...
Estudo químico e biológico de micro-organismos endofíticos associados às frutas banana, pêra e goiaba
(Universidade Federal de São Carlos, 2010-03-05)
Studies about interaction between microorganisms and plants are focused mainly in the vegetal tissues like roots, steam and leaves. Fruits are a right target for microorganism attacks. Nevertheless, endophytic microorganisms ...
Ensaios bioquímicos e celulares para a identificação de novos inibidores de TcGAPDH seletivos à HsGAPDH
(Universidade Federal de São Carlos, 2011-08-11)
Chagas disease is a tropical neglected illness; nearly 10 million people are infected, in 2008 it was responsible for the deaths of about 10 thousand people. At present, only two medicines (benznidazol and nifurtimox) are ...
Estratégias sintéticas para a preparação de novos fotossensibilizadores do tipo ftalocianinas
(Universidade Federal de São Carlos, 2013-02-28)
In this work some studies about the synthesis of a new Znphthalocyanine derivative containing 8 tert-butyl groups on peripheral positions were performed. In order to obtain this compound, a new monomeric unit were synthesized ...
Investigação do potencial antimicrobiano de Casearia sylvestris sobre microrganismo endossimbionte de Diabrotica speciosa
(Universidade Federal de São Carlos, 2013-03-27)
Diabrotica speciosa is a pest insect which occurs in most Brazilian states, standing out as one of the most important polyphagous pest of in grain crops. The understand of the role of the microbiota present in the digestive ...