Inflamação no tecido adiposo visceral em ratas ovariectomizadas : efeitos do treinamento resistido e da reposição de estrogêni
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Data
2016-03-30Autor
Rodrigues, Maria Fernanda Cury
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The ovariectomy associated with decreased estrogen is associated with increased prevalence
of obesity, a condition that increases the risk of metabolic syndrome. Evidence shows that
inflammation-induced obesity in visceral adipose tissue (VAT) promotes deregulation in the
expression of inflammatory cytokines. Hormone replacement (HR) and resistance training
(RT) have beneficial effects on postmenopausal women, but it is unclear whether these
interventions are effective in minimizing inflammation in VAT. The aim of this study was to
evaluate the effects of RT and ER in adipocyte size, gene expression and protein
concentration of inflammatory markers. Rats Sprague-Dowley females were divided into six
groups: Sham-Sedentary (Sham-Sed), Ovariectomized Sedentary (Ovx-Sed), Sham-Trained
(Sham-TR), Ovx-TR, Ovx-Sed-ER and Ovx-TR-ER. The ER was performed using Silastic®
capsules. During the 12- week RT, the animals climbed a ladder with weights attached to the
tails. The morphology was confirmed by histological analysis. The gene expression was
performed by RT-PCR and protein concentration by Multiplex / Luminex assays.
Ovariectomy increased adipocyte size and decreased expression of anti-inflammatory
molecules in TAV, which was partially restored by RE. In turn, TR, was able to minimize the
increase in inflammation in TAV of Ovx rats. We conclude that ER and TR were effective in
alleviating inflammation promoted by Ovx in TAV.