Avaliação do potencial antimicrobiano e leishmanicida de materiais orgânicos derivados da base de Schiff N,N-bis’(Salicilideno)-1,2-fenilenodiamina
Abstract
Bacteria and fungi are the main etiological agents potentially causing health care-related
infections and the fourth leading cause of death, according to the WHO. Parasitic agents
such as Leishmania infantum chagasi, the causative agent of leishmaniasis, neglected and
endemic disease, have treatments that are not always effective and have serious side effects.
Resistance to antibiotics, antimycotics and leishmanicides, has increasingly induced bioprospecting and synthesis of new substances with pharmacological properties. The Schiff
bases, especially those derived from the N, N’-bis (salylcilidene) -1,2-phenylenediamine
linker, also known as Salofen, have been studied in order to demonstrate the physical,
chemical and biological properties due to Variety of potential technological applications.
The objective of this work was to evaluate the biotechnological potential of the Schiff N,
N’-bis (salylcilidene) -1,2-phenylenediamine (Salofen) base derivative in relation to the
antimicrobial and leishmanicidal activity. Agar diffusion techniques and microdilution assays were used for bacterial and yeast studies, and the colorimetric method with Alamar
Blue® for Leishmania tests at 24 and 48 hours. Inhibition halos were observed for all
microorganisms tested, with the highest mean halos (30 mm) for Candida albicans. Dilution assays have shown promising results, with inhibition rates above 90%, emphasizing
better Gram-negative efciency. The leishmanicidal effect was also observed with IC50
at 1.06 mg.mL−1 at 24 hours and 0.66 mg.mL−1 at 48 hours. Thus, the data collected
suggest that the Schiff base tested has an antimicrobial and leishmanicidal potential of
the compound studied, suggesting a biotechnological application.