Photoredox-catalyzed synthesis of a novel class of fluoroalkyl pyrazolones

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dc.citation.issue21
dc.citation.volume367
dc.contributor.authorPissinati, Emanuele Ferrari
dc.contributor.authorAzizzade, Meysam
dc.contributor.authorOpatz, Till
dc.contributor.authorPaixão, Márcio Weber
dc.contributor.authorlatteshttp://lattes.cnpq.br/3201282953820524
dc.contributor.authorlatteshttp://lattes.cnpq.br/3773908504964104
dc.contributor.authororcidhttps://orcid.org/0000-0002-5892-8528
dc.contributor.authororcidhttps://orcid.org/0000-0002-0421-2831
dc.date.accessioned2026-10-19T17:15:57Z
dc.date.issued2025-09-13
dc.description.abstractA photoredox-enabled strategy is developed for the regioselective synthesis of fluoroalkyl 2-pyrazolin-5-ones via radical addition–cyclization cascades. This metal-free approach enables the efficient incorporation ofperfluoroalkyl and difluoromethylene groups into methacryloyl hydrazide under mild conditions. The protocoldemonstrates broad substrate scope, functions in both batch and continuous flow systems, and proceeds through aphoto-oxidative quenching mechanism. This method provides a sustainable and versatile route to fluorinated het-erocycles with promising applications in medicinal chemistry.eng
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipId2022/04597-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipId2023/12718-5, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipId2024/09943-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extente70118
dc.identifierhttps://doi.org/10.1002/adsc.70118
dc.identifier.urihttps://hdl.handle.net/20.500.14289/24860
dc.identifier.urlhttps://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.70118
dc.language.isoeng
dc.publisherUniversidade Federal de São Carlos
dc.publisher.addressCampus São Carlos
dc.publisher.departmentDepartamento de Química - DQ
dc.publisher.departmentPrograma de Pós-Graduação em Química - PPGQ
dc.publisher.initialsUFSCar
dc.publisher.programPrograma de Pós-Graduação em Química - PPGQ
dc.relation.ispartofAdvanced synthesis and catalysis
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject4CzIPNpor
dc.subjectReação em cascatapor
dc.subjectRadical fluoroalquilapor
dc.subjectFotocatálisepor
dc.subjectPirazolonaspor
dc.subjectCascade reactioneng
dc.subjectFuoroalkyl radicaleng
dc.subjectPhotocatalysiseng
dc.subjectPyrazoloneseng
dc.subject.ods3. Saúde e Bem-Estar
dc.subject.ods7. Energia limpa e acessível
dc.titlePhotoredox-catalyzed synthesis of a novel class of fluoroalkyl pyrazoloneseng
dc.title.alternativeSíntese fotoredox catalisada de uma nova classe de fluoroalquil-pirazolonaspor
dc.typeArtigo
dc.versiontypepós-print da revista

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