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O problema da fundamentação moral: uma investigação das teorias de Jürgen Habermas
(Universidade Federal de São Carlos, 2009-09-04) Persch, Danilo; Maar, Wolfgang Leo; https://lattes.cnpq.br/8746615407370574; https://lattes.cnpq.br/7603399225528544
The goal of this thesis is to study the Jürgen Habermas theories, focussing on the communicative action and the ethics of discourse. The thematic of the communicative action deals with a linguistic tour , in other words, Habermas starts to analyze the society not from a productive paradigm, known as a philosophical-historical inheritance which comes from Marx, but from an intersubjective communication paradigm. This new conception of society also requests a re-orientation under the perspective of how should be grounded the values and moral standard rules. In this sense, Habermas build together with Karl-Otto Apel the ethics of discourse, which transcribes the assumptions of the pragmatic language needed to a rational justification of standard rules from agreements or consensus. The procedure in the search for consensus is made through speeches (dialogues), which depend on a number of conditions, such as: equal rights of participation, absence of internal and external coercion, mutual recognition of all those affected by the effects of a rule, etc. With such a point of view, Habermas intends to seek to ensure the universality of the moral principle, as well as solve the problem of ethnocentrism, which caracterize the major part of the contemporary culture. In a globalized society in the technical levels, economic and social as the actual, but marked by a serious problems which affects the environment and stimulate the exploitation of labor and corruption, etc. the ethics of discourse presents itself as an attempt at moral reasoning very promising.
Estratégias para a determinação de minoxidil
(Universidade Federal de São Carlos, 2009-09-04) Sousa, Rogério Adelino de; Cavalheiro, Éder Tadeu Gomes; https://lattes.cnpq.br/4745280891704797; https://lattes.cnpq.br/0037305904937204
In this work methods for determining minoxidil (MX) in commercial samples and electrolytes of synthetic plasma and urine are presented. The minoxidil is a pharmaceutical whose blood vessel dilation property is used in the treatment of the Arterial Hypertension and in the treatment of the Alopécia Areata. Three commercial samples were analyzed, the Regaine® (Pharmacia, USA) and the magistral formulation (Porto Bianco, Brazil) both are topical use solutions, in a mixture of ethanol and propilenoglicol as vehicle, containing 2 % (20 mg mL-1) and 5 % of minoxidil (50 mg mL-1) respectively, and Loniten® (Rhodia, Brasil) containing 10 mg of MX per tablet. Three proposals for the determination of minoxidil in commercial samples and electrolytes of synthetic plasma and urine were considered. The first procedure was the determination of MX in the samples using flow injection analysis with spectrophotometric detection in two setups. For the setup procedure using single line with a wavelength of 400 nm, which can quantify the MX present in samples, showing recovery values of 99.7 and 104.8 % for Loniten® and the Regaine® respectively, and 102.5 % for the magistral sample. In merging-zones setup, the detection was in 345 nm, the MX was determined in the samples with recovery 101.3 % for Loniten® and 99.8 % to Regaine® and 103.7 % for the magistral. For both configurations, all the results from flow agree with the labeled values and the results from the chromatographic method (comparative method) in 95 % confidence (t-Student test). In the second procedure, an electroanalytical determination of MX is described using two composite electrodes, the graphite-polyurethane (GPUE) and graphite-silicone rubber (GSRE). Cyclic voltammetry was used to study the electroactive area of electrodes (GPUE = 0.093 cm2; GSRE = 0.089 cm2), the diffusion coefficient of MX (in order of 8.0 x10-6 cm2 s-1) and to study the mechanism of electro-oxidation of MX of which involves one electron per proton. With the support of analytical curves were determined the levels of MX in the samples by different voltammetric techniques; cyclic voltammetry (CV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV). The recovery values are in the range between 96.0 and 110 %, depending on the sample and the voltammetric technique. The electrochemical impedance spectroscopy showed that the mass transport is controlled by diffusion and also there is a weak and reversible adsorption that for both the electrodes. The third method describes the determination of MX and furosemide (FR) using high performance liquid chromatography (HPLC) with spectrophotometric detection. The wavelengths of 275 and 285 nm were for the detection of FR and MX respectively. The mobile phase used was methanol/triethylamine (99:1, V/V) in the flow rate of 0.5 mL min-1. The column used was a C18 Supelco®. The recoveries were 97.7 and 102.4 % for Loniten® and Lasix® respectively. Finally is presented the characterization of the product of oxidation of MX. The informations obtained from infrared spectroscopy technique, were compared with results obtained by nuclear proton magnetic resonance. Two structures were proposed as product of redox reaction between the MX and KMnO4, the desoximinoxidil and another new structure.
Desenvolvimento de um pipeline para análise genômica e transcriptômica com base em Web services
(Universidade Federal de São Carlos, 2009-09-04) Melo, Henrique Velloso Ferreira; Silva, Flávio Henrique da; https://lattes.cnpq.br/1757309852446263; https://lattes.cnpq.br/8672694921739001
Pipeline systems for genomic and transcriptomic analysis aim to create communication bridges among the existing analysis tools, therefore reducing researchers efforts. Most of the pipelines found in the literature lack important features which would be useful to the development of genome or transcriptome sequencing projects. Among them, the capacity of tracking the project results along its development, including the generation of partial reports; the presence of a collaborative environment where the involved laboratories can contribute with new data and chromatograms; the possibility to configure analysis parameters; multiple pipeline support and the possibility to include new tools and modules. In this work, a pipeline prototype was developed to overcome these shortcomings. Sequencing projects progresses are tracked along all over their developments. Chromatograms are progressively received along the development of the project and partial reports over newly received data are generated. The communication with the processing server is done via Web service, which offers a universal language interface, allowing client applications in heterogeneous platforms to submit data and execute operations and queries. Pipelines are configured in XML documents written in a predefined format, through which the researchers choose the tools and parameters to be used. The prototype offers support to multiple pipelines executed simultaneously in the same project. Pipelines are executed in parallel by the means of thread pools, what increases efficiency by distributing the workload in multiprocessed systems. Another feature of the prototype is the extensibility as each pipeline step is wrapped in a module. New modules can be easily inserted in the system through the implementation of a programming interface, therefore without the needing of recompilation. Module insertions are done in a declarative way through XML documents. A client application was also developed in the collaborative platform Sakai, allowing different research groups involved in a sequencing project to create pipelines, view results and exchange information on the project current status. To evaluate the efficiency of the prototype, a case study was carried out. Sequences generated from sequencing of Sphenophorus levis transcriptome were submitted and a pipeline was configured to analyze the data. The case study has pointed out that the prototype is efficient and produces good results.
Estudo microgravimétrico da formação de filmes de prata eletrodepositados
(Universidade Federal de São Carlos, 2009-09-04) Matos, Roberto de; Souza, Ernesto Chaves Pereira de; https://lattes.cnpq.br/1505400360366643; https://lattes.cnpq.br/7731828737626124
In this thesis, a voltammetric coupled to microgravimetry investigation about the electrodeposition of silver over polycrystalline platinum in acid medium was performed. Microgravimetry is helpful to understand the effect of different preparation variables, such as, pH, temperature, ion concentration and applied potential. This, in its turn, is a consequence of the fact that the composition in not the only important characteristic of electrodeposited metal which depends on the preparation process. We choose to study silver deposition once it is, in principle, a simple one electron process. The obtained data reveal a much more complex with several cathodic and anodic processes. First, the UPD silver deposition occurs, then the bulk and also the hydrogen evolution during the cathodic sweep. During the anodic voltammetric sweep, two current density peak were observed with molar mass equal to Ag dissolution, and then we conclude that a hydrogen rich phase or an alloy Pt-Ag were formed during the process. For one of solution investigated, a third anodic process was observed which could be associated to silver oxide formation and dissolution.