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Efeito da inflamação articular sobre o músculo esquelético: avaliação morfológica e molecular
(Universidade Federal de São Carlos, 2011-11-29)
Ramirez, Liliana Carolina Ramirez
;
Salvini, Tânia de Fátima
;
https://lattes.cnpq.br/2618210083336317
The joint inflammation is a frequent cause of activity limitation in daily life of the population. Usually, this condition also affects the muscles that are functionally related to the inflamed joint. The possible relationship between joint inflammation and the expression of genes related to muscle atrophy, differentiation and growth and muscle mass control in muscles functionally related to the inflamed joint, has not been studied. The aim of this thesis was to evaluate the effect of the tibiotarsical joint inflammation, induced by carrageenan, on the expression of genes related to muscle atrophy (atrogin-1 and MuRF-1), growth and differentiation (MyoD), muscle mass regulation (myostatin), and proinflammatory factors (p38MAPK, NFkB and TNF-alpha); and the expression of TNF-alpha protein in the tibialis anterior (TA) and soleus rat muscle. Changes in the muscle fiber cross-sectional area (CSA) were also evaluated. Wistar rats were randomly divided into four periods (2 days, 7 days and 15 days) and were assigned into four groups within each experimental period: Control, Sham, Inflammation and Immobilization. Real-time polymerase chain reaction, Western blot, immunofluorescence and muscle fiber CSA analyses were performed. The joint inflammation altered the mRNA levels of genes related to muscle atrophy, growth and differentiation, muscle mass regulation and proinflammatory factors in TA and soleus rat muscle after 2, 7, and 15 day. The joint inflammation increased the TNF-alpha protein expression only in the TA muscle at 7 days. The muscle fiber CSA was reduced in the TA at 7 days and, in the soleus muscle at 7 and 15 days. In both muscles TA and soleus, acute joint inflammation was able to stimulate the molecular pathway related to muscle atrophy with no reduction in AST fibers. Conversely, the chronic joint inflammation led to a differential response according to the muscle studied. In the TA muscle, the muscle fiber CSA reduction was related to the proteolytic pathway, while in the soleus, the muscle atrophy occurred without overexpression of genes related to the classical proteolysis pathway. These results suggest that, in soleus muscle, the atrophy could be mediated by other pathway than the ubiquitin-proteasome; suggesting the importance of the decreased protein synthesis in the reduction of protein content in the skeletal muscle. In addition, joint effusion also induced changes in gene expression, although without changes in the muscle fiber CSA. The results of this thesis have clinical relevance and indicate the importance of therapeutic interventions with the attempt to reduce the deleterious effects on muscles related to an inflamed joint.
As redes do conhecimento tradicional: análise do "Caso Cupulate"
(Universidade Federal de São Carlos, 2011-11-29)
Duran, Maria Raquel da Cruz
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Rigolin, Camila Carneiro Dias
;
https://lattes.cnpq.br/2388584081961836
;
https://lattes.cnpq.br/6803550106491499
This word was carried out in order to understand the different interpretations of the term "traditional knowledge" plays in the specific aspect of the relations between traditional knowledge, cultural heritage and intellectual property. Considering that cultural heritage involves the preservation and exaltation of a people or nation as a whole, maintenance and care of the identity of incorporation to expand the concept of culture. And the intellectual property rights involve both copyright and industrial property as those relating to protection of plant varieties and plant breeder rights - that is, assigning intellectual property rights to those who get new plant varieties and/or improvement of them - and therefore, the sustainable management of technical nature; specifically, we study such meanings from two dimensions: a) the construction of the international regulatory framework, in which two distinct networks of actors competing for establishing their perspective as guiding future legal instruments (traditional knowledge as intellectual property and traditional knowledge heritage x intangible cultural), b) the analysis of an empirical case, in which these two meanings were compared - it is the "Case Cupulate", held in mid-2000 which involved the legal challenge of a Japanese patent for a product derived a species native of Brazil.
Desenvolvimento de tecnologia para extração e recuperação de polihidroxialcanoatos obtidos a partir da sacarose de cana-de-açúcar
(Universidade Federal de São Carlos, 2011-11-30)
Mantelatto, Paulo Eduardo
;
Giulietti, Marco
;
https://lattes.cnpq.br/7703659740618915
;
https://lattes.cnpq.br/0438514538015348
The main objective of this study was to contribute to the development of a competitive and sustainable process to produce polyhydroxyalkanoates (PHA's) from the fermentation substrate sucrose cane sugar. The study involved the technical and economic evaluation of extraction, recovery, purification and drying of poly-3-hydroxybutyrate from biomass sludge produced for Cupriavidus necator, using as solvent 3-methyl-1-butanol (IAA - 2nd generation) and isoamyl propionate (IAP -3nd generation). To assist in the preparation of mass and energy balances, energy integration and comparison of the processes involved in each technology were made modeling of two processes using commercial software Aspen Plus, version 7.1. Data were collected on the pilot plant for P(3HB) production for two generations of technologies, involving, in general, the units operations of chemical treatment of the fermented, biomass sludge concentration, extraction, purification , solvent recovery and drying of the final resin. The results indicate pronounced advantage of technology that uses IAP(3G) in relation to IAA (2G), with a reduction in steam consumption of 2.44 times, the electricity consumption of 3.15 times, a reduction in price production of 1.93 times and a reduction in the total invested capital of 2.42 times. The sensitivity analysis for the best alternative (IAP), demonstrated a strong influence of increased scale of production of P (3HB) in reducing the price of the product specific investment. With the increased scale of 2,000 t of P (3HB) / year to 100,000 t of P (3HB) / year would be a reduction in the price of 1.47 times and the investment / t of P (3HB) produced 4.83 times. Through adoption of IAP (3nd G), also, there was significant improvement in the final product quality.
Avaliação da satisfação do aluno com deficiência no ensino superior: estudo de caso da UFSCar
(Universidade Federal de São Carlos, 2011-11-30)
Guerreiro, Elaine Maria Bessa Rebello
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Almeida, Maria Amélia
;
https://lattes.cnpq.br/7534553739735381
The increasing number of disabled students in higher education has raised issues that were, in the past, focused on basic education. Those issues create now an urgent need in higher education for physical infrastructure, pedagogical practices, technological resources and interpersonal relationships. Studies have been done on urban, architectonic, and attitudinal barriers, and also on the difficulties of access and permanency, reservation of vacancies and other issues regarding the inclusion of disabled people in higher education. Although some studies have shown the satisfaction of the student in higher education, the specific and necessary issues of the disabled student are still absent. Considering this, the objective of this research is to understand the level of satisfaction of the disabled student, regarding access and retention, through an instrument that was constructed for this purpose. For this, a higher education institution was chosen, in which the necessary characteristics for testing the instrument were present. Within this objective, it was proposed to identify the profile of this population, the level of satisfaction regarding the offered physical and operational structures, the level of satisfaction and attitude towards obstacles, as well as knowledge of legislation on accessibility and the NBR 9050/2004. This is a quantitativequalitative (emphasizing the first), exploratory, correlational, transversal study. The sample consisted of eighteen students: eight of them were visually disabled; six were physically disabled; three were hearing disabled; and one had learning difficulties. The constructed instrument was named Scale of Satisfaction and Attitudes of Disabled People SSA. As a result of the sample size, the techniques were used towards an exploratory rather than an inferential sense; therefore, the findings are restricted. It was verified that the average figures of the groups differ in a statistically significant way (p=0.065) by the Friedman Test, indicating that there are differences among structural, operational and psycho affective satisfaction, and the attitudes towards obstacles, in the studied group, at 90% certainty. Regarding the Structural factor, 50% of the sample tended to satisfaction, whereas the others tended to dissatisfaction and satisfaction with 25% on each side. In the Operational factor, 25% of the ones who answered to the items were dissatisfied, 50% tended to dissatisfaction and 25% were satisfied. In the Psycho Affective factor, 25% tend to satisfaction and 75% are satisfied. Regarding the Attitude towards obstacles, 25% showed certain neutrality or preference for omission, whilst 75% had a positive attitude. Regarding knowledge of legislation on accessibility and the norm NBR 9050/2004 of ABNT, it was observed that the disabled students who participated in the research that had no prior knowledge of the norm (approximately 60%) knew very little about the legislation on accessibility. The opposite is true for those who knew about the norm, that is, all of these knew the legislation on accessibility very well, and they also had a lower level of structural satisfaction. The participants with visual disability showed more knowledge regarding the legislation and the NBR 9050/2004. The students with visual and physical disabilities showed lower levels of satisfaction for the Structural factor, and the students with hearing disabilities showed lower levels for the Operational factor, especially when communicating with teachers and while in classes. However, the levels for the Psycho Affective and Attitude factors were within the range of satisfaction which compensates the low levels for Structural and Operational factors. Therefore, these findings allow us to state that the application of an instrument that measures the satisfaction of the disabled student in higher education is feasible and useful, in order to consider the direction the university is taking, when it comes to the access and the retention of these students.
Universidade aberta à terceira idade: efeitos sobre a qualidade de vida percebida
(Universidade Federal de São Carlos, 2011-11-30)
Inouye, Keika
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Pedrazzani, Elisete Silva
;
https://lattes.cnpq.br/7558935747100052
The education in the old age is intended to promote the acquisition of knowledge that determines the resizing for the fomentation of the quality of life (QoL) from the assumptions of interdisciplinarity, social participation and health promotion. With the objective of evaluating the effects of the University of the Third Age (UTA) from the Fundação Educacional São Carlos (FESC) on the QoL of the participants prior to and after the intervention and one year after their conclusion, we interviewed 56 elderly, divided in groups, thus denominated: (a) Group of students from the UTA-2008 (GA2008): graduating of Module 1 from UTA in 2008, who chose to continue in the program in 2009 even after the end of the mandatory module (Module 1); (b) Group of former students from UTA-2008 (Gex-A2008): graduates of Module 1 from UTA in 2008 that opted not to continue in the program in 2009 after the conclusion of the mandatory module; (c) Group of students from UTA-2009 (GA2009): graduates of Module 1 from UTA in 2009. The instruments for the data collection were: Elderly Characterization Form, Brazilian Economic Classification Criteria, Measure of Quality of Life (QdVDA), Scale to Measure the Satisfaction with the Life and Scale of the Positive and Negative Mood (EAPN). All the obtained data were entered into a database in the Statistical Program for Social Sciences (SPSS), version 13.0, to perform non-parametric statistical analysis. The results showed that: (a) The profile of the researched students from UTA points to a young elderly (M = 68,04 years, DP = 5,78, xmin = 60, xmax = 84), of the female sex (91,1%, n = 51), with a high level of education (30,4% had a bachelor s degree, n = 17) and high social-economic levels (50,0% in level B, n = 28); (b) There is a difference between the total scores on the QoL of the elderly students from UTA before and after the intervention (in the beginning and conclusion of the school year) and this difference is a positive one (Z = -4,541, p < 0,001); (c) There is no difference among the total scores of QoL of the elderly students from UTA in the second year of intervention (follow-up), the total scores remain (Z = -1,477, p = 0,140); (d) There is a difference between the total scores of QoL of the elderly students from UTA who did not attend the program for a year (follow-up) and this difference is a negative one (Z = -2,810, p 0,055); (d) There is a relationship between the perceived changes in the QoL and the socio-demographics characteristics of the students from UTA; (e) There is relationship among the socio-demographics, schooling variables and socio-economic level and the perceptions of QoL, satisfaction with life and moods (positive or negative) of the participants. Since the results pointed that the participation in the UTA program is favorable to the perceptions of the QoL, in terms of improvement or maintenance, we advocate in favor of this type of intervention. Therefore, is necessary that educational programs include the elderly, because the education can be an important source of support to facing another phase of the life cycle.
Avaliação de danos ambientais sobre os ecossistemas naturais, decorrentes da implantação da linha de transmissão Londrina (PR) - Araraquara (SP), no sub-trecho entre os municípios de Boa Esperança do Sul e Araraquara (SP)
(Universidade Federal de São Carlos, 2011-11-30)
Martins Filho, Carlos Augusto de Sousa
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Pires, José Salatiel Rodrigues
;
https://lattes.cnpq.br/3412204514901170
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https://lattes.cnpq.br/7700440510114989
Estudo da dinâmica da frequência cardíaca do repouso ao exercício físico em pacientes com doença arterial coronariana
(Universidade Federal de São Carlos, 2011-12-01)
Neves, Victor Ribeiro
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Catai, Aparecida Maria
;
https://lattes.cnpq.br/3476550607994320
The study of heart rate variability (HRV) has been used to assess the cardiac autonomic control in different population both on the supine position and during exercise test. The reduction of cardiac autonomic control has been observed in coronary artery disease (CAD) patients, since the progression of CAD to acute myocardial infarction (AMI) can be related with symphatovagal imbalance. The HRV has been traditionally assessed by linear methods, but in recent years, the use of some nonlinear methods has provided additional data, which does not uncovered by linear analysis. Thereby, the first study had the aim to compare the HRV of CAD patients with and without AMI (CAD-AMI) with health-matched controls by linear (spectral analysis) and nonlinear (Shannon entropy, conditional entropy and symbolic analysis). Fifty-six men were divided into three groups: healthy (n=19, 57±4 years), CAD (n=20, 56±10 years) and CAD-AMI (n=19, 54±12 years). There was no difference between the groups regarding cardiac autonomic modulation by linear (spectral analysis) and nonlinear (Shannon entropy, conditional entropy and symbolic analysis). These results may be due to beta-blocker use, coronary angioplasty, exercise capacity of healthy subjects and methodology this study. Thereby, in studied conditions, methods of analysis used showed no difference in cardiac modulation between groups. On the other hand, CAD can be to take together type 2 diabetes (T2D), which is a disease that worsens the impairment of cardiac autonomic modulation. Other method used in this study, is assessment the behavior of hear rate response and variability in the phase recovery after physical exercise. Therefore, the incidence of cardiovascular events is higher in CAD patients with type 2 diabetes (CAD+T2D) than in CAD patients without T2D. There is increasing evidence that the recovery phase after exercise is a vulnerable phase for various cardiovascular events. However, the second study had the aim to assess the autonomic regulation of CAD patients with and without T2D during post-exercise condition. One-hundred-two patients were divided into two groups: CAD (n=68, 61±5 years) e DAC+DT2 (n=64, 62±5 years), which underwent cardiopulmonary exercise testing. The result of second study indicated that DAC+T2D patients had a higher delay of heart rate recovery in comparison with DAC patients without T2D. However, there no differences between the groups in heart rate recovery after adjustment for exercise capacity, body mass index and medications. Thereby, the result of this second study suggesting impairment of cardiac autonomic control after exercise in diabetic patients compared x with non-diabetic patients is more closely related to low exercise capacity and obesity than to T2D itself.
Uso de ICP OES para controle de qualidade na produção de fertilizantes
(Universidade Federal de São Carlos, 2011-12-02)
Donato, Laiani Fischer Di
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Nóbrega, Joaquim de Araújo
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https://lattes.cnpq.br/8833989058164529
This research work employed an ICP OES with radial configuration for quality control in fertilizer production by the development of analytical procedures for the direct introduction of suspensions based fertilizers of Zn and Ca, whose particle sizes were lower than 10 μm. In addition, we studied a nanometric suspension of zinc (490 nm). Control charts were also developed for suspensions of fertilizers containing Cu, Mo and Zn. Analytical calibration curves were obtained using aqueous solutions, suspensions and solutions prepared from the suspensions, the latter being the one that best represented the nebulization, transport, atomization and excitation processes occurring for micrometric samples. For nanometric suspensions of zinc, it was possible to calibrate using diluted solutions prepared from stock solution of zinc. Samples and calibration solutions were diluted in HCl 0.012 mol / L medium and were shaken during the aspiration for sample introduction for avoiding any particle agglomeration. The accuracy was checked by comparing the results obtained by the developed procedure with those obtained by the official method established by MAPA. The use of control charts demonstrated that there is compliance in the manufacturing process of the product, since there was no significant variation of results and they can be considered reliable for the range of 95%. The implementation of the method in routine laboratory work led to numerous benefits to the company, among them, increased productivity, reduced reagent consumption, reduction of waste generated, hands-on experience with the instrumental technique, resolution of analytical difficulties, and especially professional growth. Considering the amount of hours / man at around US$ 22.00, the performance analysis of 15 suspensions per day and a reduction of 40 to 5 min of analysis time, we can estimate that there will be a reduction of US$ 20,995.00 / year, based on the amount of hours / man employed for sample preparation.
Laser de baixa intensidade e scaffold de Biosilicato®: efeitos isolados e da associação das duas modalidades terapêuticas no reparo ósseo
(Universidade Federal de São Carlos, 2011-12-02)
Rossi, Karina Nogueira Zambone Pinto
;
Peitl Filho, Oscar
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https://lattes.cnpq.br/3007441705652783
;
https://lattes.cnpq.br/4705154788194140
This study aimed to evaluate the effects of low intensity laser therapy (LLLT) (830nm, 120J/cm2, 100mW) and implantation of Biosilicate® scaffolds, associated or not, in histological aspects, biomechanical properties of the bone callus and immunoexpression of proteins, growth and transcription factors related to different stages of bone repair, at 15, 30 and 45 days after surgery of bone defects induced in the tibia.of rats. For this, three studies were performed in which a total of one hundred and twenty male Wistar rats (3 months ± 280 g) were submitted to bilateral tibial defects and randomly distributed in four experimental groups with 30 animals each. In the first study the effects of the implantation of Biosilicate® scaffolds in bone defects of rats were investigated in two groups: bone defect group (GC) and bone defect treated with Biosilicate® scaffold group (GB). The implantation of the scaffold was performed subsequent to surgery of bone defect. Histological analysis revealed that animals of GB showed newly formed bone better organized at 30 and 45 days after surgery. The immunohistochemical analysis demonstrated that the Biosilicate® scaffold promoted a higher expression of COX-2 on days 15 and 30 after surgery, immunostaining positive of RUNX-2 in all periods, increased expression of RANKL on day 15 and positive immunoexpression of BMP-9 on the 45th day. However, the Biosilicate® scaffold did not increase the mechanical properties of bone callus. Thus, the implantation of Biosilicate® scaffold was effective in stimulating the repair of tibial defects, however, was not able to improve their mechanical properties. In the second study, the spatialtemporal changes in the process of bone healing in defects treated with LLLT were evaluated in two groups: GC and bone defect treated with laser group (GL). The laser treatment started immediately following the surgery of bone defects and have been 8, 15 or 23 sessions with an interval of 48 hours between them. The histological and morphometric analysis revealed that the GL showed better tissue organization at 15 and 30 days after surgery, and biggest area of newly formed bone at day 15. The immunohistochemistry showed that the LLLT promoted higher expression of COX-2 at day 15, immunostaining of RUNX-2 positive in all periods, higher immunoexpression of BMP-9 on day 30 and higher immunoreactivity of RANKL at day 15. However, the LLLT did not increase the biomechanical properties of bone callus. Thus, the LLLT improved the process of bone healing, but was unable to improve its biomechanical properties. In the third study the effects of the association of LLLT with implants of Biosilicate® scaffolds in bone healing were investigated in three experimental groups: GC, GB and Biosilicate® scaffold irradiated with laser group (GBL). The implantation of the scaffold was performed following the surgery of bone defect. The laser treatment started immediately after surgery and were performed 8, 15 or 23 sessions with an interval of 48 hours between them. At 15 days after surgery, the histological analysis revealed granulation tissue and newly formed bone juxtaposed to the surface of scaffolds in GB and GBL. Thirty days after injury, the GB and GBL had better organized newly formed bone compared to the CG. At day 45 was possible to observe granulation tissue in the defects of the GBL. In the GB, the peak of immunoexpression of COX-2 occurred on the 15th day and in the GBL, on the 30th day. The GB and GBL showed positive immunoexpression of BMP-9 up to 45th day after surgery, while RANKL immunoexpression was higher in the GBL at day 30. However, 30 and 45 days after injury, the animals of GB and GBL showed statistically lower values of maximum load compared to the CG. Thus, the association of the scaffold Biosilicate® with laser irradiation has osteogenic activity during the bone repair, however, the scaffold Biosilicate® associated or not with the laser irradiation is not effective to improve mechanical properties of the bone callus. Finally, we concluded that LLLT (λ = 830 nm, 120J/cm2) and implantation of Biosilicate® scaffolds, associated or not, were effective to stimulate the bone consolidation by improving the development of newly formed bone and activating immunoexpression of proteins, growth and transcription factors related to different stages of bone healing in tibial defects in rats. However, these therapeutic modalities associated or not, were unable to improve mechanical properties of the bone callus.
Especificação, execução e controle de alvenaria estrutural em blocos cerâmicos de acordo com a NBR 15812
(Universidade Federal de São Carlos, 2011-12-02)
Soares, Márcia Maria Melo
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Parsekian, Guilherme Aris
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https://lattes.cnpq.br/7798651726059215
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https://lattes.cnpq.br/3083587424833017
This dissertation refers to the specification, execution and build s control in masonry structural of ceramic blocks, according to the current standard ABNT NBR 15812 (ABNT, 2010). The specification was evaluated by testing the compressive strength of mortar, blocks, grout, prisms and walls, which are materials constituted of various combinations, in order to define their efficiency factors. The relationship between the compressive strength in hollow blocks and prism and in blocks filled up with mortar or grout has been established, showing, as result, loss of strength in prism when the mortar was dosed with excess water. Also, there was a variation in resistance of the filled prism when the executive procedure was improved by the implementation of re-densification. Finally, It was explained the execution and build s control in masonry structural of ceramic blocks, according to the existing literature and recommendations of NBR 15812 (ABNT, 2010).
Investigação in vitro do efeito da restrição proteica no metabolismo do albendazol em ratos e estudos de inibição do crescimento de células tumorais humanas pelos enantiômeros do albendazol sulfóxido
(Universidade Federal de São Carlos, 2011-12-02)
Belaz, Katia Roberta Anacleto
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Oliveira, Regina Vincenzi
;
https://lattes.cnpq.br/6609377714413073
;
https://lattes.cnpq.br/3633522981711599
This work presents an in vitro investigation of protein restriction in the metabolism of albendazole (ABZ). The study was conducted with microsomal fractions obtained from Wistar rats using a High Performance Multidimensional Liquid Chromatography method which was developed and fully validated for the determination of the ABZ metabolites albendazole sulphoxide (ABZ-SO), albendazole sulphone (ABZ-SO2) and albendazole 2-aminesulphone (ABZ-SO2-NH2). The compounds were extracted from the biological matrix using a C8-RAM-BSA column (5.0 x 0.46 cm i.d.) and analyzed on a chromatographic chiral column containing amylose tris(3,5- dimethylphenylcarbamate) (15.0 x 0.46 cm i.d.) with a runtime of 35 min. The results of the biotransformation experiments showed that the protein restriction influenced the oxidative metabolism of ABZ. The production of (+) and (-)-ABZ-SO was higher in the control animals. Aditionally, the production of ABZ-SO enantiomers was enantioselective, where the (-)-ABZ-SO was formed in greater amounts than the (+)- ABZ-SO in control animals. However, this enantioselectivity was not observed when the ABZ biotransformation was conducted with microsomal fractions obtained from protein restriction animals. Four chiral polysaccharide phases were also evaluated for the enantioseparation of ABZ-SO in normal and polar organic elution modes. Among the tested conditions, the tris(3,5-dimethylphenylcarbamate) of amylose and MeOH 100% as mobile phase was selected to perform a semipreparative HPLC separation of ()-ABZ-SO. The pure enantiomers obtained were used in in vitro assays to evaluate the growth inhibitory effects on human tumor cells. Inhibition of cell growth was observed to be more pronounced with the (+)-ABZ-SO compared to (-)-ABZ-SO, particularly in MCF-7 cells where the inhibition was about four times more efficient.
Interfaces entre os avanços científicos e tecnológicos e as novas competências da área de gestão de pessoas em universidades: o caso da UFSCar
(Universidade Federal de São Carlos, 2011-12-02)
Perseguino, Silvana Aparecida
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Pedro, Wilson José Alves
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https://lattes.cnpq.br/8135701448186851
;
https://lattes.cnpq.br/7708875177512113
With the object of study the management of people in universities, this research presents an analysis of the current process of organizational change in the sector of Personnel Management of a federal public institution of higher education in the face of the National Policy for Staff Development. The objectives were to identify factors that may interfere with the implantation of a new model of management of people in universities, specifically the model based on competencies, contextualizing the role of technology in the process and the profile of professional people management; and to delineate the profile of the professional active in the area through the mapping of competencies, from the standpoint of instrumental and political, according the spectrum of the field study Science, Technology and Society (STS). This is a case study that took place a federal institution of higher education in transition in its model of people management. For this study in order to collect the data some procedures were used, such as: document research, interviews and questionnaires; and content analysis as a benchmark analysis of the findings. The results show an assessment of the role played by the area of People Management, the factors that interfere in the process of organizational change, the professional profile, based on the approach of competencies, and learning strategies used by professionals. In this context of change in the management of people in universities, there is the emergence of a new professional profile in the area, with technology playing a new role integrative of people management subsystems, leading to the possibility of adopting the model of competency management in the medium and long-term. It shows the premises of the STS field study as possible allies in the area of people management in universities, both for the development of skills such as the processes of selection and construction plans for training and professional development.
Desempenho e dispêndio metabólico-ventilatório nos testes clínicos funcionais e a influência de um programa de treinamento físico aeróbio em pacientes com doença pulmonar obstrutiva crônica
(Universidade Federal de São Carlos, 2011-12-02)
Marrara, Kamilla Tays
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Di Lorenzo, Valéria Amorim Pires
;
https://lattes.cnpq.br/9071791546812165
;
https://lattes.cnpq.br/5603964845135135
Objectives: To compare the metabolic demand ( O2/ O2peak), ventilatory demand ( E/MVV), dyspnea, fatigue on lower limbs (LL), oxygen peripheral saturation (SpO2) and functional capacity (number of climbs in step and work efficiency) at the peak of the six minutes step test (ST6) among patients with chronic obstructive pulmonary disease (COPD) stages II and III; Verify that there is relation of number of climbs in step with the first second forced expiratory volume (FEV1), BODE index, SpO2 and oxygen consumption ( O2) peak obtained in TD6, as well as with the distance walked in the six minutes walk test (6MWT) and in incremental symptom-limited cardiopulmonary test (CPT). Methods: Were evaluated 19 patients with stage II of COPD (50%  forced expiratory volume in one second (FEV1) 80%), composing the Group 1 (G1) and 16 with stage III of COPD (30%  FEV1  50%), constituting the Group 2 (G2) through ST6, 6MWT and CPT. Results: Were observed values significantly greater than dyspnea obtained at the peak of ST6 for G2, as well as significantly lower values of SpO2 at the peak of this test to the same group, as well as the number of climbs in step and distance walked in 6MWT and CPT. The number of climbs in step showed positive correlation with the SpO2 for G2, with r = 0.85. Conclusion: The patients with COPD stage III provided greater perception of dyspnea and desaturation in the ST6. In addition the same demonstrated reduced functional capacity when compared to patients with COPD stage II. And with relationship of number of climbs in ST6 with several variables, noted strong correlation with the SpO2 for patients with COPD stage III.
Geometria da observação dos movimentos aparentes do Sol e aplicações
(Universidade Federal de São Carlos, 2011-12-04)
Oliveira, Luciano de
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Salvador, José Antonio
;
https://lattes.cnpq.br/2487171069472158
The purpose of this thesis is to work content of Mathematics, which include topics of Astronomy, more specifically some aspects of the geometry of the apparent movement of the Sun. By means of direct observation of the Sun, the exploitation of animations, films and lectures they acquired knowledge for the understanding of two applications: construction of a sundial and installation of collectors of solar energy for water heating. We have developed activities with different methodologies for the students so they could really understand the need of learning contents of Mathematics. For this reason we discussed the historical necessity of the use of such knowledge and the use of it for the solution of practical problems relating to the apparent movements of the Sun. Mathematics occupy central role in the realization of the activities, but it was necessary to use knowledge from other areas such as: introduction to astronomy, geographical coordinates, energy conservation, sociology, environment, etc. for a lesson more meaningful and comprehensive of the proposal through an interdisciplinary work.
Estudo da influência da camada de engobe sobre a curvatura central de revestimentos cerâmicos
(Universidade Federal de São Carlos, 2011-12-05)
Gennari, Ronaldo Crosio
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Boschi, Anselmo Ortega
;
https://lattes.cnpq.br/3259846931278607
;
https://lattes.cnpq.br/6977866519848589
Given the importance of planarity of the tiles for covering of floor and walls, this work aims to identify the influence of engobe layer on the behavior of central curvature, and from then on, allowing a greater understanding of the phenomenon of coupling support-engobe-enamel. The engobes are currently used as intermediate layer of ceramic tiles. Among the functions provided by engobes, some can be highlighted, hide the color of the ceramic, eliminate surface defects, to prevent reactions between the substrate and the ceramic glaze. In addition, the engobe also have a role in the coupling between substrate and enamel, but this is one of the least studied in the literature. To conduct the study, distinct engobes compositions were formulated, with planned variations in their behavior during the burning (fusibility and thermal expansion). With the help of the technique of design of experiments (DOE) with 2k factorial analysis, it was possible to study the effect of these variables on the central curvature. Results helped to understand the effect of each variable and the role of engobe on the flatness of the ceramic tiles. From the analysis of the results obtained it was suggested a statistical method that can help reduce the central curvature of the tiles from the knowledge of the characteristics of the engobe to the same type of enamel.
Associações italianas no interior paulista num espaço partilhado: nacionalismo e italianidade sob a perspectiva da história local
(Universidade Federal de São Carlos, 2011-12-05)
Teixeira, Rosane Siqueira
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Truzzi, Oswaldo Mário Serra
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https://lattes.cnpq.br/5005536921435787
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https://lattes.cnpq.br/5092373584549569
This thesis seeks to develop an understanding of the trajectories of two groups of Italians who were members of the management board of two organizations, namely the Società Italiani Uniti (SIU) and the Società Italiana di Mutuo Soccorso "Gabriele D'Annunzio" ("SIMS"Gd'A ), located in Araraquara (SP) and in Catanduva (SP), respectively; this investigation was performed from the perspective of the local history, offering some reflections on the ways in which these trajectories have been significantly marked by the rise of fascism. The study covers a period from the end of the 19th century until 1942, with special focus on the 1920s and 1930s in the twentieth century. Thus, it is plausible to say that the effect of the rise of fascism in their organizations, and consequently in the trajectory of the leaders, is intrinsically related to the local conditions of each Italian colony. In this sense, Araraquara has been developed and shaped by the concepts of colonialism and there was some evidence of a closed society and a hostile environment. The social integration of Italian immigrants occurred through a gradual process. However, with respect to the political insertion, some of them have found an alternative path and joined the local Masonic Lodge. Conversely, in Catanduva, the growth of the town has occurred due to the arrival of immigrants, and it was found that there was greater permeability of social and political integration. The doctrine of fascism was incorporated into the SIU and SIMS Gd'A at different times and in different ways. In 1928, empowered by the actions of a group of partners, the SIU was recognized as a shared space where beneficent actions and fascism occurred in an open manner. Hence, the SIU began to decline in the 1930s. Therefore, the SIMS Gd'A only shared its space effectively when it became Casa d'Italia, in 1937, as agreed by consensus among the members, then becoming the only institution to represent italianity in Catanduva. Both the SIU and SIMS Gd A offered an important contribution to the consolidation of italianity in the Italian colonies. Because of access to the official records of the board meeting proceedings of these two organizations was provided, it was possible to carry out a systematic study. It was also used a wide range of public and private records, both in Brazil and in Italy (Rome). Moreover, additional data were collect through face-to-face interviews, mainly of the descendants of Italians.
Modelo Weibull modificado de longa duração
(Universidade Federal de São Carlos, 2011-12-07)
Oliveira, Cleyton Zanardo de
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Perdoná, Gleici da Silva Castro
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https://lattes.cnpq.br/0745160064860746
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Louzada Neto, Francisco
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https://lattes.cnpq.br/0994050156415890
When a group of patients is monitored until a pre-established date for observation of the recurrence time of an event, it is possible that, at the end of the monitoring period, a parcel of such group has not yet suffered the event of interest. When that happens, even if the period is extended, there is evidence that an appropriate model for the theoretical survival function of the time until the event occurs would be one model able to bear this kind of data. This class of long duration models will be defined because the form presented by the nonparametric estimation of hazard function in this type of study indicates that the model should be flexible to allow such function to be increasing, decreasing, constant or U-shaped. In this report, we present the long duration modified Weibull model (LDMW) as a proposal to contemplate the issues in the medicine area. The LDMW model has a flexible hazard curve, which enables adjustment when the hazard is decreasing, increasing, U-shaped, unimodal, initially decreasing and posteriorly unimodal and constant. The report also particularizes models already known in the literature that contemplate long duration, such as the long duration Weibull (LDW), long duration Exponential (LDE) and short duration models, such as the modified Weibull (MW), Weibull and Exponential. The simulations showed that the odds of coverage reach the nominal probability of 95% for moderately to big sized samples, that the LDMW p model parameters estimation is costless when compared to the MW and that the selection criteria of the AIC and BIC models are not adequate to discriminate the LDMW model adjustment when compared to the LDW model adjustment for small or moderately sized samples. The LDMW model and its particular cases were adjusted into two sets of real data considering the Classic and Bayesian Inference. The first data set is about the time until the seroreversion of children born from HIV-positive mothers and the second data set is about the recurrence time of breast cancer in women.
Melhoria no desempenho organizacional de uma empresa de bens de capital usando o Balanced Scorecard: um estudo de caso
(Universidade Federal de São Carlos, 2011-12-07)
Marçola, Jadilson Astorino
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Politano, Paulo Rogério
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https://lattes.cnpq.br/8738368968765884
This paper aims to verify if there was improvement in the Performance Management of an organization that uses for more than five years a Performance Management System, denominated Balanced Scorecard. It's necessary to verify if the use of the Balanced Scorecard in this period of time, improved the management system of the organization, transforming the strategy into several operational execution processes. The development of this investigation was grounded in bibliographic references, to identify and evaluate the whole process of Strategy, Planning and Performance Measurement System, as well the involvement of all the stakeholders.
Domínios ferroelétricos em cerâmicas e materiais nanoestruturados: investigação por microscopia de piezoresposta
(Universidade Federal de São Carlos, 2011-12-07)
Bastos, Wagner Benício
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Eiras, José Antônio
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https://lattes.cnpq.br/6653223814715498
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https://lattes.cnpq.br/0468842870942338
In this work, ferroelectric domain structure was investigated by Piezoresponse Force Microscopy (PFM). To this, an Atomic Force Microscope (AFM) has been modified to use it as PFM at room temperature and at high temperatures. Ferroelectric ceramics were used in the as bulk ceramic samples of Pb(Zr0,40Ti0,60)O3 (PZT 40/60) and (Pb0,79La0,21)TiO3 (PLT 21) produced by conventional methods. Nanostructured materials of Pb(Zr0,40Ti0,60)O3 (PZT 40/60) and Pb(Zr0,20Ti0,80)O3 (PZT 20/80) prepared respectively by sputtering and oxide precursors method were also studied. In a bulk ceramic PZT 40/60 was observed patterns of ferroelectric domain in twins configuration and built a three-dimensional model of its structure. The behavior of the polarization through the domain walls of 90o and 180o was investigated and widths of domains walls were estimated to be about 29 nm and 75 nm, respectively. In nanostructured samples PZT 40/60 and PZT 20/80, piezoelectric hysteresis remaining cycles, obtained by local measurements on different grains, shown a strong influence between the crystallographic orientation and the remanent polarization in each grain. Studies of polarization reorienting performed by ferroelectric lithography PFM revealed that the vertical component of the polarized material depends only on the vertical direction of the applied electric field, while the component parallel to the surface of the sample depends on the movement of the tip on its surface. This allows a procedure to control the orientation of these two components in the material. It was accompanied by images of PFM developments ferroelectric domains of ceramic PLT 21 (TC ~ 125oC) at high temperatures. The surface of the sample showed ferroelectric characteristics even at temperatures of 142°C. The results showed that the intensity of the polarization in the regions with a domain pattern decreases with increasing temperature.
Quantificação de resíduos de amoxicilina e ampicilina por injeção direta de amostras de leite de bovino
(Universidade Federal de São Carlos, 2011-12-07)
Moura, Franciane
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Cass, Quezia Bezerra
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https://lattes.cnpq.br/9197210255594409
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https://lattes.cnpq.br/0973934556750225
The development of new methods for analysis and quantification of drugs and their metabolites in biological fluids is of great interest in various areas of knowledge. The pre-treatment of complex matrices is a fundamental step for the quantification of compounds in trace levels. Methods of direct injection of samples by 2D liquid chromatography systems have led to higher precision and accuracy, and quantification limits ever smaller. The use of RAM columns allows the exclusion of proteins and other macromolecules present in biological matrix and extraction of lower molecular weight analytes through hydrophobic, ionic or affinity interactions. In this work, a number of different RAM columns were evaluated with different materials adsorbed or bound on the silica surface (BSA, methylcellulose and - lactoglobulin). As well as, columns with different modes and mechanism of the analytes retention (C8, C18, SAX, SCX) were used. Using the technique of column coupling and a mass spectrometer as detector, ampicillin, was quantified, in bovine milk samples having a RAM-BSA column, in the first dimension coupled to an ACQUITY UPLC BEH column, in the second dimension. MRM mode with three specific transitions, 350> 106, 350> 160 and 350> 192 m/z, were monitored. The first, more intense, was used for quantification while the other two were used for confirmation. The developed method is simple, with analysis time of 14 minutes without any pretreatment of samples, except for centrifugation.