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Efeito da imunização com enzimas recombinantes do metabolismo de nucleotídeos de Schistosoma mansoni sobre o desenvolvimento da esquistossomose mansônica experimental
(Universidade Federal de São Carlos, 2012-08-29) Neris, Débora Meira; Anibal, Fernanda de Freitas; https://lattes.cnpq.br/4918261968772806; https://lattes.cnpq.br/8420021026488937
Schistosimiasis mansoni is a neglected chronic parasitic disease that affects thousands of people worldwide, caused by the trematode Schistosoma mansoni. In the infected host the disease is characterized by the presence of granuloma, imunnopathological response of the cellular infiltration against egg antigens. Thus, the host-parasite relation favors hepatosplenomegaly, acite and hepatic fibrosis. Current chemotherapy is based on the use of Praziquantel (PZQ), used against all species of Schistosoma spp for over 30 years. The main issue is that the PZQ is practically inactive against immature schistosomula and favors the resistance growth of the existent lineages, which makes the study for new drugs and vaccines that can contribute to the control of this disease even more urgent. One of the paths on the search for new therapeutic targets is the study of essential enzymes to the S. mansoni. In particular, it is known that the enzymes Adenylate Kinase 1 and 2 (ADK), Uridine cytidine Kinase 1 and 2 (UCK), Hypoxanthine guanine phosphoribosyltransferase (HGPRT) e Purine nucleoside phosphorilase 1 (PNP) are found on the metabolic pathways of the parasite s nucleotide, participating in the metabolism of purines and pyrimidines. Our goals in this study were to assess the immunization with these enzymes, using the S. mansoni cercariae infected murine model, and subsequently analyze the acting in oviposition and growth of adult worms. Our results showed that the immunization in Balb/c mice with the UCK enzyme was capable of inducing a specific immune response, which favored a significant reduction of the parasitic load (adult worms). However, it was not possible to observe significant reduction in the number of eliminated eggs. Regarding the immunization with PNP and HGPRT enzymes, the mice had a reduction in the number of eggs per gram of feces. The data obtained are considered interesting and can be new targets for immunotherapy against schistosomiasis mansoni. Thereby, new assays must be made with different dosages of the enzymes for a better assessment on how these enzymes modulate the parasitic load through the eggs reduction, reduction in the adult worms retrieving, as well as the antibody levels during the murine infection by the S.mansoni.
Estudo de mise-en-bande : a dinâmica do som em Last Days, de Gus Van Sant
(Universidade Federal de São Carlos, 2012-08-29) Silveira, Juliana Panini; Miranda, Suzana Reck; https://lattes.cnpq.br/8566012598222563
This research is an analysis of Gus Van Sant s Last Days (2005) soundtrack. From the concept of mis-en-bande, that emphasizes the interactions between the different sounds of the film narrative, we propose to consider the details of the Last Days s sound organization and its crucial contribution to the proposed narrative discourse.
A morte de Vladimir Herzog e a luta contra a ditadura: a desconstrução do suicídio
(Universidade Federal de São Carlos, 2012-08-29) Kleinas, Alberto; Grün, Roberto; https://lattes.cnpq.br/6028266827740491; https://lattes.cnpq.br/7899663984177059
The case Herzog had a strong impact on the recent political history of Brazil. A journalist killed on the premises of the 2nd. Army, in Sao Paulo, which was imposed by the establishment of suicide. Suicide wrought was challenged by his peers journalists, the Journalists' Union, the Archdiocese of St. Paul and in view of the pressures, the Jewish community of Sao Paulo. His burial was in an appropriate place for those who attempted against his life, and this burial and then act on Ecumenical Cathedral, are objects of this dissertation which seeks to clarify the reasons for this fact. As a Jewish collectivity could break with the collaboration and submission to the military regime, common in immigrant communities, and attest to the murder through the burial site of Vladimir Herzog. The contradictions and institutional pressures of Sao Paulo Jewish community demonstrate how external influence, Brazilian society was important in this episode, without underestimating the importance of individual people who were exposed to the truth and the struggle for democracy and human rights.
Banco de dados georreferenciado para apoio à gestão de trânsito em cidades de pequeno e médio portes
(Universidade Federal de São Carlos, 2012-08-29) Vendrametto, Larissa Lenharo; Raia Junior, Archimedes Azevedo; https://lattes.cnpq.br/6413793013018019; https://lattes.cnpq.br/2276864795974596
The modernization of the cities has brought an improvement in the lives of the urban population, although the negative consequences weigh considerably. In any kind of transformation, the negative effects are not always considered and treated to abolish them or less minimize them. Traffic is a clear example of this fact. The significant increase in the fleet of vehicles has generated several urban problems such as high rates of occurrence and severity of traffic accidents, congestion and degradation of the urban environment, influencing the quality of life. With the enactment of the Brazilian Traffic Code (CTB) in 1988, municipalities assumed the responsibility to manage their traffic, adding to his responsibilities the authority to act in this area taking into account the interests and local peculiarities. In this sense, each municipality must municipalise directly assuming the powers specified in Article 24 of the CTB. However, municipalities have been reluctant to take charge of decentralization of traffic. According to data DENATRAN (2012), only 1,221 municipalities have effectively assumed the management of their traffic, which corresponds to 29% of 5,563 Brazilian municipalities. Many factors can be pointed as responsible for this reluctance, and one of them is the lack of knowledge of the reality of local traffic. It is important that the institutions, who are competent to intervene on the county road system and its maintenance, to know the dynamics of the space on which they intend to launch campaigns, a quality management includes the selection, acquisition, integration and use of information so systematized. The management and analysis of information associated with meaningful comparisons must adequately support the decision making process within the organization. Given this, the Geographic Information Systems - GIS become an effective tool and capable of helping the management, providing a modern and agile tool for specialized studies, with the recognition of the traffic situation as a whole. Therefore, this paper aims to contribute to the management of municipal public transit in cities small and medium-sized Brazilian, through the development of a tutorial to support the implementation of a geographic information system free - Free GIS, showing that it is not always necessary high investment amount for the production of quality information for management of a city road.
Tendências das perspectivas Ciência, Tecnologia e Sociedade (CTS) nas áreas de educação e ensino de ciências: uma análise a partir de teses e dissertações brasileiras e portuguesas
(Universidade Federal de São Carlos, 2012-08-29) Miranda, Elisangela Matias; Freitas, Denise de; https://lattes.cnpq.br/3330976062026878; https://lattes.cnpq.br/2093003152737149
Nowadays, Science and Technology developments and influences on humanistic, social, cultural and economic dimensions have raised discussions about the nature, potential and limits of those areas. Science teaching according to STS (Science-Technology-Society) education comes out as an approach that aims to integrate scientific, technological and social themes in a given content. This approach stimulates students to develop skills that enhance their ability to play their role in society in an active and mindful manner, and hence contributes to the rise of a larger number of scientifically and technologically literate citizens. In that regard, the main objective of the present study is to analyze academic studies master s and doctoral theses produced between 1992 and 2009 that have focused on the STS education field, seeking to identify STS education perspectives pointed out in those studies during that time span. The secondary objectives of this study are: (i) to identify master s and doctoral theses in Education, Science and Mathematics Teaching or related graduate programs of Brazilian and Portuguese federal or state universities, all of the works dating from 1992 to 2009 and investigating approaches related to STS education; and (ii) to characterize the thematic focuses, methodological and STS approaches in those theses. Therefore, this is a state of knowledge research conducted according to a theoretical, bibliographical, and quantitative-qualitative approach, for which the Qualitative Content Analysis method was used. Among the most relevant results, it has been found that 14% of the investigated Brazilian theses were directed towards the college level, whereas none of the Portuguese theses had the same intent. On the other hand, 79% of the Portuguese theses were aimed to the first years of school, whereas only 21% of the Brazilian theses were devoted to that education level. Analyses were also carried out in order to identify and discuss which STS approaches and/or perspectives are present in doctoral theses finished at both Brazilian and Portuguese universities. Such analyses have indicated that the main STS education model observed in the theses is Logical reasoning (40% of the theses, i.e., 10 out of 24 theses), followed by Sociocultural (39% of the theses, i.e., 9 out of 24 theses), Historical (3 theses), Socio-ecojustice (2 theses), and Application/Design (1 thesis). In general, the analyzes revealed that, even though there is a consensus among the academic community involved with studies on STS education, different interpretations of STS-based Science education have been emerging along decades, which reveals a field under construction and reconstruction.
Simulação computacional, projeto, construção e análise do desempenho de uma matriz para extrusão em canal angular dedicada ao processamento de chapas
(Universidade Federal de São Carlos, 2012-08-29) Springer, Phillip; Ferrante, Maurizio; https://lattes.cnpq.br/6067173982945625; https://lattes.cnpq.br/2504572620929191
The present work describes the design, construction and testing of an equal channel angular pressing (ECAP) die characterized by rectangular cross section channels. The main parameter of the ECAP dies is the geometry of the channels, given by the angle trough which they meet, and the curvature radii at this point. The material employed in the experiments was an Al AA1050, 7 mm thick plate. The main motivation of the project is to produce the tooling necessary for the production of samples to be employed in future studies, directed to the crystallographic texture change of the above named material so as to improve its deep drawing behavior. Indeed, there are indications that both asymmetrical rolling and ECAP processing can minimize unfavorable textures. This present investigation is composed by two sequential and complementary subprojects: (i) Numerical analysis by finite elements (FEM) of the simultaneous and independent variation of the external (R) and internal (r) curvature radii at the channels intersection, plus experimental validation, a procedure that seeks to minimize the deformation heterogeneity of the billet. Using a Pb-62% alloy twelve R-r combinations were tested and simulated, keeping constant the angle at the channels intersection. Also, the phenomenon known as "corner gap" (a detachment of the billet from the outer channel wall) was analyzed and its influence on the billet equivalent deformation determined. (ii) From the results obtained on subproject (i), and additional considerations, an ECAP die for flat billet processing was designed and constructed HAVING R =3 AND r = 0. Using FEM simulation the equivalent strain distribution was mapped for plates subjected to one and four passes. Experimental validation of such maps was carried out employing Vickers microhardness measurements of the viii plate cross section. The evolution of the tensile properties and grain size confirmed the good performance of the ECAP die design.
Internacionalização e mudança na gestão: um estudo de caso na indústria de eletrodomésticos de linha branca
(Universidade Federal de São Carlos, 2012-08-29) Milaneze, Kleber Luiz Nardoto; Rachid, Alessandra; https://lattes.cnpq.br/6981682198988902; https://lattes.cnpq.br/1273696629694839
The purpose of this study is to analyze the process of ownership change in an appliance company, checking the impacts brought by this process in its management. For this study, it was performed a case study, during which were conducted interviews with managers from different areas of the company. It was also based on a literature in academic journals, economic analysis and sector and public agencies publications on the process of internationalization, the Brazilian economic indicators, and the appliance industry. The 1990s was a period remarkable for the internationalization of the economy, with the rise in trade, finance and information between countries. Brazil was integrated through this process by the trade liberalization for imports, which, together with the macroeconomic and political stability, have made the country more attractive for foreign investment. This context coincided with a period of an overvalued exchange rate, which, together with high domestic interest rates, led to the acquisition of national capital companies in various industries, including appliance industry. Since then, this industry has become an oligopoly, dominated by a few large multinational companies with significant consequences for the management of companies in Brazil. In the studied company, there have been significant changes in the management staff, in the organizational structure, as well as its strategic position, with implications for the operations and human resources management.