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Avaliação das variáveis cardiorrespiratórias, metabólicas, marcadores inflamatórios e dos polimorfismos genéticos da APOB e da ECA, em pacientes com doença arterial coronariana e/ou fatores de risco submetidos ao treinamento físico intervalado
(Universidade Federal de São Carlos, 2015-04-16) Tamburús, Nayara Yamada; Silva, Ester da; https://lattes.cnpq.br/0120120410847507; https://lattes.cnpq.br/9131644950931827
Interval training (IT), combined with pharmacological therapy, has been strongly recommended for the management of coronary artery disease (CAD) and control of cardiovascular risk factors. However, the best protocol to be used it is still unclear. In this regard, the IT protocols based on ventilatory anaerobic threshold (VAT) can be an effective and safe strategy to prescribe the intensity of the exercise training as well as to promote improvement of the aerobic functional capacity, metabolic profile, cardiac autonomic modulation and to reduce inflammatory markers. Moreover, the adaptive responses to IT may differ between individuals. Part of this biological variability may be explained by the genetic polymorphisms involved in the synthesis of structural proteins or on the circulation enzymes. Based on this context, this thesis involved three studies. The first and second studies were conducted to investigate if the IT, based on intensities between 70 and 110% of the workload obtained in the VAT, could be effective to improve functional aerobic capacity and metabolic profile. Moreover, it was investigated if there was a relationship between the improvement in cardiac autonomic modulation with the reduction of the Creactive protein (CRP) in patients with CAD and/or cardiovascular risk factors. The results of the first study showed that the IT program increased aerobic functional capacity and reduced body mass and body mass index. The second study found that after the IT program, there was an increase of the parasympathetic autonomic modulation that was associated with a reduction in CRP levels. Given these findings, the third study was designed to investigate the improvement of the functional aerobic capacity and changes in lipid profile induced by IT, in relation to the apolipoprotein B (APOB) and the angiotensinconverting enzyme (ACE) genes polymorphisms. In this study, it was observed that the increase of the functional aerobic capacity was associated with the presence of the ACE I allele, whereas patients with polymorphism -7673G>A, in the APOB gene, presented increase of the low-density lipoprotein (LDL) levels over time. Considering the findings from these studies, the IT protocol promoted improvement of cardiac autonomic modulation, increase of aerobic functional capacity, reduction of inflammation e improvement of metabolic profile. These benefits on the cardiovascular and metabolic systems contribute to control of cardiovascular risk factors and primary and secondary prevention of CAD. Moreover, this IT protocol provides new possibilities on cardiac rehabilitation field, with respect to exercise training prescription at the VAT level.
Quantum memory based on electromagnetically induced transparency in optical cavities
(Universidade Federal de São Carlos, 2015-04-16) Oliveira, Rommel Rodrigues de; Villas-Bôas, Celso Jorge; https://lattes.cnpq.br/5700887540085418; https://lattes.cnpq.br/1239076898021486
Desconstrução espacial e produção da área central na cidade de São Paulo : o exemplo da Rua Paim, Bela Vista
(Universidade Federal de São Carlos, 2015-04-16) Ruivo, Maria Patrícia; Castro, Carolina Maria Pozzi de; https://lattes.cnpq.br/2178910002833930; Francisco, José; https://lattes.cnpq.br/0330065027402518; https://lattes.cnpq.br/3708181233596143
The data released by 2010 Census (IBGE) demonstrated a reversal in the migratory flux in the central area of São Paulo-SP. After decades of decrease in population, neglect and lack of investments, the center of the city started to gain new inhabitants in the first decade of the XXI century. The purpose of this study is to analyze these changes and investigate the production of urban space in the central area of São Paulo between the years 2000 and 2010. Through the case study of Paim Street (Bela Vista), the research intends to discuss this production, not only as a result of the guidelines defined by the city Master Plan, but also as a reaction of real estate market. Despite the legal advances, with the approval of federal Law 10.257 in 2001, the Strategic Master Plan in 2002, and the positive aspects of the population growth in the central area, the investigation indicates that the difficulties to bring about a paradigm shift in the production of urban space in the city still remain. The data show the fail in application of the main urban instruments intended to guarantee the social function of property and the difficulty in protecting the built environment, prioritizing the recovery of old buildings before encouraging the construction of new ones. The importance in understanding the period of study is the possibility to prevent and correct such distortions between theory and what is actually done in the city.