Browsing by Issue Date, starting with "2015-08-24"

Filter results by year or month

Now showing 1 - 20 of 15864

Estudo e desenvolvimento do protótipo de aplicativo móvel : “cateterismo intermitente limpo : guia de apoio para adultos”
(Universidade Federal de São Carlos, 2015-08-24)
Pereira, Barbara Juliana da Costa
;
Napoleão, Anamaria Alves
;
https://lattes.cnpq.br/8539664594837249
;
https://lattes.cnpq.br/9744833903914682
The clean intermittent catheterization (CIC) is an effective alternative to indwelling catheterization, being used for the management of bladder dysfunction including in the home environment through clean technique. The objectives of the study were: Identify, analyze and summarize the scientific evidence on caring for clean intermittent catheterization in the home environment; organize, from the review of the data, the contents of a support tab for adults; and develop a prototype application for mobile devices with organized content. It is a study with a quantitative approach, descriptive exploratory and technological development. It was carried out in three stages, being them the Integrative literature, Organization and content, and Mobile Application Prototyping. From the review, it was possible to evidence the related factors of the CIC success in the home enviroment, guiding the elaboration of the educational content. These data were organized along with other current related subject works in the literature, composing the guide’s educational content, based on recommendations on the development of health’s educational materials. The review of the data contributed to the evidence-based information to make up the mobile application prototype to be built on a digital platform, aiming to promote the improvement of care provided by nursing professionals to individuals using intermittent urinary catheterization, as it is related to the self-care education. The application prototype development involved its preparation in Unity platform by a multimedia professional, structuring the interface, preparing the navigation features and creating icons. Finally, we performed the evaluation of the usability of the built prototype that demonstrated good usability of it, though it is still necessary to carry out evaluation by experts of the end product development. We hope the results of this study can contribute to the advancement of research related to the use of CIL, by developing technologies that bring customers to scientific knowledge on the subject in order to provide these individuals the required quality and safety, and so, achieve higher levels of adherence to the practice of clean intermittent catheterization.
Planejamento e avaliação de fragmentos moleculares como inibidores da enzima cruzaína
(Universidade Federal de São Carlos, 2015-08-24)
Rangel, Karen Cristina
;
Montanari, Carlos Alberto
;
https://lattes.cnpq.br/9200533791228786
;
https://lattes.cnpq.br/4726384027462430
The available drugs for treating Chagas disease are not effective, therefore the development of new therapies is needed. Cruzain is the major Trypanosoma cruzi cysteine protease, the causative agent of the disease, and is a validated therapeutic target for the discovery of new trypanocidal agents. Our group has identified a cruzain inhibitor with fragment characteristics - [5- (2-chlorophenyl) -1,3,4- oxadiazol-2-yl] acetic acid (Neq0147) and its mode of interaction was validated by determining orthogonally its crystal structure. However, interactions of this inhibitor were not yet appropriately optimized. Therefore, this study aimed to optimize the interactions of Neq0147 to identify new fragments as non-peptide cruzain inhibitors, which was carried out through a structure-activity relationship study (SAR). Molecular modifications have been made based on Neq0147, wherein initially carboxylate was replaced by a nitrile to increase the affinity of the inhibitor and to act as an anchor to explore other modifications. Then it was made the replacement of the 1,3,4-oxadiazole ring for others heterocyclic five-membered rings, with the intention to explore interactions with Asp161 and Gly65. The position of the chlorine atom on the aromatic ring was also varied to explore interactions with amino acids in the S2 subsite. The compounds were tested against cruzain to determine its inhibition constant. From the SAR study it can be concluded that the change that generated higher affinity gain was the replacement of the carboxylate group by nitrile. It can also be seen that the presence of chlorine is essential for the fragments activity, which preferably should be present in the ortho or para positions. Among the evaluated inhibitors one fragment, Neq0617, has an affinity 14 times greater than the original fragment. Moreover, various inhibitors similar to fragments with high affinity and interaction efficiency have been identified, therefore these inhibitors are potential candidates for optimization.
Contribuição ao estudo do sistema de pré-lajes tipo painel treliçado em pavimentos de edificações
(Universidade Federal de São Carlos, 2015-08-24)
Rocha, Filipe de Lima
;
Carvalho, Roberto Chust
;
lattes.cnpq.br/3633394168236221
;
https://lattes.cnpq.br/9481565357564253
The civil construction more than ever is challenged by the circumstances faced by the country, the economic crisis experienced in these last few years puts into perspective the necessity of more rational choices avoiding unnecessary dispenses and wastes. In face of this scenario the pre-cast elements became vital to guarantee the conclusion in less time and trying to reduce constructive bottlenecks. The latticed pre-cast concrete slabs are one of the many types of pre-cast parts which can be used at the construction sites, however the national standards are confuse and vague about some aspects contained especially in the European standards. Even the last review of the NBR 6118 of 2014 adds little about the issue and the more specific standard (NBR 14680) has few constructive details regarding the connection between elements and the calculus procedures, therefore this work tries to discuss the main questions related to this kind of pavement, introduces knowledge coming from other standards trying to answer some less usual doubts, but extremely pertinent ones such as, for example, the concept of self-portance, the use of this material in bridge floors and also the type connective reinforcement needed to attain the effective monolithism at the interface between beamstructure. This dissertation also presents some examples of pre- and post-constructive deflection limits, fissured deformation and a full example of calculation for a common pavement. Some data from the experiments realized at the NEPRE in the University of São Carlos and their practical application are shown as well.
Treinamento e capacitação dos profissionais da construção civil baseados nos conceitos da mentalidade enxuta
(Universidade Federal de São Carlos, 2015-08-24)
Panaino, Brunna Bernardo de Faria
;
Paliari, José Carlos
;
https://lattes.cnpq.br/9387796929252598
;
https://lattes.cnpq.br/7981134066791604
The industry of civil construction presents frequent progress in material development, but a notable delay in management. To assist in the management process, it has been sought to adopt the concept of lean thinking that emerged in the automotive industry and it has been adapted to various segments because of its efficiency. They have developed several theoretical works on the subject, but there are still difficulties in the implementation in construction due to low education of the workforce; lack of organizational diagnosis, among others. This work aims to present a form of training for the workforce with a focus on reducing waste and loss based on the concepts of lean thinking. Classified as action research, the following steps were included: (1) literature review on teaching methods, training and lean thinking; (2) development of preliminary proposal of training and capacity and its evaluation mechanisms and subsequent (3) application and validation (4) final proposal for the training and qualification method. The application shows that the model developed contributes to filling thegap between the lean construction theory and the practice of construction. The uniqueness of the model consists of the application of the training with pedagogical foundations of learning styles to best suit the target audience.
Toxicidade, eficácia e efeitos morfofuncionais do antimicrobiano azitromicina para a tilápia Oreochromis niloticus
(Universidade Federal de São Carlos, 2015-08-24)
Shiogiri, Natália Sayuri
;
Cruz, Claudinei da
;
https://lattes.cnpq.br/1023527914463601
;
Fernandes, Marisa Narciso
;
https://lattes.cnpq.br/3021357484136942
The increase of fish production in intensive systems involves the use of antimicrobians in the treatment of diseases caused by bacteria. Therefore, the aim of this study was to evaluate acute toxicity (CL50; 48h) of the antimicrobial azithromycin (AZT) for fingerlings of tilapia (Oreochromis niloticus), the effects on young tilapia, after chronic exposure (14 days) via hematological analysis, morphology gills, liver and kidneys and antioxidant system responses in the liver, and to determine the efficacy of control of Aeromonas hydrophila via hematological analysis and innate immune response, in addition to the morphological effects gills, kidneys and liver and antioxidant system responses in the liver. The acute toxicity (LC50; 48h) of the AZT to tilapia was > 100 mg L-1 being th AZT classified as practically non-toxic. After chronic exposure, there was an increase in hematocrit (Hct), hemoglobin concentration (Hb) and in the mean corpuscular volume of erythrocytes (MCV) and no change in the other variables of the red series was observed. The leukocytes increased after exposure to 100 mg L-1 AZT. Histological changes in gills suggest defense response against irritant agent and indicate normal structure and function of the organ; in the kidney no changes was observed and in the liver changes were classified as moderate to severe. In the efficacy trial, the offering of medicated food with AZT (100 and 125 mg kg-1) to animals infected with A. hydrophila was efficient and all of the treated animals survived; of the untreated animals 22% came to death. The Hct decreased and the hematimetric indices mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration increased, the percentage of lymphocytes decreased and the percentage of neutrophil increased in untreated infected animals, but were unchanged in animals treated with AZT. No change occurred in innate immunity assessed by the activity of lysozyme, complement system and leukocytes respiratory burst activity. Gills showed no changes that could interfere in the organ function, in the liver changes were classified from mild to moderate and didn´t occurred alterations in the kidneys. Animals treated with AZT showed no adverse effects related to defense cells and the innate immune activity. The drug also caused no changes in antioxidant defense enzymes in the animals' liver after chronic exposure and did not generate oxidative stress. After challenge with A. hydrophila occurred an increased in the activity of catalase, glutathione peroxidase, glutathione transferase and glutathione level in the liver of animals treated with AZT and the glutathione level decreased in the infected group and untreated. These responses suggest that infection caused by A. hydrophila can induce an increased production of ROS and, consequently, stimulated responses of the antioxidant defenses. These responses were effective to prevent the occurrence of oxidative stress.
Geração de um programa de rotação de postos de trabalho considerando critérios ergonômicos e de produtividade
(Universidade Federal de São Carlos, 2015-08-24)
Márquez, Maria Fernanda Ramos
;
Silva, João Eduardo Azevedo Ramos da
;
https://lattes.cnpq.br/3823047207711289
;
https://lattes.cnpq.br/1999503875609726
Resumen: Las tensiones laborares que demandan esfuerzos yrepetición de actividades o posturas por periodos prolongados han sobrecargado los sistemas físicos humanos, pues estos esfuerzos son inherentemente poco naturales. La rotación de puestos de trabajo ayuda ala prevención de traumas ocasionados por estos factores, a través de la diversificación de tareas y la reducción de los períodos de exposición a elementos que podrían perjudicar a los trabajadores física o cognitivamente. Múltiples herramientas se han utilizado para la planificación de rotaciones, dentro de las cuales es posible encontrar el modelaje matemático y la simulación. Así, este trabajo tiene como objetivo proponer un modelo matemático de programación lineal entera mixta para generar programas de rotación puestos de trabajo que permitan minimizar el riesgo de desarrollar trastornos musculoesqueléticos (TME) causados por la repetición en una línea de embalaje de productos. La productividad de los trabajadores en cada estación de trabajo también es considerada. Para poner a prueba la solidez de losresultados en condiciones estocásticos, fue desarrollada una simulación computacional que tiene en cuenta paradas en el sistema de diversos orígenes, al igual que variaciones en la tasa de productividad de los trabajadores. La principal contribución de este estudio es el análisis ergonómico y productivo dela rotación de puestos de trabajo mediante la combinación de dos técnicas. El esfuerzo asociado a las tareas repetitivas se midió por utilizando el indicadorOccupational Repetitive Actions Index (OCRA).La productividad se evaluó midiendo el número de unidades procesadas por trabajadoren cada puesto de trabajo. Para evaluar la adherenciade la metodología a la realidad y la calidad de sus respuestas, un estudio de caso se realizó en una línea de embalaje manual de productos, que se caracteriza por la repetición de tareas. A partir de los datos facilitados por la empresa, se realizaron pruebas para determinar el mejorpunto deequilibrio entre la minimización de la exposición a los riesgos ergonómicos y el mantenimiento de la productividad. Las formulaciones propuestas resultaronser una representación ajustadadel sistema estudiado, en cuanto alos riesgosergonómicos y a la productividad, generando soluciones prácticas, realistas y plausibles
Recreações e artesanato em aulas de matemática
(Universidade Federal de São Carlos, 2015-08-24)
Garcia, Carmem Barrio
;
Sampaio, João Carlos Vieira
;
https://lattes.cnpq.br/8286887389013685
;
https://lattes.cnpq.br/4235065207999139
From the need to increase the concentration and the interest of students playful method of teaching was applied, by making use of a desire of the students to pro-duce elastic bracelets, introducing through this form of craft concepts of the curriculum of mathematics for the seventh year of basic education and some concepts of financial mathematics which served as reminder of the mathematical operations concepts taught previously. The result was an improvement in the levels of learning, concentration and application on carrying out and completion of the tasks proposed.
Diversidade funcional e negra de isópodes subterrâneos em áreas cársticas do centro-leste do Brasil
(Universidade Federal de São Carlos, 2015-08-24)
Fernandes, Camile Sorbo
;
Bichuette, Maria Elina
;
https://lattes.cnpq.br/8453043393798516
;
https://lattes.cnpq.br/1479234559878695
We addressed the mechanisms responsible for the composition of subterranean communities and its consequences for the maintenance of ecological processes. In the first chapter, we tested whether cave communities were assembled by the restrictive regime propitiated by permanent darkness, or by limiting similarity caused by competitive exclusion when compared to surface communities. With this purpose, we measured several niche descriptors of species from inside and outside caves using a multivariate measure of functional diversity and compared their widths. Our results showed that isopods found inside caves favourable conditions to allow occupation and diversification, with milder environmental parameters coupled with the absence of specialised predators. There is, therefore, phenotypic overdispersion and higher functional diversity in cave species when compared to surface ones. This higher functional diversity results in better efficiency in resource use, but also in lower resilience of ecological processes. In the second chapter, we tried to understand the processes underlying patterns of subterranean biodiversity and its consequences, because species do not occur in all caves or habitat patches where their occurrences are expected. We looked for the species absences, known as the dark diversity, for estimation of how much of the habitat-specific regional species pool is realised within each local cave community. We tested whether the species were absent because of their functional attributes and tried to understand the relative importance of determinants of cave biodiversity using local-regional regression models. Our results indicated that the occurrence of the species is far from its potential, considering habitat availability and ecological requirements. We found no relationship between species absences and functional traits but this is possibly an artifact of the low species number and low co-occurrences of isopods. For the same reason the regression models did not fit in the local-regional relationship. Differences between caves and regions possibly results from the amount of microhabitats, resource inputs and historical factors and, from a conservation perspective, the caves with higher completeness deserve attention, because they may be a source of migratory individuals to other areas in the vicinity. In the third chapter we compiled the current state of knowledge of oniscidean fauna in Brazilian caves by listing the described species and adding several new records from our own surveys. Among these, certainly new species will be identified. We also addressed the need of validation of the new species and identification of the unrecognized ones by proper taxonomic research, as any delay may yield loss of biodiversity.
A educação das crianças menores de 06 anos sobre a perspectiva de Heloísa Marinho, Nazira Féres Abi-Sáber, Celina Airlie Nina e Odilon de Andrade Filho : uma análise de suas ideias pedagógicas (1934-1971)
(Universidade Federal de São Carlos, 2015-08-25)
Varotto-Machado, Michele
;
Hai, Alessandra Arce
;
https://lattes.cnpq.br/3845288858275245
;
https://lattes.cnpq.br/0506121990457151
Heloísa Marinho, Celina Airlie Nina, Nazira Féres Abi-Sáber and Odilon de Andrade Filho have a range of bibliographic production, and research articles regarding the understanding of the child under 06 years in Brazil. Anchored directly to government agencies of their period, the authors sought to present their works in pedagogical ideas for the Early Childhood Education. Faced with this observation, we aimed to understand: The conceptions that concern the School movement would have been appropriate in Brazilian Early childhood education? How the ideals of John Dewey were implemented for the education of children under 06 years? So the main research hypothesis is the incorporation of educational ideas of John Dewey occurred in the core of the hygienist/assistentialist movement, which could have led to distortions and theoretical and methodological mistakes in the use of the Dewey school theory. Thus, our objective is: apprehend and analyze how the educational conceptions of John Dewey were appropriate to "think" the Brazilian Early Childhood Education from to 1934 to1971. As methodological procedures we base our analysis on the theoretical and methodological support of Depaepe (2000; 2005) and Certeau (2008) with regard to the consideration of the research object in its historical context, but also consider the assumptions highlighted by Depaepe (2000; 2005 ) on the "black box" of the classroom, "grammar of schooling" and educacionalization process. Therefore we conducted a literature review about the output for the children under 06 years, considering the period defined for this research. This survey, however, was made in the following journals: Revista Educação, Revista Sociedade e Educação and Revista Brasileira de Estudos Pedagógicos. Regarding proposals to lower education than 06 years in Brazil, it was possible to understand the political and pedagogical demands for this field. In this sense, we sought from the selected material understand the circularity of the ideas that were present in the context of life and production of the four authors selected as the object of our study. Heloisa Marinho, Celina Airlie Nina, Nazira Féres Abi-Saber and Odilon de Andrade Filho highlighted by the direct relationship with government agencies set up at the time to provide the shelter, protection and educational projects for young children in Brazil, among which out: the National Department of Children; National Institute of Pedagogical Studies (INEP); Brazilian-American Assistance Program Elementary Education (PABAEE) and the Center for Studies and Research Helena Antipoff the Pestalozzi Society of Brazil. These authors can be considered active and immersed in national and international debates in the field of Early Childhood Education, with: materials, discussions, guidelines, analysis and activity descriptions for the children. From the analysis of all this material it was found that the set of conceptions present in the New Education ideas were appropriated by these authors, but were used as species of "slogans" that represented the ideas of Dewey, Decroly, Montessori, Froebel, Pestalozzi and Claparede; these appeared as a discourse of "reform" and consequently thus "improving" for the Early Childhood Education.
Sistemas de contraventamento aplicados em estruturas pré-moldadas de concreto de múltiplos pavimentos
(Universidade Federal de São Carlos, 2015-08-25)
Santos, Luciano Ferreira
;
Almeida Filho, Fernando Menezes de
;
https://lattes.cnpq.br/0447825383222965
;
https://lattes.cnpq.br/6944939760250103
The use of precast concrete system in multi-storey buildings demand for structural solutions that enable its horizontal stability without implicating the architectural and economic aspects, its challenge is borne by the structural engineer, who often need to assign additional structures (substructures of bracing) that provide the rigidity necessary to ensure the overall stability of the assembly. This study aims to analyze and evaluate the technical and economic performance of bracing systems applied to buildings with multiple floors with precast concrete structure and can be justified by the current need to develop appropriate technically ways of choice in the constructive system. The development of this study is the analysis of global stability in multi-storey buildings with the application of bracing systems, evaluating the influence of the stiffness and the arrangement of these elements in the performance of the structure, and comparing the concrete consumption values of the structures formed by beams and columns (disregarding the slabs and the foundation), and also values of the efforts in the foundation. To develop this study we used the commercial software STRAP® as a support tool for calculations, where the results gotten by it, showed that the bracing substructures improved the behavior of the structures analyzed in the issue of global stability. Finally, they were provided the necessary subsidies for the proper choice of the wind bracing system to be employed on the structures analyzed in this work.
Identificação estrutural de metabólitos provenientes do metabolismo in vitro de compostos bioativos e estudos de fenotipagem enzimática
(Universidade Federal de São Carlos, 2015-08-25)
Cardoso, Josiane de Oliveira
;
Venâncio, Tiago
;
https://lattes.cnpq.br/4438399441102990
;
Oliveira, Regina Vincenzi
;
https://lattes.cnpq.br/6609377714413073
This work reports studies of in vitro metabolism involving the compound 3-(2-chloro-6-fluorobenzyl)- imidazolidine-2,4-dione (LPSF-PT-31), a new 2-adrenoceptor agonist and, studies of enzyme phenotyping of montelukast, a drug used for the treatment of asthma. The results of this study revealed that LPSF-PT-31 is metabolized via CYP P450s in rat and human liver microsomes, producing only one major hydroxy-metabolite. LPSFPT- 31 showed a higher rate of in vitro metabolism in rats, which suggests a greater exposure to the drug in humans. The structural identification of LPSF-PT-31 metabolite’s was achieved through LC-MSn and 1H-NMR analysis that provided data to conclude that the hydroxylation occurred in the 5th position of the imidazolidine ring yielding to the production of 3-(2-chloro-6-fluorobenzyl)-5-hydroxyimidazolidine-2,4- dione. Related to the studies of enzyme phenotyping of montelukast, it was observed that the glucuronidation is the main clearance pathway of montelukast accounting for ~85% of the total apparent in vitro Clint (CYPs +UGTs) and that the CYP-mediated oxidation accounts only for ~15% to the overall metabolism of the drug, being montelukast acyl-β-D-glucuronide and montelukast 1,2 diol the major metabolites formed via UGTs and CYPs, respectively. Kinetic studies, correlation analysis, inhibition studies and, experiments in expressed CYPs and UGTs revealed that the CYP2C9 and CYP2C8 are comparably involved in the formation of montelukast 1,2- diol. CYP3A4 was responsible for the formation of 21(R)-OH montelukast and 21(S)- OH montelukast, while multiple CYPs catalyzed the formation of 25-OH montelukast (CYP2C8>2C9>3A4>2C19). The direct glucuronidation of montelukast resulted in the formation of montelukast acyl-β-D-glucuronide and of a new metabolite (Mglucuronide) not reported previously and was exclusively catalyzed by isoform UGT1A3. In conclusion, the in vitro data suggest that the applicability of montelukast as a probe of CYP2C8 activity in vitro and in vivo may be severely compromised due to important role of UGT1A3 and involvement of multiple CYPs in its metabolism. In addition, considering the lack of selective markers for UGT1A3, montelukast may be used as a selective marker of the UGT1A3 in vitro and in vivo.
Educação no ensino médio : uma forma de inclusão excludente?
(Universidade Federal de São Carlos, 2015-08-25)
Franco, Glaziela Aparecida
;
Nascimento, Manoel Nelito Matheus
;
https://lattes.cnpq.br/4486910967478337
;
https://lattes.cnpq.br/0634326323830379
The present paper researches the exclusive inclusion occurring in the Public High School. The goal of this work is to analyze the exclusive inclusion processes which occur in the State Public High School of Minas Gerais, its policies and acting before the exclusion, as well as analyze the factor that contributes to the students’ failure and school evasion of a state school in Poços de Caldas (MG). The field research was made through interviewing school managers, teachers and students using a questionnaire. The analyzes of the interviews showed in general, that the students are guilty of failing or evading the High School, by taking for granted the free instruction given by the State. There is a little awareness that the State only provides the free instruction, but it does not guarantee the staying of the young in school. The results of the questionnaires showed that there are other social restrictions such as the need of work to help the family, a lack of family support, precocious pregnancy, among others that also contribute to this failure and evasion. Therefore it is clear that the failures and evasions are not connected only to the school, but also to the families, to the government policies, and the student itself. We consider that the school must go beyond the role as a simple knowledge and reproductive transmitter, to be a knowledge production establishment, so being strengthened by knowledge and criticality, it may break free from the shackles of neoliberal system.
“Admirável mundo do empreendedorismo”: adoção do empreendedorismo como princípio educativo no curso Técnico em Administração do Instituto Federal do Espírito Santo
(Universidade Federal de São Carlos, 2015-08-25)
Pandolfi, Marcelo de Amorim
;
Lopes, Roseli Esquerdo
;
https://lattes.cnpq.br/1507752191797249
;
https://lattes.cnpq.br/9237056901408075
This study approaches the “entrepreneurial education” under a critical perspective, which assesses its ideological and contradictory character. Particularly, it analyses the insertion of the entrepreneurship discussion in the courses addressed to the education of technician in administration of the Federal Institute of Education, Science and Technology of Espirito Santo, focusing on the meanings assigned by its students and teachers to a education for Entrepreneurship. The primary and secondary data were collected through research techniques of bibliographical survey, documentary research, interviews, applications of questionnaires and also formation of focal groups were described and discussed both from the point of view of statistical analysis and the theoretical references that determined the study. Authors considered reference in their areas were studied in order to meet the speech in favor of education with focus on Entrepreneurship and, on the other hand, it was adopted the thought of philosopher and political scientist Antonio Gramsci to discuss and analyze critically the theme. It is supported that entrepreneurship is superposed to work, as educational principle, in the coursers addressed to the education of technician in administration of IFES and that although the speech of entrepreneurship have been absorbed in the level of common sense by the students and teachers of these courses, this audience has developed, although embryonic and diffuse form, a germ of good sense in relation to the theme. It is understandable that the position of IFES naturalizes the school duality and reinforces the policy of students early professionalization, which distances, therefore, of the search for a universal and omnipresent project of human formation. Is defended in this study that the education policies of the federal schools, within the high school, incorporate a proposal of a Unitary Education in accordance with gramscian patterns.
Recuperação de metais a partir da lama vermelha
(Universidade Federal de São Carlos, 2015-08-25)
Aguirre, Marcos
;
Bernardo, André
;
https://lattes.cnpq.br/5705402824877708
;
Giulietti, Marco
;
https://lattes.cnpq.br/7703659740618915
This paper describes an integrated process for recovering aluminum, iron, titanium, sodium and silica from red mud through a hydrometallurgical treatment sequence. The disposal of red mud, which is the largest waste produced by the aluminum industry, causes considerable environmental problems, and impacts costs greatly. This work presents a proposal to deal with it. Firstly, red mud is subjected to calcination at the 500-600°C range (thermal activation) so as to modify the structure of the metals present in red mud and make the attack with sulfuric acid easier. Next, the red mud is mixed with sulfuric acid and calcinated at 250- 300 °C (acid calcination). After digestion, the metal sulfates in the cake are dissolved by leaching with water and separated from the silica by filtration . Two routes to recuperate the leached metals are presented here, and the second one is analyzed economically. In this second method, silica is separated by filtration and all other metals in the leached solution are precipitated through a hydrometallurgical process in the form of their oxides. The remaining products present high purity level, thus being more easily marketed.
A política de financiamento de uma tecnologia de cuidado. Etnografia do processo de reforma psiquiátrica do Serviço de Saúde Dr. Cândido Ferreira
(Universidade Federal de São Carlos, 2015-08-25)
Sartori, Lecy
;
Villela, Jorge Luiz Mattar
;
https://lattes.cnpq.br/8301325600502054
;
https://lattes.cnpq.br/7435592706913728
This work analyzes the established funding policy in co-management agreement between the Municipal Health Sector Campinas and the Health Service Dr. Cândido Ferreira (Serviço de Saúde Dr. Cândido Ferreira–SSCF) since 1990. From the professionals‘ speech who works in this institution, I describe how, in the SSCF, making politics is inherent to the clinical practice, the negotiating relationship with that Health Sector, the writing strategies and manufacturing agreement documents. The ethnography was held at the Agreement Monitoring Commission, at the House Commission, at the meeting of the Therapeutic Residential Services‘ Team (Serviço Residencial Terapêutico–SRT) and at one training course of this professionals in this area and at commemorative event of the 20 years of its implementation. The changes arising from the reform process within the psychiatric model, described was based on mnemonic professional‘s speech, and its effects on the life of one resident of SRT, reveals the technical and architectural rearrangements that produced the rehabilitation of the inmates, the Individual Therapeutic Project and to a support network. In SRT, a ―care technology‖ was implemented, drawn from the singularity of users, combining not only psychiatric procedures and knowledge, but also clinical, psychological and geriatric in monitoring interventions (continuous control), monitoring (monitoring the distance) and management in order to govern the conduct and the life project of those. The ―clinic of detail‖, the ―therapeutic management‖ and the ―co-management relationship‖ allows the team to evaluate, calculate and discuss the individual demand, rationalized in data which are recorded in documents and made into parameters that disseminate information between professionals enabling the latter to measure the effectiveness of therapeutic interventions and improve them, plan them and manage the SRT goals. This way of proceeding, that transmutes the information in singular knowledge that subscribe thus into documents and makes them visible to the municipal administrators, justifies funding and authorizes the government practices to the SRT.
Identificação molecular e caracterização bioquímica de bactérias endofíticas associadas à cultura do pinhão-manso (Jatropha curcas L.) com potencial biotecnológico
(Universidade Federal de São Carlos, 2015-08-25)
Machado, Paula Cristiane
;
Souza, Clovis Wesley Oliveira de
;
https://lattes.cnpq.br/0781683628437007
;
Lacava, Paulo Teixeira
;
https://lattes.cnpq.br/8947678349043750
The Jatropha (Jatropha curcas L.), which belongs to the the family of Euphorbia is a plant genetically close to the Castor Plant (Ricinus communis l.), coming from Central America and being currently distributed in all tropical regions of the globe. In Brazil, this crop has received special attention as an alternative for the supply of vegetable oil as a raw material for biodiesel manufacturing, due to the biotechnological potential of its seeds. Several studies aimed at climatic adaptations and productivity have been developed on genetic variability of J. curcas; but few studies have been developed focusing on the analysis of the microbial community associated with this species. The interior of the plant is inhabited by endophyte microorganisms, which can be isolated from disinfected surface and do not put on risk the plant tissues of the host plant. This group of microorganisms has the ability to stimulate the growth of plants by direct mechanisms, such as/biological fixation of nitrogen, solubilization of inorganic phosphate indole acetic acid production (AIA) and indirect mechanisms, such as the antagonism towards phytopathogens. Moreover, endophytic microorganisms are considered promising for bioprospecting of enzymes. The aim of this study was to perform the characterization of seventy-two endophytic bacteria associated with the J. curcas plants, with potential for promoting plant growth and enzyme production. Of this total of tested isolates 40% showed positive results for fixation of atmospheric nitrogen, 43% solubilized inorganic phosphate, 69% have produced AIA, 36% showed some antagonistic activity to phytopathogenic fungi Alternaria alternata, 12% for Ceratocystis paradoxa, 22% for Fusarium proliferatum and 23% for Fusarium verticillioides. Regarding enzymatic activity, 16% of the isolates evaluated showed amyloid activity, 29% endoglycolytic, 29% lipolytic, 20% esterase, 46% pectinolytic (18% poligalacturonase and 43% pectato lyase) 37% proteolytic. From a collection of seventy two bacterial isolates, twenty-five were identified by means of the partial 16S rDNA gene embracing seven different genres: Bacillus, Citrobacter, Curtobacterium, Enterococcus, Microbacterium, Promicromonosporaceae and Sanguibacter were isolated as endophytic bacteria of Jatropha.
Programa de Ações Afirmativas da UFSCar: o processo de construção da política de reserva de vagas nos cursos de graduação
(Universidade Federal de São Carlos, 2015-08-25)
Pizza, Samira Nathalia
;
Nascimento, Manoel Nelito Matheus
;
https://lattes.cnpq.br/4486910967478337
;
https://lattes.cnpq.br/5185380993651935
This work is placed in the universe of affirmative action in higher education, emphasizing policies of vacancies reservation for black people in graduation courses. It was analyzed the development of the construction process of the Affirmative Action Program of the Federal University of São Carlos (UFSCar), between 2004 and 2007, being that the period before the implantation of the Affirmative Action Program from UFSCar, covering the stage of discussions and outlining a proposal for an affirmative action program for this university. This study aimed to discuss the vacancy reservation policy for black people in Brazilian higher education; verify the process that led on the introduction of vacancy reservation policy on the graduation courses of UFSCar and its consequences; analyze the process of elaboration and approval of the Affirmative Action Program from UFSCar, based on institutional documents and depositions of participants in this process. It is intended to understand what were the forces that acted for the approval of this policy at UFSCar and how this movement may have contributed on the national stage for the approval of Law n° 12.711.
Análise dos Impactos da aplicação do lean office na unidade de suprimentos de uma empresa construtora
(Universidade Federal de São Carlos, 2015-08-25)
Rossiti, Ivan Sanchez Malo
;
Serra, Sheyla Mara Baptista
;
https://lattes.cnpq.br/8528385567782505
;
https://lattes.cnpq.br/1288564016608610
In the current globalized world, the market is characterized by the high competitiveness, easy access to information and high consumer demand. The analysis of the impacts of lean office application to the supply unit on a construction company is very relevant, considering that companies focused on the civil construction area depend for consolidation of their businesses, efficient management strategies and suppliers of materials and services, external to their organization. The use of lean office as a management tool in the purchasing department of construction companies offers a competitive advantage amid the current market situation. Thereby, this study seeks to clearly conceptualize the lean philosophy and its tools as well as the management of the information systems and also the management of the supply chain, among other aspects. One construction company was then selected for the design research. This company contributes with information for the accomplishment of this work. The method used in this dissertation consists in describing the company, drawing the preliminary map of the supply unit, from this, it was possible to draw up the value stream map in the present state. With this map it could be analyzed and proposing improvements in the production process and then, designed a value stream map in the future state, applying these enhancements. The results led to the identification of flaws and possible opportunities for management improvements in the company.
Expressão gênica diferencial relacionada ao conteúdo de ferro no músculo em animais nelore
(Universidade Federal de São Carlos, 2015-08-26)
Diniz, Wellison Jarles da Silva
;
Tizioto, Polyana Cristine
;
https://lattes.cnpq.br/4754030540306395
;
Regitano, Luciana Correia de Almeida
;
https://lattes.cnpq.br/9595338480545794
Iron (Fe) is an essential micronutrient for cellular homeostasis. Structural component of proteins or enzyme cofactor, Fe has participation in important metabolic pathways that include oxidative metabolism, oxygen transport, cell proliferation and immune system function. Despite of its essentiality, Fe has a toxic potential to cells when in excess. So, a sophisticated system is needed to coordinate the process of absorption, recycling, use and storage. Mutations in genes related to homeostasis of this mineral may potentially alter the cellular distribution and storage. Furthermore, the Fe levels affect biological pathways such as carbohydrate and lipid metabolism. Iron content in cattle muscle has been associated with many sensory and technological parameters of meat quality. However, to date, studies that evaluate how the iron levels in the muscle can alter gene expression and the consequences for the metabolism in cattle are still absent. Therefore, this study aims to identify differentially expressed genes, metabolic pathways, gene interactions and potential regulatory biological mechanisms of physiological processes related to meat quality parameters. Longissimus dorsi (LD) muscle were collected at slaughter for total RNA extraction and determination of CFe by optical emission spectrometry (ICP OES). Eight Nelore steers, who are representatives of extreme value for Genetic Genomic Estimate (GEBV) for iron content (CFe), were selected from a reference population of 373 animals. The sequencing of the total mRNA of extreme animals was carried out from the next generation Illumina technology, which resulted in average l9.13 million of reads per sample after quality control and trimming. Data analysis carried out by Tuxedo Suite pipeline identified 49 annotated and differentially expressed genes (DE) (FDR <0.05) between groups of extremes for GEBV value for CFe. From the DE genes, 18 genes were up-regulated and 31 down-regulated for animals of low GEBV for CFe. Candidate genes for meat quality traits were identified in this study and they are related to transport and lipid metabolism. Other pathways identified through functional enrichment analysis include cell growth and development, function of the hematological system, among others. Canonical signaling pathways (interferon signaling, thyroid receptor activation (TR/RXR) and complement system) and canonical metabolic pathways (biosynthesis of stearate, fatty acid biosynthesis and palmitate biosynthesis) were also identified. Although this study did not identify genes with direct role in the regulation of Fe content, our results suggest biological pathways influenced by this mineral and contribute with information to the understanding of their participation in processes affecting quality of meat. This information will be useful in developing strategies that contribute to the production of better quality meat, healthy and nutritionally rich. In addition, this information may help in understanding of metabolic disorders in other species, including humans.
Geração de energia elétrica domiciliar solar e eólica: análise das condições socioeconômicas para implantação em residências de baixo consumo
(Universidade Federal de São Carlos, 2015-08-26)
Ciamponi, Celso Eduardo Souza
;
Marques, Sílvio César Moral
;
https://lattes.cnpq.br/6047434055828372
;
https://lattes.cnpq.br/6185622617604451
This paper presents the results of the economic feasibility analysis of implementing a distributed generation system based on electricity produced from wind and / or solar systems in the cities of Sorocaba, São Paulo; Brasilia, Federal District; Rio Branco, Acre; Porto Alegre, Rio Grande do Sul; Manaus, Amazonas and Fortaleza, Ceará. Thus, three scenarios were raised as well as the consumption of energy generated, in full or having to be complemented with the use of the normal distribution network. For each of the scenarios considered the following indicators were raised: NPV, IRR, and Payback final balance in the life of the equipment, based on a TMA equal to the government Selic rate. As a result we had a payback between 8 and 12 years in the best case scenario and between 12 and 16 years in the worst scenario analyzed, but all were positive NPV and final balance at the end of life of equipamrnto In this way it was possible to determine for these cities that the best structure to be implemented and serve as a basis for analyzing the implementation of this same infrastructure in other locations in Brazil, particularly in more remote places where access to electrification in the centralized system becomes more difficult to arrival.