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Caracterização farmacológica dos efeitos induzidos pelo complexo de rutênio cis-[Ru(H-dcbpy-)2(Cl)(NO2- )] e Nitroprussiato de Sódio na disfunção endotelial
(Universidade Federal de São Carlos, 2016-04-15) Buzinari, Tereza Cristina; Pestana, Cezar Rangel; https://lattes.cnpq.br/2977349506621829; Rodrigues, Gerson Jhonatan; https://lattes.cnpq.br/6725550216586910; https://lattes.cnpq.br/8950184250539748
Endothelial dysfunction has been considered a marker for the presence of cardiovascular disease. It is characterized by decreased release of vasodilatory factors and increased of vasoconstrictors factors. Nitric oxide (NO) is the main endogenous vasodilator molecule that regulates the vascular tone and homeostasis. Decrease in the bioavailability of NO can be caused by a variaty of factors, including the increase in the production of superoxide radical O2 •-. The production of O2 •- can be stimulated by angiotensin II, by the enzyme complex of the NADPH oxidase activation. Thus, the objective of this work was to study the effects induced by ruthenium complex cis-[Ru(H-dcbpy-)2(Cl)(NO2 -)] (DCBPY) and sodium nitroprusside (SNP) in endothelial dysfunction model, as well as perform the pharmacological characterization of the dependent effects removal of O2 •- and release of nitric oxide (NO) induced by these drugs. Normotensive (2K) and hypertensive (2K-1C) wistar rats were used. Aortic rings with intact endothelium were placed in a myograph and incubated with DCBPY: 0.1; 1.0 ou 10 μM ou com SNP: 0.1; 1.0 ou 10 nM during 30 minutes. Curves concentration-effect of acetylcholine (ACh) were built where it was possible to analyze all concentrations DCBPY and NPS improved relaxation induced by ACh. NO was measured intracellular (for DAF-2DA probe) in HUVEC treated with 0.1 μM of DCBPY, 0.1 nM a SNP and 0.1 μM DETA-NO. It was not detected NO release of the compounds DCBPY [0.1 μM] and SNP [0.1 nM]. It also evaluated the release of NO compound DCBPY using an electrode selective for NO. The compound DCBPY spontaneously release NO in solution form concentrationdependent, starting from 10 μM concentration. DCBPY released more NO in the presence of cells. This could be due to the reduction of the compound by reducing cell. Intracellular detection of superoxide radical (O2 •-) was obtained by using the fluorescent probe (DHE). Our results show that treatment of cells with DCBPY [0.1 μM] and SNP [0.1 nM] decreased the fluorescence intensity cells stimulated with angiotensin II. Thus, it is suggested that DCBPY and SNP at a concentration which does not release NO, inside the cells, they are capable of attenuating endothelial dysfunction by inactivating superoxide.
Verdades econômicas e verdades políticas - o sistema financeiro em debate
(Universidade Federal de São Carlos, 2016-04-15) Assis, Karina Gomes de; Grün, Roberto; https://lattes.cnpq.br/6028266827740491; https://lattes.cnpq.br/4058077286734344
This thesis is dedicated to the unveiling of the building game of the Brazilian political and economic possibilities in the recent period taking into account a specific period of national political and economic debate between the presidential elections of 2002 and the first year of the Lula government. We start from the premise that such possibilities, through establishment of truths, strengthen themselves from the interplay of forces produced in the economic and political fields whose success depends on the degree of strength of actors, groups and institutions in the scenario of dispute. We look back on the debate occurred around the financial rules discussed in the National Congress, which extends and is gain ground in elections for the presidency of the republic, where Lula and Serra would dispute the first and second round. Economic issues are discussed in the light of the broader issues that concern a more general situation of planning of Brazilian society, demonstrating how this debate is part of a dispute that goes beyond economic and political issues, it really concerns the cultural order to be legitimized. In this context actors, groups and institutions, from their capital, articulate themselves in the construction of possibilities, establishing criteria of truths that conform the interpretive lens of reality, interesting point to check the trends to which is subject to Brazilian society.
Campos e redes na análise das organizações: explorando distinções teóricas e complementaridades metodológicas
(Universidade Federal de São Carlos, 2016-04-15) Candido, Silvio Eduardo Alvarez; Sacomano Neto, Mário; Côrtes, Mauro Rocha; https://lattes.cnpq.br/0194644249955417; https://lattes.cnpq.br/0000793038362058; https://lattes.cnpq.br/8988613760967305
Neste ensaio, exploramos as distinções teóricas e complementaridades metodológicas existentes entre abordagens que conceitualizam as estruturas sociais com base nas noções de campos e redes. Essas perspectivas se opõem tanto à visão atomizada quanto à supersocializada da ação e buscam superar a dicotomia entre estrutura e agência, mas possuem diferenças conceituais importantes. Aspectos epistemológicos e conceituais são discutidos, evidenciando que apesar de ambas serem consideradas relacionais, elas evitam a reificação da teoria de maneiras distintas. Apontamos que a forma como a noção de campo é utilizada por autores como Pierre Bourdieu e Neil Fligstein é articulada em um referencial teórico relacional, no qual a definição da estrutura é inseparável da de agência e do poder, possibilitando a superação de limitações da abordagem de redes. Enfim, argumentamos que o uso das técnicas de análise de redes pode ser orientado pelas teorias de campos.
Avaliação do comportamento hidrológico de poços de infiltração de águas pluviais sob diferentes concepções
(Universidade Federal de São Carlos, 2016-04-15) Ferreira, Thays Santos; Barbassa, Ademir Paceli; https://lattes.cnpq.br/2979012440240781; https://lattes.cnpq.br/5744881406566183
Infiltration wells are BMP that occupy small urban area in order to minimize the effects of urbanization and soil sealing. The BMP reduces the frequency of flooding in urban areas. The present study aims to evaluate the behavior of two infiltration wells. One (Poço1- SC) was constructed with concrete rings get laterally together with the soil without the use of lateral holes and with a granular layer at the bottom of the BMP. The other (Poço2-GHidro) comprises the use of lateral concrete rings, a granular lateral and external layer external to improve the distribution of water, a filter of geotextile in the cover, and additional filters at the bottom and at the lateral wall between the gravel and soil. The experimental program involves the soil characterization, monitoring and modeling of real and simulated rainfall events imposed two systems. In addition, physical clogging tests were conducted in order to provide the understanding of the behavior of the geotextile filter applied in infiltration wells in order to estimate the service life. After two years, significant differences between the hydrological behaviors of the two infiltration wells were not identified and significant indication of clogging, was not observed. The calibration of the Puls model applied in modeling was employed using constant and variable hydraulic conductivity (K) values. In both wells the model showed more satisfactory results when variable K is used. This was observed for both the real and simulated events. In physical clogging tests, it was concluded that the solids particle distribution presents in rainwater runoff has a significant effect in the behavior of geotextile filter. The estimated average of service life of the filter in the Poço2- GHidro, at the conditions in which it is imposed, varies from 31 to 71 years, which depends on the type of soil in rainfall water runoff.
Proposta de metodologia para avaliação de acessibilidade em cidades de porte médio : um estudo de caso em São José do Rio Preto
(Universidade Federal de São Carlos, 2016-04-15) Bernal, Luciana Mação; Ferreira, Marcos Antonio Garcia; https://lattes.cnpq.br/2643134259454260; https://lattes.cnpq.br/6245633021120476
This research aims to propose a methodology for accessibility evaluation in middle-sized cities presenting a case study held in São José do Rio Preto (SP), city in the northwest of the São Paulo state. For this, the research used is based on a quality indicator (SQI – Sidewalks Quality Index, developed by Ferreira e Sanches, 2001). The questionnaires application in wheelchair users allowed the information collection in a qualitative and quantitative level regarding of security, comfort and environment in sidewalks and crossings and the carry through of a technical evaluation in the central area of the city. From these steps, as a methodology proposal, it was possible to elaborate an Accessibility Evaluation Index (AEI). This index was applied in the central area of the case study and an auditing (validation) was realized in order to verify the correct elaboration of the index. The present research was applied in a middle-sized city, the city type that has the fastest currently increase (IBGE, 2010), making the index an important accessibility evaluation tool. Thus, it grants the correction of identified accessibility problems avoiding the formation of cities whit segregated spaces, in people with some type of deficiency, with reduced mobility or elders do not have access to the city.
Dois ensaios sobre precificação de ativos
(Universidade Federal de São Carlos, 2016-04-15) Marconi, Tamyris; Diniz, Marcio Alves; https://lattes.cnpq.br/8948404469003829; https://lattes.cnpq.br/1329040435179017
Find fair (according to some criterion) prices for assets in financial markets is one of the most important pillars of Finance Theory. To accomplish this, the Asset Pricing Theory has a mathematical formulation, based mainly on Probability Theory. In this dissertation we present such theory, which is essentially based on mar- tingales, important objects of Probability Theory. Alternatively, we also present an Asset Pricing Theory based on the Coherence Theory of Bruno de Finetti in order to compare, informally, such approaches.