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Geração de rótulo de privacidade por palavras-chaves e casamento de padrões
(Universidade Federal de São Carlos, 2016-07-13)
Pontes, Diego Roberto Gonçalves de
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Zorzo, Sérgio Donizetti
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https://lattes.cnpq.br/2523715806470871
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https://lattes.cnpq.br/0774219282520030
Users do not usually read privacy policies from online services. Among the main reasons for that is the fact that such policies are long and commonly hard to understand, which makes the user lose interest in reading them carefully. In this scenario, users are prone to agree to the policies terms without knowing what kind of data is being collected and why. This dissertation discusses how the policies' content may be presented in a more friendly way, showing information about data collection and usage in a table herein called Privacy Label. The Privacy Label is a table with lines named according to data collection terms and columns named according to expressions that reveal how the data is used by the service. The table content shows if the policy collects a particular data to a particular usage. To generate the Privacy Label, a study was made in a set of privacy policies to identify which terms repeat more often along the texts. To do so, we used techniques to find keywords, and from these keywords we were able to create privacy categories. The categories define which kind of data is being collected and why, which are represented by cells in the Privacy Label. Using word comparison techniques, a privacy policy can be analyzed and important information can be extracted by comparing its terms with the terms from the privacy categories. For each category we find, we show it in the Privacy Label. To assess the proposed approach we developed an application prototype, herein called PPMark, that analyzes a particular privacy policy, extract its keywords and generates the Privacy Label automatically. The information extracted was analyzed regarding its quality using three metrics: precision, recall and f-measure. The results show that the approach is a viable functional alternative to generate the Privacy Label and present privacy policies in a friendly manner. There are evidences of time saving by using our approach, which facilitates the process of decision making.
Crowdfunding no Brasil : um estudo sobre a plataforma Catarse
(Universidade Federal de São Carlos, 2016-07-14)
Aguiar, Carlos Eduardo Magalhães Vieira de
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Sá Neto, Arthur Autran Franco de
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https://lattes.cnpq.br/5055550097454248
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https://lattes.cnpq.br/6156043859787876
At the end of the twentieth century and early twenty-first century, with the advent of digital technologies, the proliferation of the Internet and the cheapening of audiovisual equipment, new options have emerged to produce, distribute and show films. Among these options, highlight the practice of crowdfunding, one of crowdsourcing models, as an alternative possibility of national film funding. Nevertheless crowdfunding still a recent practice and little known in the country, with many platforms being launched and also closed, and the vast majority of funded projects are especially concentrated in the southeast region. This thesis sought to discuss this scenario, taking as its starting point the authors Jeff Howe and Henry Jenkins, and also Brazilian academic research on crowdfunding published until August 2015. The study subjects were the online community Crowdfunding BR and Brazilian platform of crowdfunding Catarse, focusing on projects of this platform in the category named Film and Video. The result indicates datas able to expand the reader's understanding and stimulate critical view of this practice, based on the presentation of its origins, organization mode, propagation around the world and it insertion in Brazil, making possible the understanding of the current context and the potential not yet explored of crowdfunding in the country.
Estudo de filmes de poli(ácido lático) obtidos por fiação por sopro em solução reforçados com nanocristais de celulose
(Universidade Federal de São Carlos, 2016-07-15)
Parize, Delne Domingos da Silva
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Marconcini, José Manoel
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https://lattes.cnpq.br/5373845785326215
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Mattoso, Luiz Henrique Capparelli
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https://lattes.cnpq.br/5839043594908917
Solution blow spinning is a technique to produce micro- and nano-scale fibers, forming films with high porosity and surface area. Chemical modifications or the incorporation of nanostructures in these fibers can improve the performance of these films for various applications, such as membranes, tissue engineering and sensors. Therefore, the aim of this work was to study poly(lactic acid) (PLA) films obtained by solution blow spinning reinforced with cellulose nanocrystals (CNC). First, different solvents were evaluated in order to determine the best processing conditions and the feasibility of using the solvent dimethyl carbonate (DMC) in the production of PLA films by solution blow spinning. Polymer concentration showed to be the most significant parameter affecting fiber diameter and DMC presented advantages over 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) and chloroform due its less toxicity, and therefore, is an alternative solvent with an affordable price, using a more environmentally-friendly process. Subsequently, the CNCs were extracted from bleached eucalyptus kraft pulp by sulfuric acid hydrolysis, which were chemically modified with maleic anhydride (CNCMA). Then, composite films of PLA/CNC and PLA/CNCMA were obtained by solution blow spinning and the results indicated that the addition of nanocrystals did not significantly affected fiber diameters, although the fiber diameters tended to decrease with the increase of the nanocrystals concentration. The results also indicated that the nanocrystals may have increased the degree of PLA polymer chains orientation and that the composite films presented a more hydrophilic behavior when compared to the pure PLA film. It suggests that some of the nanocrystals may be on the surface of the fibers, indicating that these composite films are promising for filter and adsorbents membranes application.
Produção de biocombustíveis a partir de glicose e manipueira
(Universidade Federal de São Carlos, 2016-07-15)
Chogi, Marianne Akemi Neroni
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Silva, Ariovaldo José da
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https://lattes.cnpq.br/2240705120810231
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Duarte, Iolanda Cristina Silveira
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https://lattes.cnpq.br/2626035341263254
Biofuels are produced from clean alternative energy sources and one example is biobutanol, a fuel that can be produced by fermentation of different raw materials. The production of butanol is carried out by fermentative metabolism of solvent-producing microorganisms, with acetone and ethanol as major byproducts (ABE fermentation). This work aims to produce biobutanol using strains Clostridium beijerinckii (ATCC 10132) and Clostridium acetobulylicum (ATCC 824) and four different inoculum: ES - swine effluent digester located in the Água Branca Farm in the municipality of Itu; LR - UASB sludge of sewage treatment plant from the city of Porto Feliz; ES - cattle manure; SL - Soil from sugarcane cultivation in Sorocaba region. Glucose and cassava wastewater were used as substrate. The biobutanol production efficiency was evaluated for each strain and inoculum in fermentation batch reactors in which the sole substrate was glucose or cassava wastewater. Both strains produced biofuel, and C. beijerinckii (ATCC 10132) was more efficient yielding 0.33±0.08 g L -1 butanol and 1.65±0.23 g L -1 of ethanol from 30 g L -1 of glucose. When cassava wastewater was used as substrate (10 g L -1 of reducing sugar), the production of butanol was 0.64±0.1 g L -1 and ethanol was 2.47±0.07 g L-1 in comparison to 0.27±0.13 g L -1 butanol and 1.72±0.18 g L -1 of ethanol produced when C. beijerinckii were fed with glucose 10 g L -1 as control. Fermentation inocula produced only butyric acid with concentrations of 0.31±0.04 g L -1 for cattle manure and 0.12±0.013 g L -1 for swine effluent. As the cattle manure showed higher production of butyric acid, this culture was chosen for fermentation with cassava wastewater at COD 5 g L-1 . First of all the inoculum´s DNA was amplified with the pair of primers Sj-F and Sj-R specific for the genus Clostridium. With the confirmation of the clostridia presence, the fermentation with cassava wastewater at 5 g L -1 of COD was performed. This fermentation was compared with the strain C.beijerinckii growing in medium without enrichment and cattle manure with and without medium enrichment. C. beijerinckii biofuel production was 0.02 g L -1 of butanol and 0.69 g L-1 of ethanol after 12 h of fermentation, while cattle manure fermentation yielded 0.168 g L -1 of ethanol after 106 h in enriched medium and 0.026 g L-1 of ethanol in medium without enrichment after 12 h. These results demonstrate the feasibility of using cassava as a substrate for the production of biobutanol, ethanol and the possibility of producing biobutanol by cattle manure and swine effluent since butyric acid is an intermediary product of the pathway leading to butanol synthesis.
Participação dos receptores opióides mu e kappa da substância cinzenta periaquedutal na febre induzida por estresse de contenção
(Universidade Federal de São Carlos, 2016-07-15)
Silva, Caroline Cristina
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Bícego, Kênia Cardoso
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https://lattes.cnpq.br/0169967378071426
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https://lattes.cnpq.br/6987381269659614
The endogenous opioids are involved in analgesia, thermoregulation and physiological responses to various stressful stimuli such as infection, psychological stress and hypoxia. The mu and kappa receptors in the hypothalamus play a role in endotoxin-induced fever and hypoxia-induced anapyrexia (opposite response to fever), respectively. In addition, periaqueductal gray (PAG), which express both mu and kappa receptors, is involved in defence and thermoregulatory responses. Thus, our hypothesis is that mu and kappa opioid receptors in the PAG modulate the restraint-induced fever in rats by activating and inhibiting this response, respectively. To this end, body temperature (Tb) and heat loss index (HLI; inference for heat conservation/loss) and oxygen consumption (VO ; inference for thermogenesis) of unanesthetized Wistar rats submitted or not to restraint stress, was monitored before and after intra-PAG microinjection of the selective mu opioid receptor antagonist (CTAP; 1 and 10 μg/ 100 nL/ animal), the selective kappa-opioid receptor antagonist (nor-BNI; 1 and 4 μg/ 100 nL/ animal), or vehicle (saline; 100nL/ animal). CTAP and nor-BNI did not change the Tb or the HLI of the animals in euthermia. During the restraint stress, Tb increased in all groups of animals. However, this effect was significantly lower in animals treated with CTAP, and significantly higher in animals treated with nor-BNI. No treatment affected HLI, but CTAP decreased thermogenesis and nor-BNI increased thermogenesis. The results indicate that the mu and kappa opioid receptors in the PAG of rats play a pyrogenic and antipyretic role, respectively, during fever induced by restraint stress and these receptors in PAG may not be essential for the maintenance of Tb during euthermia.
Reconhecimento da ligação dos anticorpos anti-HCV com proteínas recombinantes do vírus da hepatite C por meio do teste ELISA
(Universidade Federal de São Carlos, 2016-07-15)
Souza, Laís Cristina de
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Anibal, Fernanda de Freitas
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https://lattes.cnpq.br/4918261968772806
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https://lattes.cnpq.br/2916120654952183
Viral hepatitis is a major public health problem worldwide and in Brazil. They are notifiable diseases and according to estimates, billions of people have had contact with the hepatitis and millions are chronic carriers. Infection with hepatitis C virus (VHC) is a major problem worldwide public health due to the high rate of progression to chronicity, the evolutionary potential for cirrhosis and hepatocellular carcinoma, major complications leading to death. In general it can be said that in the last decade there have been major advances in the diagnosis of hepatitis C. In this period there was progressive improvement in sensitivity and specificity of the tests used to detect antibodies against the VHC virus. However, it is necessary that more accurate tests are developed. Thus, considering that the concern for the detection of hepatitis C increases every day, especially in blood banks; the diagnostic methods of this infection are of great clinical relevance and may be used as markers chronicity and indicative of therapeutic efficacy. Therefore, this work proposed to evaluate the connection and recognition of anti-VHC antibody positive and positive genotyped samples in patients with hepatitis C through the standardization of procedures and solutions used in qualitative ELISA. There was the process of awareness of microplates with recombinant chimeric protein, made the analysis of sensitivity, specificity, reproducibility and validity of the method. We obtained from ELISA assays with standardized recombinant proteins a protocol able to have a good performance of the main components of the reaction, and antigens conjugated with good resolution. This study presented ELISA results valid 95.69%, 100% reproducibility, 94.5% sensitivity and specificity 99.3%, higher than the ELISA performed with multiepitopo protein MEHCV who presented with sensitivity (92.86%) and specificity (82.89%). The standard ELISA can be used as a qualitative serological technique aimed at detection of anti-VHC antibodies, as demonstrated with great reactivity in patients infected with VHC.
Potencial do fertilizante orgânico classe D no cultivo inicial de eucalipto
(Universidade Federal de São Carlos, 2016-07-18)
Afáz, Daniela Cristina de Souza
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Viani, Ricardo Augusto Gorne
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https://lattes.cnpq.br/3250752369062840
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Souza, Claudinei Fonseca
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https://lattes.cnpq.br/4858219292242433
Organic fertilizers are increasingly identified as an alternative route for agriculture, acting as a conditioner of soil physical, chemical and biological properties, and as a source of nutrients for crops. Therefore, this study evaluated the feasibility of use for a “class D” organic fertilizer obtained from a sewage treatment plant, as an alternative fertilizer for eucalyptus cultivation. The experiment was conducted in Agricultural Science Center-UFSCar, in Araras, SP, in a greenhouse. Cultivation occurred from November 2014 to January 2015, totalizing 75 days. We adopted a complete randomized design, with five treatments and seven repetitions, with plants cultivated in 11 L pots. The tests considered a testimony treatment with no fertilization (T1), three treatments (T2, T3, T4) with organic fertilizer addition (25%, 50% and 75% of the pot volume) and treatment (T5) with conventional fertilizers, all in sandy soil. Drip irrigation three times a day was used with a flow rate of 1 L h-1. We measured plant height and soil electrical conductivity every two weeks. Relative growth rate (RGR), plant dry mass and leaf micro and macro nutrients concentration were evaluated at the end of the experiment. Plant dry mass, relative growth rate and nutritional data were submitted to analysis of variance and the means compared by Tukey test at 5% probability. We found no significant differences in plant height. Treatments T3 and T5 had a greater relative growth rate (p < 0.01). Plants from the fertilized treatments had more leaf macro and micronutrients when compared to the testimony and, in general, leaf nutrient values were within reference values for eucalyptus growth. Soil electrical conductivity increased with the increase in the percentage of organic fertilizer in the soil, what is explained by its content of salts charges. However, the organic fertilizer did not promote salinity to plants. Thus, we conclude that the “class D” organic fertilizer we tested is a potential substitute of conventional mineral fertilization for eucalyptus cultivation.
Análise da paisagem do município de Salto de Pirapora, SP como subsídio para planejamento ambiental
(Universidade Federal de São Carlos, 2016-07-20)
Pires, Valquíria Rodrigues de Oliveira
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Toppa, Rogério Hartung
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https://lattes.cnpq.br/0673898572494729
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https://lattes.cnpq.br/3442165120089663
The disorderly process of land use and occupation in Salto de Pirapora city, resulting in an intense forest fragmentation, and the lack of research in the city, led the development of this work, organized into three chapters. With the main objective to determine areas of interest for conservation and thus provide support for Salto de Pirapora planning and environmental management. Chapter 1 describes the mapping of use and occupation of land, and was set 14 classes. The results indicated an agroforestry system matrix, with the following most representative classes in the territory: clean field representing 29.49% of the municipal area, followed by forestry class with 21.88%. The forest remnants represent 21.32% of the territory. It also describes the situation of the Protect Area of the city, that doesn’t have a decree regulating its functioning, showing an urgent need to expedite the process of its creation. Chapter 2 describes the Permanent Preservation Areas conflict, indicating that 17.16% of the city is occupied by PPA streams and springs. Of this percentage, 50.70% have vegetation and 41.94% lies in a situation of conflict, highlighting the importance of a recovery plan for the natural vegetation of these areas. Chapter 3 addresses the areas of interest for conservation selected by AHP. According to the results, 700 mapped fragments, 9 had priority Very High and 14 had High (3.29%), corresponding to 44.71% of the forest cover. Adding the fragments of Very Low and Low classes, was obtained 534 fragments (76.29%), corresponding to 32.94% of the vegetation cover. The AHP application in GIS environment for selecting conservation areas of interest was efficient in evaluating the distribution of the fragments in the landscape according to their priority, offering alternatives to assist the territorial planning and arrangement process of the city. And finally, it is concluded that the current scenario of forest cover in Salto de Pirapora city is worrisome due to the disorderly process of land use and occupation. It is hoped that these findings will contribute to the characterization of the territory and assist the decision of the planners regarding the development of conservation strategies and forest restoration programs, especially in Permanent Preservation Areas. Through multi-criteria analysis, areas of interest for conservation based on their ecological relevance can be prioritized, providing support for the process of planning and environmental management of the city and facilitates the targeting of conservation actions for the whole territory.
Sentidos no espaço urbano : os dizeres de Gentileza dentro e fora da cidade
(Universidade Federal de São Carlos, 2016-07-25)
Yado, Thaís Harumi Manfré
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Sousa, Lucília Maria Abrahão e
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https://lattes.cnpq.br/8828821460772801
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https://lattes.cnpq.br/1687549626100744
This research has as theoretical scope the principles of Discourse Analysis (DA) French second array concepts postulates by Michel Pêcheux. We have the goal of building joints and analysis between the echoes the name of the Prophet Gentileza and his work – Urban book circulated by the space of the city of Rio de Janeiro. Through the discourses present in urban areas – social, symbolic, heterogeneous spaces, memory, full of meanings, movement of senses, spaces of enunciation. In the first chapter, we present how the businessman José Datrino becomes the Gentileza, after the burning of a circus in the city of Niterói. In the second chapter, we expose the traits that the subject position Prophet suffered over time, with your symbologies and influences. In the third chapter, we report about the Urban book, as the Prophet Gentileza turned a series of walls ashes in poetry in the open and that senses this artistic intervention can influence the life of the townspeople. In the fourth chapter, we show the deletion of the work of the Prophet that happened after his death, as the power of the State is imposing, but through the power of social movements that order-deletion given by the State is reviewed and the work is retrieved and protected as cultural heritage. And in the fifth and final chapter, we present echos the voice in Gentileza caused in society and that we can hear the echoes and references from their production, these echoes were shifted to other contexts and applied differently, but we can still see the features that refer us to the Prophet and his work, Urban book.
O Grupo de Intervenção Rápida (GIR): a gestão intramuros do encarceramento em massa no Estado de São Paulo
(Universidade Federal de São Carlos, 2016-07-26)
Miranda, Yasmin Lucita
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Sinhoretto, Jacqueline
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https://lattes.cnpq.br/7743699562476490
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https://lattes.cnpq.br/6094218478877173
Taking into account the transformations and characteristics of the prison scenario of the state of São Paulo, between the decades of 1990 and 2000, defined by specificities such as mass incarceration, the new inmates' profile, the operation of criminal organizations and the expansion of the prison system throughout the state, the research aimed at understanding the social actors' perceptions surrounding the activities related to the SAP of São Paulo under the context of the elaboration and working dynamic of the GIR, that is comprised by ASP under the responsibility of the SAP. According to official informations, GIR aims to act in the prevention and intervention of rebellions and mutinies within the São Paulo prisons, its creation dates 2001.Our hypothesis is that the GIR was developed to combat the so-called criminal gangs within the prisons, especially the First Command of the Capital (PCC), because it was assigned the role of the two major riots in São Paulo prison system, the first in 2001 and the second in 2006. Along with this, we analyzed the creation of the post of Convoy Agent and Penitentiary Surveillance (AEVP), also in 2001, which characterizes an apparent demilitarization of prisons. The research was composed by qualitative methods, with the features: qualitative interview with social actors that surround the activities related to SAP, the documental research concerning laws, resolutions and projects relating to prison management and the review literature of the issues that circumscribed our interest. The analysis of the research material was accomplished following the guidelines proposed by Michel Foucault concerning speech analysis, considering, mainly, the exclusion procedures that manage and control speeches and the subjects that enunciate them. The main findings of this research show the development of political, legal and institutional arrangements within the SAP that promoted their autonomy under the Public Security of the State of São Paulo, through the expertise of its employees, especially the ASP part of the GIR and the AEVP. The replacement of the Military Police (MP) for these two groups did not mean a demilitarization of the prison. However, it became evident that the arrangements, as GIR, comprise a set of measures to assist in the management of a prison mass multiplied in a short period and imposed challenges for its administration. Moreover, these arrangements share a common characteristic that is present not only in the administration performed by SAP, but throughout the area of Public Security: the lack of transparency of the data and procedures.
Existência e semicontinuidade de atratores global, pullback e de trajetórias
(Universidade Federal de São Carlos, 2016-07-27)
Belluzi, Maykel Boldrin
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Schiabel, Karina
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https://lattes.cnpq.br/2677541143976758
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https://lattes.cnpq.br/4072119689022816
The mainly purpose of this paper is to study the asymptotic behaviour of abstract evolution equations. The first part of this work is dedicated to the attraction theory for univoque autonomous and nonautonomous problems and for multivoque autonomous problems. After that, we analyse the existence of the appropriate type of attractor for a reaction-diffusion equation (autonomous and with uniqueness property), a variation of the previous equation (which makes it no longer possible to ensure the uniqueness property) and a delayed differential equation (non-autonomous). For the two lasting equations, we also investigate the upper-semicontinuity of the families of the corresponding attractors.
Uma plataforma para disponibilização centralizada de dados abertos governamentais como suporte para aplicações no contexto de cidades inteligentes.
(Universidade Federal de São Carlos, 2016-07-27)
Veira, Daniel Ianegitz
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Álvaro, Alexandre
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https://lattes.cnpq.br/9929982894313130
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https://lattes.cnpq.br/5010369436467934
The Smart City (SC) concept aims to promote dynamic and flexible systems to the cities, that interact with each others and help to maintain the stability and scalability of it’s resources and services, usually through sensors and collectors, with high implantation and maintenance costs. On the other hand, the Open Goverment Data (OGD) are data relationated to the governamental activity, available on the Internet. The publications are fragmented in dierent and uncorrelated portals, also do not follow a standard pattern format. Thus, this work proposes a platform to collect and distribute OGD in a centralized way, in order to provide consolidated information to the context of SC. Also, two validations of this proposal are presented, the first one promoting the solidification of the platform and the second one being an experimental study applied at the academic environment, were eight graduation students where supervisionated, divided into two groups, during the development of two SC projects, consisting of comparative and graphic visualization OGD portals. The experimental group used the platform proposed here as a OGD source, and the control group used OGD collected directly through the governmental transparency portals. At the end of the study, with the intention to find benefits in the utilization of a centralized platform, statistical tests were applied to the collected metrics, and expressive advantages to the experimental group were found, related to the quantity of source-code lines and the development time, indicating that the platform oered benefits during the cycle of development of the project.
Estudo do perfil químico de Cyperus rotundus e avaliação do seu potencial de absorção de metais
(Universidade Federal de São Carlos, 2016-07-27)
Souza, Poliana Pereira de
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Silva, Maria Fátima das Graças Fernandes da
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https://lattes.cnpq.br/0457632122660653
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https://lattes.cnpq.br/6076960598053817
The following work describes the comparative study of the variation between chemical profiles of plants of the Cyperus rotundus species – where one was collected at Vale S.A.’s dumping ground in Canaã dos Carajás city, Sossego Mine (an area contaminated by heavy metals), and compared with another of the same species collected at an adjacent area (noncontaminated by heavy metals) – through the development of analytical methods such as HPLC-UV, NMR, LC-UVSPE-NMR, LC-MS/MS, as well as through the use of chemometric tools (PCA). Statistical methodologies and chemometric analyses associated with data generated by NMR allowed, through fingerprint profiles, the discrimination between the contaminated and non-contaminated plants and the characterization of some compounds that contributed significantly to such discrimination. ICP-AES analyses were also made, in order to determine metal concentrations in different plant tissues. When analyzing the variation between chemical profiles of plants of the Cyperus rotundus species through fingerprints and data obtained from HPLC-UV-SPE-NMR and LC-MS/MS, it was possible to detect variations regarding mainly phenylpropanoid acids, fatty acids, carbohydrates and aromatic compounds, among others, which were found sometimes in the contaminated plant, sometimes in the non-contaminated plant, sometimes in both, although at different concentrations. It was also observed that in most samples spectra showed much more intense and well-defined peaks for the contaminated, thus highlighting that these compounds can be involved in the defense mechanism of the plant in a situation of oxidative stress caused by metal contamination. The results of the metal determination analyzes by ICP-AES showed much higher concentrations of the Cu element in the vegetative aerial parts of contaminated plants (921 mg/kg) in relation to the non-contaminated (3.7 mg/kg), due to this metal being the main resulting product of the local mining site. It was found that practically all metal concentrations are considerably larger in the contaminated plants when compared with the non-contaminated, therefore suggesting the hyperaccumulating behavior of the Cyperus rotundus species
Resolubilidade local para duas classes de campos de vetores suaves complexos
(Universidade Federal de São Carlos, 2016-07-28)
Nunes, Luciele Rodrigues
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Santos Filho, José Ruidival Soares dos
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https://lattes.cnpq.br/6112529384454347
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https://lattes.cnpq.br/0471344391122229
This work study complex linear partial differential operators of order one without having terms of zero order (complex vector fields). We have established a necessary and suficient condition for local solvability of a class of operators which are not elliptic precisely in a 1-dimensional submanifold and we construct solutions for a class of operators satisfying the condition (P) and which are not elliptic precisely in a point.
Citotoxicidade de complexos de rutênio contendo aminoácidos sulfurados em células tumorais
(Universidade Federal de São Carlos, 2016-07-28)
Leite, Celisnolia Morais
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Batista, Alzir Azevedo
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https://lattes.cnpq.br/6469642481998660
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Moreira, Wania da Conceição
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https://lattes.cnpq.br/3016270106775634
The work presents the synthesis and characterization of three new ruthenium II complexes containing sulfur amino acids, to evaluate the probable influence of the amino acids on the complexes cytotoxic activity. The complexes were characterized by 31P, 1H and 13C NMR, infrared and UV-visible spectroscopies, cyclic voltammetry and differential pulse voltammetry, molar conductivity, elemental analysis, and monocrystal X-ray diffraction. The studies of lipophilicity showed Log P values for the compounds, within the limits indicated by the literature for good absorption. The reactivity study of the complexes showed that in compounds 1 and 2 there is an exchange of ligands when exposed to DMSO, generating several species in solution after the period of 48 h. While in compound 3 this exchange did not occur. In the interaction studies of the complexes with the DNA, results of spectrophotometric titration and viscosity were obtained, which indicated that the compounds interact weakly with the DNA, which may be electrostatic or between the grooves. In the study of the interaction of the complexes with the HSA, by spectrofluorimetric titration, the compounds showed a binding constant (Kb) of the order of 104, which indicated that the compounds interact with the HSA, with the mechanism of static interaction and the involved forces, are hydrophobic forces. The cytotoxicity of the complexes also evaluated against breast cancer cell lines (MDA-MB-231 and MCF-7) and a non-tumor cell, V79 (Chinese hamster fibroblasts), in which the compounds were active. The complex 2 stood out for presenting a selectivity index good (3.79) about the triple-negative breast tumor line (MDA-MB-231). Therefore, the results obtained in this study were relevant to contribute to the generation of knowledge about the importance of amino acids in the planning of new compounds as potential antitumor agents
Relação entre a certificação pela norma NBR ISO 14001 e a ocorrência de penalidades ambientais em organizações do estado de São Paulo
(Universidade Federal de São Carlos, 2016-07-28)
Rino, Carlos Alberto Ferreira
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Salvador, Nemésio Neves Batista
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https://lattes.cnpq.br/9930582531600560
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https://lattes.cnpq.br/7281970846784858
This work had as general-purpose search for a relationship between certification by Standard ISO 14001 and the occurrence of environmental penalties in organizations in the São Paulo State. It also had the objective to develop and apply a Penalty Reduction Indicator (PRI) to evaluate quantitatively the effectiveness of environmental management systems in relation to the reduction of penalties and a critical analysis of the accreditation and certification systems in Brazil. First, the INMETRO site, was conducted the survey of companies certified by ISO 14001 in the state of São Paulo. Later, lifting the number of penalties applied by CETESB these certified companies was done from January 2001 to June 2015. From there, we analyzed which companies had reduced the number of penalties after the implementation and certification ISO 14001. It used as intentional sampling criteria the companies that received more than five penalties in the period, thus forming a group of fourteen companies. Through qualitative analysis, on eleven companies verified the benefit of reducing the number of penalties. In four of these companies, the benefit occurred over time. In three companies has not verified the benefit of the reduction in penalties. The quantitative analysis performed by applying the IRP was possible for eleven of the selected companies. The IRP calculated showed that seven of these eleven companies (63.6%) had the indicators acceptable rating ("GREAT" and "GOOD"). Four companies (36.4%) were the indicators classified "REASONABLE" and "BAD", indicating that, for these, the Environmental Management System is not yet consolidated, improvements should occur. IRP was robust and efficient, indicating the importance of quantitative analysis and the use of a numeric indicator to corroborate the results obtained in the qualitative analysis. It is concluded that the implementation and certification of an Environmental Management System according to ISO 14001 can bring benefits to businesses because the implementation of a preventive culture, development of methodologies and procedures for environmental aspects and impacts, actions and responses to control and emergency documents (all items of ISO 14001). These can lead to a reduction in number of penalties. Finally, this study found that for the accreditation system, the activities developed by INMETRO are important to the pursuit of quality of certification bodies and consequently the certification processes. However, it found that this system still has some deficiencies. The paper also pointed out some deficiencies in the certification system, with recommendations for improvements.
Tris(trimethylsilyl)silane and visible-light irradiation : a new metal- and additive-free photochemical process for the synthesis of indoles and oxindoles
(Universidade Federal de São Carlos, 2016-07-29)
Silva, Gustavo Piva da
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Paixão, Márcio Weber
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https://lattes.cnpq.br/3773908504964104
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https://lattes.cnpq.br/0433962216004187
A combined tris(trimethylsilyl)silane and visible-light-promoted intramolecular reductive cyclization protocol for the synthesis of indoles and oxindoles has been developed (Scheme 1).1 This straightforward and efficient protocol shows a broad functional-group tolerance and enables rapid and practical synthesis of functionalized nitrogen-based heterocycles in high/moderate yields under additive and metal-free, mild photochemical conditions. Besides the synthetic developments, the reaction mechanism was also investigated by a set of controlled experiments and UVvisible analyses, as well as kinetic study.2 From these studies, we have concluded that the reaction pathway for this strategy occurs through an Electron Donor-Acceptor (EDA) complex.3 to be continued ...
Fadiga de ligas de titânio com superfície modificada com nanotubos
(Universidade Federal de São Carlos, 2016-07-29)
Bortolan, Carolina Catanio
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Oliveira, Nilson Tadeu Camarinho de
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https://lattes.cnpq.br/5165925219822865
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Bolfarini, Claudemiro
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https://lattes.cnpq.br/9231627080617037
Among the surface modification techniques to improve the fixation, biocompatibility and corrosion resistance of titanium implants, one of the most recent and promising is the electrochemical anodization in electrolytes with fluoride ions. This technique results in the formation of highly ordered arrays of titanium oxide nanotubes on the surface of these materials. Many researchers evaluated the biological performance of these arrays and obtained satisfactory results, showing that the formation of hydroxyapatite and cellular development are higher after its formation. However, there are no records about the study of fatigue behavior of titanium alloys after this surface treatment; an essential evaluation since the surface conditions of the implants influence the fatigue properties, especially crack nucleation, and the orthopedic implants are subjected to cyclic loads when in service. In this context, the objective of this research was to evaluate the effect of the formation of TiO2 nanotubes, through electrochemical anodization technique in a solution containing fluoride ions, on the fatigue performance of Ti-6Al-4V and Ti-6Al-7Nb alloys, using the staircase method to develop fatigue tests and taking the polished surface condition as reference. SEM, AFM and XRD techniques were applied to characterize the surfaces and to support the fatigue results. The fatigue limit for 5 million cycles, calculated by the statistical method of Dixon-Mood, was maintained for the Ti-6Al-4V alloy (846MPa ± 13 MPa) after the formation of nanotubes on its surface and presented an insignificant reduction in statistical terms for the Ti-6Al-7Nb alloy (846 MPa ± 13 MPa for the polished surface condition and 825MPa ± 11 MPa for the modified surface). The maintenance of fatigue properties of the alloys after electrochemical anodization was mainly attributed to the small scale of the average lengths of the nanotubes and to the existence of a compact oxide layer in contact with the metal substrate (corresponding to the completely closed bottom of nanotubes).
A geometria no ciclo de alfabetização : outros olhares a partir do PNAIC 2014
(Universidade Federal de São Carlos, 2016-07-29)
Francischetti, Elisângela Aparecida
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Passos, Cármen Lúcia Brancaglion
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https://lattes.cnpq.br/2297203444364327
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https://lattes.cnpq.br/3590894642507602
The present research aims to identify the perceptions of four literacy teachers, based on their own perspective, regarding the received continued formation; identify and analyze pedagogical practices for mathematical literacy from the perspective of literacy; and identify the marks of this formation in relation to the teaching and learning of geometry, as a result of the National Pact for Literacy in the Right Age (PNAIC), in 2014. The methodology of this study is qualitative in nature. Data collection was carried out in two schools of a municipal school network in the interior of São Paulo and consisted in the following instruments: questionnaires and semistructured interviews provided by the teachers, and classroom observations of the pedagogical practices of mathematical literacy, containing the perceptions of the researcher, recorded in a field diary. The research on teacher training was based on the contributions of Nóvoa (1999), Tardif and Raymond (2000), Tardif (2000; 2002), Mizukami et al. (2002), Reali (2009), Imbernón (2010) and Candau (2011). In relation to the teaching of mathematics in the initial years, we considered the studies of Nacarato, Mengali and Passos (2011) and Serrazina (2012) and, regarding the teaching and learning of geometry in the initial years, we referred to the research of Lorenzato (1993), Passos (2000), Pavanello (1989, 1993, 2004), Nacarato and Passos (2003, 2014) and Conti (2015). The results, products of the analysis of the answers emitted by the surveyed teachers, show that from the formations of the PNAIC there was an amplification of teaching practices contextualized in the classes of mathematics, fruit of didactic interventions that stimulated the construction of the mathematical knowledge in a significant way considering the teaching role as a key element of this construction of teaching knowledge. The program also developed, in the teachers, a greater awareness on the importance of the development of geometric thinking since the early years of the literacy cycle, expanding the pedagogical possibilities both in the figural and the conceptual elements. The pertinence of this research is based on the social relevance of the theme, seeking a theoretical deepening on the concepts of mathematical literacy in the perspective of geometry literacy, teaching and learning in the literacy cycle, as well as professional teacher development; thus, collaborating to the development processes of the professional's autonomy and consequently aiming at improving the quality of mathematics teaching in the literacy cycle.
Nanoestructured catalysts for organic reactions: design, synthesis and applications
(Universidade Federal de São Carlos, 2016-07-29)
Lima, Carolina Guimarães de Souza
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Paixão, Márcio Weber
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https://lattes.cnpq.br/3773908504964104
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https://lattes.cnpq.br/8050810029110335
The development of more efficient and selective catalysts actively contributes for the design of safer, cleaner and less energy-demanding processes, and, therefore, catalysis is one of the cornerstones of green chemistry. In this sense, supported-heterogeneous catalysts represent a great advance in this field, especially because they overcome the difficulty in catalyst separation associated to homogeneous catalysts. In this context, this thesis is focused on the development of nanostructured materials for application in Organic Synthesis. In Chapter 1, a brief introduction regarding fundamental concepts in catalysis is presented, focusing on the synthesis and application of magnetically recoverable catalysts. Chapter 2 described the design, preparation and characterization of a new magnetically recoverable niobium nanocatalyst for application in the synthesis of 3,4-dihydropyrimidinones via Biginelli reaction. The catalyst (Fe3O4@Nb2O5) was prepared by coating magnetite nanoparticles with niobium oxide by using a simple wet impregnation method. The developed protocol was applicable to a wide range of aliphatic and aromatic substrates, and structurally diverse products were obtained in excellent yields. Additionally, the nanocatalyst could be easily separated from the reaction mixture with the aid of a magnetic field and reused several times without any losses in its catalytic activity. Moreover, experimental observations provided an insight into the reaction pathway. Chapter 3 describes the synthesis and characterization of a magnetic ZSM-5 zeolite with core-shell type structure for application on the valorization of bio-derived furfuryl alcohol. The magnetic HZSM-5 zeolite catalyst was prepared by the encapsulation of magnetite particles in the zeolite grains using a cationic polymer followed by calcination and next, an ion exchange to obtain the zeolite in its acid form. Remarkably, the catalytic system displayed a tunable selectivity to γ- valerolactone, alkyl levulinates and even levulinic acid by simply changing the reaction conditions. Furthermore, the catalyst could be easily recovered and reused for several reaction cycles without significant losses in its catalytic activity.