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Resolubilidade local para duas classes de campos de vetores suaves complexos
(Universidade Federal de São Carlos, 2016-07-28) Nunes, Luciele Rodrigues; Santos Filho, José Ruidival Soares dos; https://lattes.cnpq.br/6112529384454347; https://lattes.cnpq.br/0471344391122229
This work study complex linear partial differential operators of order one without having terms of zero order (complex vector fields). We have established a necessary and suficient condition for local solvability of a class of operators which are not elliptic precisely in a 1-dimensional submanifold and we construct solutions for a class of operators satisfying the condition (P) and which are not elliptic precisely in a point.
Citotoxicidade de complexos de rutênio contendo aminoácidos sulfurados em células tumorais
(Universidade Federal de São Carlos, 2016-07-28) Leite, Celisnolia Morais; Batista, Alzir Azevedo; https://lattes.cnpq.br/6469642481998660; Moreira, Wania da Conceição; https://lattes.cnpq.br/3016270106775634; https://lattes.cnpq.br/9638881050186865
The work presents the synthesis and characterization of three new ruthenium II complexes containing sulfur amino acids, to evaluate the probable influence of the amino acids on the complexes cytotoxic activity. The complexes were characterized by 31P, 1H and 13C NMR, infrared and UV-visible spectroscopies, cyclic voltammetry and differential pulse voltammetry, molar conductivity, elemental analysis, and monocrystal X-ray diffraction. The studies of lipophilicity showed Log P values for the compounds, within the limits indicated by the literature for good absorption. The reactivity study of the complexes showed that in compounds 1 and 2 there is an exchange of ligands when exposed to DMSO, generating several species in solution after the period of 48 h. While in compound 3 this exchange did not occur. In the interaction studies of the complexes with the DNA, results of spectrophotometric titration and viscosity were obtained, which indicated that the compounds interact weakly with the DNA, which may be electrostatic or between the grooves. In the study of the interaction of the complexes with the HSA, by spectrofluorimetric titration, the compounds showed a binding constant (Kb) of the order of 104, which indicated that the compounds interact with the HSA, with the mechanism of static interaction and the involved forces, are hydrophobic forces. The cytotoxicity of the complexes also evaluated against breast cancer cell lines (MDA-MB-231 and MCF-7) and a non-tumor cell, V79 (Chinese hamster fibroblasts), in which the compounds were active. The complex 2 stood out for presenting a selectivity index good (3.79) about the triple-negative breast tumor line (MDA-MB-231). Therefore, the results obtained in this study were relevant to contribute to the generation of knowledge about the importance of amino acids in the planning of new compounds as potential antitumor agents
Relação entre a certificação pela norma NBR ISO 14001 e a ocorrência de penalidades ambientais em organizações do estado de São Paulo
(Universidade Federal de São Carlos, 2016-07-28) Rino, Carlos Alberto Ferreira; Salvador, Nemésio Neves Batista; https://lattes.cnpq.br/9930582531600560; https://lattes.cnpq.br/7281970846784858
This work had as general-purpose search for a relationship between certification by Standard ISO 14001 and the occurrence of environmental penalties in organizations in the São Paulo State. It also had the objective to develop and apply a Penalty Reduction Indicator (PRI) to evaluate quantitatively the effectiveness of environmental management systems in relation to the reduction of penalties and a critical analysis of the accreditation and certification systems in Brazil. First, the INMETRO site, was conducted the survey of companies certified by ISO 14001 in the state of São Paulo. Later, lifting the number of penalties applied by CETESB these certified companies was done from January 2001 to June 2015. From there, we analyzed which companies had reduced the number of penalties after the implementation and certification ISO 14001. It used as intentional sampling criteria the companies that received more than five penalties in the period, thus forming a group of fourteen companies. Through qualitative analysis, on eleven companies verified the benefit of reducing the number of penalties. In four of these companies, the benefit occurred over time. In three companies has not verified the benefit of the reduction in penalties. The quantitative analysis performed by applying the IRP was possible for eleven of the selected companies. The IRP calculated showed that seven of these eleven companies (63.6%) had the indicators acceptable rating ("GREAT" and "GOOD"). Four companies (36.4%) were the indicators classified "REASONABLE" and "BAD", indicating that, for these, the Environmental Management System is not yet consolidated, improvements should occur. IRP was robust and efficient, indicating the importance of quantitative analysis and the use of a numeric indicator to corroborate the results obtained in the qualitative analysis. It is concluded that the implementation and certification of an Environmental Management System according to ISO 14001 can bring benefits to businesses because the implementation of a preventive culture, development of methodologies and procedures for environmental aspects and impacts, actions and responses to control and emergency documents (all items of ISO 14001). These can lead to a reduction in number of penalties. Finally, this study found that for the accreditation system, the activities developed by INMETRO are important to the pursuit of quality of certification bodies and consequently the certification processes. However, it found that this system still has some deficiencies. The paper also pointed out some deficiencies in the certification system, with recommendations for improvements.