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Unicidade para equações dos tipos: Burgers, Kuramoto-Sivashinsky e Schrödinger
(Universidade Federal de São Carlos, 2017-12-15)
Zapata, Miguel Angel Cuayla
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Kondo, Cezar Issao
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https://lattes.cnpq.br/0900348462714778
;
Santos Filho, José Ruidival Soares dos
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https://lattes.cnpq.br/6112529384454347
Based on Carleman's estimates and under certain conditions of linear exponential decay we prove uniqueness for equations of type: Burgers, Kuramoto-Sivashinsky and Schrödinger.
Uma apresentação dos métodos de Pontos Interiores na radioterapia e sua comparação com o método Simplex
(Universidade Federal de São Carlos, 2017-12-15)
Freitas, Paula Renata de Morais Gomes
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Carvalho, Silvia Maria Simões de
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https://lattes.cnpq.br/8244087426759161
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https://lattes.cnpq.br/0040475583715968
This work aims to present the Internal Points Methods and to compare the Simplex Method, when applied in the resolution of problems related to the optimal concentration of radiation in the treatment of cancer through radiotherapy. The optimum concentration is related to the higher intensity of radiation associated with less damage to the vital organs. This dissertation was based on works on radiotherapy treatment, aiming to make a comparison between two methods widely used to find an optimal concentration.
Estratégias competitivas e tecnologia de informação no polo calçadista de Jaú/SP
(Universidade Federal de São Carlos, 2017-12-15)
Moschetto, Danilo Augusto
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Alves Filho, Alceu Gomes
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https://lattes.cnpq.br/7885557554922569
;
https://lattes.cnpq.br/0234923460537082
This thesis aims to investigate how Information Technology (IT) can support the formulation and implementation of competitive strategies in small and medium-sized companies in the footwear hub of Jaú / SP. Technological development in the areas of IT and telecommunications, especially since the end of the 20th century, has resulted in dramatic changes in society and, among the most visible effects, is the increase in communication capacity and access to information. Along with the hardware development, several systems and methods were created and implemented to support and improve various business activities: from simple spreadsheet use in customer tabulation to complete management of activities through systems such as Enterprise Resource Planning (ERP). Despite the development of IT, companies make little use of technology to support the development and deployment of their competitive strategies. Few papers in the literature discuss this relationship of support to competitive strategy, especially in the footwear industry, where literature is scarce. This study was developed in two stages: a survey was carried out, aiming to collect data on the general state of the APL (local productive arrangement) in relation to the producers of footwear and their competitive strategies, and then five case studies were carried out. The results show that companies employ diverse competitive strategies as well have different levels of automation and IT support in their tasks. Although issues related to cost, labor and training are still considered limiting factors in the implementation of support systems, some companies employ IT in the development of differentiated competitive strategies, which gives them better conditions to operate in the market. The main results of this work include, in addition to the discussion of the IT support to competitive strategies of the companies: the presentation of a scenario of the local footwear industry from the survey data, which confirmed some indications from the literature; the creation of a model of IT used by companies that includes their driving elements (legal and industry requirements, administrative complexity and support of the competitive strategy); the theoretical and practical identification of strategic actions supported by IT elements; and the discussion about how IT can help the development of competitive strategies through the support of administrative operations and the creative elements of them.
Adição de resíduo termofixo em matriz de polipropileno reciclado: análise de propriedades térmicas e mecânicas
(Universidade Federal de São Carlos, 2017-12-15)
Prestes Pires, Pamela Galera
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Botaro, Vagner Roberto
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https://lattes.cnpq.br/2907189124654066
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Paiva, Jane Maria Faulstich de
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https://lattes.cnpq.br/7926832511513537
The proper disposal of solid waste has driven studies to enable the use of recycled materials and waste. So, in this work were molded composites using raw materials from industrial waste and evaluated several mechanical and thermal properties of composites developed. As thermoplastic matrix was used recycled polypropylene (PP) and as filler was used the residue containing thermosetting powder from high-pressure laminate manufacture process (HPL) in the proportions 10%, 14%, 20%, 30% and 40% by weight, obtaining the composites. In order to evaluate the mechanical properties of recycled PP and their composites were performed test of tensile, flexural and Charpy impact. In order to evaluate the thermal properties were performed test of softening temperature, thermal deflection temperature, dynamic-mechanical thermal analysis (DMTA), thermal behavior by differential scanning calorimetry (DSC) and degree of crystallinity. In addition, were performed analyzes of density and morphological analysis by scanning electron microscopy (SEM).The elongation, tensile and flexural strength reduced with the addition of the HPL. The flexural modulus did not change until an addition of 20%, however, the stiffness increased with 30% and 40% of HPL which contains thermosetting. The softening temperatures in relation to the recycled PP increased with the addition of 40% of the HPL. In the temperature of thermal deflection the addition of 40% of the residue caused increase when compared to the recycled PP. The presence of thermoset residue reduced tenacity of the recycled matrix from addition of 14% of HPL. The density showed increase from adding 10% of HPL. The storage modulus improved with the addition of filler. There was no change in the melting and crystallization temperature. The degree of crystallinity of recycled matrix increases with increasing amount of HPL present in the composite; and an addition of HPL showed good dispersion in the recycled PP matrix. In general, it is considered that the best results of mechanical properties (flexion and tensile) and thermal properties of composites were obtained with addition of 40% of HPL. So the use of HPL as reinforcing filler in composites is feasible and can be used for example in the manufacture of supermarket boxes, pallets, chairs, internal coating of vehicles and among others.
Eosinófilos como células apresentadoras de antígeno durante a infecção experimental por toxocara canis
(Universidade Federal de São Carlos, 2017-12-15)
Rodolpho, Joice Margareth de Almeida
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Anibal, Fernanda de Freitas
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https://lattes.cnpq.br/4918261968772806
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https://lattes.cnpq.br/4211898266944174
Eosinophils are multifunctional cells that have pro-inflammatory cytotoxic activities and stimulate CD4 + T cells in experimental models of allergy and parasitic infections. Eosinophils, when exposed to antigens are activated and express CD38 / CD69 molecules and exhibit increased expression of the Major Histocompatibility Complex (MHC-II), CD80 and CD86, suggesting their role as atypical cells in the Presentation of Antigens. In the present study, we evaluated the hypothesis that, in addition to professional APCs (monocyte, dendritic and B cell), eosinophils are activated by Toxocara canis antigens and express a range of cell surface markers characteristic of antigen presenting cells. Thus, contributing to the immune responses induced in the experimental model by Visceral Migrans Larva syndrome associated with T. canis infection (VLMS). By means of flow cytometric assays the cell profiles of antigen-presenting cells were evaluated during T. canis experimental infection. Data analysis demonstrated that, during murine T. canis infection, peripheral blood, spleen and bone marrow eosinophils showed regulated expression of CD69 / MHC-II / CD80 / CD86, assuming a role as APC in comparison with the antigen presenting cells. Unlike eosinophils of the spleen and bone marrow, circulating eosinophils showed increased expression of activation markers along with APC-related molecules after T. canis infection. The same activation was not observed for professional APCs in the same compartments. Improved connectivity between eosinophils and T cells in T. canis infected mice in all three compartments (peripheral blood, spleen and bone marrow) also supports the hypothesis that eosinophils may play a role as PCA during T. canis infection. In addition, in vitro stimulation of T. canis antigen resulted in activation and elevation of regulation of APC-related molecules by eosinophils derived from bone marrow. These findings strongly suggest that T. canis infection reshapes eosinophils to act as APCs in this infection and not only as an effector cell in the control of parasitic infection.
Aspectos da docência no processo de apropriação da cultura escolar do curso de licenciatura em Química da UFSCar/Araras
(Universidade Federal de São Carlos, 2017-12-15)
Rinzo, Tiemi
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Furlan, Elaine Gomes Matheus
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https://lattes.cnpq.br/3179865576965852
This monograph aimed to understand aspects of teaching within the context of the appropriation of school culture, as experienced by undergraduate students in the Chemistry program at UFSCar/Araras. The theoretical framework was supported by authors such as Julia, Chervel, Forquin, Viñao Frago, and Perez Gomez, important references when it comes to reflections on school culture, and Tardif, for more specific discussions on teaching knowledge. The final paper adopted qualitative research principles as its investigative premise, also supported by Bogdan and Biklen (1994). The methodological procedure used semi-structured interviews with both beginning and graduating students. The results were described and analyzed under three general categories: student characterizations; the students' trajectories from elementary school to university admission; and university and teacher education. The data allowed us to identify various aspects of teaching that permeate practices, norms, customs, values, expectations, hierarchy, in the information that circulates within the university environment; in short, in the university experience.
Intervenção cirúrgica e tratamento fisioterapêutico no pós-operatório do câncer de mama: efeitos na cinemática escapular, morbidade dos membros superiores e qualidade de vida
(Universidade Federal de São Carlos, 2017-12-15)
Ribeiro, Ivana Leão
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Camargo, Paula Rezende
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https://lattes.cnpq.br/7602596349127054
;
Salvini, Tânia de Fátima
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https://lattes.cnpq.br/4391969032505723
The major dysfunctions of the upper extremity related to postoperative (PO) breast cancer, such as functional limitations and muscle weakness, have been studied. The three-dimensional (3D) scapula movement may be altered in the short and long term, but conclusive studies on this subject are still lacking. Although upper extremity rehabilitation programs are recommended after surgery, the great variability in intervention protocols associated with the lack of specificity of training hinders referral to clinical practice. Thus, the general objectives of this Doctorate project were: to evaluate the 3D scapula movement during both elevation and lowering of the arm of individuals treated by breast cancer surgery and to compare with a healthy and asymptomatic control group for shoulder pain; to evaluate the effectiveness of early physiotherapy interventions in the preservation of upper limb function; to investigate the short-term effects of surgery on kinematics and scapuloumeral rhythm after a physical therapy program in the immediate postoperative period. The thesis gave rise to three studies: 1 - Case-control study of 3D kinematics of the scapula, 2 - Systematic review on physiotherapy in the immediate PO, 3 - A series of cases of the short-term effects of surgery on kinematics and rhythm after a physiotherapy program in the immediate postoperative period. A total of 47 women (Study 1, n = 21 surgery group and n = 21 control group, Study 3, n = 05) participated in this study. The 3D kinematics were collected using superficial electromagnetic sensors during arm movement in the scapular plane, the range of motion (ROM) and shoulder muscle strength were evaluated by a digital inclinometer and manual dynamometer, respectively. Pain intensity, upper limb function, and quality of life were assessed using the Visual Analogue Scale (EVA), Disabilities of the arm, shoulder and hand questionnaire (DASH), 36-item Short Form Health Survey (SF36), respectively. A series of databases were consulted to select the studies relevant to the review, based on the Cochrane recommendations, the PEDro scale was used to verify the methodological quality of the included studies and the GRADE was used to analyze the synthesis of evidence (Study 2). Data from studies 1 and 3 were analyzed according to the comparisons between groups (Study 1) and within groups (Studies 1 and 3), using the SPSS version 21 program and the Cohen d index to calculate the effect size. The main results of study 1 were: lower superior rotation of the scapula (120º), lower ROM and shoulder strength, in addition, high scores of EVA, DASH and SF36 in the surgery group; study 2: moderate level of evidence regarding the efficacy of both isolated and associated ROM exercises to muscle strength training for shoulder ROM gain; study 3: lower upward rotation and more anterior scapula tilt along the arm movement, decrease of the scapulohumeral rhythm, high EVA and DASH scores during the evaluations; After the surgery of the breast cancer functional alterations of the scapular kinematics, ROM and shoulder strength, scapuloumeral rhythm as well as self-report of pain and incapacities are evidenced. Early rehabilitation of the upper limb after surgery should be focused primarily on the preservation of shoulder ROM. Future randomized and controlled clinical trials should investigate the efficacy of physiotherapeutic treatment to restore upper limb function, especially considering periods of long-term treatment.
Entre pesos e medidas : discursos sobre a silhueta feminina no Brasil (1901-2017)
(Universidade Federal de São Carlos, 2017-12-15)
Lopes, Michelle Aparecida Pereira
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Sargentini, Vanice Maria Oliveira
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https://lattes.cnpq.br/1406919572611392
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https://lattes.cnpq.br/4408019951524400
This thesis is part of the analysis of the French discourse, building on the reflection on how, historically, in the media discourse and in its associated domain, the female body was objectified and subjectified, as regards the control of its weight and its measures, receiving different denominations, raising different perceptions and, thus, producing senses and subjectivities. Our research is developed in the light of Michel Foucault, based on an archegenealogical methodology, in which the concept of device impels us to recognize the network in which the discursive and non-discursive practices on the female body, its weight and its measures were constituted / constitute; and looks for ways of analysis in the perspective of the Historical Semiology traced by Jean-Jacques Courtine. From the immense archive on the body, throughout the analysed period, historians have given us clues that the media discourse could be the right cutting: from printed publications from the early 1900s to the online of this 21st century, the sayings about woman, her body and her silhouette, in each age, showed themselves by naming the body of the woman, now supporting patterns, sometimes building them. In the announcements of Modernity, the first exclusively feminine journal - Revista Feminina - associated with the so-called journals considered as current – The Cigarra and FonFon - the woman of the early 20th century, envisioned the possibility of reaching new social positions, however, impelled to control other spheres of herself: the belly and, in sequence, the whole body. From the 1950s, the lifestyle sought by Brazilians was the US lifestyle: many appliances and a lot of ready and industrialized food were consumed, especially in the more affluent classes. At the same time, capitalist consumerism established as one of its enunciative regularities the use of the image of a woman with a long line silhouette in her major advertising campaigns. In addition, magazines such as Manchete, and the newspapers like O Globo discussed the causes of obesity, disseminating in society the medical knowledge built for this pathology. Since the 1990s, the national government has begun to consider the increase in obesity rates among the Brazilian population as a prerogative for the development of other onerous diseases to the State. Therefore, discourses based on biopolitical strategies came into play, so that the responsibility for the control of obesity fell on the subject, thus legitimating an intense vigilance over the body, as we can perceive it in the 21st century: in the statements that circulate in the various print and online media, obesity must be fought by every social body. Therefore, we can say that the control device of the female body, during the period observed by us, has expanded its strategic configuration, from controlling the behaviour to the tight control of weights and measures.
O trabalho formativo do coordenador pedagógico junto aos professores que ensinam matemática
(Universidade Federal de São Carlos, 2017-12-15)
Langona, Neichelli Fabrício
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Gama, Renata Prenstteter
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https://lattes.cnpq.br/4153572041829838
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https://lattes.cnpq.br/6219464742319161
The present study has as general objective to analyze the dimensions and centrality of the work developed by the pedagogical coordinators in the continuing formation in service of teachers who teach mathematics in the initial years of Elementary School in the Municipal Network of education of a city in the interior of the state of. This objective is broken down into three other specific objectives: (i) identify the responsibilities of the pedagogical coordinator; (ii) to select and analyze training proposals developed by the pedagogical coordinators on mathematics teaching; and (iii) seek, together with the pedagogical coordinators, the challenges and possibilities of formative work for the teaching of mathematics. For this, the research was qualitative and interpretative, using as a tool the first stage of the data collection a mixed questionnaire, offered to all the coordinators of the initial years of Elementary School of the municipal network. In the second stage of data collection, used and triangulated three instruments (questionnaire, interview and training projects) of two coordinators. For the analysis of the data we find the theoretical contribution referring to the work of the pedagogical coordinator, the formative work performed by this professional, authors who defend the school as a space of continuous formation, teacher training and about the teacher who teaches mathematics. As a result, we verified that the pedagogical coordinator has four different natures that correspond to the teaching and learning processes, school organization, democratic and participatory environment, and teacher training.
Cognições sobre o passado: avaliação do pensamento contrafactual em grupos específicos
(Universidade Federal de São Carlos, 2017-12-15)
Justino, Florença Lucia Coelho
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Schelini, Patrícia Waltz
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https://lattes.cnpq.br/6185333517392859
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https://lattes.cnpq.br/9103038882479439
Imagining and reasoning about hypothetical possibilities is an exclusively human characteristic and confers on cognition an important status for the study of different themes. The need for studies about imaginative processes is based on the inventive capacity of the human mind and on the flexibility that it must take in the face of the technological evolutions of today's world. Counterfactual thinking is a type of imaginative thinking characterized by mental simulation of alternatives to past events to alter the sequence of events to arrive at a different outcome from what actually occurred. Studies have indicated that this type of cognition is involved in different cognitive processes, such as decision making processes, moral judgments, motivations, inferences that enable behavioral changes and the adaptation of the individual and emotional elaborations. The studies on cognitions about past events in specific groups are necessary since they can give indications of the function that this type of thinking has for each group and also to focus on the different ways that the groups have in perceiving and to modify their thoughts in relation to the lived reality, as well as the consequences of thinking counterfactually to the emotions, cognitions and behaviors of each group from its specific characteristics. This doctoral thesis is organized in the form of three articles. The first one refers to the literature review of the area of counterfactual thinking that aimed to gather, evaluate and systematize the main findings of research on the subject between the years 2005 and 2015. The second article refers to the evaluation of counterfactual thinking in two specific groups: women victims of intrafamily violence and women with indicative of depression and analyzed the modifications from explicit request, called directed counterfactual thoughts. The third and last article deals with the evaluation of counterfactual thoughts elaborated spontaneously and under the choice of pre-defined alternatives.
Devir corpo
(Universidade Federal de São Carlos, 2017-12-17)
Ambrosio, Leticia
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Silva, Carla Regina
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https://lattes.cnpq.br/6417501858864106
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https://lattes.cnpq.br/8433188990022599
;
https://lattes.cnpq.br/8433188990022599
This text, which is presented as a Course Conclusion Paper, intends to gather in its composition a knowledge incorporated over five years while studying undergraduate in Occupational Therapy, at the Federal University of São Carlos - UFSCar. During these years, I looked at three theoretical references outside of Occupational Therapy to try to understand the human body - Nietzsche, Merleau-Ponty and Deleuze-, who will be my interlocutors almost all the time, as they have been in the last five years, as well as other interlocutors. occupational therapists who served as inspiration - Marcus Vinícius Machado de Almeida, Flávia Liberman, Elizabeth MFA Lima, Eliane Dias Castro, Mariângela Quarentei, among others. Lewis Carroll's writings on Alice and Wonderland will be part of this composition, because, through experiences lived by my own body, I found in Alice thousands of intensities, pulsations and identities that fit me for now and serve as an artistic representation of these experiences. Throughout the text, drawings, paintings and photographs will be presented which, like Alice's tale, serve me as an artistic representation, but in addition, they serve me as a representation closer to the reality of my body's experiences. After all, a book without illustrations is not a book, Alice
O Cio da Terra: diálogos entre música caipira e globalização
(Universidade Federal de São Carlos, 2017-12-18)
Pereira, Synclair Antonio Vieira
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Mariano, Neusa de Fátima
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https://lattes.cnpq.br/5003743301847104
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https://lattes.cnpq.br/3973353251484647
Music, sometimes neglected in the human sciences, is one of the ways in which space, Geography’s object of study, can be analyzed, allowing new possibilities of comprehension of the reality. This work, studying the lyrics and the structure of Brazilians music genres caipira and sertanejo, through evolution processes of themselves in time, seeks to understand how music consume and production happens in Brazilian space in face of globalization. Based in the relation between both musical genres, we seek to understand the contradictions between rural and urban space, as well as local and global space.
Efeitos dos agrotóxicos Kraft® 36 EC (abamectina) e Score® 250 EC (difenoconazol), isolados e em misturas, sobre organismos zooplanctônicos
(Universidade Federal de São Carlos, 2017-12-18)
Moreira, Raquel Aparecida
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Daam, Michiel Adriaan
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https://lattes.cnpq.br/5357327697116655
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Rocha, Odete
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https://lattes.cnpq.br/7577441794992601
Toxic effects of the pesticides Kraft® 36 EC (i.a. abamectina) and Score® 250 EC (i.a. difenoconazol), isolated and in mixtures were evaluated on zoplanktonic organisms. Daphnia magna was used as test-organism to evaluate pesticide effects using the biochemical biomarkers cholinesterase (ChE), catalase (CAT) and lipid peroxidation (LPO), besides energy-related parameters (total proteins and lipids) together and energy consumption (EC). Possible effects of agrochemicals on tropical aquatic ecosystems were simulated and evaluated by acute and chronic toxicity tests with surface runoff from soil experimentally contaminated with both agrochemicals. The native cladoceran Macrothrix flabelligera was used as test-organism. Potential risks related to exposure to isolated compounds and their combinations were evaluated through microcosm experiments. A review of literature was performed to analyze the use of rotifers species as test-organisms for pesticide toxicity evaluation in aquatic ecosystems with emphasis on tropical configurations. It was found that there is great potential for using rotifers as test-organisms for toxicity evaluations and risk assessment. An evidence of this potential was a higher sensitivity of native species exposed to fungicides if compared to D. magna. The isolated compounds did not have effects on cholinesterase (ChE) and catalase (CAT), but their mixture induced an increase on these biochemical. Lipid peroxidation (LPO) was induced for D. magna was exposed to the fungicide. Reproductive output was small but protein was not quantitatively affected, but the highest combination of both pesticides resulted increased lipid reserves. Consumed energy was highly affected and stimulated in all treatments for both, isolated compounds and mixtures. For M. flabelligera, tests with mixtures revealed a concentration dependent deviation (DL) by IA model, with antagonism in low and synergism in high mixture concentrations. The microcosms receiving runoff from experimental soil contaminated with individual pesticides did not cause toxicity to the test-organism, however their mixture caused immobility. The microcosm treated by spray drift with both pesticides showed the highest toxicity effects. Our results suggest potential risk of the selected pesticides in environmentally relevant concentrations, especially if occurring together.
Educação ambiental e transformação de espaços urbanos: novas formas de habitar, múltiplas formas de aprender
(Universidade Federal de São Carlos, 2017-12-18)
Alberto, Regiane de Sá
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Oliveira, Haydée Torres de
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https://lattes.cnpq.br/5458113597909705
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https://lattes.cnpq.br/1522488332723318
All over the world today, there are more people living in cities than in the countryside. The accelerated urbanization associated with the socioenvironmental impacts of the capitalist mode of production is presented as one of the main problems of modernity. However, we can highlight in this destabilizing scenario initiatives aimed at reconciling urban environment and nature and the articulation between people in search of better cities to live and live together. Discussing the current environmental crisis requires taking into account actions articulated in the spheres of politics, economics, knowledge production and education, seeking the linkage between the real nature of environmental issues, human activities and educational processes. Critical environmental education can be seen as a possible translator of the language of collectives who bring alternative projects for the construction of a less predatory urban society. The focus of this investigation refers to the educational dimension of social practices of public intervention, admittedly guided by another environmental praxis. This praxis is revealed in the daily work of all those who are included as promoters of this new inhabit in realities of communitarian spaces that are proposed to new ways of working in and with the urban space. The concern that motivated this research is: were these interventions of transformation of urban spaces an environmental education happening in practice? And how do these people educate themselves and others in this group in this reality? In view of these questions, it was intended to understand this environmental educator process of transformation-re-signification-reoccupation of the spaces, from a contextual cut in the communitarian urban gardens that are spread and promote the environmentalization of the São Paulo/SP metropolis. Corresponding to our theoretical-methodological horizon, for this qualitative research, we take the position of participant observation and insert ourselves as participants in the context to be investigated. This point of departure and arrival allowed us a better understanding of the phenomenon (s) that involves (s) the action of humans between themselves and humans in / towards the environment. We conclude that this study focused on the experiences of transformation of urban spaces, with a cut to the context of some initiatives in urban community agriculture in the city of São Paulo/SP, confirms the prerogative of which we learn everywhere and can enrich the field of research in environmental non-school education, which involves efforts not only to look at the institutional and political relationships of educating themselves, but also m qualify its practice from the space in which it takes place. This is an effort that we have achieved by highlighting educational processes in the social practices of transforming public spaces in cities.
Fadiga em peças de madeira para uso estrutural
(Universidade Federal de São Carlos, 2017-12-18)
Carvalho, Johnny Soares de
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Christoforo, André Luis
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https://lattes.cnpq.br/7623383075429186
;
https://lattes.cnpq.br/6710887043385415
The purpose of present study was to create a theoretical model that allowed with security and reliability to obtain, values of strength and stiffness to which the structural element will be submitted throughout its useful life. The effect was studied for strength and stiffness properties, and the modulus of elasticity (EM) and bending strength (fM) were evaluated according to the increasing number of cycles of the fatigue test for the five classes of hardwoods, recommended by NBR 7190/1997. These results allowed to construct a fatigue curve, relating the two variables as a function of the number of cycles (Nc) - construction of the curves E x Ncicles and σ x Ncicles. The fatigue effect was present and pronounced in all resistance classes. A reduction in strength and stiffness properties was observed with increasing loading Nc applied at all frequencies. From the multivariate regression models and the respective determination coefficients, a generic model was obtained for the set involving the five wood species, emphasizing the insertion of the apparent density as an independent variable, which allowed a greater generalization of the use of the adjustments in the estimation of the EM and fM properties, presenting significant determination coefficients.
Caracterização funcional e bioquímica do fator de transcrição rlmA e da interação de PkcA e Hsp90 no fungo Aspergillus fumigatus
(Universidade Federal de São Carlos, 2017-12-18)
Rocha, Marina Campos
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Malavazi, Iran
;
https://lattes.cnpq.br/1569614985704317
;
https://lattes.cnpq.br/9004361100176439
Aspergillus fumigatus is an opportunistic human pathogen that causes systemic infections, including invasive pulmonary aspergillosis in immunocompromised individuals. Survival of this fungus is highly dependent on the cell wall organization and function of its structural components. Cell wall integrity pathway (CWIP) is the primary signaling cascade that controls de novo synthesis of the cell wall. In Sacharomyces cerevisiae, this event depends on the RLM1 transcription factor that contains the MADS-box domain. In this work, we investigated the function of RlmARLM1 in the CWIP of A. fumigatus. We show that the ΔrlmA strain presents an altered cell wall composition, besides defects related to vegetative growth and cell wall integrity in the presence of cell wall stressors agents. Genetic assays indicated that rlmA is positioned downstream of pkcA and mpkA genes in CWIP, and, as a consequence, the loss of rlmA function results in alteration of genes expression of the encoding cell wall related proteins. The transcription factor RlmA positively regulates the phosphorylation of MpkA, which is induced in both protein and transcriptional levels during cell wall stress. rlmA is also involved in tolerance to oxidative stress, whereas the main genes that regulate tolerance to reactive oxygen species had their expression reduced in the ΔrlmA mutant. In addition, ΔrlmA strain presents attenuated virulence in a murine model of invasive pulmonary aspergillosis and induced increased secretion of TNF-α. There was a higher rate of conidia phagocytosis of the mutant ΔrlmA in comparison to the wild type. The ΔrlmA mutant exhibits reduced asexual sporulation, and regulates transcription of the major transcription factors involved in conidiogenesis in Aspergillus ssp., i.e. brlA and abaA. RlmA is also important in the production of secondary metabolites, including gliotoxin and fumiquinazoline (Fq) C, and positively regulates the transcription of the genes cluster responsible for Fq biosynthesis. A biological characterization showed that activity of FqC increase the production of the inflammatory cytokines TNF-α, IL-6, and pore formation in the plasma membrane, suggesting that this is a defense mechanism against other microorganisms or soil predators. Additionally, the role of the second transcription factor (SebA) in the production of FqC in A. fumigatus was reported. We have shown that maintenance of cell wall integrity is associated with thermotolerance in A. fumigatus, and the Hsp90, one of the main chaperone involved in the heat shock response, physically interacts with PkcA, MpkA, and RlmA. Furthermore, partial or total loss of function of these genes results in altered expression of the principal genes related to heat shock response in A. fumigatus. Additionally, the proteins MpkA and Hsp90 had their structure partially characterized. Overall results suggest that RlmA works as a transcription factor associated with the A. fumigatus CWIP acting downstream of the PkcA-MpkA signaling and regulating the response to several stresses caused to the fungal cell which emphasizes the importance of this pathway in the virulence and pathogenicity of this fungus.
Compósitos de polipropileno com fibra e nanofibrilas celulósicas preparados com auxílio da pulverização por cisalhamento no estado sólido - S3P
(Universidade Federal de São Carlos, 2017-12-18)
Oliveira, Gean Henrique Marcatto de
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Canto, Leonardo Bresciani
;
https://lattes.cnpq.br/7287108960864123
;
Lucas, Alessandra de Almeida
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https://lattes.cnpq.br/9754332336954137
In this study, polypropylene (PP) compounds were prepared using three types of cellulose fiber, pulp fiber (CF), cellulose nanofibrils (CNF) and lignocellulosic nanofibrils (LCNF) extracted from Eucalyptus grandis. The cellulosic fiber content of the compounds ranged from 10 to 30% by weight. Polypropylene grafted with maleic anhydride (PP-g-MAH) was also used as a compatibilizer. The solid state shear pulverization technique (S3P) was employed with the aim of improving the blending and dispersion of fibers in the matrix and a comparison with the compounds containing freeze dried nanofibrils (FD) was performed. X-ray diffraction (XRD) was used to measure the crystallinity index of cellulosic fibers, as well as scanning electron microscopy (SEM) was used for morphological characterization. With the aid of the modules processed by S3P, the PP / FC 70/30 sample presented results in the best mechanical tensile results, with a 100% increase in tensile strength and 75% in Young's modulus in relation to PP pure. Agglomerated was observed by scanning electron microscope with dimensions around 200 μm in the composites with nanofibrils (NFC and NFLC). Formulas with 30% by mass of cellulosic fibers- FD (FC, NFC and NFLC) were processed directly by solid state extrusion (MSE) for comparison with an S3P technique. The composite PP / FC 70/30 was released by S3P was released at 10% over time and the impact at the same time was 15% lower than the composite processed directly by extrusion in the molten state, while samples containing nanofibrils (NFC and NFLC) their independent traction and impact properties are not subjected to the S3P technique. The S3P technique is viable in the preparation of composites with the cellulosic fibers in the presence of water, keeping the mechanical and morphological properties similar to the composites prepared with lyophilized nanofibrils.
O Ministério da Educação (MEC) na Educação de Jovens e Adultos (EJA) : linguagem e discurso
(Universidade Federal de São Carlos, 2017-12-18)
Teixeira, Odinei Inacio
;
Abreu, Ana Silvia Couto de
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https://lattes.cnpq.br/7461517670259813
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https://lattes.cnpq.br/0720999467723577
In this research, we aim to interpret the construction of meanings through the curricular guidelines published in the Curriculum Proposals, in the Notebooks about the EJA and in the Advertising Campaign of 2016, through these officials discourses and the interpretation of their representations on the EJA (Young People and Adults), because "the sense, for AD, is not already fixed a priori as the essence of the words, nor can it be any: there is a historical determination. Still one in-between. (ORLANDI, 2012, p. 27). Thus, the political discourse of the MEC (Ministry of Education) for the EJA constitutes subsidies for the development of educational projects that directly affect this public with the effectiveness or the non-effectiveness of these educational public policies and their respective social consequences. This research is based on the theoretical framework of Discourse Analysis postulated by Pêcheux (1988; 1990) and also on the theoretical aspects postulated by Orlandi (2007a; 2007b; 2007c; 2012). We understand that the ideology of government permeates the MEC and is manifested in the Curriculum Proposals for the EJA, in the Notebooks and in the Advertising Campaign, and according to this movement of meanings, the government ends up perpetuating its dominant ideology with the society, with the subjects and , consequently, in relation to public educational policies. In this way, we have the presence of memory in relation to discourse, that is, interdiscourse. Given the choice of our research object, we adopted the following way from a qualitative research perspective in order to select the statements and images to interpretation, analysis and discussion: a) Visits to the MEC website, specifically, SECADI - Secretariat for Continuing Education, Literacy, Diversity and Inclusion - for the selection of documents, especially curricular guidelines about the EJA; b) Selection of the Curriculum Proposals for the EJA and the notebooks Working with the EJA; c) Visits to MEC profiles on social networks, especially on YouTube and Facebook for the selection of the Advertising Campaign movie (2016) with a recent approach to the EJA; d) Selection and organization of Proposals and Notebooks statements, and of the images obtained through screenshots from the Advertising Campaign for the construction of the discursive sequences in accordance with the selected themes; e) Analysis and interpretation of the discursive sequences supported in our theoretical framework, in order to understand the concepts that belong to the discursive phenomena under study. Our analyzes have made possible to understand that the illusion that government discourse constitutes a stable and closed space for interpretation and its construction of meanings, closes the spaces destined to the profusion of meanings different from those established by the enunciator, and which prevent us from seeing the need of public policies that meet the needs of young and adults learners. In accordance with this position, there is the interdiction of meanings and the construction of the illusion that society, as well as the governmental discourse on the EJA, is also stable and homogeneous. However, the rupture with stability and openness to interpretation show the need for the frequent elaboration of educational public policies that, in fact, meet the needs of the subjects not schooled at the regular age, allowing them a greater autonomy that could potentially be due to schooling.
Proposta de um modelo para refeições digitais
(Universidade Federal de São Carlos, 2017-12-18)
Leandro, Sandra Maria
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Pessoa, José Dalton Cruz
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https://lattes.cnpq.br/4212703554284544
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https://lattes.cnpq.br/2434970483997012
Innovation is an imperative demand in the food sector, since the segment needs to respond quickly or even anticipate the new demands of consumers. Additive manufacturing food is a disruptive approach that allows to create personalized foods, introducing convenience and practicality. The problem that motivates this research is to answer the following question: "how to define a digital food?". Digital foods correspond to a field of knowledge under construction in the scientific literature. Consequently there is a need to create terminologies and a model to systematize some concepts. In order to fill this gap, this thesis proposes a digital food model that includes the sensorial, organoleptic and nutritional specifications of the individual. Some common cooking materials are also analyzed to identify the possibilities and limitations of solid freeform fabrication (SFF). From these analyzes is proposed a printer for foods and an interface for mobile devices, tablets and smartphones, able to simulate the steps that define and precede the customization of a digital food. The evaluation of results indicates that additive manufacture food can exert significant influence on individuals by introducing new designs, textures, flavor, colors and personalized eating experiences. Digital foods will not solve all nutritional and does not replace the existing food processing techniques, but tend to complement the daily intake.
Trajetórias acadêmicas de pessoas com deficiência no ensino superior brasileiro
(Universidade Federal de São Carlos, 2017-12-18)
Morgado, Liz Amaral Saraiva
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Orlando, Rosimeire Maria
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https://lattes.cnpq.br/4254571422608459
;
https://lattes.cnpq.br/4792151711883696
The research had as main theme the access and permanence of students with disabilities in Higher Education Institutions (HEI) as well as the investigation of how the students' academic trajectory and the impact within the institutions occur. The objects were to analyze the educational trajectory of people with disabilities in Brazilian Higher Education; to describe the conditions of access and permanence of persons with disabilities in Brazilian Higher Education; to indicate, within the academic trajectory, the conflicts in the political construction of accessibility; to verify the restructurings caused by the policies related to the access of people with disabilities in Brazilian Higher Education. The study was of qualitative character. The data were collected through semi-structured interviews. Participated in the research nine subjects who were contacted and selected previously. The data were analyzed and divided into three categories: i) access and permanence in Higher Education with four subcategories: selective process, affirmative actions, sports and supports; ii) Restructuring of Higher Education Institutions with the presence of people with disabilities and iii) accessibility groups. The results of the research demonstrated a great necessity to ensure adequate educational care for the access and permanence of students with disabilities at the University. The institution needs to promote more directive policies for the inclusion of the person with disabilities in the academic environment.